TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.638 | Formula: C32H33N5
H donors: 0 H acceptors: 2 LogP: 4.85 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccc(cc1)Cn1cncc1CN1CCCN(CC1)C1c2ccccc2CCc2c1cccc2
InChi: 1S/C32H33N5/c33-20-25-10-12-26(13-11-25)22-37-24-34-21-29(37)23-35-16-5-17-36(19-18-35)32-30-8-3-1-6-27(30)14-15-28-7-2-4-9-31(28)32/h1-4,6-13,21,24,32H,5,14-19,22-23H2
InChiKey: HMPHPOPMNDWMRM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	farnesyltransferase, CAAX box, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Giardia lamblia	Rab geranylgeranyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium vivax	prenyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative	Get druggable targets OG5_128459	All targets in OG5_128459
Babesia bovis	protein prenyltransferase alpha subunit repeat domain containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium falciparum	protein farnesyltransferase subunit alpha	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium hominis	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium knowlesi	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium parvum	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus granulosus	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Theileria parva	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium berghei	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Neospora caninum	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0193	0.0727	0.7285
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0092	0.0267	0.0396
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0046	0.006	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0152
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.0078	0.0137
Echinococcus granulosus	7tm_1 domain containing protein	0.0135	0.0463	0.0402
Loa Loa (eye worm)	melatonin receptor type 1A	0.0135	0.0463	0.0613
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0135	0.0463	0.0402
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0135	0.0463	0.0603
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.013	0.0443	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Giardia lamblia	Rab geranylgeranyltransferase	0.0193	0.0727	0.4538
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0135	0.0463	0.0688
Brugia malayi	hypothetical protein	0.0135	0.0463	0.0603
Loa Loa (eye worm)	proprotein convertase 2	0.0259	0.1027	0.1462
Onchocerca volvulus		0.013	0.0443	0.0662
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0135	0.0463	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1113	0.1592
Echinococcus multilocularis	g protein coupled receptor	0.0135	0.0463	0.0402
Schistosoma mansoni	cercarial elastase (S01 family)	0.013	0.0443	0.0659
Schistosoma mansoni	neuropeptide F-like receptor	0.0135	0.0463	0.0688
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0463	0.0688
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0463	0.0688
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0278	0.1113	1
Brugia malayi	follicle stimulating hormone receptor	0.0135	0.0463	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1506	0.6694	1
Schistosoma mansoni	neuropeptide receptor	0.0135	0.0463	0.0688
Schistosoma mansoni	opsin-like receptor	0.0135	0.0463	0.0688
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0247	0.0975	1
Brugia malayi	Trypsin family protein	0.013	0.0443	0.0573
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0193	0.0727	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0135	0.0463	0.0402
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0047	0.0064	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.0727	0.2532
Schistosoma mansoni	hypothetical protein	0.004	0.0032	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Echinococcus multilocularis	G protein coupled receptor 139	0.0135	0.0463	0.0402
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.005	0.0078	0.0113
Plasmodium falciparum	cysteine repeat modular protein 1	0.0247	0.0975	1
Toxoplasma gondii	hypothetical protein	0.005	0.0078	0.0158
Brugia malayi	cathepsin B-like cysteine proteinase	0.0278	0.1113	0.1583
Trypanosoma brucei	RNA helicase, putative	0.0105	0.0327	1
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.1009	0.4435	0.6624
Echinococcus granulosus	neuropeptide Y receptor	0.0135	0.0463	0.0402
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0261	0.1039	0.0982
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0092	0.0267	0.773
Echinococcus granulosus	orexin receptor type 2	0.0135	0.0463	0.0402
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0067	0.0157	0.0152
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.013	0.0443	0.0382
