TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.468 | Formula: C22H26N4O
H donors: 1 H acceptors: 3 LogP: 5.25 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(C(c1ccccc1)Nc1nc(C)c(nc1C)Oc1nccc(c1)C)C
InChi: 1S/C22H26N4O/c1-14(2)20(18-9-7-6-8-10-18)26-21-16(4)25-22(17(5)24-21)27-19-13-15(3)11-12-23-19/h6-14,20H,1-5H3,(H,24,26)
InChiKey: FNPQLDDEJNBIMV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	corticotropin releasing hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	Get druggable targets OG5_130760	All targets in OG5_130760
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130760	All targets in OG5_130760
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760
Schistosoma japonicum	IPR001879,Hormone receptor, extracellular,domain-containing	Get druggable targets OG5_130760	All targets in OG5_130760

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	corticotropin releasing hormone receptor 1	444 aa	445 aa	25.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0208	0.1296	0.0049
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0208	0.1296	0.0688
Schistosoma mansoni	biogenic amine receptor	0.0208	0.1296	0.1296
Leishmania major	DNA polymerase delta catalytic subunit, putative	0.1013	1	1
Schistosoma mansoni	hypothetical protein	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Echinococcus granulosus	biogenic amine 5HT receptor	0.0208	0.1296	0.0049
Echinococcus multilocularis	neuropeptide receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0208	0.1296	0.1296
Loa Loa (eye worm)	TYRA-2 protein	0.0208	0.1296	0.0688
Toxoplasma gondii	DNA polymerase	0.1013	1	1
Trypanosoma brucei	DNA polymerase delta catalytic subunit, putative	0.1013	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0208	0.1296	0.0049
Echinococcus multilocularis	neuropeptide receptor A26	0.0208	0.1296	0.0049
Plasmodium vivax	DNA polymerase delta catalytic subunit, putative	0.1013	1	1
Schistosoma mansoni	opsin-like receptor	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Onchocerca volvulus	DNA polymerase delta catalytic subunit homolog	0.1013	1	1
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus granulosus	allatostatin A receptor	0.0208	0.1296	0.0049
Echinococcus multilocularis	neuropeptide receptor	0.0208	0.1296	0.0049
Loa Loa (eye worm)	melatonin receptor type 1A	0.0208	0.1296	0.0688
Schistosoma mansoni	opsin-like receptor	0.0208	0.1296	0.1296
Trypanosoma brucei	DNA polymerase alpha catalytic subunit	0.0334	0.266	0.266
Trypanosoma brucei	DNA polymerase epsilon catalytic subunit, putative	0.0334	0.266	0.266
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Schistosoma mansoni	myosin xvIII	0.0208	0.1296	0.1296
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0208	0.1296	0.1296
Schistosoma mansoni	amine GPCR	0.0208	0.1296	0.1296
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0208	0.1296	0.1296
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0208	0.1296	0.1296
Echinococcus multilocularis	neuropeptides capa receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	neuropeptide F-like receptor	0.0208	0.1296	0.1296
Echinococcus multilocularis	neuropeptide Y receptor	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1051	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Onchocerca volvulus	DNA polymerase homolog	0.0334	0.266	0.1566
Echinococcus granulosus	neuropeptide receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0208	0.1296	0.1296
Giardia lamblia	DNA polymerase delta, catalytic subunit	0.1013	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0208	0.1296	0.0049
Schistosoma mansoni	neuropeptide receptor	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Schistosoma mansoni	amine GPCR	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus multilocularis	DNA polymerase alpha catalytic subunit	0.0334	0.266	0.1608
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus multilocularis	DNA polymerase delta catalytic subunit	0.1013	1	1
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus multilocularis	DNA polymerase zeta catalytic subunit	0.0334	0.266	0.1608
Echinococcus granulosus	sex peptide receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0208	0.1296	0.1296
Echinococcus granulosus	tm gpcr rhodopsin	0.0208	0.1296	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Leishmania major	DNA polymerase I alpha catalytic subunit, putative	0.0334	0.266	0.2147
Leishmania major	DNA polymerase epsilon catalytic subunit, putative	0.0334	0.266	0.2147
Trypanosoma cruzi	DNA polymerase I alpha catalytic subunit, putative	0.0334	0.266	0.2147
Schistosoma mansoni	DNA polymerase delta catalytic subunit	0.1013	1	1
Schistosoma mansoni	DNA polymerase epsilon catalytic subunit	0.0334	0.266	0.266
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	histamine h1 receptor	0.0208	0.1296	0.1296
Echinococcus granulosus	7tm_1 domain containing protein	0.0208	0.1296	0.0049
Echinococcus granulosus	serotonin receptor	0.0208	0.1296	0.0049
Echinococcus granulosus	orexin receptor type 2	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0334	0.266	0.2147
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0208	0.1296	0.1296
