Detailed information for compound 460338

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 395.515 | Formula: C23H25NO3S
  • H donors: 0 H acceptors: 3 LogP: 3.45 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCC2(C(=C1)CCN(C2)S(=O)(=O)c1ccc(cc1)C)Cc1ccccc1
  • InChi: 1S/C23H25NO3S/c1-18-7-9-22(10-8-18)28(26,27)24-14-12-20-15-21(25)11-13-23(20,17-24)16-19-5-3-2-4-6-19/h2-10,15H,11-14,16-17H2,1H3
  • InChiKey: PBCHVOHGQQCJAZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii subtilisin SUB1 0.0084 0.0075 0.1176
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0159 0.0418 0.05
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0467 0.1833 0.3596
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0105 0.017 0.4593
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0159 0.0418 0.05
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0105 0.017 0.017
Echinococcus granulosus hypothetical protein 0.0159 0.0418 0.0346
Brugia malayi putative neuropeptide receptor 0.0159 0.0418 0.0443
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.0418 0.05
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0159 0.0418 0.0418
Loa Loa (eye worm) G-protein coupled receptor 0.0159 0.0418 0.05
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0159 0.0418 0.2739
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0159 0.0418 0.05
Trypanosoma brucei Aminopeptidase M1, putative 0.0105 0.017 0.3216
Brugia malayi Dopamine receptor 0.0159 0.0418 0.0443
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0159 0.0418 0.0418
Plasmodium vivax plasmepsin IV, putative 0.0123 0.025 0.4723
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0159 0.0418 0.05
Plasmodium vivax aspartyl proteinase, putative 0.0123 0.025 0.4723
Trichomonas vaginalis cyclins, putative 0.0149 0.037 0.0652
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0123 0.025 0.0412
Echinococcus multilocularis g protein coupled receptor 0.0159 0.0418 0.0418
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0105 0.017 0.017
Echinococcus granulosus neuropeptide Y receptor 0.0159 0.0418 0.0346
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0105 0.017 0.017
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0159 0.0418 0.05
Brugia malayi Peptidase family M1 containing protein 0.0105 0.017 0.0144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.0418 0.05
Echinococcus granulosus serotonin receptor 0.0159 0.0418 0.0346
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0467 0.1833 0.3596
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Schistosoma mansoni hypothetical protein 0.0159 0.0418 0.05
Brugia malayi Cyclin, N-terminal domain containing protein 0.0093 0.0114 0.0077
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Toxoplasma gondii subtilisin SUB6 0.0084 0.0075 0.1176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.0418 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0382 0.1444 0.2815
Schistosoma mansoni serine-type protease inhibitor 0.0428 0.1656 0.1978
Plasmodium falciparum plasmepsin I 0.0123 0.025 0.4723
Echinococcus multilocularis neuropeptides capa receptor 0.0159 0.0418 0.0418
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0189 0.0558 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0382 0.1444 0.2815
Echinococcus granulosus g protein coupled receptor 0.0159 0.0418 0.0346
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0159 0.0418 0.0346
Echinococcus multilocularis sex peptide receptor 0.0159 0.0418 0.0418
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 0.0418 0.0346
Loa Loa (eye worm) hypothetical protein 0.0084 0.0075 0.009
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0189 0.0558 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0159 0.0418 0.0346
Echinococcus multilocularis G-protein coupled receptor, putative 0.0159 0.0418 0.0418
Brugia malayi ORL1-like opioid receptor 0.0159 0.0418 0.0443
Schistosoma mansoni opsin-like receptor 0.0159 0.0418 0.05
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0105 0.017 0.0203
Plasmodium falciparum plasmepsin IV 0.0123 0.025 0.4723
Echinococcus granulosus cyclins 0.0093 0.0114 0.0039
Schistosoma mansoni biogenic amine receptor 0.0159 0.0418 0.05
Giardia lamblia Furin precursor putative serine protease 0.0382 0.1444 0.483
Onchocerca volvulus 0.0159 0.0418 0.2739
Echinococcus multilocularis membrane bound transcription factor site 1 0.0084 0.0075 0.0075
Echinococcus granulosus g protein coupled receptor 0.0159 0.0418 0.0346
