Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | 5-enolpyruvylshikimate-3-phosphate synthetase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0254 | 0.1948 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0115 | 0.104 | 0.104 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0118 | 0.0908 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0254 | 0.1948 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0139 | 0.1303 | 1 |
Schistosoma mansoni | patched 1 | 0.0049 | 0.0333 | 0.2554 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0139 | 0.1303 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0314 | 0.2407 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0357 | 0.3658 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0118 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0115 | 0.104 | 0.6617 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0314 | 0.2407 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0164 | 0.1571 | 1 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0357 | 0.3658 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0314 | 0.2407 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0115 | 0.104 | 0.7979 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0218 | 0.2157 | 0.3627 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0139 | 0.1303 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0049 | 0.0333 | 0.2118 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0254 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0333 | 0.2553 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0314 | 0.2407 |
Echinococcus multilocularis | protein dispatched 1 | 0.0056 | 0.0408 | 0.0408 |
Echinococcus multilocularis | expressed conserved protein | 0.0108 | 0.0964 | 0.0964 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.104 | 0.7979 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0118 | 0.0908 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0049 | 0.0333 | 0.2553 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0118 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0118 | 1 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0218 | 0.2157 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0049 | 0.0333 | 0.2118 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.1303 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0118 | 0.0323 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0116 | 0.1059 | 0.8127 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0049 | 0.0333 | 0.0333 |
Echinococcus granulosus | expressed conserved protein | 0.0108 | 0.0964 | 0.6139 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0254 | 0.1948 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0452 | 0.3471 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0006 | 0.0046 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0115 | 0.104 | 1 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0218 | 0.2157 | 0.3627 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0254 | 0.1616 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.0333 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.1303 | 1 |
Echinococcus multilocularis | protein patched | 0.0049 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.1303 | 1 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0357 | 0.3658 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0164 | 0.1571 | 0.1571 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0118 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0218 | 0.2157 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0118 | 1 |
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.0357 | 0.3658 | 1 |
Brugia malayi | CHE-14 protein | 0.0049 | 0.0333 | 0.2553 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0118 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0118 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.18 mM | Inhibition of E. coli EPSP(5-enolpyruvyl-shikimate-3-phosphate) Synthase | ChEMBL. | No reference |
IC50 (binding) | = 0.18 mM | Inhibition of E. coli EPSP(5-enolpyruvyl-shikimate-3-phosphate) Synthase | ChEMBL. | No reference |
Kd (binding) | = 1 uM | Dissociation constant of the compound was calculated for E. coli EPSP(5-enolpyruvyl-shikimate-3-phosphate) Synthase | ChEMBL. | No reference |
Kd (binding) | = 1 uM | Dissociation constant of the compound was calculated for E. coli EPSP(5-enolpyruvyl-shikimate-3-phosphate) Synthase | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.