Detailed information for compound 459273

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 409.564 | Formula: C25H35N3O2
  • H donors: 0 H acceptors: 2 LogP: 5.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(CC1CCCCC1)(C#Cc1ncnc2c1cc(OC)c(c2)OC)C)CC
  • InChi: 1S/C25H35N3O2/c1-6-28(7-2)25(3,17-19-11-9-8-10-12-19)14-13-21-20-15-23(29-4)24(30-5)16-22(20)27-18-26-21/h15-16,18-19H,6-12,17H2,1-5H3
  • InChiKey: YVFYLFQVQFEOSK-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0213 0.0311 0.043
Mycobacterium ulcerans hypothetical protein 0.0213 0.0311 0.0603
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0087 0.0104 0.0104
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0107 0.0135 0.0219
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.3137 0.5144 1
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0823 0.132 0.132
Echinococcus granulosus calpain 0.0107 0.0135 0.0134
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0523 0.0824 0.0824
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0523 0.0824 0.1476
Schistosoma mansoni calpain C (C02 family) 0.0107 0.0135 0.0132
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0213 0.0311 0.0603
Echinococcus granulosus calpain A 0.0107 0.0135 0.0134
Schistosoma mansoni aldehyde dehydrogenase 0.0087 0.0104 0.0101
Trypanosoma cruzi CYC2-like cyclin, putative 0.0088 0.0105 0.017
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0523 0.0824 0.0821
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0213 0.0311 0.0308
Entamoeba histolytica protein kinase, putative 0.0134 0.018 0.0327
Giardia lamblia Kinase, CMGC CDK 0.0129 0.0172 0.0328
Giardia lamblia Hypothetical protein 0.0052 0.0045 0.0081
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.2314 0.3784 1
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.2314 0.3784 0.6127
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0213 0.0311 0.0319
Leishmania major hypothetical protein, conserved 0.0032 0.0012 0.0012
Trichomonas vaginalis cyclin B, putative 0.0088 0.0105 0.0198
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0213 0.0311 0.0603
Leishmania major acetyl-CoA carboxylase, putative 0.6075 1 1
Schistosoma mansoni tyrosine kinase 0.018 0.0257 0.0254
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0032 0.0012 0.002
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0823 0.132 0.3333
Loa Loa (eye worm) hypothetical protein 0.0179 0.0255 0.0261
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0032 0.0012 0.002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.008 0.0076
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.0257 0.0263
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0032 0.0012 0.002
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0374 0.0578 0.0574
Brugia malayi calpain 5 0.0032 0.0012 0.0009
Echinococcus multilocularis cyclins 0.0052 0.0045 0.0042
Echinococcus multilocularis cyclins 0.0052 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0176 0.025 0.0256
Loa Loa (eye worm) hypothetical protein 0.0208 0.0303 0.0311
Onchocerca volvulus 0.0176 0.025 0.805
Schistosoma mansoni calpain-7 (C02 family) 0.0107 0.0135 0.0132
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0159 0.0223 0.0427
Trypanosoma brucei unspecified product 0.1521 0.2474 0.2474
Trypanosoma brucei protein kinase, putative 0.0143 0.0196 0.0196
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.6075 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.018 0.0177
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0823 0.132 0.3333
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0213 0.0311 0.0311
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0148 0.0203 0.02
Giardia lamblia Fructose-bisphosphate aldolase 0.0159 0.0223 0.0427
Echinococcus multilocularis cyclin b3 0.0052 0.0045 0.0042
Trypanosoma cruzi cyclin, putative 0.0088 0.0105 0.017
Loa Loa (eye worm) hypothetical protein 0.0088 0.0105 0.0106
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.3137 0.5144 0.5144
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.3137 0.5144 0.712
Trypanosoma cruzi acetyl-CoA carboxylase 0.3761 0.6175 1
Trypanosoma brucei calpain, putative 0.0032 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0212 0.0309 0.0317
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0143 0.0196 0.0192
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0823 0.132 0.1319
Echinococcus multilocularis cyclins 0.0052 0.0045 0.0042
Trypanosoma brucei calpain, putative 0.0032 0.0012 0.0012
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.3137 0.5144 1
Trichomonas vaginalis set domain proteins, putative 0.0212 0.031 0.0596
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0134 0.018 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0012 0.0018