Mycobacterium ulcerans	hypothetical protein	0.013	0.0443	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0135	0.0463	0.0613
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0193	0.0727	0.0668
Brugia malayi	Trypsin-like protease protein 5	0.013	0.0443	0.0573
Echinococcus granulosus	tissue type plasminogen activator	0.0247	0.0975	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0152
Loa Loa (eye worm)	hypothetical protein	0.013	0.0443	0.0583
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0135	0.0463	0.0402
Schistosoma mansoni	cercarial elastase (S01 family)	0.013	0.0443	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0164	0.0163
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0067	0.0157	0.0152
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0047	0.0064	0.0091
Brugia malayi	hypothetical protein	0.0135	0.0463	0.0603
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0135	0.0463	0.0688
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.0814	0.2862
Schistosoma mansoni	growth hormone secretagogue receptor	0.0135	0.0463	0.0688
Giardia lamblia	Furin precursor putative serine protease	0.0212	0.0814	0.5143
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0092	0.0267	0.0777
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.0078	0.0137
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0135	0.0463	0.0613
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Loa Loa (eye worm)	hypothetical protein	0.013	0.0443	0.0583
Echinococcus multilocularis	Furin 1	0.0259	0.1027	0.0969
Onchocerca volvulus		0.1506	0.6694	1
Loa Loa (eye worm)	hypothetical protein	0.1506	0.6694	1
Schistosoma mansoni	histamine h1 receptor	0.0135	0.0463	0.0688
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Schistosoma mansoni	hypothetical protein	0.013	0.0443	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.0727	0.2532
Brugia malayi	hypothetical protein	0.013	0.0443	0.0573
Schistosoma mansoni	hypothetical protein	0.0105	0.0327	0.0485
Schistosoma mansoni	amine GPCR	0.0135	0.0463	0.0688
Schistosoma mansoni	hypothetical protein	0.0135	0.0463	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Echinococcus granulosus	sex peptide receptor	0.0135	0.0463	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Brugia malayi	endoprotease bli-4 precursor	0.1009	0.4435	0.6593
Loa Loa (eye worm)	G-protein coupled receptor	0.0135	0.0463	0.0613
Echinococcus multilocularis	neuropeptide Y receptor	0.0135	0.0463	0.0402
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0135	0.0463	0.0613
Echinococcus granulosus	neuroendocrine convertase 2	0.0644	0.2777	0.2731
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0135	0.0463	0.0688
Onchocerca volvulus		0.013	0.0443	0.0662
Echinococcus multilocularis	fmrfamide receptor	0.0135	0.0463	0.0402
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0259	0.1027	0.3674
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.005	0.0078	0.0547
Onchocerca volvulus		0.0247	0.0975	0.1456
Loa Loa (eye worm)	hypothetical protein	0.1009	0.4435	0.6597
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.005	0.0078	0.0158
Onchocerca volvulus		0.0075	0.0193	0.0288
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0135	0.0463	0.0402
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0135	0.0463	0.0692
Plasmodium falciparum	sortilin	0.0136	0.0471	0.4466
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0259	0.1027	0.3674
Brugia malayi	hypothetical protein	0.0135	0.0463	0.0603
Echinococcus multilocularis	serotonin receptor	0.0135	0.0463	0.0402
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0265	0.0315
Plasmodium vivax	sortilin, putative	0.0136	0.0471	0.4466
Brugia malayi	hypothetical protein	0.0135	0.0463	0.0603
Onchocerca volvulus		0.0135	0.0463	0.0692
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0135	0.0463	0.0688
Echinococcus multilocularis	tissue type plasminogen activator	0.0247	0.0975	0.0917
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0078	0.0547
Schistosoma mansoni	opsin-like receptor	0.0135	0.0463	0.0688
Echinococcus multilocularis	glycoprotein Antigen 5	0.013	0.0443	0.0382
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0135	0.0463	0.0603
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0135	0.0463	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0164	0.0163
Onchocerca volvulus		0.0135	0.0463	0.0692
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0135	0.0463	0.0688
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.013	0.0443	0.0659
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.005	0.0078	0.0055
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0135	0.0463	0.0402
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0078	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0152
