Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 0.368 | 0.6546 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.2327 | 0.3339 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.2327 | 0.2327 |
Schistosoma mansoni | proliferating cell nuclear antigen | 0.0031 | 0.03 | 0.0534 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.2327 | 0.414 |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 0.368 | 0.6546 |
Trichomonas vaginalis | proliferating cell nuclear antigen, putative | 0.0031 | 0.03 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.0365 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.2327 | 0.3339 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.2327 | 0.414 |
Echinococcus granulosus | proliferating cell nuclear antigen | 0.0031 | 0.03 | 0.03 |
Plasmodium falciparum | carbonic anhydrase | 0.0101 | 0.2327 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0251 | 0.6691 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.2327 | 0.3339 |
Echinococcus granulosus | carbonic anhydrase II | 0.0214 | 0.5622 | 0.5622 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0101 | 0.2327 | 0.3478 |
Schistosoma mansoni | carbonic anhydrase | 0.0101 | 0.2327 | 0.414 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.2327 | 0.2327 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0 | 0.5 |
Plasmodium vivax | proliferating cell nuclear antigen, putative | 0.0031 | 0.03 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2327 | 0.3478 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.5622 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.2327 | 0.2327 |
Toxoplasma gondii | hypothetical protein | 0.0101 | 0.2327 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0 | 0.5 |
Giardia lamblia | PcnA | 0.0031 | 0.03 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0026 | 0.016 | 0.016 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0127 | 0.3089 | 0.3089 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.2327 | 0.2327 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0214 | 0.5622 | 0.8065 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.2327 | 0.3339 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.2327 | 0.2327 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.2327 | 0.414 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0.5622 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0251 | 0.6691 | 0.96 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0251 | 0.6691 | 0.96 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 0.5622 | 0.8401 |
Loa Loa (eye worm) | proliferating cell nuclear antigen | 0.0031 | 0.03 | 0.0448 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0026 | 0.016 | 0.016 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.2327 | 0.414 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0214 | 0.5622 | 0.5622 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.5622 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.2327 | 0.3339 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.3089 | 0.5495 |
Trichomonas vaginalis | proliferating cell nuclear antigen, putative | 0.0031 | 0.03 | 0.5 |
Entamoeba histolytica | proliferating cell nuclear antigen, putative | 0.0031 | 0.03 | 0.5 |
Echinococcus multilocularis | proliferating cell nuclear antigen | 0.0031 | 0.03 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.6658 | 0.995 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0261 | 0.697 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0026 | 0.016 | 0.016 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0.5622 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 0.5622 | 0.8065 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2327 | 0.3478 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.5622 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0147 | 0.368 | 0.368 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2327 | 0.3478 |
Schistosoma mansoni | proliferating cell nuclear antigen | 0.0031 | 0.03 | 0.0534 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0127 | 0.3089 | 0.3089 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.2327 | 0.2327 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.5622 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 0.5622 | 0.8401 |
Brugia malayi | proliferating cell nuclear antigen (PCNA) | 0.0031 | 0.03 | 0.043 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 23 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 23 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 105 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 105 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 250 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Ki (binding) | = 250 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.