TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 320.385 | Formula: C20H20N2O2
H donors: 0 H acceptors: 2 LogP: 4.52 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc2c(ncnc2cc1OCC)/C=C/c1ccccc1
InChi: 1S/C20H20N2O2/c1-3-23-19-12-16-17(11-10-15-8-6-5-7-9-15)21-14-22-18(16)13-20(19)24-4-2/h5-14H,3-4H2,1-2H3/b11-10+
InChiKey: MVIQZBWZLCMZGF-ZHACJKMWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0836	1	1
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Brugia malayi	cathepsin L-like precursor	0.056	0.645	0.645
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1243	0.1243
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0154	0.1243	0.1243
Echinococcus granulosus	cathepsin L	0.0154	0.1243	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0276	0.2811	0.2811
Echinococcus granulosus	epidermal growth factor receptor	0.018	0.1574	0.1574
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0836	1	1
Giardia lamblia	Cathepsin B precursor	0.0154	0.1243	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Brugia malayi	Cathepsin L-like precursor	0.0836	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.1243	0.1243
Brugia malayi	cathepsin F-like cysteine proteinase	0.0276	0.2811	0.2811
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0836	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0836	1	1
Giardia lamblia	Cathepsin L precursor	0.0154	0.1243	0.5
Schistosoma mansoni	cathepsin S (C01 family)	0.0154	0.1243	0.1243
Entamoeba histolytica	cysteine proteinase, putative	0.056	0.645	0.5946
Loa Loa (eye worm)	TK/EGFR protein kinase	0.018	0.1574	0.1574
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0154	0.1243	0.1243
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0836	1	1
Loa Loa (eye worm)	hypothetical protein	0.0276	0.2811	0.2811
Leishmania major	cathepsin L-like protease	0.0836	1	1
Giardia lamblia	Cathepsin B precursor	0.0154	0.1243	0.5
Leishmania major	cathepsin L-like protease	0.0836	1	1
Giardia lamblia	Cathepsin L-like protease	0.0154	0.1243	0.5
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Giardia lamblia	Cathepsin L precursor	0.0154	0.1243	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0836	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.1243	0.1243
Brugia malayi	Cathepsin L-like precursor	0.0836	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0836	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.1243	0.1243
Echinococcus multilocularis	cathepsin L	0.0154	0.1243	0.1243
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0154	0.1243	0.1243
Loa Loa (eye worm)	ctsf protein	0.0836	1	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1243	0.1243
Brugia malayi	cathepsin L-like cysteine proteinase	0.0154	0.1243	0.1243
Leishmania major	cathepsin L-like protease	0.0836	1	1
Loa Loa (eye worm)	hypothetical protein	0.056	0.645	0.645
Loa Loa (eye worm)	hypothetical protein	0.056	0.645	0.645
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.1243	0.1243
Plasmodium vivax	vivapain-2	0.0836	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0431	0.4793	0.4793
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0836	1	1
Schistosoma mansoni	tyrosine kinase	0.0096	0.0491	0.0491
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0154	0.1243	0.1243
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0276	0.2811	0.2811
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0836	1	1
Echinococcus multilocularis	cathepsin b	0.0154	0.1243	0.1243
Giardia lamblia	Cathepsin B precursor	0.0154	0.1243	0.5
Schistosoma mansoni	tyrosine kinase	0.0097	0.0504	0.0504
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0431	0.4793	0.4054
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0154	0.1243	0.1243
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0836	1	1
Plasmodium vivax	vivapain-2	0.0836	1	1
Schistosoma mansoni	tyrosine kinase	0.018	0.1574	0.1574
Giardia lamblia	Cysteine protease	0.0154	0.1243	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0836	1	1
Loa Loa (eye worm)	fibroinase	0.0836	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Giardia lamblia	Cathepsin B precursor	0.0154	0.1243	0.5
Onchocerca volvulus		0.0836	1	1
Onchocerca volvulus		0.0836	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0836	1	1
Leishmania major	cathepsin L-like protease	0.0836	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0431	0.4793	0.4054
Onchocerca volvulus		0.0836	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0431	0.4793	0.4793
Entamoeba histolytica	cysteine proteinase 1, putative	0.0431	0.4793	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0431	0.4793	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0431	0.4793	0.4793
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0154	0.1243	0.1243
