Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Muscarinic acetylcholine receptor M2 | Starlite/ChEMBL | References |
Rattus norvegicus | Muscarinic acetylcholine receptor M3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tissue type plasminogen activator | 0.0058 | 0.0091 | 0.1633 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1574 | 0.6198 |
Onchocerca volvulus | 0.0329 | 0.1574 | 1 | |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0728 | 0.3755 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0044 | 0.0013 | 0.0052 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0058 | 0.0091 | 0.5 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1142 | 0.602 | 0.3627 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0044 | 0.0013 | 0.0035 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1142 | 0.602 | 0.5 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0728 | 0.3755 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.0091 | 0.05 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.1574 | 0.6198 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1142 | 0.602 | 0.3627 |
Echinococcus multilocularis | geminin | 0.0131 | 0.0491 | 0.1601 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0603 | 0.307 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0091 | 0.0359 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0044 | 0.0013 | 0.0043 |
Brugia malayi | Kringle domain containing protein | 0.0058 | 0.0091 | 0.05 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0491 | 0.1309 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0044 | 0.0013 | 0.0035 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0058 | 0.0091 | 0.0359 |
Schistosoma mansoni | ets-related | 0.0163 | 0.0668 | 0.1779 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.187 | 1 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0728 | 0.3755 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0054 | 0.0069 | 0.0354 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.187 | 1 | 1 |
Schistosoma mansoni | gabp alpha | 0.0054 | 0.0069 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.254 | 1 |
Brugia malayi | hypothetical protein | 0.0329 | 0.1574 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0058 | 0.0091 | 0.5 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0054 | 0.0069 | 0.1156 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0044 | 0.0013 | 0.0043 |
Echinococcus granulosus | geminin | 0.0131 | 0.0491 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0054 | 0.0069 | 0.0354 |
Schistosoma mansoni | jumonji domain containing protein | 0.0044 | 0.0013 | 0.0035 |
Leishmania major | hypothetical protein, conserved | 0.0058 | 0.0091 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0058 | 0.0091 | 0.0297 |
Brugia malayi | Fli-1 protein | 0.0163 | 0.0668 | 0.4193 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0491 | 0.1309 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0026 | 0.0102 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.254 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0058 | 0.0091 | 0.5 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1142 | 0.602 | 0.5 |
Loa Loa (eye worm) | fli-1 protein | 0.0163 | 0.0668 | 0.2629 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0054 | 0.0069 | 0.027 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0054 | 0.0069 | 0.0223 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0091 | 0.0243 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 12.3 nM | Displacement of [3H]N-methylscopolamine from muscarinic M3 receptor in rat submandibular gland | ChEMBL. | 17629699 |
Ki (binding) | = 12.3 nM | Displacement of [3H]N-methylscopolamine from muscarinic M3 receptor in rat submandibular gland | ChEMBL. | 17629699 |
Ki (binding) | = 646 nM | Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart | ChEMBL. | 17629699 |
Ki (binding) | = 646 nM | Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart | ChEMBL. | 17629699 |
Ratio Ki (binding) | = 52 | Selectivity for rat muscarinic M3 receptor over rat muscarinic M2 receptor | ChEMBL. | 17629699 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.