Loa Loa (eye worm) hypothetical protein 0.0143 0.0346 0.0413
Brugia malayi G protein-coupled receptor F59B2.13 0.0159 0.0418 0.0443
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0105 0.017 0.3216
Trichomonas vaginalis cyclin B, putative 0.0149 0.037 0.0652
Onchocerca volvulus 0.0159 0.0418 0.2739
Plasmodium falciparum cyclin 0.0093 0.0114 0.1043
Trypanosoma brucei RNA helicase, putative 0.01 0.0147 0.2431
Mycobacterium ulcerans aminopeptidase N PepN 0.0105 0.017 0.1963
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Onchocerca volvulus 0.0159 0.0418 0.2739
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Brugia malayi hypothetical protein 0.0159 0.0418 0.0443
Schistosoma mansoni neuropeptide f receptor 76f 0.0159 0.0418 0.05
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0096 0.0126 0.0151
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus multilocularis cyclin b3 0.0093 0.0114 0.0114
Mycobacterium leprae probable zinc metalloprotease 0.0189 0.0558 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Onchocerca volvulus 0.0159 0.0418 0.2739
Echinococcus multilocularis Furin 1 0.0467 0.1833 0.1833
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0159 0.0418 0.0418
Onchocerca volvulus 0.0159 0.0418 0.2739
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus multilocularis cyclins 0.0093 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0114 0.0137
Brugia malayi SWIRM domain containing protein 0.0297 0.1055 0.1208
Loa Loa (eye worm) neuropeptide F receptor 0.0159 0.0418 0.05
Brugia malayi hypothetical protein 0.0159 0.0418 0.0443
Onchocerca volvulus 0.0357 0.1328 1
Trichomonas vaginalis cyclin D, putative 0.0093 0.0114 0.0137
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0382 0.1444 0.2815
Echinococcus multilocularis g protein coupled receptor 0.0159 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus multilocularis cyclins 0.0093 0.0114 0.0114
Toxoplasma gondii aspartyl protease ASP5 0.0115 0.0215 0.373
Brugia malayi follicle stimulating hormone receptor 0.0159 0.0418 0.0443
Brugia malayi Serotonin receptor 0.0159 0.0418 0.0443
Trichomonas vaginalis cyclin B, putative 0.0149 0.037 0.0652
Loa Loa (eye worm) peptidase family M1 containing protein 0.0289 0.1015 0.1212
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0159 0.0418 0.0443
Echinococcus granulosus cyclin b3 0.0093 0.0114 0.0039
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Schistosoma mansoni cyclins 0.0093 0.0114 0.0136
Echinococcus multilocularis neuroendocrine convertase 2 0.1197 0.5192 0.5192
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0159 0.0418 0.05
Onchocerca volvulus 0.0149 0.037 0.2353
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0105 0.017 0.017
Toxoplasma gondii subtilisin SUB11 0.0084 0.0075 0.1176
Schistosoma mansoni neprilysin-2 (M13 family) 0.0096 0.0126 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.0418 0.0346
Leishmania major cyclin 0.0149 0.037 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.014 0.0331 0.0395
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0159 0.0418 0.05
Trichomonas vaginalis cyclin B, putative 0.0093 0.0114 0.0137
Brugia malayi Tachykinin-like peptides receptor 99D 0.0831 0.3508 0.4155
Onchocerca volvulus 0.0159 0.0418 0.2739
Echinococcus multilocularis cyclin B3 1 0.0093 0.0114 0.0114
Brugia malayi GnHR receptor homolog 0.0159 0.0418 0.0443
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Echinococcus granulosus tachykinin peptides receptor 99D 0.0159 0.0418 0.0346
Onchocerca volvulus 0.0159 0.0418 0.2739
Toxoplasma gondii aspartyl protease ASP1 0.0123 0.025 0.438
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0159 0.0418 0.05
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0159 0.0418 0.0443
Trypanosoma brucei mitotic cyclin 6 0.0149 0.037 1
Echinococcus multilocularis neuropeptide s receptor 0.0159 0.0418 0.0418
Trypanosoma cruzi CYC2-like cyclin, putative 0.0149 0.037 1
Trichomonas vaginalis conserved hypothetical protein 0.0382 0.1444 0.2815
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0159 0.0418 0.0346
Schistosoma mansoni hypothetical protein 0.01 0.0147 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0075 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0084 0.0075 0.003
Trichomonas vaginalis cyclin A, putative 0.0149 0.037 0.0652
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.0418 0.05
Schistosoma mansoni amine GPCR 0.0159 0.0418 0.05
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0105 0.017 0.0096