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0208	0.1296	0.0049
Echinococcus multilocularis	g-protein coupled receptor	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Schistosoma mansoni	hypothetical protein	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus multilocularis	sex peptide receptor	0.0208	0.1296	0.0049
Loa Loa (eye worm)	DNA-directed DNA polymerase III	0.1013	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0208	0.1296	0.1296
Echinococcus granulosus	neuropeptides capa receptor	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus granulosus	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Schistosoma mansoni	amine GPCR	0.0208	0.1296	0.1296
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0208	0.1296	0.1296
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0208	0.1296	0.0688
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0208	0.1296	0.0049
Echinococcus granulosus	DNA polymerase alpha catalytic subunit	0.0334	0.266	0.1608
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Onchocerca volvulus	DNA polymerase epsilon catalytic subunit A homolog	0.0334	0.266	0.1566
Echinococcus granulosus	dna polymerase epsilon catalytic subunit a	0.0334	0.266	0.1608
Echinococcus granulosus	tm gpcr rhodopsin	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Schistosoma mansoni	DNA polymerase zeta catalytic subunit	0.0334	0.266	0.266
Echinococcus multilocularis	g protein coupled receptor	0.0208	0.1296	0.0049
Plasmodium falciparum	DNA polymerase delta catalytic subunit	0.1013	1	1
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Loa Loa (eye worm)	neuropeptide F receptor	0.0208	0.1296	0.0688
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0208	0.1296	0.0049
Schistosoma mansoni	amine GPCR	0.0208	0.1296	0.1296
Loa Loa (eye worm)	G-protein coupled receptor	0.0208	0.1296	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0245	0.1699	0.1119
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0208	0.1296	0.1296
Echinococcus granulosus	tm gpcr rhodopsin	0.0208	0.1296	0.0049
Plasmodium falciparum	DNA polymerase epsilon catalytic subunit A, putative	0.0186	0.1051	0.0426
Brugia malayi	DNA polymerase alpha catalytic subunit	0.0334	0.266	0.1566
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0245	0.1699	0.0462
Trichomonas vaginalis	DNA polymerase zeta catalytic subunit, putative	0.1013	1	1
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus multilocularis	dro:myosuppressin receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0208	0.1296	0.1296
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Schistosoma mansoni	hypothetical protein	0.0208	0.1296	0.1296
Echinococcus granulosus	neuropeptide s receptor	0.0208	0.1296	0.0049
Echinococcus granulosus	hypothetical protein	0.0208	0.1296	0.0049
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0208	0.1296	0.1296
Echinococcus granulosus	fmrfamide receptor	0.0208	0.1296	0.0049
Echinococcus granulosus	7TM GPCR rhodopsin	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0208	0.1296	0.1296
Trypanosoma cruzi	DNA polymerase epsilon catalytic subunit, putative	0.0334	0.266	0.2147
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0208	0.1296	0.0049
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0208	0.1296	0.0049
Echinococcus granulosus	g protein coupled receptor	0.0208	0.1296	0.0049
Echinococcus granulosus	somatostatin receptor	0.0208	0.1296	0.0049
Giardia lamblia	DNA polymerase epsilon, catalytic subunit	0.0334	0.266	0.2147
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0208	0.1296	0.0688
Echinococcus granulosus	g protein coupled receptor	0.0208	0.1296	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus granulosus	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Schistosoma mansoni	adenoreceptor	0.0208	0.1296	0.1296
Echinococcus granulosus	G protein coupled receptor 139	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0208	0.1296	0.1296
Trichomonas vaginalis	DNA polymerase alpha catalytic subunit, putative	0.0186	0.1051	0.0426
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Schistosoma mansoni	growth hormone secretagogue receptor	0.0208	0.1296	0.1296
Schistosoma mansoni	hypothetical protein	0.0208	0.1296	0.1296
Echinococcus multilocularis	dna polymerase epsilon catalytic subunit a	0.0334	0.266	0.1608
Echinococcus granulosus	neuropeptide receptor	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0208	0.1296	0.0049
Echinococcus multilocularis	fmrfamide receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	DNA polymerase alpha catalytic subunit	0.0334	0.266	0.266
Schistosoma mansoni	neuropeptide f receptor 76f	0.0208	0.1296	0.1296
Brugia malayi	DNA polymerase family B containing protein	0.0334	0.266	0.1566
Echinococcus multilocularis	g protein coupled receptor	0.0208	0.1296	0.0049
Entamoeba histolytica	DNA polymerase delta catalytic subunit, putative	0.1013	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Schistosoma mansoni	neuropeptide receptor	0.0208	0.1296	0.1296
Trypanosoma cruzi	DNA polymerase delta catalytic subunit, putative	0.0827	0.7993	0.7853
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0208	0.1296	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0208	0.1296	0.1296