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0135	0.0463	0.0402
Echinococcus multilocularis	somatostatin receptor	0.0135	0.0463	0.0402
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0463	0.0688
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.0814	0.2862
Echinococcus granulosus	cathepsin b	0.0278	0.1113	0.1056
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0157	0.0152
Echinococcus granulosus	neuropeptide Y receptor	0.0135	0.0463	0.0402
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.0814	0.2862
Brugia malayi	neuroendocrine convertase 1 precursor	0.0644	0.2777	0.4092
Brugia malayi	Protein kinase domain containing protein	0.0247	0.0975	0.1374
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0134	0.0459	0.0607
Trypanosoma brucei	hypothetical protein, conserved	0.005	0.0078	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Brugia malayi	G protein-coupled receptor	0.0135	0.0463	0.0603
Loa Loa (eye worm)	G-protein coupled receptor	0.0135	0.0463	0.0613
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0091	0.0265	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Brugia malayi	GnHR receptor homolog	0.0135	0.0463	0.0603
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0135	0.0463	0.0402
Echinococcus granulosus	somatostatin receptor	0.0135	0.0463	0.0402
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0193	0.0727	0.1001
Onchocerca volvulus		0.0135	0.0463	0.0692
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0193	0.0727	0.1083
Brugia malayi	celfurPC protein	0.0797	0.3472	0.514
Schistosoma mansoni	serine-type protease inhibitor	0.1317	0.5836	0.8717
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0193	0.0727	0.1011
Echinococcus multilocularis	fmrfamide receptor	0.0135	0.0463	0.0402
Loa Loa (eye worm)	subtilase	0.0047	0.0064	0.0011
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0079	0.0212	0.5
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0143	0.05	0.1665
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Echinococcus granulosus	glycoprotein Antigen 5	0.013	0.0443	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0212	0.0814	0.2862
Schistosoma mansoni	cercarial elastase (S01 family)	0.013	0.0443	0.0659
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0135	0.0463	0.0688
Echinococcus multilocularis	g protein coupled receptor	0.0135	0.0463	0.0402
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0278	0.1113	0.166
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Schistosoma mansoni	amine GPCR	0.0135	0.0463	0.0688
Schistosoma mansoni	glutamate receptor NMDA	0.0047	0.0064	0.0092
Echinococcus granulosus	allatostatin A receptor	0.0135	0.0463	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Echinococcus granulosus	enteropeptidase	0.013	0.0443	0.0382
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0135	0.0463	0.0402
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0046	0.006	0.0086
Brugia malayi	proprotein convertase 2	0.0644	0.2777	0.4092
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0166	0.0166
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0278	0.1113	0.166
Echinococcus multilocularis	neuropeptide receptor	0.0135	0.0463	0.0402
Schistosoma mansoni	hypothetical protein	0.013	0.0443	0.0659
Brugia malayi	Trypsin family protein	0.013	0.0443	0.0573
Loa Loa (eye worm)	trypsin family protein	0.013	0.0443	0.0583
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0078	0.0547
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0212	0.0814	0.2862
Echinococcus multilocularis	dro:myosuppressin receptor	0.0135	0.0463	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Loa Loa (eye worm)	neuropeptide F receptor	0.0135	0.0463	0.0613
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.013	0.0443	0.0659
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.013	0.0443	0.0659
Echinococcus multilocularis	g protein coupled receptor	0.0135	0.0463	0.0402
Schistosoma mansoni	cercarial elastase (S01 family)	0.013	0.0443	0.0659
Echinococcus granulosus	Furin 1	0.0259	0.1027	0.0969
Loa Loa (eye worm)	TYRA-2 protein	0.0135	0.0463	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.2233	1	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0259	0.1027	0.153
Brugia malayi	Furin-like cysteine rich region family protein	0.0134	0.0459	0.0597
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.013	0.0443	0.0659
Echinococcus granulosus	sortilin	0.0136	0.0471	0.0409
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.005	0.0078	0.0015
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0624	0.2685	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0135	0.0463	0.0688
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0135	0.0463	0.0402
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0135	0.0463	0.0402
