Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.011 | 0.063 | 0.063 |
Brugia malayi | thymidylate synthase | 0.013 | 0.0896 | 0.0896 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.011 | 0.063 | 0.0526 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.011 | 0.063 | 0.0526 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.0896 | 0.0795 |
Brugia malayi | Trypsin family protein | 0.011 | 0.063 | 0.063 |
Schistosoma mansoni | dihydrofolate reductase | 0.026 | 0.2616 | 0.2535 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.011 | 0.063 | 0.0526 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.0896 | 0.1338 |
Chlamydia trachomatis | dihydrofolate reductase | 0.026 | 0.2616 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0821 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.026 | 0.2616 | 0.2616 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.063 | 0.0526 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.011 | 0.063 | 0.0526 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.0896 | 0.1338 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.011 | 0.063 | 0.0526 |
Brugia malayi | Trypsin family protein | 0.011 | 0.063 | 0.063 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.0896 | 0.3423 |
Brugia malayi | Dihydrofolate reductase | 0.026 | 0.2616 | 0.2616 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.011 | 0.063 | 0.0526 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.026 | 0.2616 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.026 | 0.2616 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.011 | 0.063 | 0.063 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.011 | 0.063 | 0.0526 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.0896 | 0.0284 |
Echinococcus multilocularis | dihydrofolate reductase | 0.026 | 0.2616 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.2637 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.0896 | 0.1338 |
Loa Loa (eye worm) | hypothetical protein | 0.0821 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.011 | 0.063 | 0.0526 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.2637 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.011 | 0.063 | 0.0526 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.011 | 0.063 | 0.0526 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.011 | 0.063 | 0.063 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.011 | 0.063 | 0.0526 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.026 | 0.2616 | 0.212 |
Brugia malayi | hypothetical protein | 0.011 | 0.063 | 0.063 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.2637 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.026 | 0.2616 | 1 |
Onchocerca volvulus | 0.013 | 0.0896 | 0.0284 | |
Onchocerca volvulus | 0.0712 | 0.8558 | 0.8461 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0262 | 0.2637 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.2637 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.011 | 0.063 | 0.0526 |
Onchocerca volvulus | 0.0821 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.063 | 0.0526 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.2637 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0821 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.011 | 0.063 | 0.0526 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.011 | 0.063 | 0.0526 |
Loa Loa (eye worm) | hypothetical protein | 0.0821 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.011 | 0.063 | 0.0526 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.026 | 0.2616 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.011 | 0.063 | 0.0526 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.011 | 0.063 | 0.0526 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.684 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 5.9208 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 6.6383 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 230 nM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 230 nM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 1200 nM | Inhibitory activity against rat liver dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 1200 nM | Inhibitory activity against rat liver dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 20700 nM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 20700 nM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 microM dihydrofolic acid) | ChEMBL. | 8691474 |
IC50 (binding) | = 0.23 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.23 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 2.9 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 2.9 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 20.7 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 20.7 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 4.684 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 5.9208 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 6.6383 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
Selectivity ratio (binding) | = 0.06 | Selectivity ratio is defined as IC50 rlDHFR/IC50 pcDHFR | ChEMBL. | 8691474 |
Selectivity ratio (binding) | = 5.2 | Selectivity ratio is defined as IC50 rlDHFR/IC50 tgDHFR | ChEMBL. | 8691474 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.