Detailed information for compound 461087

Basic information

Technical information
  • TDR Targets ID: 461087
  • Name: N-[2-(3-methoxyphenoxy)ethyl]-5-(4-methylpipe razin-1-yl)-2-nitroaniline
  • MW: 386.445 | Formula: C20H26N4O4
  • H donors: 1 H acceptors: 2 LogP: 3.86 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)OCCNc1cc(ccc1[N+](=O)[O-])N1CCN(CC1)C
  • InChi: 1S/C20H26N4O4/c1-22-9-11-23(12-10-22)16-6-7-20(24(25)26)19(14-16)21-8-13-28-18-5-3-4-17(15-18)27-2/h3-7,14-15,21H,8-13H2,1-2H3
  • InChiKey: FGVSCDYMZJJBRE-UHFFFAOYSA-N  

Network

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Synonyms

  • N-[2-(3-methoxyphenoxy)ethyl]-5-(4-methylpiperazin-1-yl)-2-nitro-aniline
  • N-[2-(3-methoxyphenoxy)ethyl]-5-(4-methyl-1-piperazinyl)-2-nitroaniline
  • 2-(3-methoxyphenoxy)ethyl-[5-(4-methylpiperazino)-2-nitro-phenyl]amine
  • 2-(3-methoxyphenoxy)ethyl-[5-(4-methylpiperazin-1-yl)-2-nitro-phenyl]amine
  • EU-0002766
  • STK016677