Giardia lamblia Cyclin A 0.0052 0.0045 0.0081
Echinococcus multilocularis survival motor neuron protein 1 0.0212 0.0309 0.0306
Loa Loa (eye worm) hypothetical protein 0.0213 0.0311 0.0319
Toxoplasma gondii hypothetical protein 0.0032 0.0012 0.0011
Plasmodium falciparum protein kinase 5 0.0129 0.0172 0.0221
Loa Loa (eye worm) calpain 0.0107 0.0135 0.0137
Toxoplasma gondii hypothetical protein 0.0039 0.0024 0.0023
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0032 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0043 0.0031 0.0027
Trypanosoma cruzi cyclin, putative 0.0088 0.0105 0.017
Echinococcus multilocularis calpain A 0.0304 0.0461 0.0458
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0374 0.0578 0.0575
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0213 0.0311 0.0308
Schistosoma mansoni calpain (C02 family) 0.0107 0.0135 0.0132
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0087 0.0104 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0172 0.0169
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0143 0.0196 0.0192
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.3137 0.5144 0.833
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0148 0.0203 0.02
Echinococcus multilocularis cyclin B3 1 0.0052 0.0045 0.0042
Trichomonas vaginalis cyclin D, putative 0.0052 0.0045 0.0081
Loa Loa (eye worm) calpain D 0.0032 0.0012 0.0009
Trypanosoma brucei hypothetical protein 0.0032 0.0012 0.0012
Brugia malayi calpain 7 0.0107 0.0135 0.0137
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0213 0.0311 0.0308
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.2314 0.3784 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0012 0.0018
Trypanosoma brucei RNA helicase, putative 0.0039 0.0024 0.0024
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0213 0.0311 0.0311
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0213 0.0311 0.0319
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Brugia malayi Protein kinase domain containing protein 0.0129 0.0172 0.0175
Trichomonas vaginalis cyclin B, putative 0.0088 0.0105 0.0198
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.3137 0.5144 0.833
Schistosoma mansoni tyrosine kinase 0.0058 0.0054 0.0051
Entamoeba histolytica cyclin, putative 0.0052 0.0045 0.0064
Giardia lamblia G2/mitotic-specific cyclin B 0.0088 0.0105 0.0198
Echinococcus granulosus cyclin dependent kinase 0.0129 0.0172 0.017
Trypanosoma brucei acetyl-CoA carboxylase 0.6075 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0196 0.0374
Entamoeba histolytica cell division protein kinase 2, putative 0.0129 0.0172 0.0311
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0213 0.0311 0.0311
Echinococcus multilocularis calpain 7 (C02 family) 0.0107 0.0135 0.0132
Trypanosoma brucei Calpain-like protein 1.2 0.0032 0.0012 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0172 0.0328
Leishmania major calpain family cysteine protease-like protein 0.0032 0.0012 0.0012
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0213 0.0311 0.0603
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0213 0.0311 0.0308
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0032 0.0012 0.0012
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0107 0.0135 0.0135
Schistosoma mansoni tyrosine kinase 0.0096 0.0118 0.0114
Loa Loa (eye worm) hypothetical protein 0.025 0.0373 0.0384
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0159 0.0223 0.0427
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.2314 0.3784 0.6127
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0179 0.0255 0.0261
Treponema pallidum pyruvate carboxylase subunit B 0.0213 0.0311 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.002
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.002
Trypanosoma cruzi cdc2-related kinase 3 0.0129 0.0172 0.0278
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0159 0.0223 0.0427
Brugia malayi RNA recognition motif domain containing protein 0.0057 0.0053 0.0051
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.3137 0.5144 0.5143
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0032 0.0012 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0159 0.0223 0.0427
Entamoeba histolytica protein kinase, putative 0.0134 0.018 0.0327
Loa Loa (eye worm) hypothetical protein 0.0125 0.0166 0.0168
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Schistosoma mansoni tyrosine kinase 0.0096 0.0118 0.0114
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0057 0.0053 0.0052
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0823 0.132 0.132
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0107 0.0135 0.0219
Brugia malayi hypothetical protein 0.0068 0.0072 0.0071
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0823 0.132 0.2905
