TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 340.423 | Formula: C18H24N6O
H donors: 1 H acceptors: 3 LogP: 0.9 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N[C@H]1CN(C[C@H]1C(=O)N1CCCC1)Cc1ccc(cc1)n1ncnc1
InChi: 1S/C18H24N6O/c19-17-11-22(10-16(17)18(25)23-7-1-2-8-23)9-14-3-5-15(6-4-14)24-13-20-12-21-24/h3-6,12-13,16-17H,1-2,7-11,19H2/t16-,17+/m1/s1
InChiKey: FMAPRDREHYFIMQ-SJORKVTESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dipeptidyl-peptidase 4	Starlite/ChEMBL	References
Homo sapiens	dipeptidyl-peptidase 8	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129743	All targets in OG5_129743
Leishmania mexicana	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	Get druggable targets OG5_129743	All targets in OG5_129743
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus multilocularis	Dipeptidyl peptidase 9	Get druggable targets OG5_129743	All targets in OG5_129743
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	Get druggable targets OG5_129743	All targets in OG5_129743
Leishmania infantum	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Echinococcus granulosus	Dipeptidyl peptidase 9	Get druggable targets OG5_129743	All targets in OG5_129743
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_129743	All targets in OG5_129743
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Trypanosoma brucei gambiense	dipeptidyl-peptidase 8-like serine protease	Get druggable targets OG5_129743	All targets in OG5_129743
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	Get druggable targets OG5_129743	All targets in OG5_129743
Leishmania donovani	serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Leishmania braziliensis	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma japonicum	ko:K08656 dipeptidyl-peptidase 9, putative	Get druggable targets OG5_129743	All targets in OG5_129743

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Plasmodium falciparum	subtilisin-like protease 3	0.0046	0.0171	0.4956
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1719	0.2816
Echinococcus multilocularis	Furin 1	0.0253	0.2157	0.2646
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1719	0.2816
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0253	0.2157	0.3557
Toxoplasma gondii	hypothetical protein	0.0033	0.0051	0.0468
Toxoplasma gondii	pyruvate kinase PyK1	0.0035	0.0066	0.0609
Trypanosoma cruzi	subtilisin peptidase	0.0046	0.0171	0.072
Schistosoma mansoni	memapsin-2 (A01 family)	0.0428	0.3836	0.3836
Trypanosoma brucei	pyruvate kinase 1, putative	0.0035	0.0066	0.0091
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0044	0.0157	0.8838
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0141	0.1082	1
Loa Loa (eye worm)	subtilase	0.0046	0.0171	0.0171
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0044	0.0157	0.455
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0046	0.0171	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0095	0.0647	0.0647
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0033	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0073	0.0073
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0046	0.0171	1
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1719	0.2816
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0044	0.0157	0.455
Toxoplasma gondii	histone lysine-specific demethylase	0.0044	0.0157	0.1454
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0033	0.0051	0.0468
Brugia malayi	prolyl oligopeptidase family protein	0.0208	0.1727	0.1727
Plasmodium falciparum	subtilisin-like protease 2	0.0046	0.0171	0.4956
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0033	0.0051	0.0051
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0208	0.1727	1
Entamoeba histolytica	hypothetical protein, conserved	0.0033	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0218	0.1823	0.1823
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0253	0.2157	0.3557
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0046	0.0171	0.0152
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0033	0.0051	0.5
Onchocerca volvulus		0.0046	0.0171	0.071
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1719	0.2816
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0253	0.2157	0.3557
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0044	0.0157	0.8838
Loa Loa (eye worm)	endoprotease bli-4	0.1071	1	1
Echinococcus multilocularis		0.0863	0.8014	1
Brugia malayi	hypothetical protein	0.0044	0.0157	0.0157
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0046	0.0171	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Echinococcus multilocularis	neuroendocrine convertase 2	0.0673	0.6185	0.7703
Brugia malayi	SWIRM domain containing protein	0.0236	0.2	0.2
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0046	0.0171	0.0171