Entamoeba histolytica	cysteine proteinase, putative	0.0431	0.4793	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0431	0.4793	0.4054
Echinococcus multilocularis	cathepsin L	0.0431	0.4793	0.4793
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1243	0.1243
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0154	0.1243	0.5
Echinococcus granulosus	cysteine protease	0.0431	0.4793	0.4793
Plasmodium vivax	unspecified product	0.0431	0.4793	0.4054
Schistosoma mansoni	tyrosine kinase	0.0096	0.0491	0.0491
Plasmodium vivax	vivapain-3	0.0431	0.4793	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0836	1	1
Onchocerca volvulus		0.0836	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0836	1	1
Giardia lamblia	Cathepsin L precursor	0.0154	0.1243	0.5
Onchocerca volvulus		0.0836	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0154	0.1243	0.1243
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0836	1	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0154	0.1243	0.1243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0836	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.1243	0.1243
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0154	0.1243	0.1243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.056	0.645	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0431	0.4793	0.4054
Brugia malayi	fibroinase precursor	0.0154	0.1243	0.1243
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0836	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0431	0.4793	0.4793
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Giardia lamblia	Cathepsin L-like protease	0.0154	0.1243	0.5
Brugia malayi	cathepsin L precursor	0.0154	0.1243	0.1243
Entamoeba histolytica	cysteine protease, putative	0.0836	1	1
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0431	0.4793	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.4793	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0836	1	1
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Giardia lamblia	Cysteine protease	0.0154	0.1243	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0097	0.0504	0.0504
Schistosoma mansoni	tyrosine kinase	0.0096	0.0491	0.0491
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0836	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0836	1	1
Echinococcus granulosus	cathepsin b	0.0154	0.1243	0.1243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0154	0.1243	0.1243
Plasmodium vivax	vivapain-1	0.0431	0.4793	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.0276	0.2811	0.1791
Echinococcus granulosus	cathepsin l1	0.0836	1	1
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0154	0.1243	0.1243
Giardia lamblia	Cysteine protease	0.0154	0.1243	0.5
Loa Loa (eye worm)	hypothetical protein	0.0836	1	1
Giardia lamblia	Cathepsin L precursor	0.0154	0.1243	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0097	0.0504	0.0504
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Giardia lamblia	Cathepsin B precursor	0.0154	0.1243	0.5
Schistosoma mansoni	tyrosine kinase	0.0097	0.0504	0.0504
Brugia malayi	cathepsin F-like cysteine proteinase	0.0154	0.1243	0.1243
Echinococcus granulosus	cathepsin L	0.0431	0.4793	0.4793
Onchocerca volvulus	Cathepsin F homolog	0.0836	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0431	0.4793	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1243	0.1243
Echinococcus multilocularis	cathepsin L cysteine protease	0.0836	1	1
Echinococcus granulosus	cathepsin l1	0.056	0.645	0.645
Giardia lamblia	Cathepsin B precursor	0.0154	0.1243	0.5
Brugia malayi	Cathepsin L-like precursor	0.0836	1	1
Loa Loa (eye worm)	cathepsin B	0.0154	0.1243	0.1243
Echinococcus granulosus	epidermal growth factor receptor	0.0097	0.0504	0.0504
Brugia malayi	Cathepsin L-like precursor	0.0836	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0836	1	1
Leishmania major	cathepsin L-like protease	0.0836	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0836	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0154	0.1243	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0836	1	1
Giardia lamblia	Cysteine protease	0.0154	0.1243	0.5
Leishmania major	cathepsin L-like protease	0.0836	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.018	0.1574	0.1574
Plasmodium vivax	unspecified product	0.0276	0.2811	0.1791
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0836	1	1
Echinococcus granulosus	cathepsin b	0.0154	0.1243	0.1243
Echinococcus multilocularis	cysteine protease	0.0836	1	1
Brugia malayi	Cathepsin L-like precursor	0.056	0.645	0.645
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0836	1	1
Loa Loa (eye worm)	cysteine protease	0.0836	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0276	0.2811	0.1791
