TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 331.451 | Formula: C23H25NO
H donors: 0 H acceptors: 1 LogP: 3.77 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCC2(C(=C1)CCN(C2)Cc1ccccc1)Cc1ccccc1
InChi: 1S/C23H25NO/c25-22-11-13-23(16-19-7-3-1-4-8-19)18-24(14-12-21(23)15-22)17-20-9-5-2-6-10-20/h1-10,15H,11-14,16-18H2
InChiKey: WJNYVLIWINIFFI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0038	0.0992	1
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Onchocerca volvulus		0.0038	0.0992	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0764	0.1074
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0038	0.0992	0.1405
Toxoplasma gondii	cathepsin B	0.0044	0.1307	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0135	0.5397	0.7789
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0038	0.0992	0.1839
Echinococcus granulosus	expressed conserved protein	0.0095	0.3597	0.5181
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0992	0.1405
Echinococcus granulosus	dro:myosuppressin receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	geminin	0.0168	0.6922	1
Onchocerca volvulus		0.0038	0.0992	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0038	0.0992	0.1839
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0038	0.0992	0.1405
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0992	0.1405
Brugia malayi	G protein-coupled receptor	0.0038	0.0992	0.1839
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0135	0.5397	0.7789
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0038	0.0992	1
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.2241	0.4152
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	hypothetical protein	0.0032	0.0764	0.1074
Echinococcus granulosus	allatostatin A receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0038	0.0992	0.1405
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0044	0.1307	0.186
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0038	0.0992	0.1839
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0968	0.5
Giardia lamblia	Cathepsin B precursor	0.0044	0.1307	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Onchocerca volvulus		0.0038	0.0992	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0038	0.0992	0.1405
Onchocerca volvulus		0.0038	0.0992	1
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	hypothetical protein	0.0032	0.0764	0.1074
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.3944	0.7308
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0038	0.0992	0.1839
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.2241	0.3215
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.2241	0.3215
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0614	0.1137
Schistosoma mansoni	hypothetical protein	0.0032	0.0764	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0499	0.0925
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0764	0.1074
Echinococcus multilocularis	allatostatin A receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0038	0.0992	0.1405
Echinococcus granulosus	cathepsin b	0.0135	0.5397	0.7789
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Brugia malayi	beta-lactamase	0.0037	0.0968	0.1794
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0038	0.0992	0.1405
Brugia malayi	neuropeptide F receptor	0.0038	0.0992	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus multilocularis	serotonin receptor	0.0038	0.0992	0.1405
Onchocerca volvulus		0.0038	0.0992	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0992	0.1405
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0968	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0038	0.0992	0.1839
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0044	0.1307	0.2389
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0719	0.1332
Giardia lamblia	Cathepsin B precursor	0.0044	0.1307	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0038	0.0992	0.1839
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0992	0.1405
Echinococcus granulosus	GPCR family 2	0.0032	0.0764	0.1074
Brugia malayi	Dopamine receptor protein 1	0.0038	0.0992	0.1839
Brugia malayi	RNA binding protein	0.0065	0.2241	0.4152
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0992	0.1405
Echinococcus granulosus	neuropeptide receptor A26	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0968	0.1794
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0614	0.1137
Echinococcus multilocularis	neuropeptide s receptor	0.0038	0.0992	0.1405
Brugia malayi	G-protein coupled receptor	0.0038	0.0992	0.1839
Brugia malayi	neuropeptide F receptor	0.0038	0.0992	0.1839
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0992	0.1405
Echinococcus granulosus	serotonin receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Brugia malayi	beta-lactamase family protein	0.0037	0.0968	0.1794
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0968	0.1794
Echinococcus granulosus	Niemann Pick C1 protein	0.0101	0.3875	0.5583
Echinococcus granulosus	somatostatin receptor	0.0038	0.0992	0.1405
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0992	0.1405
Echinococcus multilocularis	expressed conserved protein	0.0095	0.3597	0.5181
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0992	0.1405
Schistosoma mansoni	adenoreceptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	somatostatin receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus multilocularis	lamin dm0	0.0029	0.0614	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0103	0.3944	0.7308