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.002
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0213 0.0311 0.0414
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0027 0.0004 0.0003
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.0257 0.0254
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0107 0.0135 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.002
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0032 0.0012 0.002
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0172 0.0328
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0213 0.0311 0.0308
Giardia lamblia Kinase, CMGC GSK 0.0143 0.0196 0.0374
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0032 0.0012 0.002
Echinococcus multilocularis cyclin dependent kinase 5 0.0129 0.0172 0.0169
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0087 0.0104 0.0102
Toxoplasma gondii pyruvate carboxylase 0.2314 0.3784 0.3783
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0213 0.0311 0.0309
Brugia malayi cathepsin B-like cysteine proteinase 0.0073 0.008 0.0079
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.137 0.2223 0.5777
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0134 0.018 0.0183
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0107 0.0135 0.0219
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.3137 0.5144 0.7115
Loa Loa (eye worm) calpain 5 0.0075 0.0083 0.0082
Loa Loa (eye worm) calpain family protein 1 0.0208 0.0303 0.0311
Mycobacterium ulcerans aldehyde dehydrogenase 0.0087 0.0104 0.0043
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0823 0.132 0.3333
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.4396 0.7225 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0159 0.0223 0.0427
Entamoeba histolytica cyclin family protein 0.0052 0.0045 0.0064
Entamoeba histolytica protein kinase domain containing protein 0.0143 0.0196 0.0357
Loa Loa (eye worm) TAR-binding protein 0.0057 0.0053 0.0052
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0823 0.132 0.3233
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0213 0.0311 0.0603
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0032 0.0012 0.002
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0052 0.0045 0.0042
Trichomonas vaginalis cyclins, putative 0.0088 0.0105 0.0198
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0129 0.0172 0.0175
Leishmania major carbamoyl-phosphate synthase, putative 0.0523 0.0824 0.0824
Echinococcus granulosus survival motor neuron protein 1 0.0212 0.0309 0.0307
Schistosoma mansoni calpain-7 (C02 family) 0.0107 0.0135 0.0132
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.2314 0.3784 0.3784
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0213 0.0311 0.0504
Entamoeba histolytica protein kinase, putative 0.0143 0.0196 0.0357
Trypanosoma brucei mitotic cyclin 6 0.0088 0.0105 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0053 0.005
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.3137 0.5144 1
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0021
Brugia malayi Carboxyl transferase domain containing protein 0.5862 0.9648 1
Trichomonas vaginalis calpain, putative 0.0032 0.0012 0.0018
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Entamoeba histolytica acetyl-coA carboxylase, putative 0.1036 0.1672 0.3233
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0012 0.0018
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0107 0.0135 0.0219
Echinococcus granulosus cyclins 0.0052 0.0045 0.0043
Toxoplasma gondii carbamoylphosphate synthetase 0.0523 0.0824 0.0823
Trypanosoma brucei cysteine peptidase C (CPC) 0.0027 0.0003 0.0003
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0107 0.0135 0.0135
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0032 0.0012 0.002
Echinococcus multilocularis 0.0056 0.0051 0.0048
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0143 0.0196 0.02
Echinococcus multilocularis calpain family protein 1, d 0.0208 0.0303 0.03
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0213 0.0311 0.031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0159 0.0223 0.0427
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0303 0.046 0.0459
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.3137 0.5144 0.533
Brugia malayi calpain D 0.0032 0.0012 0.0009
Echinococcus multilocularis insulin receptor 0.0058 0.0054 0.0051
Echinococcus granulosus cyclin dependent kinase 1 0.0129 0.0172 0.017
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0213 0.0311 0.0414
Schistosoma mansoni tyrosine kinase 0.0058 0.0054 0.0051
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.0257 0.0263
Trichomonas vaginalis cyclin A, putative 0.0088 0.0105 0.0198
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0823 0.132 0.3333
