TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 282.312 | Formula: C17H15FN2O
H donors: 1 H acceptors: 1 LogP: 1.96 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)CC1(O)c2ccccc2C2=NCCN12
InChi: 1S/C17H15FN2O/c18-13-7-5-12(6-8-13)11-17(21)15-4-2-1-3-14(15)16-19-9-10-20(16)17/h1-8,21H,9-11H2
InChiKey: SCDKGODFOWORKQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nuclear hormone receptor family member odr-7	0.00934682	0.230929	0.156072
Brugia malayi	hypothetical protein	0.00934682	0.230929	0.156072
Loa Loa (eye worm)	hypothetical protein	0.00427118	0.0725488	0.0461966
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0104893	0.26658	1
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0104893	0.26658	1
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0104893	0.26658	1
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.00206902	0.00383254	0.5
Loa Loa (eye worm)	nuclear hormone receptor	0.00934682	0.230929	0.209077
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0206248	0.582848	0.553342
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.011278	0.29119	0.226746
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.00494466	0.093564	0.169699
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0206248	0.582848	0.570995
Echinococcus granulosus	sterol regulatory element binding protein	0.00954729	0.237185	0.166271
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0104893	0.26658	1
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0104893	0.26658	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.00934682	0.230929	0.159266
Loa Loa (eye worm)	hypothetical protein	0.011278	0.29119	0.27105
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0104893	0.26658	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0107559	0.274898	0.204321
Brugia malayi	ecdysteroid receptor	0.0339933	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0206248	0.582848	0.553342
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0206248	0.582848	0.542245
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0206248	0.582848	0.542245
Schistosoma mansoni	hypothetical protein	0.00553203	0.111892	0.0259699
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0206248	0.582848	0.570995
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0063402	0.137111	0.578075
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Echinococcus granulosus	Nuclear hormone receptor HR96	0.00934682	0.230929	0.159266
Echinococcus granulosus	Niemann Pick C1 protein	0.0203032	0.572812	0.542104
Loa Loa (eye worm)	hypothetical protein	0.00486452	0.0910634	0.0652374
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0334077	0.981725	0.981205
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0206248	0.582848	0.553342
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.011278	0.29119	0.226746
Mycobacterium ulcerans	oxidoreductase	0.00942673	0.233423	0.873805
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.011278	0.29119	0.226746
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0104893	0.26658	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.00934682	0.230929	0.159266
Schistosoma mansoni	coup transcription factor	0.0206248	0.582848	0.553342
Loa Loa (eye worm)	hypothetical protein	0.011278	0.29119	0.27105
Loa Loa (eye worm)	hypothetical protein	0.00427118	0.0725488	0.0461966
Echinococcus granulosus	nuclear receptor nhr 48	0.00934682	0.230929	0.159266
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.00934682	0.230929	0.209077
Loa Loa (eye worm)	hypothetical protein	0.0047888	0.0887005	0.0628074
Brugia malayi	nuclear receptor RXR	0.00934682	0.230929	0.156072
Loa Loa (eye worm)	hypothetical protein	0.011278	0.29119	0.27105
Trypanosoma cruzi	DNA topoisomerase II, putative	0.00570725	0.11736	1
Loa Loa (eye worm)	hypothetical protein	0.0206248	0.582848	0.570995
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0206248	0.582848	0.542245
Schistosoma mansoni	hypothetical protein	0.00553203	0.111892	0.0259699
Mycobacterium leprae	putative cytochrome p450	0.0104893	0.26658	0.5
Loa Loa (eye worm)	hypothetical protein	0.011278	0.29119	0.27105
Brugia malayi	ecdysone receptor	0.00934682	0.230929	0.156072
Plasmodium falciparum	DNA topoisomerase 2	0.0063402	0.137111	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0206248	0.582848	0.542245
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Loa Loa (eye worm)	hypothetical protein	0.0206248	0.582848	0.570995
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0104893	0.26658	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0206248	0.582848	0.553342
Trichomonas vaginalis	conserved hypothetical protein	0.00954729	0.237185	1
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0104893	0.26658	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0206248	0.582848	0.553342
Chlamydia trachomatis	DNA gyrase subunit B	0.00346456	0.0473791	1
Onchocerca volvulus		0.00934682	0.230929	0.161168
Echinococcus multilocularis	expressed conserved protein	0.0103966	0.263685	0.195946
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.00934682	0.230929	0.159266
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.00934682	0.230929	0.161168
Echinococcus granulosus	FTZ F1 alpha	0.0206248	0.582848	0.553342
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0206248	0.582848	0.553342
Echinococcus multilocularis	protein dispatched 1	0.00990664	0.248398	0.178828
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.00934682	0.230929	0.159266
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0206248	0.582848	0.570995
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0104893	0.26658	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.00934682	0.230929	0.159266
Brugia malayi	nuclear receptor NHR-88	0.00934682	0.230929	0.156072
Brugia malayi	Steroid receptor seven-up type 2	0.0206248	0.582848	0.542245
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0206248	0.582848	0.570995
