Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine proteinase, putative | 0.0114 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0221 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0114 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0221 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0041 | 0 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0221 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0221 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0041 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0221 | 1 | 1 |
Echinococcus granulosus | calpain A | 0.0058 | 0.0967 | 0.0967 |
Echinococcus multilocularis | cysteine protease | 0.0221 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0114 | 0.4054 | 0.4054 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0221 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0148 | 0.5946 | 0.5946 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5946 | 0.5946 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.5946 | 0.5946 |
Echinococcus granulosus | cathepsin l1 | 0.0148 | 0.5946 | 0.5946 |
Giardia lamblia | Encystation-specific protease | 0.0041 | 0 | 0.5 |
Plasmodium vivax | vivapain-3 | 0.0114 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0073 | 0.1791 | 0.1791 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0148 | 0.5946 | 0.5946 |
Leishmania major | cathepsin L-like protease | 0.0221 | 1 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0056 | 0.0827 | 0.0827 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Brugia malayi | calpain family protein 1 | 0.0056 | 0.0827 | 0.0827 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0041 | 0.0012 | 0.0012 |
Giardia lamblia | Cathepsin L precursor | 0.0041 | 0 | 0.5 |
Giardia lamblia | Cathepsin L precursor | 0.0041 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0073 | 0.1791 | 0.1791 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0041 | 0 | 0.5 |
Plasmodium vivax | vivapain-1 | 0.0114 | 0.4054 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0221 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0221 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0221 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0148 | 0.5946 | 0.5946 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0041 | 0 | 0.5 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0114 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0221 | 1 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0114 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0477 | 0.0477 |
Trypanosoma cruzi | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0114 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0221 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0221 | 1 | 1 |
Giardia lamblia | Cathepsin L-like protease | 0.0041 | 0 | 0.5 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0114 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Schistosoma mansoni | cathepsin s | 0.0073 | 0.1791 | 0.1791 |
Brugia malayi | Cathepsin L-like precursor | 0.0221 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0041 | 0 | 0.5 |
Echinococcus granulosus | cathepsin L | 0.0114 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0148 | 0.5946 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Giardia lamblia | Cysteine protease | 0.0041 | 0 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0221 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0221 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0114 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0114 | 0.4054 | 0.4054 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0058 | 0.0967 | 0.0967 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0114 | 0.4054 | 0.4054 |
Giardia lamblia | Cathepsin L precursor | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0114 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0221 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0827 | 0.0827 |
Brugia malayi | cathepsin L-like precursor | 0.0148 | 0.5946 | 0.5946 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0114 | 0.4054 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0221 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0221 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0148 | 0.5946 | 0.5946 |
Giardia lamblia | Cathepsin B precursor | 0.0041 | 0 | 0.5 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0041 | 0 | 0.5 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5946 | 0.5946 |
Giardia lamblia | Cathepsin B precursor | 0.0041 | 0 | 0.5 |
Onchocerca volvulus | 0.0221 | 1 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0148 | 0.5946 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0221 | 1 | 1 |
Onchocerca volvulus | 0.0148 | 0.5946 | 0.5946 | |
Echinococcus multilocularis | cysteine protease | 0.0221 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0114 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0221 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0041 | 0 | 0.5 |
Onchocerca volvulus | 0.0221 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0221 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0221 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0114 | 0.4054 | 0.4054 |
Echinococcus granulosus | cysteine protease | 0.0114 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0114 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0221 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1791 | 0.1791 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | ctsf protein | 0.0221 | 1 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0073 | 0.1791 | 0.1791 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0114 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0221 | 1 | 1 |
Giardia lamblia | Cysteine protease | 0.0041 | 0 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0221 | 1 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0058 | 0.0967 | 0.0967 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0114 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0221 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0221 | 1 | 1 |
Brugia malayi | calpain family protein 1 | 0.0056 | 0.0827 | 0.0827 |
Giardia lamblia | Cathepsin L-like protease | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0012 | 0.0012 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0221 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0221 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0221 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0221 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0041 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0114 | 0.4054 | 0.4054 |
Plasmodium vivax | vivapain-2 | 0.0221 | 1 | 1 |
Giardia lamblia | Cysteine protease | 0.0041 | 0 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Plasmodium vivax | unspecified product | 0.0114 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0221 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0114 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0148 | 0.5946 | 0.5946 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1791 | 0.1791 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0221 | 1 | 1 |
Giardia lamblia | Cathepsin B-like cysteine proteinase 3 precursor | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0221 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0221 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5946 | 0.5946 |
Onchocerca volvulus | 0.0221 | 1 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0041 | 0 | 0.5 |
Echinococcus multilocularis | calpain A | 0.0058 | 0.0967 | 0.0967 |
Leishmania major | cathepsin L-like protease | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0221 | 1 | 1 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0041 | 0.0012 | 0.0012 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0073 | 0.1791 | 0.1791 |
Giardia lamblia | Cathepsin L precursor | 0.0041 | 0 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0221 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0221 | 1 | 1 |
Giardia lamblia | Cysteine protease | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | cysteine protease | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0221 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0221 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0221 | 1 | 1 |
Giardia lamblia | Cathepsin L precursor | 0.0041 | 0 | 0.5 |
Onchocerca volvulus | 0.0221 | 1 | 1 | |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0114 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0221 | 1 | 1 |
Giardia lamblia | Cathepsin L precursor | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0056 | 0.0827 | 0.0827 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0221 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0073 | 0.1791 | 0.1791 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0058 | 0.0967 | 0.0967 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0221 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0073 | 0.1791 | 0.1791 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0073 | 0.1791 | 0.1791 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Onchocerca volvulus | Cathepsin L homolog | 0.0221 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0221 | 1 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0058 | 0.0967 | 0.0967 |
Leishmania major | cathepsin L-like protease | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0221 | 1 | 1 |
Onchocerca volvulus | 0.0221 | 1 | 1 | |
Leishmania major | cysteine peptidase A (CPA) | 0.0221 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0114 | 0.4054 | 0.4054 |
Echinococcus granulosus | cathepsin l1 | 0.0221 | 1 | 1 |
Onchocerca volvulus | 0.0221 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0221 | 1 | 1 |
Onchocerca volvulus | 0.0221 | 1 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1791 | 0.1791 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0221 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0221 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0221 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0221 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0114 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0114 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0221 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | < 0.000002 M | Ability of the compound to inhibit the release of histamine in the rat peritoneal fluids by 50% | ChEMBL. | 6208360 |
IC50 (functional) | = 0.000013 M | Ability of the compound to inhibit the release of extravasated dye in the rat peritoneal fluids by 50% | ChEMBL. | 6208360 |
Kd (functional) | = 4 | H1-antihistamine activity on guinea pig ileum | ChEMBL. | 6208360 |
pA2 (functional) | = 4 | H1-antihistamine activity on guinea pig ileum | ChEMBL. | 6208360 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.