Trypanosoma cruzi cdc2-related kinase 3 0.0129 0.0172 0.0278
Echinococcus multilocularis calpain 5 0.0107 0.0135 0.0132
Brugia malayi hypothetical protein 0.0212 0.0309 0.0317
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0053 0.005
Leishmania major hypothetical protein, unknown function 0.0032 0.0012 0.0012
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0823 0.132 0.3333
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0032 0.0012 0.002
Loa Loa (eye worm) RNA binding protein 0.0057 0.0053 0.0052
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0213 0.0311 0.0311
Brugia malayi hypothetical protein 0.0179 0.0255 0.0261
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0012 0.0018
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0143 0.0196 0.0317
Schistosoma mansoni survival motor neuron protein 0.0043 0.0031 0.0027
Brugia malayi cell division control protein 2 homolog 0.0129 0.0172 0.0175
Brugia malayi Cyclin, N-terminal domain containing protein 0.0088 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0282 0.0426 0.0438
Leishmania major calpain protease-like protein 0.0032 0.0012 0.0012
Plasmodium falciparum carbamoyl phosphate synthetase 0.0523 0.0824 0.1125
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0213 0.0311 0.0504
Trichomonas vaginalis cyclin B, putative 0.0052 0.0045 0.0081
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.2314 0.3784 1
Echinococcus granulosus cyclins 0.0052 0.0045 0.0043
Echinococcus multilocularis dual specificity 0.0134 0.018 0.0177
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0012 0.0018
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0107 0.0135 0.0219
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0374 0.0578 0.0576
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.0054 0.0053
Leishmania major carboxylase, putative 0.2314 0.3784 0.3784
Trypanosoma brucei cdc2-related kinase 3 0.0129 0.0172 0.0172
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0213 0.0311 0.0308
Echinococcus granulosus cyclin dependent kinase 5 0.0129 0.0172 0.017
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.0119 0.0117
Brugia malayi Protein kinase domain containing protein 0.0058 0.0054 0.0053
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0523 0.0824 0.114
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0196 0.0374
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.6075 1 1
Trichomonas vaginalis cyclin D, putative 0.0052 0.0045 0.0081
Echinococcus granulosus cyclins 0.0052 0.0045 0.0043
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.2314 0.3784 1
Echinococcus granulosus insulin receptor 0.0058 0.0054 0.0053
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0823 0.132 0.3333
Echinococcus granulosus calpain A 0.0304 0.0461 0.046
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0172 0.0328
Trichomonas vaginalis hypothetical protein 0.0032 0.0012 0.0018
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0129 0.0172 0.0175
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0523 0.0824 0.1991
Trypanosoma brucei Calpain-like protein 2 0.0032 0.0012 0.0012
Entamoeba histolytica cell division protein kinase 2, putative 0.0129 0.0172 0.0311
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0027 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0032 0.0012 0.0009
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0088 0.0105 0.0105
Chlamydia trachomatis biotin carboxylase 0.2101 0.3432 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0045 0.0081
Trypanosoma brucei antigen, putative 0.0107 0.0135 0.0135
Brugia malayi TAR-binding protein 0.0057 0.0053 0.0051
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0213 0.0311 0.0311
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.2314 0.3784 0.3782
Trichomonas vaginalis cyclins, putative 0.0088 0.0105 0.0198
Echinococcus multilocularis cathepsin b 0.0073 0.008 0.0076
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0213 0.0311 0.031
Echinococcus multilocularis Biotin lipoyl attachment 0.0213 0.0311 0.0308
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Trypanosoma brucei cysteine peptidase, putative 0.0032 0.0012 0.0012
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0823 0.132 0.2137
Plasmodium vivax protein kinase Crk2 0.0129 0.0172 0.0238
Brugia malayi RNA binding protein 0.0057 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0036 0.0019 0.0017
Entamoeba histolytica protein kinase domain containing protein 0.0134 0.018 0.0327
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0105 0.0132 0.0119
Toxoplasma gondii aldehyde dehydrogenase 0.0087 0.0104 0.0103
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0143 0.0196 0.0194
Trypanosoma brucei Calpain-like protein CALP1.3 0.0032 0.0012 0.0012
Schistosoma mansoni acetyl-CoA carboxylase 0.6075 1 1
