Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.3281 | 1 | 0.5 |
Echinococcus granulosus | insulin receptor | 0.0058 | 0.004 | 0.004 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.0419 | 0.0419 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.3281 | 1 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.004 | 0.004 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.0419 | 0.0419 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0045 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.004 | 0.004 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0162 | 0.0162 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0158 | 0.0158 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus multilocularis | 0.3281 | 1 | 1 | |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.0162 | 0.0162 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.3281 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.004 | 0.004 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0058 | 0.004 | 0.004 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.3281 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0045 | 0 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Echinococcus multilocularis | 0.0056 | 0.0035 | 0.0035 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.004 | 0.004 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0162 | 0.0162 |
Mycobacterium ulcerans | hypothetical protein | 0.1432 | 0.4288 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.3281 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.0419 | 0.0419 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.3281 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0158 | 0.0158 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.0419 | 0.0419 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.1432 | 0.4288 | 0.5 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0058 | 0.004 | 0.004 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.3281 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.004 | 0.004 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.3281 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.0162 | 0.0162 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.0419 | 0.0419 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0158 | 0.0158 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7300 nM | Inhibition of partially purified EGFR tyrosine kinase from human A431 cells | ChEMBL. | 17869510 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.