Echinococcus multilocularis	sterol regulatory element binding protein	0.00954729	0.237185	0.166271
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.00934682	0.230929	0.159266
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.00570725	0.11736	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0206248	0.582848	0.542245
Schistosoma mansoni	retinoic acid receptor RXR	0.0206248	0.582848	0.553342
Brugia malayi	steroid hormone receptor	0.0206248	0.582848	0.542245
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0063402	0.137111	0.054209
Schistosoma mansoni	DNA topoisomerase II	0.0063402	0.137111	0.054209
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0147712	0.400191	0.348804
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0104893	0.26658	1
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0104893	0.26658	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0206248	0.582848	0.553342
Echinococcus multilocularis	Niemann Pick C1 protein	0.0203032	0.572812	0.542104
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0104893	0.26658	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0206248	0.582848	0.545009
Brugia malayi	CHE-14 protein	0.00954729	0.237185	0.162937
Leishmania major	mitochondrial DNA topoisomerase II	0.00494466	0.093564	0.169699
Echinococcus granulosus	Niemann Pick C1 protein	0.0107559	0.274898	0.208502
Loa Loa (eye worm)	hypothetical protein	0.011278	0.29119	0.27105
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0206248	0.582848	0.553342
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0206248	0.582848	0.542245
Brugia malayi	nuclear hormone receptor family member nhr-6	0.00934682	0.230929	0.156072
Trypanosoma brucei	DNA topoisomerase ii	0.00494466	0.093564	0.169699
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0206248	0.582848	0.553342
Brugia malayi	photoreceptor-specific nuclear receptor	0.0206248	0.582848	0.542245
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0334077	0.981725	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0206248	0.582848	0.570995
Schistosoma mansoni	thyroid hormone receptor	0.0206248	0.582848	0.553342
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0206248	0.582848	0.553342
Brugia malayi	hypothetical protein	0.00934682	0.230929	0.156072
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0104893	0.26658	1
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Brugia malayi	Nuclear hormone receptor-like 1	0.0206248	0.582848	0.542245
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0104893	0.26658	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.011278	0.29119	0.27105
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0063402	0.137111	0.0531219
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.00954729	0.237185	0.215511
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.00570725	0.11736	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0206248	0.582848	0.553342
Brugia malayi	Nuclear hormone receptor E75	0.00934682	0.230929	0.156072
Giardia lamblia	DNA topoisomerase II	0.00606243	0.128443	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.00934682	0.230929	0.159266
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.00494466	0.093564	0.169699
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.00934682	0.230929	0.161168
Loa Loa (eye worm)	hypothetical protein	0.0206248	0.582848	0.570995
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0206248	0.582848	0.553342
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0334077	0.981725	1
Brugia malayi	Probable DNA topoisomerase II	0.0063402	0.137111	0.0531219
Schistosoma mansoni	nuclear hormone receptor	0.00934682	0.230929	0.159266
Echinococcus multilocularis	protein patched	0.00954729	0.237185	0.166271
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0063402	0.137111	1
Onchocerca volvulus		0.0206248	0.582848	0.545009
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0063402	0.137111	0.054209
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0107559	0.274898	1
Leishmania major	DNA topoisomerase ii	0.00570725	0.11736	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0206248	0.582848	0.553342
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0206248	0.582848	0.542245
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0206248	0.582848	0.553342
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0206248	0.582848	0.553342
Brugia malayi	orphan nuclear receptor NR2E1	0.00934682	0.230929	0.156072
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Brugia malayi	nuclear receptor NHR-67	0.00934682	0.230929	0.156072
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0206248	0.582848	0.542245
Schistosoma mansoni	nuclear hormone receptor	0.00934682	0.230929	0.159266
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0104893	0.26658	1
Echinococcus multilocularis	FTZ F1 alpha	0.0206248	0.582848	0.553342
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0104893	0.26658	1
Trypanosoma cruzi	DNA topoisomerase II, putative	0.00570725	0.11736	1
Brugia malayi	Nuclear hormone receptor-like 1	0.011278	0.29119	0.222198
Brugia malayi	conserved hypotetical protein	0.00934682	0.230929	0.156072
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0104893	0.26658	1
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0206248	0.582848	0.553342
Brugia malayi	nuclear hormone receptor	0.0206248	0.582848	0.542245
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0206248	0.582848	0.542245
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0334077	0.981725	1
Onchocerca volvulus		0.00934682	0.230929	0.161168
Schistosoma mansoni	nuclear receptor	0.00934682	0.230929	0.159266
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0206248	0.582848	0.553342
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0063402	0.137111	0.0531219
Schistosoma mansoni	nuclear receptor nhr-48	0.00934682	0.230929	0.159266