Schistosoma mansoni	myosin xvIII	0.0135	0.0463	0.0688
Schistosoma mansoni	neuropeptide F-like receptor	0.0135	0.0463	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Brugia malayi	G-protein coupled receptor	0.0135	0.0463	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Schistosoma mansoni	cercarial elastase (S01 family)	0.013	0.0443	0.0659
Echinococcus granulosus	hypothetical protein	0.0135	0.0463	0.0402
Onchocerca volvulus		0.005	0.0078	0.0117
Echinococcus multilocularis	Mastin	0.013	0.0443	0.0382
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Brugia malayi	Melatonin receptor type 1A	0.0135	0.0463	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Schistosoma mansoni	hypothetical protein	0.0135	0.0463	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.005	0.0078	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0164	0.0163
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0135	0.0463	0.0402
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.005	0.0078	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Echinococcus multilocularis	g-protein coupled receptor	0.0135	0.0463	0.0402
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0135	0.0463	0.0688
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0135	0.0463	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Echinococcus multilocularis	serotonin receptor	0.0135	0.0463	0.0402
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Brugia malayi	hypothetical protein	0.0135	0.0463	0.0603
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0079	0.0212	0.7352
Brugia malayi	neuropeptide F receptor	0.0135	0.0463	0.0603
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0261	0.1039	0.0982
Onchocerca volvulus		0.1375	0.6102	0.9115
Echinococcus granulosus	g protein coupled receptor	0.0135	0.0463	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0727	0.1011
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0046	0.006	0.0086
Echinococcus multilocularis	expressed protein	0.0384	0.1597	0.1543
Schistosoma mansoni	neuropeptide receptor	0.0135	0.0463	0.0688
Onchocerca volvulus		0.0135	0.0463	0.0692
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0135	0.0463	0.0603
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0135	0.0463	0.0613
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0078	0.0137
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.013	0.0443	0.0382
Onchocerca volvulus		0.0135	0.0463	0.0692
Onchocerca volvulus		0.0135	0.0463	0.0692
Onchocerca volvulus		0.013	0.0443	0.0662
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0278	0.1113	0.166
Loa Loa (eye worm)	cathepsin B	0.0092	0.0267	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0265	0.0315
Schistosoma mansoni	hypothetical protein	0.0212	0.0814	0.1212
Echinococcus granulosus	tm gpcr rhodopsin	0.0135	0.0463	0.0402
Echinococcus granulosus	endothelin converting enzyme 1	0.0091	0.0265	0.0203
Brugia malayi	Trypsin family protein	0.1506	0.6694	1
Schistosoma mansoni	adenoreceptor	0.0135	0.0463	0.0688
Schistosoma mansoni	cercarial elastase (S01 family)	0.013	0.0443	0.0659
Echinococcus multilocularis	neuropeptides capa receptor	0.0135	0.0463	0.0402
Brugia malayi	hypothetical protein	0.0135	0.0463	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Brugia malayi	hypothetical protein	0.0135	0.0463	0.0603
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0135	0.0463	0.0402
Toxoplasma gondii	subtilisin SUB12	0.0062	0.0132	0.0751
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0135	0.0463	0.0603
Echinococcus granulosus	dro:myosuppressin receptor	0.0135	0.0463	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Schistosoma mansoni	sortilin	0.0097	0.029	0.0429
Onchocerca volvulus		0.0045	0.0056	0.0084
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0135	0.0463	0.0688
Loa Loa (eye worm)	endoprotease bli-4	0.1009	0.4435	0.6597
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0135	0.0463	0.0402
Schistosoma mansoni	cercarial elastase (S01 family)	0.013	0.0443	0.0659
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.013	0.0443	0.0382
Brugia malayi	hypothetical protein	0.0135	0.0463	0.0603
Echinococcus granulosus	transmembrane protease serine 3	0.013	0.0443	0.0382
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0079	0.0212	0.5
Onchocerca volvulus		0.0135	0.0463	0.0692
Brugia malayi	Kringle domain containing protein	0.0247	0.0975	0.1374
Toxoplasma gondii	hypothetical protein	0.0143	0.05	0.4791
Schistosoma mansoni	hypothetical protein	0.0247	0.0975	0.1452
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0135	0.0463	0.0402
Giardia lamblia	Cathepsin B precursor	0.0092	0.0267	0.1323
Echinococcus multilocularis	neuropeptide s receptor	0.0135	0.0463	0.0402