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0072 0.0243 0.0706
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0072 0.0243 0.6422
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Echinococcus granulosus dna polymerase kappa 0.0038 0.0059 0.0101
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0072 0.0243 0.0706
Schistosoma mansoni hypothetical protein 0.0036 0.0046 0.0059
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0072 0.0243 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0282
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0214 0.102 0.1394
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0059 0.0043
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0072 0.0243 0.6422
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0363 0.1099
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0195 0.0547
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0072 0.0243 0.0706
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0243 0.6422
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0028 0.009
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0072 0.0243 0.0706
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0028 0.009
Plasmodium falciparum thioredoxin reductase 0.0094 0.0363 1
Leishmania major hypothetical protein, conserved 0.0072 0.0243 0.6422
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0072 0.0243 0.0706
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0518 0.2683 0.8709
Mycobacterium tuberculosis Probable dehydrogenase 0.0214 0.102 0.1394
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0072 0.0243 0.081
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0028 0.009
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0059 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0072 0.0243 0.6422
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Toxoplasma gondii thioredoxin reductase 0.0094 0.0363 0.1178
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0195 0.0547
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.0363 0.0471
Trypanosoma brucei unspecified product 0.0038 0.0059 0.0922
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0072 0.0243 0.0706
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0072 0.0243 0.0706
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0072 0.0243 0.0706
Plasmodium vivax phosphodiesterase gamma, putative 0.0072 0.0243 0.6422
Schistosoma mansoni hypothetical protein 0.0336 0.1687 0.5442
Mycobacterium tuberculosis Probable oxidoreductase 0.0238 0.115 0.1578
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 0.6422
Trichomonas vaginalis MYB, putative 0.0027 0.0001 0.0029
Plasmodium falciparum phosphodiesterase gamma, putative 0.0072 0.0243 0.6422
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0053 0.017
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.059 0.3076 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0072 0.0243 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0518 0.2683 0.8712
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0072 0.0243 0.0706
Entamoeba histolytica hypothetical protein 0.0036 0.0046 0.7823
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0072 0.0243 0.0706
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0059 0.0922
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.059 0.3076 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0072 0.0243 0.0706
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 0.6422
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0346 0.1742 0.5623
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1333 0.7139 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0523 0.2712 0.2691
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0072 0.0243 0.081
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.0363 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0122 0.0352
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0059 0.0031
Leishmania major trypanothione reductase 0.0094 0.0363 1
Leishmania major DNA polymerase eta, putative 0.0037 0.0053 0.0738
Echinococcus multilocularis dna polymerase eta 0.0063 0.0197 0.0553
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0072 0.0243 0.0706
Echinococcus granulosus geminin 0.0336 0.1687 0.5442
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0059 0.0101
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0072 0.0243 0.0682
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0027 0.0001 0.0029
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0036 0.0029
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0243 0.6422
Brugia malayi RNA binding protein 0.0063 0.0195 0.0628
Plasmodium falciparum phosphodiesterase delta, putative 0.0072 0.0243 0.6422
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.1144 0.3646
Entamoeba histolytica hypothetical protein 0.0036 0.0046 0.7823
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0523 0.2712 0.2691
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Schistosoma mansoni hypothetical protein 0.0034 0.0036 0.0025
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1857 1 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0243 0.0682
Mycobacterium tuberculosis Probable reductase 0.0214 0.102 0.1394
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1857 1 1
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0059 0.0101
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0028 0.1162
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0072 0.0243 0.6422
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0214 0.102 0.1394
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0243 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0195 0.0547
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0072 0.0243 0.0706
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0072 0.0243 0.0706
Loa Loa (eye worm) glutathione reductase 0.0094 0.0363 0.1076
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0243 0.6422
Entamoeba histolytica hypothetical protein 0.0036 0.0046 0.7823
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0243 0.0682
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0059 0.0922
Giardia lamblia DINP protein human, muc B family 0.0038 0.0059 0.019
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Brugia malayi TAR-binding protein 0.0063 0.0195 0.0628
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0059 0.2431
Echinococcus granulosus dna polymerase eta 0.0063 0.0197 0.0553
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0072 0.0243 1
Leishmania major hypothetical protein, conserved 0.0072 0.0243 0.6422
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0046 0.0059
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0059 0.0076
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0523 0.2712 0.2766
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0053 0.0738
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0363 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0195 0.0547
Loa Loa (eye worm) hypothetical protein 0.0072 0.0243 0.0682
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0072 0.0243 0.6422
Echinococcus multilocularis geminin 0.0336 0.1687 0.5442
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0243 0.6422
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 0.6422
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0518 0.2683 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0523 0.2712 0.8816
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Leishmania major DNA polymerase eta, putative 0.0063 0.0197 0.5031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0072 0.0243 0.0706
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0072 0.0243 0.6422
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Echinococcus granulosus tar DNA binding protein 0.0063 0.0195 0.0547
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0518 0.2683 0.8712
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0072 0.0243 0.6422
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.059 0.3076 1
Brugia malayi hypothetical protein 0.0036 0.0046 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0243 1
Leishmania major DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0072 0.0243 0.6422
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0243 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0072 0.0243 0.6422
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0059 0.0101
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0059 0.0031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.059 0.3076 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 0.6422
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0072 0.0243 0.6422
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0059 0.0116
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Schistosoma mansoni hypothetical protein 0.0336 0.1687 0.5442
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0243 0.6422
Plasmodium vivax glutathione reductase, putative 0.0094 0.0363 1
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1857 1 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0195 0.0547
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.1144 0.3646
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0122 0.0282
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0072 0.0243 0.0706
Brugia malayi glutathione reductase 0.0094 0.0363 0.1261
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Loa Loa (eye worm) RNA binding protein 0.0063 0.0195 0.0523
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0059 0.0101
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Plasmodium falciparum glutathione reductase 0.0094 0.0363 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0214 0.102 0.1394
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0072 0.0243 0.0706
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 0.6422
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0046 0.0059
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0195 0.0628
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0059 0.0043
Loa Loa (eye worm) hypothetical protein 0.059 0.3076 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1333 0.7139 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0072 0.0243 0.6422
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0072 0.0243 0.0706
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0363 0.1099
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0072 0.0243 0.081
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.059 0.3076 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0072 0.0243 0.6422
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0059 0.2431
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0195 0.0547
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0238 0.115 0.1578
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0046 0.0059
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Brugia malayi MH2 domain containing protein 0.0237 0.1144 0.4204
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0072 0.0243 0.0706
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0072 0.0243 0.0706
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0122 0.0352
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0243 0.6422
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.0363 0.1076
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Loa Loa (eye worm) hypothetical protein 0.0063 0.0197 0.0529
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0238 0.115 0.1578
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 0.6422
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0059 0.0922
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0059 0.0922
Loa Loa (eye worm) PDE1B protein 0.0072 0.0243 0.0682
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0214 0.102 0.1394
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0197 0.0634
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0059 0.0101
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Giardia lamblia hypothetical protein 0.0072 0.0243 0.0789
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0072 0.0243 0.081
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0072 0.0243 0.6422
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0243 0.6422
Trypanosoma brucei trypanothione reductase 0.0094 0.0363 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Schistosoma mansoni DNA polymerase eta 0.0063 0.0197 0.0553
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0195 0.0523
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0238 0.115 0.0213
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.059 0.3076 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.059 0.3076 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0072 0.0243 0.081
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0922
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0243 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0072 0.0243 0.0706
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0072 0.0243 0.081
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 0.6422
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0072 0.0243 0.6422
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0027 0.0001 0.0029
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0072 0.0243 0.0706
Brugia malayi Thioredoxin reductase 0.0094 0.0363 0.1261
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0072 0.0243 0.6422
Entamoeba histolytica hypothetical protein 0.0036 0.0046 0.7823
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Giardia lamblia Hypothetical protein 0.0072 0.0243 0.0789
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.0197 0.5031
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.0197 0.5031
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0028 0.1162
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0243 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0243 0.0789
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0195 0.0523
Leishmania major cAMP-specific phosphodiesterase, putative 0.0072 0.0243 0.6422

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 22 % Displacement of [3H]LSD from 5HT6 receptor expressed in HEK293 cells at 10 uM ChEMBL. 17892934
Activity (binding) = 22 % Displacement of [3H]LSD from 5HT6 receptor expressed in HEK293 cells at 10 uM ChEMBL. 17892934

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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