Schistosoma mansoni	hypothetical protein	0.0038	0.0992	0.1405
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0968	0.7363
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0038	0.0992	0.1405
Onchocerca volvulus		0.0037	0.0968	0.9508
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0043	0.123	0.1749
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0968	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	histamine h1 receptor	0.0038	0.0992	0.1405
Brugia malayi	larval opioid receptor	0.0038	0.0992	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0968	0.1794
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0038	0.0992	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0968	0.1794
Onchocerca volvulus		0.0038	0.0992	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0968	0.1794
Schistosoma mansoni	amine GPCR	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	hypothetical protein	0.0042	0.1188	0.1688
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Echinococcus granulosus	hypothetical protein	0.0038	0.0992	0.1405
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.2241	0.3215
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.2241	0.3215
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Loa Loa (eye worm)	calpain family protein 1	0.0031	0.0719	0.1332
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0135	0.5397	0.7789
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0968	0.1794
Brugia malayi	AKH receptor	0.0038	0.0992	0.1839
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0968	0.1794
Loa Loa (eye worm)	cathepsin B	0.0044	0.1307	0.2421
Brugia malayi	ORL1-like opioid receptor	0.0038	0.0992	0.1839
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0038	0.0992	0.1405
Brugia malayi	hypothetical protein	0.0038	0.0992	0.1839
Brugia malayi	CHE-14 protein	0.0043	0.1259	0.2333
Brugia malayi	RE15519p	0.0038	0.0992	0.1839
Onchocerca volvulus		0.0038	0.0992	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Leishmania major	hypothetical protein, conserved	0.0037	0.0968	0.7363
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Brugia malayi	Niemann-Pick C1 protein precursor	0.0101	0.3875	0.7181
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0135	0.5397	1
Brugia malayi	calpain 7	0.0016	0.0023	0.0043
Loa Loa (eye worm)	hypothetical protein	0.007	0.2472	0.4581
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1259	0.8591
Brugia malayi	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus multilocularis	Niemann Pick C1 protein	0.0101	0.3875	0.5583
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0764	0.1416
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0968	0.137
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Schistosoma mansoni	amine GPCR	0.0038	0.0992	0.1405
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0038	0.0992	0.1405
Schistosoma mansoni	neuropeptide f receptor 76f	0.0038	0.0992	0.1405
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0968	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.2241	0.4152
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus granulosus	geminin	0.0168	0.6922	1
Loa Loa (eye worm)	calpain family protein 1	0.0043	0.123	0.2279
Schistosoma mansoni	growth hormone secretagogue receptor	0.0038	0.0992	0.1405
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0045	0.1318	0.1877
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0992	0.1405
Schistosoma mansoni	hypothetical protein	0.0042	0.1188	0.1688
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0038	0.0992	0.1839
Loa Loa (eye worm)	calpain	0.0016	0.0023	0.0043
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0038	0.0992	0.1839
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0038	0.0992	0.1405
Brugia malayi	Serotonin receptor	0.0038	0.0992	0.1839
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.1039	0.1473
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus granulosus	Niemann Pick C1 protein	0.0144	0.5842	0.8434
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	opsin-like receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0992	0.1405
Brugia malayi	Serotonin receptor	0.0038	0.0992	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0038	0.101	0.1872
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.2241	0.3215
Giardia lamblia	Cathepsin B precursor	0.0044	0.1307	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Onchocerca volvulus		0.0037	0.0968	0.9508
Echinococcus granulosus	calpain A	0.0045	0.1318	0.1877
Brugia malayi	sulfakinin receptor protein	0.0038	0.0992	0.1839
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0038	0.0992	0.1839
Echinococcus multilocularis	sex peptide receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus multilocularis	serotonin receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0038	0.0992	0.1405
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0044	0.1307	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0038	0.0992	0.1405
Echinococcus granulosus	7tm_1 domain containing protein	0.0038	0.0992	0.1405
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	hypothetical protein	0.0168	0.6922	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.3944	0.7308