Echinococcus multilocularis 0.3137 0.5144 0.5143
Onchocerca volvulus 0.0143 0.0196 0.6275
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.3137 0.5144 1
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.2314 0.3784 1
Onchocerca volvulus 0.0212 0.031 1
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0823 0.132 0.3333
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0213 0.0311 0.0504
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0107 0.0135 0.0219
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0129 0.0172 0.0175
Brugia malayi calpain family protein 1 0.0282 0.0426 0.0438
Loa Loa (eye worm) hypothetical protein 0.0073 0.008 0.0079
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0823 0.132 0.3333
Echinococcus granulosus cyclin B3 1 0.0052 0.0045 0.0043
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Brugia malayi protein-S isoprenylcysteine O-methyltransferase, putative 0.3137 0.5144 0.533
Echinococcus multilocularis hypothetical protein 0.0107 0.0135 0.0132
Brugia malayi Pre-SET motif family protein 0.0186 0.0267 0.0273
Echinococcus granulosus calpain 7 C02 family 0.0107 0.0135 0.0134
Schistosoma mansoni pyruvate carboxylase 0.2314 0.3784 0.3782
Echinococcus multilocularis cyclins 0.0052 0.0045 0.0042
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0143 0.0196 0.0195
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.1036 0.1672 0.3245
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0172 0.0169
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0523 0.0824 0.0821
Trypanosoma brucei kinesin, putative 0.0075 0.0083 0.0083
Plasmodium falciparum cyclin 0.0052 0.0045 0.0046
Schistosoma mansoni tyrosine kinase 0.0097 0.0119 0.0116
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0213 0.0311 0.0504
Mycobacterium ulcerans aldehyde dehydrogenase 0.0087 0.0104 0.0043
Leishmania major kinesin, putative 0.0075 0.0083 0.0083
Loa Loa (eye worm) calpain family protein 1 0.0282 0.0426 0.0438
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0129 0.0172 0.0172
Trichomonas vaginalis cyclin B, putative 0.0088 0.0105 0.0198
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0143 0.0196 0.0196
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.3137 0.5144 1
Onchocerca volvulus 0.0043 0.0031 0.0888
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.2314 0.3784 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0148 0.0203 0.0208
Echinococcus granulosus leukotriene A 4 hydrolase 0.0148 0.0203 0.0202
Entamoeba histolytica calpain large subunit domain III containing protein 0.0075 0.0083 0.0137
Trypanosoma cruzi cdc2-related kinase 1 0.0129 0.0172 0.0278
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0107 0.0135 0.0135
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0186 0.0267 0.0274
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.002
Trypanosoma cruzi cdc2-related kinase 1 0.0129 0.0172 0.0278
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0087 0.0104 0.01
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Trichomonas vaginalis calpain, putative 0.0032 0.0012 0.0018
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0107 0.0135 0.0135
Trichomonas vaginalis cyclin B, putative 0.0088 0.0105 0.0198
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0213 0.0311 0.0311
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.2314 0.3784 0.3783
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0159 0.0223 0.0427
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0134 0.018 0.0292
Trichomonas vaginalis cyclins, putative 0.0088 0.0105 0.0198
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.2314 0.3784 0.3784
Loa Loa (eye worm) hypothetical protein 0.013 0.0174 0.0177
Echinococcus multilocularis cathepsin b 0.0073 0.008 0.0076
Schistosoma mansoni aldehyde dehydrogenase 0.0087 0.0104 0.0101
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.002
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.0119 0.0117
Echinococcus granulosus Biotin lipoyl attachment 0.0213 0.0311 0.0309
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0213 0.0311 0.0603
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0053 0.005
Brugia malayi Cyclin, N-terminal domain containing protein 0.0088 0.0105 0.0105
Echinococcus multilocularis cyclins 0.0052 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0213 0.0311 0.0319
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.2314 0.3784 0.3784
Loa Loa (eye worm) hypothetical protein 0.013 0.0174 0.0177
Echinococcus granulosus cyclin B 0.0088 0.0105 0.0103
Trichomonas vaginalis calpain, putative 0.0032 0.0012 0.0018
Brugia malayi calpain 5 0.0075 0.0083 0.0082
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0107 0.0135 0.0219
Plasmodium vivax calpain, putative 0.0107 0.0135 0.0187