Brugia malayi	Papain family cysteine protease containing protein	0.0431	0.4793	0.4793
Giardia lamblia	Encystation-specific protease	0.0154	0.1243	0.5
Toxoplasma gondii	cathepsin CPL	0.0836	1	1
Giardia lamblia	Hypothetical protein	0.0154	0.1243	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0836	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0836	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0836	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0836	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0836	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.1243	0.1243
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.1243	0.1243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0836	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.1243	0.1243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0836	1	1
Leishmania major	cathepsin L-like protease	0.0836	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.1243	0.1243
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.1243	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0276	0.2811	0.2811
Giardia lamblia	Hypothetical protein	0.0154	0.1243	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0836	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0431	0.4793	0.4054
Giardia lamblia	Cathepsin L precursor	0.0154	0.1243	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0276	0.2811	0.2811
Brugia malayi	Cathepsin L-like precursor	0.0276	0.2811	0.2811
Entamoeba histolytica	cysteine proteinase, putative	0.0431	0.4793	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0836	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.056	0.645	0.645
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0836	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0154	0.1243	0.5
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1243	0.1243
Echinococcus multilocularis	cathepsin b	0.0154	0.1243	0.1243
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0154	0.1243	0.1243
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0836	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0836	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0836	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.056	0.645	0.5946
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0836	1	1
Giardia lamblia	Cathepsin L precursor	0.0154	0.1243	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0836	1	1
Loa Loa (eye worm)	hypothetical protein	0.056	0.645	0.645
Trypanosoma cruzi	cysteine peptidase, putative	0.0836	1	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0154	0.1243	0.1243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0836	1	1
Giardia lamblia	Cathepsin B precursor	0.0154	0.1243	0.5
Onchocerca volvulus		0.0836	1	1
Entamoeba histolytica	cysteine proteinase 2	0.0431	0.4793	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0431	0.4793	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0836	1	1
Schistosoma mansoni	cathepsin C	0.0154	0.1243	0.1243
Entamoeba histolytica	cysteine proteinase, putative	0.0836	1	1
Brugia malayi	Cathepsin L-like precursor	0.056	0.645	0.645
Trypanosoma cruzi	cruzipain precursor, putative	0.0836	1	1
Onchocerca volvulus		0.056	0.645	0.5946
Schistosoma mansoni	cathepsin s	0.0276	0.2811	0.2811
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.1243	0.1243
Leishmania major	cathepsin L-like protease	0.0836	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0836	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0154	0.1243	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.056	0.645	0.645
Giardia lamblia	Cathepsin B precursor	0.0154	0.1243	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0431	0.4793	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1243	0.1243
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.056	0.645	0.5946
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.1243	0.1243
Onchocerca volvulus		0.0836	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0431	0.4793	0.4054
Echinococcus granulosus	cathepsin L cysteine protease	0.0431	0.4793	0.4793
Entamoeba histolytica	cysteine protease, putative	0.0431	0.4793	0.4054
Brugia malayi	Furin-like cysteine rich region family protein	0.018	0.1574	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1243	0.1243
Echinococcus multilocularis	cysteine protease	0.0836	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0836	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 15 nM	Inhibition of partially purified EGFR tyrosine kinase from human A431 cells	ChEMBL.	17869510
IC50 (binding)	= 15 nM	Inhibition of partially purified EGFR tyrosine kinase from human A431 cells	ChEMBL.	17869510

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 459277