TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 651.781 | Formula: C27H36F3N3O6S3
H donors: 3 H acceptors: 6 LogP: 4.33 Rotable bonds: 17
Rule of 5 violations (Lipinski): 2
SMILES: CSCC[C@@H](C(=O)NS(=O)(=O)C)NC(=O)[C@@H](N[C@H](C(F)(F)F)c1ccc(cc1)c1ccc(cc1)S(=O)(=O)C)CC(C)C
InChi: 1S/C27H36F3N3O6S3/c1-17(2)16-23(25(34)32-22(14-15-40-3)26(35)33-42(5,38)39)31-24(27(28,29)30)20-8-6-18(7-9-20)19-10-12-21(13-11-19)41(4,36)37/h6-13,17,22-24,31H,14-16H2,1-5H3,(H,32,34)(H,33,35)/t22-,23-,24-/m0/s1
InChiKey: JCLILPCUNVIOFL-HJOGWXRNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin K	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	fibroinase	0.0027	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.6296	0.6296
Brugia malayi	Cathepsin L-like precursor	0.0027	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Echinococcus multilocularis	orexin receptor type 2	0.0022	0.6296	0.6296
Echinococcus granulosus	g protein coupled receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Schistosoma mansoni	hypothetical protein	0.0022	0.6296	0.6296
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0022	0.6296	0.6296
Echinococcus granulosus	neuropeptide s receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0022	0.6296	0.6296
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.6296	0.6296
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0027	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0027	1	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0022	0.6296	0.4568
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.3182	0.3182
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.6296	0.6296
Brugia malayi	hypothetical protein	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Onchocerca volvulus		0.0022	0.6296	0.4568
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Brugia malayi	G-protein coupled receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.6296	0.6296
Brugia malayi	hypothetical protein	0.0022	0.6296	0.6296
Brugia malayi	neuropeptide F receptor	0.0022	0.6296	0.6296
Leishmania major	cathepsin L-like protease	0.0027	1	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.6296	0.6296
Echinococcus multilocularis	neuropeptide receptor A26	0.0022	0.6296	0.6296
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Onchocerca volvulus		0.0027	1	1
Onchocerca volvulus		0.0022	0.6296	0.4568
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0022	0.6296	0.4568
Echinococcus multilocularis	sex peptide receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	somatostatin receptor	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0022	0.6296	0.6296
Brugia malayi	G protein-coupled receptor F59B2.13	0.0022	0.6296	0.6296
Loa Loa (eye worm)	TYRA-2 protein	0.0022	0.6296	0.4568
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	1	1
Brugia malayi	Cathepsin L-like precursor	0.0027	1	1
Brugia malayi	Dopamine receptor protein 2	0.0022	0.6296	0.6296
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Onchocerca volvulus		0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Plasmodium vivax	vivapain-2	0.0027	1	1
Brugia malayi	hypothetical protein	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Onchocerca volvulus		0.0022	0.6296	0.4568
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0022	0.6296	0.4568
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.6296	0.6296
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Entamoeba histolytica	cysteine protease, putative	0.0027	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0027	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Toxoplasma gondii	cathepsin CPL	0.0027	1	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.6296	0.6296
Brugia malayi	neuropeptide F receptor	0.0022	0.6296	0.6296
Echinococcus multilocularis	cysteine protease	0.0027	1	1
Onchocerca volvulus		0.0022	0.6296	0.4568
Brugia malayi	cathepsin L-like precursor	0.0018	0.3182	0.3182
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.6296	0.6296
Brugia malayi	putative neuropeptide receptor NPR1	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Brugia malayi	Serotonin receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Schistosoma mansoni	biogenic amine receptor	0.0022	0.6296	0.6296
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.3182	0.3182
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0022	0.6296	0.6296
Brugia malayi	hypothetical protein	0.0022	0.6296	0.6296
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.6296	0.4568
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.6296	0.6296
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	1	1
Brugia malayi	hypothetical protein	0.0022	0.6296	0.6296
Brugia malayi	hypothetical protein	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0022	0.6296	0.4568
Onchocerca volvulus		0.0022	0.6296	0.4568
Onchocerca volvulus		0.0022	0.6296	0.4568
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.6296	0.4568
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0022	0.6296	0.4568
Echinococcus granulosus	serotonin receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.6296	0.6296
Brugia malayi	follicle stimulating hormone receptor	0.0022	0.6296	0.6296