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0012 0.0018
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0303 0.046 0.0457
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0129 0.0172 0.0172
Schistosoma mansoni tyrosine kinase 0.0096 0.0118 0.0114
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0823 0.132 0.1318
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0523 0.0824 0.1334
Echinococcus multilocularis cyclin B 0.0088 0.0105 0.0102
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0823 0.132 0.2137
Brugia malayi intracellular kinase 0.0143 0.0196 0.0199
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0213 0.0311 0.0311
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0213 0.0311 0.0414
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.0054 0.0051
Giardia lamblia Kinase, CMGC CDK 0.0129 0.0172 0.0328
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.002
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0213 0.0311 0.0309
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0213 0.0311 0.0504
Plasmodium vivax glycogen synthase kinase 3, putative 0.0143 0.0196 0.0271
Trypanosoma cruzi kinesin, putative 0.0075 0.0083 0.0134
Trypanosoma brucei cdc2-related kinase 1 0.0129 0.0172 0.0172
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.0088 0.0105 0.0106
Plasmodium vivax SET domain protein, putative 0.0027 0.0004 0.0005
Schistosoma mansoni tyrosine kinase 0.0097 0.0119 0.0116
Giardia lamblia Kinase, CMGC GSK 0.0143 0.0196 0.0374
Echinococcus multilocularis cyclins 0.0052 0.0045 0.0042
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0129 0.0172 0.017
Loa Loa (eye worm) hypothetical protein 0.0213 0.0311 0.0319
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0107 0.0135 0.0219
Schistosoma mansoni cyclin B3 0.0052 0.0045 0.0042
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0134 0.018 0.018
Onchocerca volvulus 0.0088 0.0105 0.3318
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.3137 0.5144 0.5144
Echinococcus multilocularis cyclins 0.0052 0.0045 0.0042
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.002
Trypanosoma cruzi kinesin, putative 0.0075 0.0083 0.0134
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0129 0.0172 0.0171
Trypanosoma cruzi cyclin 6, putative 0.0088 0.0105 0.017
Echinococcus multilocularis tar DNA binding protein 0.0057 0.0053 0.005
Trypanosoma brucei calpain-like protein, putative 0.0107 0.0135 0.0135
Echinococcus granulosus cyclin b3 0.0052 0.0045 0.0043
Trypanosoma brucei calpain-like protein, putative 0.0107 0.0135 0.0135
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0823 0.132 0.132
Trichomonas vaginalis cyclins, putative 0.0088 0.0105 0.0198
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.2314 0.3784 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Plasmodium falciparum glycogen synthase kinase 3 0.0143 0.0196 0.0254
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.3137 0.5144 1
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0213 0.0311 0.031
Echinococcus granulosus cyclins 0.0052 0.0045 0.0043
Brugia malayi calpain family protein 1 0.0282 0.0426 0.0438
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.3137 0.5144 0.5143
Schistosoma mansoni calpain-2 (C02 family) 0.0032 0.0012 0.0009
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0032 0.0012 0.0012
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0213 0.0311 0.0311
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0107 0.0135 0.0219
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0523 0.0824 0.1334
Entamoeba histolytica protein kinase domain containing protein 0.0143 0.0196 0.0357
Trypanosoma cruzi conserved protein 0.0032 0.0012 0.002
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.6075 1 1
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0823 0.132 0.2137
Entamoeba histolytica hypothetical protein 0.0134 0.018 0.0327
Trichomonas vaginalis cyclin B3, putative 0.0052 0.0045 0.0081
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0043 0.0031 0.0028
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0073 0.008 0.0129
Loa Loa (eye worm) cyclin domain-containing protein 0.0052 0.0045 0.0043
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0073 0.008 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0012 0.0018
Entamoeba histolytica protein kinase, putative 0.0078 0.0089 0.0149
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0726 0.1159 0.1156
Mycobacterium ulcerans epoxide hydrolase EphA 0.0105 0.0132 0.0119
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.3137 0.5144 0.5144
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.008 0.0076
Echinococcus multilocularis cyclin dependent kinase 1 0.0129 0.0172 0.0169
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0159 0.0223 0.041