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0046	0.0171	1
Loa Loa (eye worm)	pyruvate kinase	0.0035	0.0066	0.0066
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0044	0.0157	0.0637
Echinococcus granulosus	Furin 1	0.0253	0.2157	0.2117
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0046	0.0171	0.0121
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1719	0.2816
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0044	0.0157	0.8838
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0231	0.0231
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.028	0.2414	0.2375
Loa Loa (eye worm)	prolyl oligopeptidase	0.028	0.2414	0.2414
Toxoplasma gondii	aspartyl protease ASP1	0.0064	0.0346	0.3195
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0035	0.0066	0.0091
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1719	0.2816
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0651	0.5973	0.5952
Loa Loa (eye worm)	pyruvate kinase	0.0035	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0157	0.0157
Brugia malayi	celfurPC protein	0.0863	0.8014	0.8014
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0764	0.0764
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0033	0.0051	0.5
Leishmania major	pyruvate kinase	0.0035	0.0066	0.0091
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0066	0.0273
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0046	0.0171	0.072
Leishmania major	subtilisin-like serine peptidase	0.0046	0.0171	0.072
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0253	0.2157	0.3557
Loa Loa (eye worm)	proprotein convertase 2	0.0253	0.2157	0.2157
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0046	0.0171	0.072
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0046	0.0171	0.0171
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0046	0.0171	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0046	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0346	0.0346
Leishmania major	UDP-galactopyranose mutase	0.0044	0.0157	0.0637
Plasmodium vivax	plasmepsin IV, putative	0.0064	0.0346	1
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1719	0.2816
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0046	0.0171	1
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1719	0.2816
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0046	0.0171	1
Giardia lamblia	Pyruvate kinase	0.0035	0.0066	0.0044
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0208	0.1727	0.2105
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0046	0.0171	0.0152
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.0647	0.0749
Trichomonas vaginalis	pyruvate kinase, putative	0.0035	0.0066	0.0026
Plasmodium vivax	subtilisin-like protease 2, putative	0.0046	0.0171	0.4956
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0218	0.1823	0.1781
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0095	0.0647	0.0647
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.0647	0.0599
Trypanosoma brucei	pyruvate kinase 1	0.0035	0.0066	0.0091
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0171	0.0204
Schistosoma mansoni	amine oxidase	0.0044	0.0157	0.0157
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0064	0.0346	0.3195
Onchocerca volvulus	CoRest homolog	0.0182	0.1481	0.6136
Echinococcus granulosus	survival motor neuron protein 1	0.0246	0.2096	0.2056
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0073	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0171	0.0204
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0046	0.0171	1
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.028	0.2414	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.0695	0.0695
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0033	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0051	0.0051
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0651	0.5973	1
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0208	0.1727	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0246	0.2096	0.2569
Schistosoma mansoni	cathepsin D (A01 family)	0.0156	0.1228	0.1228
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0177	0.1431	0.1431
Toxoplasma gondii	subtilisin SUB4	0.0046	0.0171	0.1583
Brugia malayi	hypothetical protein	0.0108	0.0764	0.0764
Plasmodium vivax	pyruvate kinase, putative	0.0035	0.0066	0.1906
Brugia malayi	prolyl oligopeptidase family protein	0.0033	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0157	0.0157
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0035	0.0066	0.0066
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0046	0.0171	0.072
Plasmodium falciparum	plasmepsin IV	0.0064	0.0346	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0033	0.0051	0.5
Schistosoma mansoni	survival motor neuron protein	0.005	0.0215	0.0215
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0171	0.0204