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.013	0.0443	0.0659
Echinococcus granulosus	serotonin receptor	0.0135	0.0463	0.0402
Giardia lamblia	Cathepsin B precursor	0.0092	0.0267	0.1323
Onchocerca volvulus		0.0135	0.0463	0.0692
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0193	0.0727	0.7285
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Echinococcus multilocularis	epidermal growth factor receptor	0.0134	0.0459	0.0398
Schistosoma mansoni	cercarial elastase (S01 family)	0.013	0.0443	0.0659
Echinococcus granulosus	expressed protein	0.0384	0.1597	0.1543
Schistosoma mansoni	cercarial elastase (S01 family)	0.013	0.0443	0.0659
Onchocerca volvulus		0.0135	0.0463	0.0692
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0463	0.0688
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0091	0.0265	0.0393
Echinococcus granulosus	neuropeptide receptor	0.0135	0.0463	0.0402
Onchocerca volvulus		0.0135	0.0463	0.0692
Brugia malayi	putative neuropeptide receptor NPR1	0.0135	0.0463	0.0603
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.005	0.0078	0.0158
Echinococcus granulosus	furin	0.1009	0.4435	0.4399
Echinococcus granulosus	cathepsin b	0.0278	0.1113	0.1056
Schistosoma mansoni	amine GPCR	0.0135	0.0463	0.0688
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0259	0.1027	0.3674
Schistosoma mansoni	opsin-like receptor	0.0135	0.0463	0.0688
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0135	0.0463	0.0613
Schistosoma mansoni	cercarial elastase (S01 family)	0.013	0.0443	0.0659
Echinococcus granulosus	g-protein coupled receptor	0.0135	0.0463	0.0402
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.0814	0.2862
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.0814	0.2862
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0278	0.1113	0.166
Echinococcus multilocularis	sortilin	0.0136	0.0471	0.0409
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.0814	0.2862
Schistosoma mansoni	biogenic amine receptor	0.0135	0.0463	0.0688
Echinococcus multilocularis	neuropeptides capa receptor	0.0135	0.0463	0.0402
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0135	0.0463	0.0402
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0212	0.0814	0.2862
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0135	0.0463	0.0402
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0624	0.2685	1
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.005	0.0078	0.0158
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0135	0.0463	0.0688
Trichomonas vaginalis	hypothetical protein	0.0212	0.0814	0.2862
Schistosoma mansoni	glutamate receptor NMDA	0.0261	0.1039	0.1549
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.0814	0.2862
Brugia malayi	Serotonin receptor	0.0135	0.0463	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Schistosoma mansoni	biogenic amine receptor	0.0135	0.0463	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Schistosoma mansoni	tyrosine kinase	0.0134	0.0459	0.0682
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0135	0.0463	0.0613
Loa Loa (eye worm)	hypothetical protein	0.013	0.0443	0.0583
Echinococcus granulosus	neuropeptide s receptor	0.0135	0.0463	0.0402
Schistosoma mansoni	cercarial elastase (S01 family)	0.013	0.0443	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0164	0.0163
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Schistosoma mansoni	amine GPCR	0.0135	0.0463	0.0688
Brugia malayi	G-protein coupled receptor	0.0135	0.0463	0.0603
Schistosoma mansoni	hypothetical protein	0.0135	0.0463	0.0688
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0259	0.1027	0.3674
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0463	0.0688
Echinococcus granulosus	g protein coupled receptor	0.0135	0.0463	0.0402
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0193	0.0727	0.2532
Echinococcus multilocularis	endothelin converting enzyme 1	0.0091	0.0265	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0046	0.006	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Onchocerca volvulus		0.0135	0.0463	0.0692
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0135	0.0463	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Schistosoma mansoni	neuropeptide receptor	0.0135	0.0463	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Brugia malayi	Trypsin family protein	0.013	0.0443	0.0573
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0135	0.0463	0.0402
Echinococcus multilocularis	orexin receptor type 2	0.0135	0.0463	0.0402
Echinococcus granulosus	7TM GPCR rhodopsin	0.0135	0.0463	0.0402
Schistosoma mansoni	amine GPCR	0.0135	0.0463	0.0688
Onchocerca volvulus		0.0135	0.0463	0.0692
Echinococcus multilocularis	nmda type glutamate receptor	0.011	0.0353	0.0291
Brugia malayi	ORL1-like opioid receptor	0.0135	0.0463	0.0603