Echinococcus multilocularis	somatostatin receptor	0.0208	0.1296	0.0049
Trypanosoma cruzi	DNA polymerase delta catalytic subunit, putative	0.1013	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0208	0.1296	0.1296
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0208	0.1296	0.0049
Echinococcus granulosus	neuropeptide Y receptor	0.0208	0.1296	0.0049
Echinococcus granulosus	dro:myosuppressin receptor	0.0208	0.1296	0.0049
Trichomonas vaginalis	DNA polymerase alpha catalytic subunit, putative	0.0334	0.266	0.2147
Schistosoma mansoni	neuropeptide F-like receptor	0.0208	0.1296	0.1296
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Toxoplasma gondii	DNA polymerase (pol2) superfamily protein	0.0334	0.266	0.2147
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Trypanosoma cruzi	DNA polymerase epsilon catalytic subunit, putative	0.0334	0.266	0.2147
Echinococcus multilocularis	allatostatin A receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	neuropeptide receptor	0.0208	0.1296	0.1296
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0208	0.1296	0.0049
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0208	0.1296	0.1296
Echinococcus multilocularis	G protein coupled receptor 139	0.0208	0.1296	0.0049
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0208	0.1296	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Loa Loa (eye worm)	neuropeptide F receptor	0.0208	0.1296	0.0688
Schistosoma mansoni	biogenic amine receptor	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Brugia malayi	DNA polymerase family B, exonuclease domain containing protein	0.0334	0.266	0.1566
Echinococcus multilocularis	g protein coupled receptor	0.0208	0.1296	0.0049
Echinococcus granulosus	g protein coupled receptor	0.0208	0.1296	0.0049
Echinococcus granulosus	neuropeptide Y receptor	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Schistosoma mansoni	amine GPCR	0.0208	0.1296	0.1296
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0208	0.1296	0.0049
Echinococcus granulosus	DNA polymerase delta catalytic subunit	0.1013	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0208	0.1296	0.0049
Echinococcus granulosus	g-protein coupled receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	neuropeptide receptor	0.0208	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus multilocularis	neuropeptide Y receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	biogenic amine receptor	0.0208	0.1296	0.1296
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0208	0.1296	0.0049
Echinococcus multilocularis	orexin receptor type 2	0.0208	0.1296	0.0049
Schistosoma mansoni	opsin-like receptor	0.0208	0.1296	0.1296
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0208	0.1296	0.0049
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0208	0.1296	0.0049
Loa Loa (eye worm)	DNA polymerase epsilon catalytic subunit	0.0186	0.1051	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Echinococcus granulosus	neuropeptide FF receptor 2	0.0208	0.1296	0.0049
Trichomonas vaginalis	DNA polymerase delta catalytic subunit, putative	0.0334	0.266	0.2147
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0208	0.1296	0.0049
Echinococcus granulosus	neuropeptides capa receptor	0.0208	0.1296	0.0049
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0208	0.1296	0.1296
Loa Loa (eye worm)	G-protein coupled receptor	0.0208	0.1296	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus granulosus	DNA polymerase zeta catalytic subunit	0.0334	0.266	0.1608
Echinococcus multilocularis	neuropeptide s receptor	0.0208	0.1296	0.0049
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0208	0.1296	0.0049
Echinococcus multilocularis	serotonin receptor	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Trichomonas vaginalis	DNA polymerase alpha catalytic subunit, putative	0.0334	0.266	0.2147
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0208	0.1296	0.0688
Echinococcus multilocularis	serotonin receptor	0.0208	0.1296	0.0049
Echinococcus granulosus	biogenic amine 5HT receptor	0.0208	0.1296	0.0049
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Echinococcus multilocularis	neuropeptides capa receptor	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Trichomonas vaginalis	DNA polymerase II, putative	0.0334	0.266	0.2147
Echinococcus granulosus	neuropeptide receptor A26	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Toxoplasma gondii	DNA polymerase family B protein	0.0334	0.266	0.2147
Echinococcus granulosus	rhodopsin orphan GPCR	0.0208	0.1296	0.0049
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0208	0.1296	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1296	0.0688
Onchocerca volvulus	DNA polymerase alpha catalytic subunit homolog	0.0334	0.266	0.1566
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1051	0.0426
Trypanosoma brucei	DNA polymerase zeta catalytic subunit, putative	0.0334	0.266	0.266

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 2376 nM	Displacement of [125I]Tyr-o-CRF from CRF1 receptor in IMR32 cells	ChEMBL.	17888659
Ki (binding)	= 2376 nM	Displacement of [125I]Tyr-o-CRF from CRF1 receptor in IMR32 cells	ChEMBL.	17888659

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 461318