Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-X-C motif) receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.005 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0074 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0063 | 0.5611 | 0.5611 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Brugia malayi | Cytochrome P450 family protein | 0.0063 | 0.5611 | 0.5611 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.005 | 0 | 0.5 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Inhibition of CYP2D6 | ChEMBL. | 17964154 | |
Activity (ADMET) | 0 | Inhibition of CYP2D6 | ChEMBL. | 17964154 |
CL (ADMET) | 0 | Intrinsic clearance in mouse microsomes at 0.5 uM | ChEMBL. | 17964154 |
Ki (binding) | = 0.68 uM | Binding affinity to human CXCR3 receptor expressed in CHO membrane by ITAC-stimulated GTP gammaS assay | ChEMBL. | 17964154 |
Ki (binding) | = 0.68 uM | Binding affinity to human CXCR3 receptor expressed in CHO membrane by ITAC-stimulated GTP gammaS assay | ChEMBL. | 17964154 |
Log D | = 4.7 | Partition coefficient, log D of the compound at pH 7.4 | ChEMBL. | 17964154 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.