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0066	0.0273
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0035	0.0066	0.1268
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0046	0.0171	0.0171
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0171	0.0204
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.028	0.2414	0.2968
Toxoplasma gondii	subtilisin SUB7	0.0046	0.0171	0.1583
Schistosoma mansoni	hypothetical protein	0.0207	0.1719	0.1719
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0044	0.0157	0.0134
Toxoplasma gondii	subtilisin SUB6	0.0046	0.0171	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0066	0.0066
Schistosoma mansoni	pyruvate kinase	0.0035	0.0066	0.0066
Plasmodium vivax	hypothetical protein, conserved	0.0044	0.0157	0.455
Loa Loa (eye worm)	pyruvate kinase	0.0035	0.0066	0.0066
Mycobacterium leprae	Possible secreted protease	0.0046	0.0171	1
Plasmodium falciparum	plasmepsin VI	0.0064	0.0346	1
Trichomonas vaginalis	hypothetical protein	0.0207	0.1719	0.2816
Trichomonas vaginalis	pyruvate kinase, putative	0.0035	0.0066	0.0026
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1719	0.2816
Loa Loa (eye worm)	hypothetical protein	0.0236	0.2	0.2
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0035	0.0066	0.1268
Schistosoma mansoni	hypothetical protein	0.005	0.0215	0.0215
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0046	0.0171	0.0171
Echinococcus granulosus	membrane bound transcription factor site 1	0.0046	0.0171	0.0121
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0046	0.0171	0.072
Mycobacterium ulcerans	pyruvate kinase	0.0035	0.0066	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2096	0.2096
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0334	0.0334
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.028	0.2414	0.2414
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Onchocerca volvulus		0.0236	0.2	0.8284
Plasmodium vivax	hypothetical protein, conserved	0.0044	0.0157	0.455
Echinococcus multilocularis	pyruvate kinase	0.0035	0.0066	0.0019
Toxoplasma gondii	subtilisin SUB12	0.0046	0.0171	0.1583
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Toxoplasma gondii	subtilisin SUB11	0.0046	0.0171	0.1583
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Toxoplasma gondii	subtilisin SUB2	0.0046	0.0171	0.1583
Schistosoma mansoni	cathepsin D (A01 family)	0.0156	0.1228	0.1228
Plasmodium falciparum	plasmepsin I	0.0064	0.0346	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0647	0.0647
Echinococcus granulosus	neuroendocrine convertase 2	0.0673	0.6185	0.6165
Loa Loa (eye worm)	hypothetical protein	0.042	0.376	0.376
Plasmodium vivax	aspartyl proteinase, putative	0.0064	0.0346	1
Plasmodium vivax	subtilisin-like serine protease, putative	0.0046	0.0171	0.4956
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0044	0.0157	0.455
Echinococcus multilocularis		0.0044	0.0157	0.0134
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0046	0.0171	1
Plasmodium falciparum	pyruvate kinase	0.0035	0.0066	0.1906
Echinococcus granulosus	pyruvate kinase	0.0035	0.0066	0.0015
Leishmania major	pyruvate kinase	0.0035	0.0066	0.0091
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0064	0.0346	0.0346
Brugia malayi	prolyl oligopeptidase family protein	0.028	0.2414	0.2414
Toxoplasma gondii	subtilisin SUB8	0.0046	0.0171	0.1583
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0033	0.0051	0.5
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0035	0.0066	0.0066
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0215	0.0215
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0033	0.0051	0.0051
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0044	0.0157	1
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0208	0.1727	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1431	0.1431
Toxoplasma gondii	subtilisin SUB5	0.0046	0.0171	0.1583
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Brugia malayi	Subtilase family protein	0.0046	0.0171	0.0171
Toxoplasma gondii	subtilisin SUB10	0.0046	0.0171	0.1583
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0208	0.1727	1
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.1071	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0171	0.0171
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0044	0.0157	0.1454
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0253	0.2157	0.3557
Plasmodium falciparum	peptidase, putative	0.0033	0.0051	0.1463
Toxoplasma gondii	prolyl endopeptidase	0.0033	0.0051	0.0468
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0218	0.1823	0.1823
Brugia malayi	neuroendocrine convertase 1 precursor	0.0673	0.6185	0.6185
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.0647	0.0599
Mycobacterium tuberculosis	Possible oxidoreductase	0.0044	0.0157	0.8838