Brugia malayi Myb-like DNA-binding domain containing protein 0.0174 0.0489 0.0527
Onchocerca volvulus 0.0159 0.0418 0.2739
Trichomonas vaginalis conserved hypothetical protein 0.0382 0.1444 0.2815
Schistosoma mansoni serine-type protease inhibitor 0.0428 0.1656 0.1978
Echinococcus multilocularis g protein coupled receptor 0.0159 0.0418 0.0418
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0159 0.0418 0.0418
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0159 0.0418 0.0346
Schistosoma mansoni adenoreceptor 0.0159 0.0418 0.05
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0467 0.1833 0.3596
Brugia malayi Dopamine receptor protein 1 0.0159 0.0418 0.0443
Echinococcus granulosus furin 0.1888 0.8374 0.8362
Echinococcus multilocularis G protein coupled receptor 139 0.031 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0084 0.0075 0.009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Loa Loa (eye worm) hypothetical protein 0.0297 0.1055 0.126
Brugia malayi proprotein convertase 2 0.1197 0.5192 0.6177
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.0418 0.05
Brugia malayi hypothetical protein 0.0105 0.017 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0075 0.0059
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0123 0.025 0.025
Brugia malayi G protein-coupled receptor 0.0159 0.0418 0.0443
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.0418 0.0346
Echinococcus granulosus cyclin B3 1 0.0093 0.0114 0.0039
Echinococcus multilocularis neuropeptides capa receptor 0.0159 0.0418 0.0418
Echinococcus multilocularis cyclins 0.0093 0.0114 0.0114
Entamoeba histolytica aminopeptidase, putative 0.0105 0.017 0.219
Trichomonas vaginalis cyclin B3, putative 0.0093 0.0114 0.0137
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0159 0.0418 0.0418
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0274 0.0948 0.1132
Brugia malayi AKH receptor 0.0159 0.0418 0.0443
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus multilocularis 0.1506 0.6616 0.6616
Trypanosoma cruzi cyclin, putative 0.0149 0.037 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0159 0.0418 0.05
Echinococcus multilocularis orexin receptor type 2 0.0159 0.0418 0.0418
Plasmodium falciparum plasmepsin V 0.0165 0.0446 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0105 0.017 0.025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.0418 0.0418
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.0418 0.05
Echinococcus granulosus neuropeptides capa receptor 0.0159 0.0418 0.0346
Loa Loa (eye worm) hypothetical protein 0.0143 0.0346 0.0413
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus multilocularis aminopeptidase N 0.0357 0.1328 0.1328
Brugia malayi Peptidase family M1 containing protein 0.0357 0.1328 0.1536
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Schistosoma mansoni hypothetical protein 0.0159 0.0418 0.05
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus granulosus fmrfamide receptor 0.0159 0.0418 0.0346
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0096 0.0126 0.0151
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus multilocularis neuropeptide receptor 0.031 0.1113 0.1113
Toxoplasma gondii subtilisin SUB10 0.0084 0.0075 0.1176
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0159 0.0418 0.0418
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0075 0.0059
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0105 0.017 0.0096
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0084 0.0075 0.203
Brugia malayi hypothetical protein 0.0159 0.0418 0.0443
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0075 0.0059
Brugia malayi Subtilase family protein 0.0084 0.0075 0.003
Onchocerca volvulus 0.0159 0.0418 0.2739
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0084 0.0075 0.003
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus granulosus lysine specific histone demethylase 1A 0.0274 0.0948 0.088
Schistosoma mansoni furin-1 (S08 family) 0.0815 0.3434 0.4101
Echinococcus multilocularis fmrfamide receptor 0.0159 0.0418 0.0418
Toxoplasma gondii subtilisin SUB9 0.0084 0.0075 0.1176
Trichomonas vaginalis cyclins, putative 0.0149 0.037 0.0652
Echinococcus multilocularis cyclins 0.0093 0.0114 0.0114
Loa Loa (eye worm) TYRA-2 protein 0.0159 0.0418 0.05
Schistosoma mansoni biogenic amine receptor 0.0159 0.0418 0.05
Onchocerca volvulus 0.0159 0.0418 0.2739
Brugia malayi G-protein coupled receptor 0.0159 0.0418 0.0443
Onchocerca volvulus 0.0159 0.0418 0.2739
