Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0239 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0239 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0239 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0113 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | DR-78 | 0.0113 | 0.4413 | 0.4413 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0239 | 1 | 1 |
Leishmania major | P-type ATPase, putative | 0.0016 | 0.0148 | 0.4509 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0239 | 1 | 1 |
Plasmodium vivax | P-type ATPase4, putative | 0.002 | 0.0329 | 0.5 |
Mycobacterium tuberculosis | Possible metal cation transporting P-type ATPase CtpH | 0.0014 | 0.0039 | 0.5 |
Onchocerca volvulus | 0.0113 | 0.4413 | 0.3324 | |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0113 | 0.4413 | 0.4413 |
Schistosoma mansoni | ATPase | 0.002 | 0.0329 | 0.0183 |
Brugia malayi | nuclear receptor RXR | 0.0113 | 0.4413 | 0.4413 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0113 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0726 | 0.0726 |
Brugia malayi | nuclear receptor NHR-88 | 0.0113 | 0.4413 | 0.4413 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0239 | 1 | 1 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.002 | 0.0329 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0239 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0113 | 0.4413 | 0.4329 |
Loa Loa (eye worm) | Na,K-ATPase alpha subunit | 0.005 | 0.1631 | 0.1631 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0239 | 1 | 1 |
Schistosoma mansoni | ATPase | 0.002 | 0.0329 | 0.0183 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0113 | 0.4413 | 0.4413 |
Echinococcus multilocularis | sarco:endoplasmic reticulum calcium ATPase | 0.002 | 0.0329 | 0.0183 |
Schistosoma mansoni | Na+/K+ transporting ATPase subunit alpha | 0.005 | 0.1631 | 0.1505 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0239 | 1 | 1 |
Echinococcus granulosus | calcium transporting ATPase type 2C member | 0.002 | 0.0329 | 0.0183 |
Brugia malayi | hypothetical protein | 0.0126 | 0.5011 | 0.5011 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Brugia malayi | Membrane calcium atpase protein 3 | 0.0016 | 0.0148 | 0.0148 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.002 | 0.0329 | 1 |
Echinococcus granulosus | sarco:endoplasmic reticulum calcium ATPase | 0.002 | 0.0329 | 0.0183 |
Trichomonas vaginalis | cation-transporting ATPase fungi, putative | 0.002 | 0.0329 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0239 | 1 | 1 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.002 | 0.0329 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0113 | 0.4413 | 0.4413 |
Brugia malayi | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0239 | 1 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.002 | 0.0329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.5011 | 0.5011 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0113 | 0.4413 | 0.4329 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0126 | 0.5011 | 0.4936 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0113 | 0.4413 | 0.4329 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0239 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0239 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0239 | 1 | 1 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase, putative | 0.002 | 0.0329 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0239 | 1 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.002 | 0.0329 | 1 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.002 | 0.0329 | 0.5 |
Brugia malayi | hypothetical protein | 0.0126 | 0.5011 | 0.5011 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0113 | 0.4413 | 0.4413 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0126 | 0.5011 | 0.4936 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0239 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0113 | 0.4413 | 0.4329 |
Mycobacterium ulcerans | metal cation transporter p-type ATPase a | 0.005 | 0.1631 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0239 | 1 | 1 |
Brugia malayi | Na,K-ATPase alpha subunit | 0.005 | 0.1631 | 0.1631 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0113 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1055 | 0.1055 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.002 | 0.0329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Brugia malayi | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0113 | 0.4413 | 0.4329 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0113 | 0.4413 | 0.3324 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Toxoplasma gondii | sarco/endoplasmic reticulum Ca2+-ATPase | 0.002 | 0.0329 | 1 |
Toxoplasma gondii | plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 | 0.0016 | 0.0148 | 0.4509 |
Schistosoma mansoni | thyroid hormone receptor | 0.0239 | 1 | 1 |
Toxoplasma gondii | P-type ATPase4, putative | 0.002 | 0.0329 | 1 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha chain, putative | 0.0043 | 0.1341 | 0.1341 |
Plasmodium falciparum | non-SERCA-type Ca2+ -transporting P-ATPase | 0.002 | 0.0329 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.002 | 0.0329 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0113 | 0.4413 | 0.4329 |
Schistosoma mansoni | thyroid hormone receptor | 0.0239 | 1 | 1 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.002 | 0.0329 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0113 | 0.4413 | 0.4413 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.002 | 0.0329 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Mycobacterium ulcerans | metal cation-transporting p-type ATPase F, CtpF | 0.002 | 0.0329 | 0.1823 |
Brugia malayi | nuclear receptor NHR-67 | 0.0113 | 0.4413 | 0.4413 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0113 | 0.4413 | 0.4329 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0113 | 0.4413 | 0.4329 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0113 | 0.4413 | 0.4329 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0016 | 0.0148 | 0.4509 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1631 | 0.1631 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0126 | 0.5011 | 0.5011 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0239 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0113 | 0.4413 | 0.4329 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0239 | 1 | 1 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.002 | 0.0329 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0239 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0126 | 0.5011 | 0.4936 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0239 | 1 | 1 |