Brugia malayi	G-protein coupled receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	1	1
Echinococcus granulosus	cathepsin l1	0.0018	0.3182	0.3182
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0018	0.3182	0.3182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	1	1
Schistosoma mansoni	opsin-like receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0027	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.6296	0.6296
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0027	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	myosin xvIII	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Echinococcus granulosus	neuropeptide FF receptor 2	0.0022	0.6296	0.6296
Echinococcus granulosus	g protein coupled receptor	0.0022	0.6296	0.6296
Leishmania major	cathepsin L-like protease	0.0027	1	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Echinococcus granulosus	neuropeptide receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	opsin-like receptor	0.0022	0.6296	0.6296
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	hypothetical protein	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0022	0.6296	0.4568
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.6296	0.6296
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Schistosoma mansoni	opsin-like receptor	0.0022	0.6296	0.6296
Leishmania major	cathepsin L-like protease	0.0027	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	1	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0022	0.6296	0.6296
Echinococcus granulosus	dro:myosuppressin receptor	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	1	1
Onchocerca volvulus		0.0022	0.6296	0.4568
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Plasmodium vivax	vivapain-2	0.0027	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0022	0.6296	0.6296
Leishmania major	cathepsin L-like protease	0.0027	1	0.5
Echinococcus granulosus	hypothetical protein	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Schistosoma mansoni	neuropeptide f receptor 76f	0.0022	0.6296	0.6296
Echinococcus granulosus	sex peptide receptor	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	1	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Brugia malayi	RE15519p	0.0022	0.6296	0.6296
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0022	0.6296	0.6296
Brugia malayi	hypothetical protein	0.0022	0.6296	0.6296
Brugia malayi	Dopamine receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	biogenic amine receptor	0.0022	0.6296	0.6296
Echinococcus multilocularis	allatostatin A receptor	0.0022	0.6296	0.6296
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.3182	0.3182
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Echinococcus granulosus	7tm_1 domain containing protein	0.0022	0.6296	0.6296
Brugia malayi	ORL1-like opioid receptor	0.0022	0.6296	0.6296
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0022	0.6296	0.6296
Leishmania major	cathepsin L-like protease	0.0027	1	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0027	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0022	0.6296	0.6296
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0022	0.6296	0.4568
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Echinococcus granulosus	g protein coupled receptor	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Echinococcus granulosus	neuropeptide receptor A26	0.0022	0.6296	0.6296
Brugia malayi	putative neuropeptide receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	neuropeptide receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Schistosoma mansoni	hypothetical protein	0.0022	0.6296	0.6296
Echinococcus granulosus	7TM GPCR rhodopsin	0.0022	0.6296	0.6296
Brugia malayi	Cathepsin L-like precursor	0.0027	1	1
Brugia malayi	Cathepsin L-like precursor	0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0022	0.6296	0.4568
Brugia malayi	GnHR receptor homolog	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	1	1
Brugia malayi	hypothetical protein	0.0022	0.6296	0.6296
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	1	1
Leishmania major	cathepsin L-like protease	0.0027	1	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0022	0.6296	0.6296
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.3182	0.3182
Echinococcus multilocularis	serotonin receptor	0.0022	0.6296	0.6296
Brugia malayi	Dopamine receptor protein 1	0.0022	0.6296	0.6296
Schistosoma mansoni	amine GPCR	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Loa Loa (eye worm)	cysteine protease	0.0027	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0022	0.6296	0.4568
Schistosoma mansoni	adenoreceptor	0.0022	0.6296	0.6296
Schistosoma mansoni	hypothetical protein	0.0022	0.6296	0.6296
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0022	0.6296	0.4568
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0022	0.6296	0.4568
Echinococcus multilocularis	somatostatin receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	neuropeptide receptor	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0022	0.6296	0.4568
Echinococcus multilocularis	G protein coupled receptor 139	0.0022	0.6296	0.6296
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Leishmania major	cathepsin L-like protease	0.0027	1	0.5
