Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0144 | 0.0344 | 0.0082 |
Plasmodium vivax | hypothetical protein, conserved | 0.0131 | 0.027 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0238 | 0.0868 | 0.1474 |
Echinococcus granulosus | acetylcholinesterase | 0.0855 | 0.4331 | 1 |
Schistosoma mansoni | gliotactin | 0.0144 | 0.0344 | 0.0181 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0131 | 0.027 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0144 | 0.0344 | 0.0761 |
Brugia malayi | Carboxylesterase family protein | 0.0144 | 0.0344 | 0.0761 |
Echinococcus multilocularis | neuroligin | 0.0144 | 0.0344 | 0.0761 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0131 | 0.027 | 0.059 |
Echinococcus granulosus | acetylcholinesterase | 0.0855 | 0.4331 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0131 | 0.027 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0855 | 0.4331 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1733 | 0.9263 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0144 | 0.0344 | 0.0761 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0144 | 0.0344 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0855 | 0.4331 | 1 |
Brugia malayi | indoleamine 2,3-dioxygenase | 0.0238 | 0.0868 | 0.1977 |
Echinococcus multilocularis | acetylcholinesterase | 0.0855 | 0.4331 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0131 | 0.027 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0144 | 0.0344 | 0.0761 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0344 | 0.0793 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0344 | 0.0793 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0131 | 0.027 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0131 | 0.027 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0855 | 0.4331 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0855 | 0.4331 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0131 | 0.027 | 0.5 |
Brugia malayi | hypothetical protein | 0.0131 | 0.027 | 0.059 |
Echinococcus granulosus | neuroligin | 0.0144 | 0.0344 | 0.0761 |
Onchocerca volvulus | 0.0144 | 0.0344 | 1 | |
Brugia malayi | hypothetical protein | 0.0144 | 0.0344 | 0.0761 |
Loa Loa (eye worm) | indoleamine 2,3-dioxygenase | 0.0238 | 0.0868 | 0.2005 |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 0.4331 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0144 | 0.0344 | 0.0076 |
Loa Loa (eye worm) | carboxylesterase | 0.0144 | 0.0344 | 0.0793 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.027 | 0.0623 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0144 | 0.0344 | 0.0761 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0144 | 0.0344 | 0.0181 |
Echinococcus multilocularis | 0.0131 | 0.027 | 0.059 | |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.027 | 0.0623 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.027 | 0.0623 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0144 | 0.0344 | 0.0761 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0144 | 0.0344 | 0.0181 |
Onchocerca volvulus | 0.0144 | 0.0344 | 1 | |
Onchocerca volvulus | 0.0144 | 0.0344 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.027 | 0.0623 |
Brugia malayi | Carboxylesterase family protein | 0.0855 | 0.4331 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0238 | 0.0868 | 0.1474 |
Onchocerca volvulus | 0.0144 | 0.0344 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0855 | 0.4331 | 1 |
Onchocerca volvulus | 0.0144 | 0.0344 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0344 | 0.0793 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0144 | 0.0344 | 0.0761 |
Brugia malayi | SWIRM domain containing protein | 0.0131 | 0.027 | 0.059 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0131 | 0.027 | 0.059 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0144 | 0.0344 | 0.0181 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0144 | 0.0344 | 0.0761 |
Echinococcus granulosus | carboxylesterase 5A | 0.0855 | 0.4331 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0344 | 0.0793 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0131 | 0.027 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 0.4331 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0855 | 0.4331 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0144 | 0.0344 | 0.0082 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0144 | 0.0344 | 0.0761 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0131 | 0.027 | 0.059 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0144 | 0.0344 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0144 | 0.0344 | 0.0181 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0131 | 0.027 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.027 | 0.0623 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0131 | 0.027 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0131 | 0.027 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0131 | 0.027 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0344 | 0.0793 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0344 | 0.0793 |
Echinococcus granulosus | indoleamine 23 dioxygenase 2 | 0.0238 | 0.0868 | 0.1977 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0144 | 0.0344 | 0.0181 |
Plasmodium vivax | hypothetical protein, conserved | 0.0131 | 0.027 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1864 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0144 | 0.0344 | 0.0793 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0131 | 0.027 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0144 | 0.0344 | 0.0761 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0144 | 0.0344 | 0.0181 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0131 | 0.027 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.027 | 0.0623 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0131 | 0.027 | 0.5 |
Echinococcus multilocularis | indoleamine 2,3 dioxygenase 2 | 0.0238 | 0.0868 | 0.1977 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0344 | 0.0793 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0144 | 0.0344 | 0.0082 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 300 uM | Dose required to reduce the viablity of mock-infected cells by 50% | ChEMBL. | 9154967 |
CC50 (functional) | > 300 uM | Dose required to reduce the viablity of mock-infected cells by 50% | ChEMBL. | 9154967 |
EC50 (functional) | = 150 uM | Dose required to achieve 50% protection of MT-4 cells from the HIV-1 induced cytopathogenicity in mock-infected MT-4 cells | ChEMBL. | 9154967 |
EC50 (functional) | = 150 uM | Dose required to achieve 50% protection of MT-4 cells from the HIV-1 induced cytopathogenicity in mock-infected MT-4 cells | ChEMBL. | 9154967 |
Ratio (functional) | > 2 | Selectivity index is the ratio of CC50 to EC50 | ChEMBL. | 9154967 |
Ratio (functional) | > 2 | Selectivity index is the ratio of CC50 to EC50 | ChEMBL. | 9154967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.