Giardia lamblia | Plasma membrane calcium-transporting ATPase 2 | 0.002 | 0.0329 | 0.1388 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.5011 | 0.5011 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1012 | 0.1012 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0239 | 1 | 1 |
Leishmania major | calcium motive p-type ATPase, putative | 0.0016 | 0.0148 | 0.4509 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.002 | 0.0329 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0239 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0239 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0113 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.5011 | 0.5011 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.002 | 0.0329 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0113 | 0.4413 | 0.3324 |
Echinococcus multilocularis | Tetracycline resistance leader peptide, TetL | 0.002 | 0.0329 | 0.0183 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0239 | 1 | 1 |
Echinococcus granulosus | Na:K ATPase alpha subunit | 0.0046 | 0.1451 | 0.1322 |
Leishmania major | calcium-translocating P-type ATPase | 0.002 | 0.0329 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0239 | 1 | 1 |
Plasmodium vivax | calcium-transporting ATPase, putative | 0.002 | 0.0329 | 0.5 |
Trypanosoma cruzi | Calcium ATPase SERCA-like | 0.002 | 0.0329 | 1 |
Onchocerca volvulus | 0.0239 | 1 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0239 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0239 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0113 | 0.4413 | 0.4329 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0239 | 1 | 1 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 2 | 0.002 | 0.0329 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0239 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0113 | 0.4413 | 0.4329 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0239 | 1 | 1 |
Giardia lamblia | Potassium-transporting ATPase alpha chain 1 | 0.0046 | 0.1451 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0239 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0239 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0113 | 0.4413 | 0.4329 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0113 | 0.4413 | 0.4329 |
Brugia malayi | steroid hormone receptor | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0113 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0239 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0239 | 1 | 1 |
Schistosoma mansoni | na+/k+ atpase alpha subunit | 0.0046 | 0.1451 | 0.1322 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.5011 | 0.5011 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0239 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | sodium/potassium-transporting ATPase subunit alpha | 0.0043 | 0.1341 | 0.1341 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0113 | 0.4413 | 0.4329 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0239 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0239 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0113 | 0.4413 | 0.4329 |
Brugia malayi | ecdysone receptor | 0.0113 | 0.4413 | 0.4413 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0016 | 0.0148 | 0.4509 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 1 | 0.002 | 0.0329 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0016 | 0.0148 | 0.4509 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0239 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0239 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0113 | 0.4413 | 0.4413 |
Brugia malayi | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0016 | 0.0148 | 0.0148 |
Echinococcus multilocularis | calcium transporting ATPase type 2C member | 0.002 | 0.0329 | 0.0183 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0239 | 1 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.002 | 0.0329 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0126 | 0.5011 | 0.4936 |
Trypanosoma brucei | calcium-translocating P-type ATPase | 0.0016 | 0.0148 | 0.4509 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0113 | 0.4413 | 0.4329 |
Mycobacterium leprae | PROBABLE CATION-TRANSPORTER ATPASE I CTPI | 0.0043 | 0.1341 | 0.5 |
Onchocerca volvulus | 0.0113 | 0.4413 | 0.3324 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0126 | 0.5011 | 0.5011 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0113 | 0.4413 | 0.4329 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0113 | 0.4413 | 0.4329 |
Entamoeba histolytica | calcium-transporting P-type ATPase, putative | 0.002 | 0.0329 | 0.5 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0113 | 0.4413 | 0.4329 |
Brugia malayi | tailless protein | 0.0113 | 0.4413 | 0.4413 |
Trypanosoma brucei | calcium motive p-type ATPase, putative | 0.0016 | 0.0148 | 0.4509 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0239 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0239 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0329 | 0.0329 |
Leishmania major | calcium-transporting ATPase, putative | 0.0016 | 0.0148 | 0.4509 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.002 | 0.0329 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.5011 | 0.5011 |
Toxoplasma gondii | calcium-translocating P-type ATPase, PMCA-type protein | 0.002 | 0.0329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4413 | 0.4413 |
Brugia malayi | nuclear receptor RXR | 0.0126 | 0.5011 | 0.5011 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0126 | 0.5011 | 0.5011 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Echinococcus multilocularis | Na+:K+ ATPase alpha subunit | 0.0046 | 0.1451 | 0.1322 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase 2 | 0.002 | 0.0329 | 0.0183 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0239 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13 nM | Inhibition of [3H]-ouabain binding to Digitalis receptor in dog heart microsomes | ChEMBL. | 9154966 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.