Brugia malayi	RE15519p	0.0135	0.0463	0.0603
Toxoplasma gondii	peptidase family M13 protein	0.0091	0.0265	0.2215
Brugia malayi	Dopamine receptor protein 1	0.0135	0.0463	0.0603
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0092	0.0267	0.1942
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.0814	0.2862
Echinococcus multilocularis	allatostatin A receptor	0.0135	0.0463	0.0402
Echinococcus granulosus	Mastin	0.013	0.0443	0.0382
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.005	0.0078	0.0033
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0135	0.0463	0.0402
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0135	0.0463	0.0692
Schistosoma mansoni	biogenic amine receptor	0.0135	0.0463	0.0688
Echinococcus granulosus	biogenic amine 5HT receptor	0.0135	0.0463	0.0402
Giardia lamblia	Cathepsin B precursor	0.0092	0.0267	0.1323
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Schistosoma mansoni	hypothetical protein	0.0135	0.0463	0.0688
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0135	0.0463	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0164	0.0163
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.0814	0.2862
Echinococcus multilocularis		0.0797	0.3472	0.343
Onchocerca volvulus		0.0135	0.0463	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0064	0.0011
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0047	0.0064	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Brugia malayi	AKH receptor	0.0135	0.0463	0.0603
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0135	0.0463	0.0688
Schistosoma mansoni	furin-1 (S08 family)	0.0432	0.1814	0.2707
Schistosoma mansoni	neuropeptide f receptor 76f	0.0135	0.0463	0.0688
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.0814	0.2862
Brugia malayi	Dopamine receptor	0.0135	0.0463	0.0603
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0463	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0385	0.1601	0.2327
Echinococcus granulosus	neuropeptides capa receptor	0.0135	0.0463	0.0402
Echinococcus granulosus	G protein coupled receptor 139	0.0135	0.0463	0.0402
Chlamydia trachomatis	glutamine binding protein	0.0079	0.0212	0.5
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0046	0.006	0.0086
Loa Loa (eye worm)	hypothetical protein	0.013	0.0443	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0193	0.0206
Trypanosoma cruzi	hypothetical protein, conserved	0.0247	0.0975	0.8679
Brugia malayi	larval opioid receptor	0.0135	0.0463	0.0603
Onchocerca volvulus		0.0135	0.0463	0.0692
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0259	0.1027	0.3674
Echinococcus multilocularis	enteropeptidase	0.013	0.0443	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0247	0.0975	0.1384
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0069	0.0166	0.0103
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0135	0.0463	0.0688
Echinococcus granulosus	g protein coupled receptor	0.0135	0.0463	0.0402
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0259	0.1027	0.3674
Echinococcus granulosus	neuropeptide receptor A26	0.0135	0.0463	0.0402
Giardia lamblia	High cysteine membrane protein Group 2	0.0365	0.1509	1
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0078	0.0137
Mycobacterium leprae	probable zinc metalloprotease	0.0091	0.0265	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0164	0.0163
Loa Loa (eye worm)	hypothetical protein	0.013	0.0443	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Echinococcus granulosus	neuropeptide FF receptor 2	0.0135	0.0463	0.0402
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0135	0.0463	0.0603
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.005	0.0078	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Echinococcus granulosus	tm gpcr rhodopsin	0.0135	0.0463	0.0402
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.0814	0.2862
Echinococcus granulosus	epidermal growth factor receptor	0.0134	0.0459	0.0398
Brugia malayi	Dopamine receptor protein 2	0.0135	0.0463	0.0603
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Onchocerca volvulus		0.0135	0.0463	0.0692
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.013	0.0443	0.0382
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0091	0.0265	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.011	0.0353	0.0291
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0069	0.0166	0.0103
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0193	0.0727	0.0668
Mycobacterium ulcerans	zinc metalloprotease	0.0091	0.0265	0.5313
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0135	0.0463	0.0402
Schistosoma mansoni	serine-type protease inhibitor	0.1317	0.5836	0.8717
Echinococcus granulosus	neuropeptide receptor	0.0135	0.0463	0.0402
