Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 14 (membrane-inserted) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | DNA-directed RNA polymerase subunit beta/beta' | 0.0424 | 0.4279 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0083 | 0.0382 | 0.0811 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.2233 | 0.6069 |
Plasmodium falciparum | DNA-directed RNA polymerase subunit beta, putative | 0.0424 | 0.4279 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.4789 | 1 |
Mycobacterium ulcerans | DNA-directed RNA polymerase subunit beta | 0.0424 | 0.4279 | 0.4052 |
Chlamydia trachomatis | DNA-directed RNA polymerase subunit beta | 0.0424 | 0.4279 | 0.5 |
Mycobacterium tuberculosis | DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) | 0.0424 | 0.4279 | 0.4052 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD2 | 0.0924 | 1 | 1 |
Trypanosoma brucei | isopentenyl-diphosphate delta-isomerase (type II) | 0.0331 | 0.3217 | 1 |
Brugia malayi | Hemopexin family protein | 0.0097 | 0.0538 | 0.1554 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0152 | 0.1165 | 0.4894 |
Entamoeba histolytica | isopentenyl-diphosphate delta-isomerase, putative | 0.0331 | 0.3217 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0336 | 0.327 | 1 |
Treponema pallidum | hypothetical protein | 0.0924 | 1 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.014 | 0.1029 | 0.1502 |
Mycobacterium leprae | DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) | 0.0424 | 0.4279 | 0.4052 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0538 | 0.2719 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0336 | 0.327 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0252 | 0.2317 | 0.4599 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.1979 | 0.5105 |
Schistosoma mansoni | hypothetical protein | 0.009 | 0.0461 | 0.2331 |
Brugia malayi | Matrixin family protein | 0.0252 | 0.2317 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.014 | 0.1029 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1206 | 0.2174 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD1 | 0.0331 | 0.3217 | 0.2948 |
Mycobacterium tuberculosis | Possible L-lactate dehydrogenase (cytochrome) LldD2 | 0.0924 | 1 | 1 |
Mycobacterium ulcerans | isopentenyl pyrophosphate isomerase | 0.0331 | 0.3217 | 0.2948 |
Loa Loa (eye worm) | matrixin family protein | 0.0152 | 0.1165 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0382 | 0.0373 |
Onchocerca volvulus | Matrilysin homolog | 0.0239 | 0.216 | 1 |
Onchocerca volvulus | 0.0097 | 0.0538 | 0.1679 | |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0155 | 0.1206 | 0.6094 |
Leishmania major | isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative | 0.0331 | 0.3217 | 0.5 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0105 | 0.0633 | 0.2003 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0105 | 0.0633 | 0.3196 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.1979 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8 nM | Inhibition of TACE by FRET assay | ChEMBL. | 17531482 |
IC50 (binding) | = 8 nM | Inhibition of TACE by FRET assay | ChEMBL. | 17531482 |
IC50 (binding) | = 1100 nM | Inhibition of MMP13 | ChEMBL. | 17531482 |
IC50 (binding) | = 1100 nM | Inhibition of MMP13 | ChEMBL. | 17531482 |
IC50 (binding) | = 1630 nM | Inhibition of MMP2 | ChEMBL. | 17531482 |
IC50 (binding) | = 1630 nM | Inhibition of MMP2 | ChEMBL. | 17531482 |
IC50 (binding) | = 7440 nM | Inhibition of MMP14 | ChEMBL. | 17531482 |
IC50 (binding) | = 7440 nM | Inhibition of MMP14 | ChEMBL. | 17531482 |
IC50 (functional) | = 0.75 uM | Inhibition of LPS-stimulated TNFalpha production in RAW cells | ChEMBL. | 17531482 |
IC50 (functional) | = 0.75 uM | Inhibition of LPS-stimulated TNFalpha production in RAW cells | ChEMBL. | 17531482 |
IC50 (functional) | = 26 uM | Inhibition of LPS-stimulated TNFalpha production in human whole blood | ChEMBL. | 17531482 |
IC50 (functional) | = 26 uM | Inhibition of LPS-stimulated TNFalpha production in human whole blood | ChEMBL. | 17531482 |
Ratio IC50 (binding) | = 14 | Selectivity for TACE over MMP13 | ChEMBL. | 17531482 |
Ratio IC50 (binding) | > 100 | Selectivity for TACE over MMP14 | ChEMBL. | 17531482 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 17531482 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.