Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0683 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0683 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0683 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0683 | 1 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0187 | 0.1258 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0683 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0683 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0187 | 0.1258 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0683 | 1 | 1 |
Onchocerca volvulus | 0.0115 | 0 | 0.5 | |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0187 | 0.1258 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0187 | 0.1258 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0683 | 1 | 1 |
Onchocerca volvulus | 0.0115 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0187 | 0.1258 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0187 | 0.1258 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0683 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0683 | 1 | 1 |
Onchocerca volvulus | 0.0115 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0683 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0187 | 0.1258 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0187 | 0.1258 | 0.5 |
Onchocerca volvulus | 0.0115 | 0 | 0.5 | |
Onchocerca volvulus | 0.0115 | 0 | 0.5 | |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0187 | 0.1258 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0683 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 30 uM | Inhibition of hypoxia induced HIF1alpha transcriptional activity in human Sk-Hep1 cells by reporter gene assay | ChEMBL. | 17884495 |
IC50 (binding) | > 30 uM | Inhibition of hypoxia induced HIF1alpha transcriptional activity in human Hep3B cells by reporter gene assay | ChEMBL. | 17884495 |
IC50 (binding) | > 30 uM | Inhibition of hypoxia induced HIF1alpha transcriptional activity in human AGS cells by reporter gene assay | ChEMBL. | 17884495 |
IC50 (binding) | > 30 uM | Inhibition of hypoxia induced HIF1alpha transcriptional activity in human Sk-Hep1 cells by reporter gene assay | ChEMBL. | 17884495 |
IC50 (binding) | > 30 uM | Inhibition of hypoxia induced HIF1alpha transcriptional activity in human Hep3B cells by reporter gene assay | ChEMBL. | 17884495 |
IC50 (binding) | > 30 uM | Inhibition of hypoxia induced HIF1alpha transcriptional activity in human AGS cells by reporter gene assay | ChEMBL. | 17884495 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.