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0992	0.1405
Echinococcus granulosus	g-protein coupled receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	hypothetical protein	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus multilocularis	orexin receptor type 2	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Onchocerca volvulus		0.0038	0.0992	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0045	0.1318	0.1877
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Echinococcus granulosus	7TM GPCR rhodopsin	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0135	0.5397	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0968	0.1794
Echinococcus multilocularis	protein dispatched 1	0.005	0.1537	0.2194
Echinococcus multilocularis	cathepsin b	0.0135	0.5397	0.7789
Loa Loa (eye worm)	TYRA-2 protein	0.0038	0.0992	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0992	0.1405
Schistosoma mansoni	lamin	0.0029	0.0614	0.0856
Brugia malayi	hypothetical protein	0.0039	0.1039	0.1926
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	hypothetical protein	0.0042	0.1188	0.1688
Echinococcus granulosus	neuropeptide FF receptor 2	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0044	0.1307	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0992	0.1405
Schistosoma mansoni	opsin-like receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0992	0.1405
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.1259	0.1791
Echinococcus multilocularis	cathepsin b	0.0135	0.5397	0.7789
Echinococcus multilocularis	neuropeptide receptor A26	0.0038	0.0992	0.1405
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0968	0.1759
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0614	0.0856
Schistosoma mansoni	hypothetical protein	0.0042	0.1188	0.1688
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0992	0.1405
Brugia malayi	cathepsin B-like cysteine proteinase	0.0135	0.5397	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0764	0.1074
Mycobacterium ulcerans	lipase LipD	0.0037	0.0968	0.5
Schistosoma mansoni	hypothetical protein	0.0032	0.0764	0.1074
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	protein patched	0.0043	0.1259	0.1791
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0968	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0992	0.1405
Brugia malayi	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	opsin-like receptor	0.0038	0.0992	0.1405
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.1259	0.1791
Brugia malayi	intermediate filament protein	0.0029	0.0614	0.1137
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0764	0.1416
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0992	0.1405
Echinococcus granulosus	lamin dm0	0.0029	0.0614	0.0856
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0968	0.137
Echinococcus multilocularis	lamin	0.0029	0.0614	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	lamin	0.0029	0.0614	0.0856
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0992	0.1405
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.2241	0.4152
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0992	0.1405
Onchocerca volvulus		0.0029	0.0614	0.2322
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0614	0.1137
Brugia malayi	beta-lactamase family protein	0.0037	0.0968	0.1794
Onchocerca volvulus		0.0038	0.0992	1
Brugia malayi	calpain family protein 1	0.0043	0.123	0.2279
Brugia malayi	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Onchocerca volvulus		0.0038	0.0992	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0992	0.1839
Echinococcus multilocularis	Niemann Pick C1 protein	0.0144	0.5842	0.8434
Brugia malayi	GnHR receptor homolog	0.0038	0.0992	0.1839
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0968	0.1759
Loa Loa (eye worm)	hypothetical protein	0.0101	0.3875	0.7181
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0038	0.0992	0.1839
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	musashi	0.0029	0.0614	0.0856
Schistosoma mansoni	hypothetical protein	0.0039	0.1039	0.1473
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.3944	0.7308
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0968	0.137
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0038	0.0992	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0992	0.1405
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	patched 1	0.0043	0.1259	0.1791
Brugia malayi	hypothetical protein	0.0038	0.0992	0.1839
Brugia malayi	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.2241	0.3215
Brugia malayi	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0968	0.137
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0992	0.1405
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0968	1
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.1259	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Brugia malayi	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0038	0.0992	0.1405
Onchocerca volvulus		0.0038	0.0992	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0764	0.1416
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Brugia malayi	TAR-binding protein	0.0065	0.2241	0.4152
Schistosoma mansoni	amine GPCR	0.0038	0.0992	0.1405
Echinococcus granulosus	intermediate filament protein	0.0029	0.0614	0.0856
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0764	0.1074