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0213 0.0311 0.031
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0143 0.0196 0.02
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.2314 0.3784 0.3782
Echinococcus granulosus cyclins 0.0052 0.0045 0.0043
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0058 0.0054 0.0053
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0823 0.132 0.3333
Schistosoma mansoni aspartate carbamoyltransferase 0.0523 0.0824 0.0821
Echinococcus granulosus cathepsin b 0.0073 0.008 0.0078
Trypanosoma brucei calpain-like protein, putative 0.0107 0.0135 0.0135
Trichomonas vaginalis cyclins, putative 0.0049 0.004 0.0072
Echinococcus multilocularis cyclin dependent kinase 1 0.0129 0.0172 0.0169
Brugia malayi Cyclin, N-terminal domain containing protein 0.0052 0.0045 0.0043
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0213 0.0311 0.0319
Leishmania major cyclin 0.0088 0.0105 0.0105
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0303 0.046 0.0457
Echinococcus granulosus dual specificity 0.0134 0.018 0.0178
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0213 0.0311 0.0603
Echinococcus multilocularis protein kinase shaggy 0.0143 0.0196 0.0192
Echinococcus granulosus tar DNA binding protein 0.0057 0.0053 0.0051
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0282 0.0426 0.0423
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0213 0.0311 0.0603
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0823 0.132 0.3333
Entamoeba histolytica cyclin family protein 0.0052 0.0045 0.0064
Echinococcus granulosus epidermal growth factor receptor 0.018 0.0257 0.0255
Mycobacterium ulcerans hypothetical protein 0.137 0.2223 0.5777
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0009
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0027 0.0003 0.0005
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0823 0.132 0.1317
Schistosoma mansoni Mername-AA248 (C02 family) 0.0107 0.0135 0.0132
Toxoplasma gondii cathepsin B 0.0027 0.0003 0.0002
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0032 0.0012 0.002
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0213 0.0311 0.043
Schistosoma mansoni cyclins 0.0052 0.0045 0.0042
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.4396 0.7225 1
Mycobacterium ulcerans pyruvate carboxylase 0.2314 0.3784 1
Trypanosoma brucei calpain-like protein, putative 0.0107 0.0135 0.0135
Trichomonas vaginalis cyclins, putative 0.0052 0.0045 0.0081
Echinococcus granulosus calpain 5 0.0107 0.0135 0.0134
Brugia malayi Protein kinase domain containing protein 0.0134 0.018 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0053 0.005
Echinococcus multilocularis cyclin dependent kinase 0.0129 0.0172 0.0169
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0823 0.132 0.1317
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0134 0.018 0.0292
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.2314 0.3784 0.3782
Echinococcus granulosus cathepsin b 0.0073 0.008 0.0078
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.008 0.0076
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0303 0.046 0.0457
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0823 0.132 0.3333
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0213 0.0311 0.031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0159 0.0223 0.0427
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0107 0.0135 0.0219
Echinococcus multilocularis calpain 0.0107 0.0135 0.0132
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.0119 0.0116
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0159 0.0223 0.041
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0052 0.0045 0.0043
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0032 0.0012 0.002
Entamoeba histolytica cyclin, putative 0.0088 0.0105 0.0181
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0012 0.0012
Trypanosoma brucei Calpain-like protein 1.1 0.0032 0.0012 0.0012
Echinococcus granulosus protein kinase shaggy 0.0143 0.0196 0.0194
Echinococcus granulosus histone lysine methyltransferase setb 0.0027 0.0004 0.0002
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0213 0.0311 0.0504
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0213 0.0311 0.0504
Schistosoma mansoni cyclin B 0.0088 0.0105 0.0102
Loa Loa (eye worm) hypothetical protein 0.0374 0.0578 0.0596
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.5862 0.9648 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0087 0.0104 0.0043

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1100 nM Inhibition of partially purified EGFR tyrosine kinase from human A431 cells ChEMBL. 17869510

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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