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0047888	0.0887005	0.323002
Loa Loa (eye worm)	TOPoisomerase family member	0.0063402	0.137111	0.112593
Brugia malayi	hypothetical protein	0.011278	0.29119	0.222198
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0206248	0.582848	0.553342
Loa Loa (eye worm)	hypothetical protein	0.00954729	0.237185	0.215511
Brugia malayi	nuclear receptor RXR	0.011278	0.29119	0.222198
Mycobacterium tuberculosis	Probable oxidoreductase	0.00942673	0.233423	0.873805
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0206248	0.582848	0.553342
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.011278	0.29119	0.226746
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0104893	0.26658	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0206248	0.582848	0.545009
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.00934682	0.230929	0.159266
Loa Loa (eye worm)	hypothetical protein	0.0206248	0.582848	0.570995
Brugia malayi	Nuclear hormone receptor-like 1	0.011278	0.29119	0.222198
Loa Loa (eye worm)	hypothetical protein	0.0206248	0.582848	0.570995
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0206248	0.582848	0.553342
Echinococcus granulosus	ecdysone induced protein 78C	0.0206248	0.582848	0.553342
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0104893	0.26658	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.00934682	0.230929	0.159266
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0104893	0.26658	1
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0104893	0.26658	1
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0104893	0.26658	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0206248	0.582848	0.553342
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0206248	0.582848	0.542245
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0206248	0.582848	0.553342
Schistosoma mansoni	nuclear receptor	0.00934682	0.230929	0.159266
Echinococcus multilocularis	ecdysone induced protein 78C	0.0206248	0.582848	0.553342
Onchocerca volvulus	Bile acid receptor homolog	0.0339933	1	1
Plasmodium vivax	DNA topoisomerase II, putative	0.0063402	0.137111	1
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0104893	0.26658	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0206248	0.582848	0.542245
Echinococcus granulosus	expressed conserved protein	0.0103966	0.263685	0.195946
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0206248	0.582848	0.570995
Loa Loa (eye worm)	hypothetical protein	0.0206248	0.582848	0.570995
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0206248	0.582848	0.542245
Loa Loa (eye worm)	hypothetical protein	0.0107559	0.274898	0.254295
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.00206902	0.00383254	0.5
Echinococcus granulosus	Protein patched homolog 1	0.00954729	0.237185	0.166271
Schistosoma mansoni	zinc finger protein	0.00934682	0.230929	0.159266
Schistosoma mansoni	hypothetical protein	0.00553203	0.111892	0.0259699
Loa Loa (eye worm)	steroid hormone receptor	0.0206248	0.582848	0.570995
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0104893	0.26658	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0206248	0.582848	0.553342
Brugia malayi	nuclear hormone receptor	0.00934682	0.230929	0.156072
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.00934682	0.230929	0.159266
Brugia malayi	tailless protein	0.00934682	0.230929	0.156072
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.00934682	0.230929	0.156072
Loa Loa (eye worm)	hypothetical protein	0.0206248	0.582848	0.570995
Schistosoma mansoni	patched 1	0.00954729	0.237185	0.166271
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.00934682	0.230929	0.159266
Brugia malayi	hypothetical protein	0.011278	0.29119	0.222198
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0206248	0.582848	0.542245
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0334077	0.981725	0.979946
Echinococcus multilocularis	Niemann Pick C1 protein	0.0107559	0.274898	0.208502
Brugia malayi	nuclear receptor NHR-88	0.0206248	0.582848	0.542245
Loa Loa (eye worm)	hypothetical protein	0.0339933	1	1
Brugia malayi	Nuclear hormone receptor E75	0.00934682	0.230929	0.156072
Schistosoma mansoni	hypothetical protein	0.00553203	0.111892	0.0259699
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0104893	0.26658	1
Loa Loa (eye worm)	hypothetical protein	0.00934682	0.230929	0.209077
Loa Loa (eye worm)	nuclear receptor NHR-67	0.00934682	0.230929	0.209077
Schistosoma mansoni	nuclear hormone receptor	0.0206248	0.582848	0.553342
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.00934682	0.230929	0.159266
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0206248	0.582848	0.570995
Loa Loa (eye worm)	DR-78	0.00934682	0.230929	0.209077

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 5.5 %	Anxiolytic effect in Albino ICR mouse assessed as number of entries in open arms of elevated plus-maze test at 15 mg/kg, ip	ChEMBL.	17507222
Activity (functional)	= 5.5 %	Anxiolytic effect in Albino ICR mouse assessed as number of entries in open arms of elevated plus-maze test at 15 mg/kg, ip	ChEMBL.	17507222
Activity (functional)	= 22.9 %	Anxiolytic effect in Albino ICR mouse assessed as time spent on open arms of elevated plus-maze test at 15 mg/ kg, ip	ChEMBL.	17507222
Activity (functional)	= 22.9 %	Anxiolytic effect in Albino ICR mouse assessed as time spent on open arms of elevated plus-maze test at 15 mg/ kg, ip	ChEMBL.	17507222
IC50 (functional)	= 4.2 uM	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O positive erythrocytes after 48 hrs by SYBR green-I based fluorescence assay	ChEMBL.	21940072
Ratio IC50 (functional)	< 1	Ratio of chloroquine IC50 to Compound IC50 for chloroquine-sensitive Plasmodium falciparum 3D7	ChEMBL.	21940072

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	21940072

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL248405

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 460508