Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Schistosoma japonicum | ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Schistosoma mansoni | retinoic acid receptor RXR | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dopamine receptor protein 2 | 0.0025 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0025 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0025 | 0 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0025 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0025 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0025 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0025 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0025 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0123 | 0.9533 | 1 |
Brugia malayi | Melatonin receptor type 1A | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0128 | 1 | 1 |
Brugia malayi | G protein-coupled receptor | 0.0025 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0025 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0025 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0025 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0025 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0025 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0025 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 76 % | Activation of RXR-LXR heterodimer in human THP1 cells assessed as induction of ABCA1 mRNA relative to 5-((3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(trifluoromethoxy)phenyl)methylene)thiazolidine-2,4-dione | ChEMBL. | 17485209 |
Activity (binding) | = 86 % | Activity at RXRalpha by GAL4DNA cotransfection assay relative to 5-((3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(trifluoromethoxy)phenyl)methylene)thiazolidine-2,4-dione | ChEMBL. | 17485209 |
Activity (binding) | = 86 % | Activity at RXRalpha by GAL4DNA cotransfection assay relative to 5-((3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(trifluoromethoxy)phenyl)methylene)thiazolidine-2,4-dione | ChEMBL. | 17485209 |
Activity (binding) | = 240 % | Activity at RXR-PPARgamma in primary human preadipocytes assessed as induction of adipocytes fatty acid binding protein by bDNA assay relative to 5-((3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(trifluoromethoxy)phenyl)methylene)thiazolidine-2,4-dione | ChEMBL. | 17485209 |
EC50 (binding) | = 61.2 nM | Activity at RXRalpha by GAL4DNA cotransfection assay | ChEMBL. | 17485209 |
EC50 (binding) | = 61.2 nM | Activity at RXRalpha by GAL4DNA cotransfection assay | ChEMBL. | 17485209 |
EC50 (binding) | = 163 nM | Activity at RXR-LXR heterodimer in human THP1 cells assessed as induction of ABCA1 mRNA | ChEMBL. | 17485209 |
EC50 (binding) | > 3000 nM | Activity at RXR-PPARgamma heterodimer in primary human preadipocytes assessed as induction of adipocytes fatty acid binding protein by bDNA assay | ChEMBL. | 17485209 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.