Echinococcus granulosus peptide allatostatin:somatostatin 0.0159 0.0418 0.0346
Brugia malayi Melatonin receptor type 1A 0.0159 0.0418 0.0443
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Schistosoma mansoni cyclin B3 0.0093 0.0114 0.0136
Echinococcus granulosus tm gpcr rhodopsin 0.0159 0.0418 0.0346
Echinococcus multilocularis serotonin receptor 0.0159 0.0418 0.0418
Plasmodium falciparum plasmepsin VI 0.0123 0.025 0.4723
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0123 0.025 0.0299
Schistosoma mansoni alpha-1 adrenergic receptor 0.0159 0.0418 0.05
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0159 0.0418 0.05
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0105 0.017 0.017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Echinococcus granulosus neuropeptide FF receptor 2 0.0831 0.3508 0.3459
Loa Loa (eye worm) cyclin domain-containing protein 0.0093 0.0114 0.0136
Loa Loa (eye worm) peptidase family M13 containing protein 0.014 0.0331 0.0395
Loa Loa (eye worm) hypothetical protein 0.0143 0.0346 0.0413
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus granulosus dro:myosuppressin receptor 0.0159 0.0418 0.0346
Plasmodium falciparum plasmepsin II 0.0123 0.025 0.4723
Echinococcus granulosus alpha 1A adrenergic receptor 0.0159 0.0418 0.0346
Schistosoma mansoni hypothetical protein 0.0382 0.1444 0.1725
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Schistosoma mansoni neuropeptide F-like receptor 0.0159 0.0418 0.05
Brugia malayi Serotonin receptor 0.0159 0.0418 0.0443
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0105 0.017 0.0203
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0159 0.0418 0.0418
Toxoplasma gondii subtilisin SUB12 0.0084 0.0075 0.1176
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.0418 0.0346
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0159 0.0418 0.0443
Brugia malayi hypothetical protein 0.0159 0.0418 0.0443
Brugia malayi hypothetical protein 0.0159 0.0418 0.0443
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Brugia malayi hypothetical protein 0.0159 0.0418 0.0443
Trypanosoma cruzi cyclin, putative 0.0149 0.037 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0159 0.0418 0.0418
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Schistosoma mansoni hypothetical protein 0.0159 0.0418 0.05
Echinococcus multilocularis cyclins 0.0093 0.0114 0.0114
Brugia malayi hypothetical protein 0.0159 0.0418 0.0443
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0382 0.1444 0.2815
Schistosoma mansoni neuropeptide receptor 0.0159 0.0418 0.05
Onchocerca volvulus CoRest homolog 0.0179 0.0512 0.3489
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0084 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus granulosus neuropeptide s receptor 0.0159 0.0418 0.0346
Onchocerca volvulus 0.0105 0.017 0.0757
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.014 0.0331 0.0395
Echinococcus granulosus cyclins 0.0093 0.0114 0.0039
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0189 0.0558 0.0611
Onchocerca volvulus 0.0094 0.0118 0.0345
Loa Loa (eye worm) hypothetical protein 0.1888 0.8374 1
Onchocerca volvulus 0.0159 0.0418 0.2739
Toxoplasma gondii subtilisin SUB8 0.0084 0.0075 0.1176
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Loa Loa (eye worm) subtilase 0.0084 0.0075 0.009
Loa Loa (eye worm) melatonin receptor type 1A 0.0159 0.0418 0.05
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.1158 0.5015 0.5015
Echinococcus granulosus cyclins 0.0093 0.0114 0.0039
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Schistosoma mansoni neuropeptide receptor 0.031 0.1113 0.1329
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus granulosus aminopeptidase N 0.0357 0.1328 0.1263
Loa Loa (eye worm) G-protein coupled receptor 0.0159 0.0418 0.05
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 0.0418 0.05
Toxoplasma gondii subtilisin SUB4 0.0084 0.0075 0.1176
Trichomonas vaginalis cyclin B, putative 0.0149 0.037 0.0652
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0105 0.017 0.0096
Toxoplasma gondii subtilisin SUB7 0.0084 0.0075 0.1176
Schistosoma mansoni tyrosine kinase 0.0134 0.0303 0.0361
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0159 0.0418 0.05
Echinococcus granulosus neuroendocrine convertase 2 0.1197 0.5192 0.5155
Brugia malayi Cyclin, N-terminal domain containing protein 0.0149 0.037 0.0385
Onchocerca volvulus Neuropeptide F receptor homolog 0.0159 0.0418 0.2739
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0149 0.037 1
