Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1363 | 0.3887 | 0.3887 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1363 | 0.3887 | 0.3887 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1363 | 0.3887 | 0.3887 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.3311 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.1363 | 0.3887 | 0.3887 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1363 | 0.3887 | 0.3887 |
Loa Loa (eye worm) | hypothetical protein | 0.1363 | 0.3887 | 0.3887 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3311 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3311 | 1 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.3311 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3311 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3311 | 1 | 0.5 |
Echinococcus multilocularis | protein patched | 0.1363 | 0.3887 | 0.3887 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.3311 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.3311 | 1 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1363 | 0.3887 | 0.3887 |
Echinococcus multilocularis | protein dispatched 1 | 0.1363 | 0.3887 | 0.3887 |
Brugia malayi | CHE-14 protein | 0.1363 | 0.3887 | 0.3887 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1363 | 0.3887 | 0.3887 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1553 | 0.4484 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1553 | 0.4484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3311 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1553 | 0.4484 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1363 | 0.3887 | 0.3887 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1553 | 0.4484 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Binding affinity to Bcl-XL by fluorescence polarization assay | ChEMBL. | 17555961 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.