Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MPL proto-oncogene, thrombopoietin receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0071 | 0.1936 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0071 | 0.1936 | 0.1936 |
Trypanosoma brucei | cytochrome P450, putative | 0.0071 | 0.1936 | 0.2196 |
Schistosoma mansoni | alpha-glucosidase | 0.0093 | 0.2704 | 0.3424 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0099 | 0.2904 | 0.3678 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0071 | 0.1936 | 0.5 |
Brugia malayi | CHE-14 protein | 0.0099 | 0.2904 | 0.2904 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0024 | 0.0259 | 0.0259 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0071 | 0.1936 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0071 | 0.1936 | 0.1936 |
Schistosoma mansoni | patched 1 | 0.0099 | 0.2904 | 0.3678 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0071 | 0.1936 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0108 | 0.3236 | 0.3236 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0299 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0071 | 0.1936 | 0.2196 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0155 | 0.4891 | 0.6194 |
Brugia malayi | Cytochrome P450 family protein | 0.0071 | 0.1936 | 0.1936 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.4891 | 0.4891 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0112 | 0.3392 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0083 | 0.2351 | 0.2978 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.2904 | 0.3678 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.4891 | 0.4891 |
Brugia malayi | Trypsin family protein | 0.0155 | 0.4891 | 0.4891 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0071 | 0.1936 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0071 | 0.1936 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0071 | 0.1936 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.4891 | 0.4891 |
Echinococcus multilocularis | protein patched | 0.0099 | 0.2904 | 0.3678 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0071 | 0.1936 | 0.2196 |
Mycobacterium leprae | putative cytochrome p450 | 0.0071 | 0.1936 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0071 | 0.1936 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0071 | 0.1936 | 0.2196 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.024 | 0.7896 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0155 | 0.4891 | 0.6194 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0155 | 0.4891 | 0.6194 |
Schistosoma mansoni | alpha glucosidase | 0.0024 | 0.0259 | 0.0329 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0071 | 0.1936 | 0.5 |
Brugia malayi | cytochrome P450 | 0.0071 | 0.1936 | 0.1936 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0155 | 0.4891 | 0.6194 |
Brugia malayi | Trypsin family protein | 0.0155 | 0.4891 | 0.4891 |
Brugia malayi | Cytochrome P450 family protein | 0.0071 | 0.1936 | 0.1936 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.4891 | 0.4891 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0155 | 0.4891 | 0.6194 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0071 | 0.1936 | 0.2196 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Schistosoma mansoni | cytochrome P450 | 0.0071 | 0.1936 | 0.2452 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0071 | 0.1936 | 0.2196 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0099 | 0.2904 | 0.8444 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0071 | 0.1936 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0071 | 0.1936 | 0.2452 |
Onchocerca volvulus | 0.0155 | 0.4891 | 1 | |
Echinococcus multilocularis | Mastin | 0.0155 | 0.4891 | 0.6194 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0155 | 0.4891 | 0.4891 |
Echinococcus granulosus | enteropeptidase | 0.0155 | 0.4891 | 0.6194 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.2351 | 0.2978 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0071 | 0.1936 | 0.2196 |
Echinococcus multilocularis | 0.0071 | 0.1936 | 0.2452 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0071 | 0.1936 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.4891 | 0.4891 |
Echinococcus granulosus | geminin | 0.0105 | 0.3114 | 0.3944 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0071 | 0.1936 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0108 | 0.3236 | 0.3236 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0083 | 0.2351 | 0.2978 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.7896 | 0.7896 |
Brugia malayi | Trypsin family protein | 0.0155 | 0.4891 | 0.4891 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0071 | 0.1936 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0071 | 0.1936 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.2904 | 0.3678 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.4891 | 0.4957 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0071 | 0.1936 | 0.1936 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0099 | 0.2904 | 0.3678 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0071 | 0.1936 | 0.1936 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0024 | 0.0259 | 0.0329 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0112 | 0.3392 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.4891 | 0.4891 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1936 | 0.2452 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0071 | 0.1936 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0071 | 0.1936 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0155 | 0.4891 | 0.6194 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Brugia malayi | Cytochrome P450 family protein | 0.0071 | 0.1936 | 0.1936 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0024 | 0.0259 | 0.0259 |
Onchocerca volvulus | 0.0155 | 0.4891 | 1 | |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0071 | 0.1936 | 0.5 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0071 | 0.1936 | 0.2196 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0108 | 0.3236 | 0.4098 |
Echinococcus multilocularis | geminin | 0.0105 | 0.3114 | 0.3944 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.024 | 0.7896 | 0.7896 |
Echinococcus multilocularis | enteropeptidase | 0.0155 | 0.4891 | 0.6194 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0024 | 0.0259 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0099 | 0.2904 | 0.2904 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.3114 | 0.3944 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.024 | 0.7896 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.024 | 0.7896 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.024 | 0.7896 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.024 | 0.7896 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0093 | 0.2704 | 0.3424 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0071 | 0.1936 | 0.1936 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0108 | 0.3236 | 0.4098 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0071 | 0.1936 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0071 | 0.1936 | 0.1936 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.4891 | 0.6194 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0071 | 0.1936 | 0.5 |
Brugia malayi | hypothetical protein | 0.0155 | 0.4891 | 0.4891 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0108 | 0.3236 | 0.4098 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0071 | 0.1936 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.4891 | 0.6194 |
Schistosoma mansoni | lipoxygenase | 0.0058 | 0.1467 | 0.1857 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0099 | 0.2904 | 0.3678 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0024 | 0.0259 | 0.0329 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Onchocerca volvulus | 0.0155 | 0.4891 | 1 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Onchocerca volvulus | 0.0155 | 0.4891 | 1 | |
Leishmania major | cytochrome p450-like protein | 0.0071 | 0.1936 | 0.2196 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.3114 | 0.3944 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0112 | 0.3392 | 1 |
Loa Loa (eye worm) | trypsin family protein | 0.0155 | 0.4891 | 0.4891 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.2904 | 0.2904 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0112 | 0.3392 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.024 | 0.7896 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0024 | 0.0259 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.024 | 0.7896 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0155 | 0.4891 | 0.6194 |
Echinococcus multilocularis | protein dispatched 1 | 0.0099 | 0.2904 | 0.3678 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.2904 | 0.3678 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.4891 | 0.4891 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0155 | 0.4891 | 0.6194 |
Onchocerca volvulus | 0.0155 | 0.4891 | 1 | |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0071 | 0.1936 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Onchocerca volvulus | 0.0062 | 0.1623 | 0.3319 | |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0232 | 0.7621 | 0.9652 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Leishmania major | cytochrome p450-like protein | 0.0071 | 0.1936 | 0.2196 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0071 | 0.1936 | 0.5 |
Echinococcus granulosus | Mastin | 0.0155 | 0.4891 | 0.6194 |
Brugia malayi | Trypsin family protein | 0.0155 | 0.4891 | 0.4891 |
Onchocerca volvulus | 0.0155 | 0.4891 | 1 | |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.024 | 0.7896 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0071 | 0.1936 | 0.2196 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0155 | 0.4891 | 0.4891 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0155 | 0.4891 | 0.6194 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.