Toxoplasma gondii peptidase family M13 protein 0.0189 0.0558 1
Loa Loa (eye worm) hypothetical protein 0.0252 0.0845 0.1009
Echinococcus granulosus sex peptide receptor 0.0159 0.0418 0.0346
Loa Loa (eye worm) hypothetical protein 0.0189 0.0558 0.0666
Giardia lamblia High cysteine membrane protein Group 2 0.0692 0.2869 1
Trichomonas vaginalis conserved hypothetical protein 0.0382 0.1444 0.2815
Brugia malayi Peptidase family M13 containing protein 0.0189 0.0558 0.0611
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.0418 0.0346
Echinococcus multilocularis cyclin B 0.0149 0.037 0.037
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0159 0.0418 0.0418
Schistosoma mansoni biogenic amine receptor 0.0159 0.0418 0.05
Echinococcus granulosus g protein coupled receptor 0.0159 0.0418 0.0346
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0159 0.0418 0.0443
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.0418 0.0346
Echinococcus granulosus endothelin converting enzyme 1 0.0189 0.0558 0.0487
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus multilocularis allatostatin A receptor 0.0159 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0094 0.0118 0.0141
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0159 0.0418 0.05
Echinococcus granulosus 7TM GPCR rhodopsin 0.0159 0.0418 0.0346
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Brugia malayi larval opioid receptor 0.0159 0.0418 0.0443
Echinococcus multilocularis neuropeptide receptor A26 0.0159 0.0418 0.0418
Echinococcus granulosus neuropeptide receptor A26 0.0159 0.0418 0.0346
Schistosoma mansoni hypothetical protein 0.0159 0.0418 0.05
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.0418 0.0346
Echinococcus granulosus neuropeptides capa receptor 0.0159 0.0418 0.0346
Loa Loa (eye worm) hypothetical protein 0.0189 0.0558 0.0666
Loa Loa (eye worm) neuropeptide F receptor 0.0159 0.0418 0.05
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0159 0.0418 0.0346
Brugia malayi hypothetical protein 0.0159 0.0418 0.0443
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1158 0.5015 1
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0084 0.0075 0.009
Toxoplasma gondii subtilisin SUB2 0.0084 0.0075 0.1176
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Schistosoma mansoni amine GPCR 0.0159 0.0418 0.05
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0159 0.0418 0.05
Loa Loa (eye worm) hypothetical protein 0.0274 0.0948 0.1132
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0467 0.1833 0.3596
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0105 0.017 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0075 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0382 0.1444 0.2815
Loa Loa (eye worm) hypothetical protein 0.0143 0.0346 0.0413
Brugia malayi sulfakinin receptor protein 0.0159 0.0418 0.0443
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0467 0.1833 0.3596
Toxoplasma gondii subtilisin SUB5 0.0084 0.0075 0.1176
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0096 0.0126 0.0151
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.0418 0.0418
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0084 0.0075 0.203
Brugia malayi putative neuropeptide receptor NPR1 0.0159 0.0418 0.0443
Schistosoma mansoni neuropeptide receptor 0.0159 0.0418 0.05
Brugia malayi hypothetical protein 0.0159 0.0418 0.0443
Loa Loa (eye worm) hypothetical protein 0.014 0.0331 0.0395
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0093 0.0114 0.0039
Trypanosoma cruzi aminopeptidase, putative 0.0105 0.017 0.4593
Loa Loa (eye worm) hypothetical protein 0.0179 0.0512 0.0612
Echinococcus granulosus allatostatin A receptor 0.0159 0.0418 0.0346
Brugia malayi endoprotease bli-4 precursor 0.1888 0.8374 1
Schistosoma mansoni amine GPCR 0.0159 0.0418 0.05
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0093 0.0114 0.0114
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1888 0.8374 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0105 0.017 0.3216
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0096 0.0126 0.0151
Schistosoma mansoni memapsin-2 (A01 family) 0.0451 0.1762 0.2104
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0105 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.032 0.1158 0.1383
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0159 0.0418 0.05
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0159 0.0418 0.0346
Giardia lamblia G2/mitotic-specific cyclin B 0.0149 0.037 0.0929