Brugia malayi	amine oxidase, flavin-containing family protein	0.0063	0.0334	0.0334
Mycobacterium ulcerans	oxidoreductase	0.0044	0.0157	0.8838
Brugia malayi	prolyl oligopeptidase family protein	0.0033	0.0051	0.0051
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0044	0.0157	0.0637
Echinococcus multilocularis	pyruvate kinase	0.0035	0.0066	0.0019
Plasmodium falciparum	protoporphyrinogen oxidase	0.0044	0.0157	0.455
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0171	0.0204
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0051	0.1463
Loa Loa (eye worm)	hypothetical protein	0.1071	1	1
Mycobacterium ulcerans	dehydrogenase	0.0044	0.0157	0.8838
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0253	0.2157	0.3557
Giardia lamblia	Furin precursor putative serine protease	0.0207	0.1719	0.4769
Brugia malayi	prolyl oligopeptidase family protein	0.0033	0.0051	0.0051
Loa Loa (eye worm)	prolyl oligopeptidase	0.0033	0.0051	0.0051
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0033	0.0051	0.0051
Brugia malayi	hypothetical protein	0.0246	0.2096	0.2096
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0208	0.1727	0.1685
Schistosoma mansoni	hypothetical protein	0.0036	0.0073	0.0073
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0044	0.0157	0.0107
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0044	0.0157	0.455
Mycobacterium ulcerans	monoamine oxidase	0.0044	0.0157	0.8838
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0647	0.0647
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0064	0.0346	0.0346
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0207	0.1719	0.2816
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0064	0.0346	0.0498
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0044	0.0157	0.8838
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0207	0.1719	0.2816
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0044	0.0157	0.8838
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0651	0.5973	1
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0253	0.2157	0.2157
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0218	0.1823	0.2226
Plasmodium falciparum	subtilisin-like protease 1	0.0046	0.0171	0.4956
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.0647	0.0749
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0647	0.0647
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0231	0.0231
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0046	0.0171	0.0171
Schistosoma mansoni	amine oxidase	0.0044	0.0157	0.0157
Plasmodium vivax	subtilisin-like protease 1	0.0046	0.0171	0.4956
Echinococcus granulosus	pyruvate kinase	0.0035	0.0066	0.0015
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0651	0.5973	0.7437
Brugia malayi	proprotein convertase 2	0.0673	0.6185	0.6185
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0066	0.0273
Plasmodium falciparum	plasmepsin II	0.0064	0.0346	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1481	0.1481
Toxoplasma gondii	subtilisin SUB9	0.0046	0.0171	0.1583
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0044	0.0157	0.0157
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0208	0.1727	0.1727
Echinococcus granulosus	furin	0.1071	1	1
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0035	0.0066	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0051	0.0051
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0207	0.1719	0.2816
Trypanosoma brucei	subtilisin peptidase	0.0046	0.0171	0.072
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1719	0.2816
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Toxoplasma gondii	subtilisin SUB1	0.0046	0.0171	0.1583
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0064	0.0346	0.0371
Schistosoma mansoni	furin-1 (S08 family)	0.0466	0.4199	0.4199
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0218	0.1823	0.1823
Schistosoma mansoni	pyruvate kinase	0.0035	0.0066	0.0066
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0064	0.0346	0.0297
Onchocerca volvulus		0.005	0.0215	0.0889
Giardia lamblia	High cysteine membrane protein Group 2	0.0398	0.3548	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0231	0.0231
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0033	0.0051	0.021
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0208	0.1727	1
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1719	0.2816
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0046	0.0171	0.0204

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 69 nM	Inhibition of human DPP4	ChEMBL.	17977724
IC50 (binding)	= 69 nM	Inhibition of human DPP4	ChEMBL.	17977724
IC50 (binding)	= 4.7 uM	Inhibition of human DPP8	ChEMBL.	17977724
IC50 (binding)	= 4.7 uM	Inhibition of human DPP8	ChEMBL.	17977724

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL249174

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 460873