Echinococcus multilocularis	neuropeptide receptor A26	0.0135	0.0463	0.0402
Echinococcus granulosus	neuropeptides capa receptor	0.0135	0.0463	0.0402
Onchocerca volvulus		0.013	0.0443	0.0662
Loa Loa (eye worm)	hypothetical protein	0.1506	0.6694	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0079	0.0212	0.5
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0092	0.0267	0.2237
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.005	0.0078	0.0015
Onchocerca volvulus		0.013	0.0443	0.0662
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1506	0.6694	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Brugia malayi	G protein-coupled receptor F59B2.13	0.0135	0.0463	0.0603
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0463	0.0688
Echinococcus granulosus	nmda type glutamate receptor	0.011	0.0353	0.0291
Echinococcus multilocularis	cathepsin b	0.0278	0.1113	0.1056
Brugia malayi	Peptidase family M13 containing protein	0.0091	0.0265	0.0304
Onchocerca volvulus		0.0047	0.0064	0.0095
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0463	0.0688
Onchocerca volvulus		0.0135	0.0463	0.0692
Toxoplasma gondii	cathepsin B	0.0092	0.0267	0.2237
Brugia malayi	SWIRM domain containing protein	0.0075	0.0193	0.0195
Loa Loa (eye worm)	TK/ROR protein kinase	0.0247	0.0975	0.1384
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Echinococcus granulosus	biogenic amine 5HT receptor	0.0135	0.0463	0.0402
Brugia malayi	neuropeptide F receptor	0.0135	0.0463	0.0603
Echinococcus multilocularis	neuroendocrine convertase 2	0.0644	0.2777	0.2731
Brugia malayi	Serotonin receptor	0.0135	0.0463	0.0603
Toxoplasma gondii	sortilin, putative	0.0136	0.0471	0.4466
Brugia malayi	hypothetical protein	0.0135	0.0463	0.0603
Echinococcus multilocularis	transmembrane protease serine 3	0.013	0.0443	0.0382
Brugia malayi	sulfakinin receptor protein	0.0135	0.0463	0.0603
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0047	0.0064	0.0091
Toxoplasma gondii	kringle domain-containing protein	0.0247	0.0975	1
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0069	0.0166	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0463	0.0613
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0135	0.0463	0.0402
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0624	0.2685	0.2638
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0079	0.0212	0.3907
Leishmania major	hypothetical protein, conserved	0.0247	0.0975	1
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0624	0.2685	0.2638
Echinococcus multilocularis	sex peptide receptor	0.0135	0.0463	0.0402
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0463	0.0402
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0463	0.0688
Echinococcus multilocularis	neuropeptide receptor	0.0135	0.0463	0.0402
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0135	0.0463	0.0688
Echinococcus granulosus	fmrfamide receptor	0.0135	0.0463	0.0402
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.013	0.0443	0.0573
Onchocerca volvulus		0.0135	0.0463	0.0692
Echinococcus multilocularis	neuropeptide Y receptor	0.0135	0.0463	0.0402
Schistosoma mansoni	neuropeptide receptor	0.0135	0.0463	0.0688
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0135	0.0463	0.0402
Brugia malayi	putative neuropeptide receptor	0.0135	0.0463	0.0603
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0135	0.0463	0.0402
Echinococcus multilocularis	cathepsin b	0.0278	0.1113	0.1056
Brugia malayi	hypothetical protein	0.0135	0.0463	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0265	0.0315
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0135	0.0463	0.0603

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	0	Antiproliferative activity against PC3 cells by colorimetric MTT assay	ChEMBL.	17827015
IC50 (binding)	= 285 nM	Inhibition of FTase by fluorescence spectrometry technique	ChEMBL.	17827015
IC50 (binding)	= 285 nM	Inhibition of FTase by fluorescence spectrometry technique	ChEMBL.	17827015
IC50 (functional)	= 41 uM	Antiproliferative activity against MCF7 cells by colorimetric MTT assay	ChEMBL.	17827015
IC50 (functional)	= 41 uM	Antiproliferative activity against MCF7 cells by colorimetric MTT assay	ChEMBL.	17827015
IC50 (functional)	= 51.3 uM	Antiproliferative activity against DU145 cells by colorimetric MTT assay	ChEMBL.	17827015
IC50 (functional)	= 51.3 uM	Antiproliferative activity against DU145 cells by colorimetric MTT assay	ChEMBL.	17827015
Inhibition (functional)	= 34 %	Antiproliferative activity against L1210 cells by colorimetric MTT assay at 10 uM	ChEMBL.	17827015
Inhibition (functional)	= 34 %	Antiproliferative activity against L1210 cells by colorimetric MTT assay at 10 uM	ChEMBL.	17827015

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 459450