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.0418 0.0346
Echinococcus granulosus 7tm_1 domain containing protein 0.0159 0.0418 0.0346
Loa Loa (eye worm) TK/EGFR protein kinase 0.0134 0.0303 0.0361
Schistosoma mansoni site-1 peptidase (S08 family) 0.0084 0.0075 0.009
Echinococcus granulosus neuropeptide receptor 0.031 0.1113 0.1046
Loa Loa (eye worm) hypothetical protein 0.0149 0.037 0.0442
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0159 0.0418 0.0418
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0467 0.1833 0.3596
Echinococcus granulosus cyclins 0.0093 0.0114 0.0039
Onchocerca volvulus 0.0297 0.1055 0.782
Echinococcus granulosus orexin receptor type 2 0.0159 0.0418 0.0346
Loa Loa (eye worm) hypothetical protein 0.073 0.3046 0.3637
Schistosoma mansoni opsin-like receptor 0.0159 0.0418 0.05
Trypanosoma cruzi cyclin 6, putative 0.0149 0.037 1
Echinococcus granulosus cyclin B 0.0149 0.037 0.0297
Echinococcus multilocularis cyclins 0.0093 0.0114 0.0114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.0418 0.0418
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Onchocerca volvulus 0.0159 0.0418 0.2739
Echinococcus multilocularis g-protein coupled receptor 0.0159 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0079 0.005 0.0059
Echinococcus multilocularis serotonin receptor 0.0159 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.014 0.0331 0.0395
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0123 0.025 0.0299
Trichomonas vaginalis cyclins, putative 0.0149 0.037 0.0652
Loa Loa (eye worm) hypothetical protein 0.0149 0.037 0.0442
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0159 0.0418 0.05
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0159 0.0418 0.0418
Echinococcus granulosus epidermal growth factor receptor 0.0134 0.0303 0.0229
Loa Loa (eye worm) hypothetical protein 0.0174 0.0489 0.0584
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 0.0418 0.0346
Plasmodium vivax plasmepsin V, putative 0.0165 0.0446 1
Echinococcus multilocularis neuropeptide Y receptor 0.0159 0.0418 0.0418
Schistosoma mansoni growth hormone secretagogue receptor 0.0159 0.0418 0.05
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0084 0.0075 0.203
Trypanosoma cruzi subtilisin peptidase 0.0084 0.0075 0.203
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0467 0.1833 0.2189
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0105 0.017 0.3216
Schistosoma mansoni myosin xvIII 0.0159 0.0418 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0382 0.1444 0.2815
Loa Loa (eye worm) hypothetical protein 0.0123 0.025 0.0299
Loa Loa (eye worm) hypothetical protein 0.0143 0.0346 0.0413
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Schistosoma mansoni cathepsin D (A01 family) 0.0307 0.1098 0.1311
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0123 0.025 0.438
Brugia malayi hypothetical protein 0.0159 0.0418 0.0443
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 0.0418 0.05
Loa Loa (eye worm) hypothetical protein 0.0274 0.0948 0.1132
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Loa Loa (eye worm) aminopeptidase N 0.0105 0.017 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0382 0.1444 0.2815
Loa Loa (eye worm) hypothetical protein 0.0143 0.0346 0.0413
Loa Loa (eye worm) endoprotease bli-4 0.1888 0.8374 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0105 0.017 0.4593
Trypanosoma brucei Aminopeptidase M1, putative 0.0105 0.017 0.3216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.0418 0.0418
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.0418 0.05
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Trichomonas vaginalis cyclins, putative 0.0149 0.037 0.0652
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1158 0.5015 1
Echinococcus multilocularis neuropeptide Y receptor 0.0159 0.0418 0.0418
Echinococcus granulosus tm gpcr rhodopsin 0.0159 0.0418 0.0346
Loa Loa (eye worm) hypothetical protein 0.0831 0.3508 0.419
Brugia malayi RE15519p 0.0159 0.0418 0.0443
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Trichomonas vaginalis cyclin D, putative 0.0093 0.0114 0.0137
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.1158 0.5015 0.4977
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0382 0.1444 0.2815
Onchocerca volvulus 0.0159 0.0418 0.2739
Echinococcus granulosus neuropeptide Y receptor 0.0159 0.0418 0.0346
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.0418 0.0418
Schistosoma mansoni neuropeptide F-like receptor 0.0159 0.0418 0.05