Echinococcus multilocularis	g-protein coupled receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0045	0.1318	0.1877
Schistosoma mansoni	amine GPCR	0.0038	0.0992	0.1405
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0038	0.0992	0.1405
Onchocerca volvulus		0.0038	0.0992	1
Onchocerca volvulus		0.0029	0.0614	0.2322
Echinococcus multilocularis	calpain family protein 1, d	0.0031	0.0719	0.1008
Loa Loa (eye worm)	melatonin receptor type 1A	0.0038	0.0992	0.1839
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.1039	0.1473
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0992	0.1405
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0043	0.123	0.2279
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0045	0.1318	0.1877
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0992	0.1405
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0038	0.0992	0.1839
Echinococcus multilocularis	dro:myosuppressin receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0103	0.3946	0.5686
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0992	0.1405
Brugia malayi	Dopamine receptor	0.0038	0.0992	0.1839
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0992	0.1405
Onchocerca volvulus		0.0038	0.0992	1
Brugia malayi	Dopamine receptor protein 2	0.0038	0.0992	0.1839
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0135	0.5397	0.7789
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	myosin xvIII	0.0038	0.0992	0.1405
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0614	0.1137
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Brugia malayi	G-protein coupled receptor	0.0038	0.0992	0.1839
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0764	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1701	0.3153
Echinococcus granulosus	lamin	0.0029	0.0614	0.0856
Brugia malayi	calpain family protein 1	0.0043	0.123	0.2279
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1259	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0968	0.1794
Brugia malayi	putative neuropeptide receptor	0.0038	0.0992	0.1839
Brugia malayi	hypothetical protein	0.0038	0.0992	0.1839
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0764	0.1416
Schistosoma mansoni	hypothetical protein	0.0038	0.0992	0.1405
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0992	0.1405
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.2472	0.4581
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	hypothetical protein	0.0168	0.6922	1
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Echinococcus granulosus	tar DNA binding protein	0.0065	0.2241	0.3215
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0992	0.1405
Schistosoma mansoni	hypothetical protein	0.007	0.2472	0.355
Echinococcus granulosus	neuropeptide s receptor	0.0038	0.0992	0.1405
Echinococcus granulosus	cathepsin b	0.0135	0.5397	0.7789
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Brugia malayi	Melatonin receptor type 1A	0.0038	0.0992	0.1839
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0992	0.1839
Brugia malayi	follicle stimulating hormone receptor	0.0038	0.0992	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.1259	0.1791
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0992	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0044	0.1307	1
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0968	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0992	0.1405
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0992	0.1405
Echinococcus granulosus	sex peptide receptor	0.0038	0.0992	0.1405
Brugia malayi	hypothetical protein	0.0038	0.0992	0.1839
Brugia malayi	putative neuropeptide receptor NPR1	0.0038	0.0992	0.1839
Echinococcus multilocularis	G protein coupled receptor 139	0.0038	0.0992	0.1405
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0992	0.1839
Schistosoma mansoni	amine GPCR	0.0038	0.0992	0.1405
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0992	0.1405
Onchocerca volvulus		0.0037	0.0968	0.9508
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0992	0.1405
Onchocerca volvulus		0.0038	0.0992	1
Echinococcus granulosus	orexin receptor type 2	0.0038	0.0992	0.1405
Schistosoma mansoni	hypothetical protein	0.0038	0.0992	0.1405
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0038	0.0992	0.1405
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0992	0.1405
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0101	0.3875	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.1039	0.1473
Onchocerca volvulus		0.0038	0.0992	1
Echinococcus granulosus	G protein coupled receptor 139	0.0038	0.0992	0.1405
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0992	0.1405
Echinococcus multilocularis	calpain A	0.0045	0.1318	0.1877
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0992	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0589	0.1092
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0992	0.1405
Echinococcus granulosus	fmrfamide receptor	0.0038	0.0992	0.1405
Onchocerca volvulus		0.0038	0.0992	1
Loa Loa (eye worm)	RNA binding protein	0.0065	0.2241	0.4152
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0992	0.1839

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 3700 nM	Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus	ChEMBL.	17822897
Ki (binding)	= 3700 nM	Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus	ChEMBL.	17822897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 460320