Echinococcus multilocularis	cysteine protease	0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.6296	0.6296
Echinococcus granulosus	allatostatin A receptor	0.0022	0.6296	0.6296
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0022	0.6296	0.6296
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.6296	0.6296
Loa Loa (eye worm)	melatonin receptor type 1A	0.0022	0.6296	0.4568
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.6296	0.6296
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	fmrfamide receptor	0.0022	0.6296	0.6296
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	ctsf protein	0.0027	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	1	1
Brugia malayi	AKH receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	orexin receptor type 2	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0022	0.6296	0.6296
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0022	0.6296	0.6296
Brugia malayi	Cathepsin L-like precursor	0.0018	0.3182	0.3182
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Brugia malayi	hypothetical protein	0.0022	0.6296	0.6296
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Echinococcus granulosus	g-protein coupled receptor	0.0022	0.6296	0.6296
Brugia malayi	hypothetical protein	0.0022	0.6296	0.6296
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0022	0.6296	0.6296
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0027	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Onchocerca volvulus	Cathepsin L homolog	0.0027	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	1	1
Echinococcus multilocularis	serotonin receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Onchocerca volvulus		0.0027	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0022	0.6296	0.4568
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	G protein coupled receptor 139	0.0022	0.6296	0.6296
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.6296	0.4568
Brugia malayi	Serotonin receptor	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	1	1
Schistosoma mansoni	biogenic amine receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	neuropeptide receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.6296	0.4568
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.6296	0.6296
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	1	1
Brugia malayi	G protein-coupled receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0022	0.6296	0.4568
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.6296	0.6296
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0022	0.6296	0.6296
Schistosoma mansoni	amine GPCR	0.0022	0.6296	0.6296
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0022	0.6296	0.6296
Echinococcus multilocularis	g-protein coupled receptor	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0027	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.6296	0.6296
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Brugia malayi	larval opioid receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Schistosoma mansoni	histamine h1 receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	amine GPCR	0.0022	0.6296	0.6296
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0022	0.6296	0.4568
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	1	1
Echinococcus granulosus	neuropeptide receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0022	0.6296	0.4568
Brugia malayi	Melatonin receptor type 1A	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0022	0.6296	0.4568
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Leishmania major	cysteine peptidase A (CPA)	0.0027	1	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Schistosoma mansoni	amine GPCR	0.0022	0.6296	0.6296
Echinococcus granulosus	cathepsin l1	0.0027	1	1
Schistosoma mansoni	amine GPCR	0.0022	0.6296	0.6296
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Brugia malayi	sulfakinin receptor protein	0.0022	0.6296	0.6296
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.6296	0.6296
Schistosoma mansoni	neuropeptide receptor	0.0022	0.6296	0.6296
Echinococcus multilocularis	neuropeptide s receptor	0.0022	0.6296	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.6296	0.6296
Entamoeba histolytica	cysteine proteinase, putative	0.0027	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0027	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0018	0.3182	0.3182
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0022	0.6296	0.6296
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.6296	0.6296
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.6296	0.6296
Brugia malayi	Cathepsin L-like precursor	0.0027	1	1
Leishmania major	cathepsin L-like protease	0.0027	1	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.6296	0.6296
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.6296	0.6296
Onchocerca volvulus		0.0027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.6296	0.4568
Brugia malayi	Cathepsin L-like precursor	0.0018	0.3182	0.3182
Onchocerca volvulus	Cathepsin F homolog	0.0027	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 238 nM	Inhibition of humanized rabbit cathepsin K	ChEMBL.	17544269
IC50 (binding)	= 238 nM	Inhibition of humanized rabbit cathepsin K	ChEMBL.	17544269

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 459358