Schistosoma mansoni neuropeptide receptor 0.0159 0.0418 0.05
Schistosoma mansoni cyclin B 0.0149 0.037 0.0442
Brugia malayi Cyclin, N-terminal domain containing protein 0.0149 0.037 0.0385
Entamoeba histolytica cyclin, putative 0.0149 0.037 1
Echinococcus granulosus cyclins 0.0093 0.0114 0.0039
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Onchocerca volvulus 0.0159 0.0418 0.2739
Echinococcus granulosus neuropeptide receptor 0.0159 0.0418 0.0346
Echinococcus multilocularis fmrfamide receptor 0.0159 0.0418 0.0418
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0274 0.0948 0.0948
Trichomonas vaginalis conserved hypothetical protein 0.0382 0.1444 0.2815
Schistosoma mansoni cathepsin D (A01 family) 0.0307 0.1098 0.1311
Onchocerca volvulus 0.0159 0.0418 0.2739
Brugia malayi Dopamine receptor protein 2 0.0159 0.0418 0.0443
Schistosoma mansoni histamine h1 receptor 0.0159 0.0418 0.05
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus multilocularis somatostatin receptor 0.0159 0.0418 0.0418
Brugia malayi neuroendocrine convertase 1 precursor 0.1197 0.5192 0.6177
Echinococcus multilocularis neuropeptide FF receptor 2 0.0831 0.3508 0.3508
Loa Loa (eye worm) hypothetical protein 0.0189 0.0558 0.0666
Trichomonas vaginalis cyclins, putative 0.0093 0.0114 0.0137
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Mycobacterium ulcerans zinc metalloprotease 0.0189 0.0558 1
Trichomonas vaginalis conserved hypothetical protein 0.0382 0.1444 0.2815
Brugia malayi neuropeptide F receptor 0.0159 0.0418 0.0443
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0159 0.0418 0.0443
Schistosoma mansoni amine GPCR 0.0159 0.0418 0.05
Schistosoma mansoni site-1 peptidase (S08 family) 0.0084 0.0075 0.009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.0418 0.05
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0159 0.0418 0.05
Echinococcus multilocularis dro:myosuppressin receptor 0.0159 0.0418 0.0418
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0159 0.0418 0.05
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0159 0.0418 0.0418
Trichomonas vaginalis hypothetical protein 0.0382 0.1444 0.2815
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Brugia malayi Furin-like cysteine rich region family protein 0.0134 0.0303 0.0304
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Echinococcus multilocularis endothelin converting enzyme 1 0.0189 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0105 0.017 0.0096
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0123 0.025 0.0177
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2242 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0382 0.1444 0.2815
Trichomonas vaginalis cyclin B, putative 0.0149 0.037 0.0652
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Loa Loa (eye worm) proprotein convertase 2 0.0467 0.1833 0.2189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.0418 0.05
Echinococcus granulosus somatostatin receptor 0.0159 0.0418 0.0346
Brugia malayi G-protein coupled receptor 0.0159 0.0418 0.0443
Echinococcus granulosus g-protein coupled receptor 0.0159 0.0418 0.0346
Echinococcus multilocularis epidermal growth factor receptor 0.0134 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Loa Loa (eye worm) peptidase family M13 containing protein 0.014 0.0331 0.0395
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0159 0.0418 0.0418
Echinococcus multilocularis neuropeptide receptor 0.0159 0.0418 0.0418
Echinococcus multilocularis cyclins 0.0093 0.0114 0.0114
Echinococcus granulosus G protein coupled receptor 139 0.0159 0.0418 0.0346
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Loa Loa (eye worm) hypothetical protein 0.0159 0.0418 0.05
Schistosoma mansoni amine GPCR 0.0159 0.0418 0.05
Onchocerca volvulus 0.0159 0.0418 0.2739
Brugia malayi neuropeptide F receptor 0.0159 0.0418 0.0443
Brugia malayi celfurPC protein 0.1506 0.6616 0.7888
Schistosoma mansoni opsin-like receptor 0.0159 0.0418 0.05
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0075 0.0059
Echinococcus granulosus Furin 1 0.0467 0.1833 0.1771
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0159 0.0418 0.05

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 99 nM Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus ChEMBL. 17822897
Ki (binding) = 99 nM Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus ChEMBL. 17822897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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