Detailed information for compound 46672

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.481 | Formula: C23H29NO3
  • H donors: 1 H acceptors: 2 LogP: 4.14 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]1[C@H](C)C(=O)C2C34C1C(Cc1c4c(O2)c(cc1)O)N(CC3)CC1CCC1
  • InChi: 1S/C23H29NO3/c1-12-13(2)20(26)22-23-8-9-24(11-14-4-3-5-14)16(18(12)23)10-15-6-7-17(25)21(27-22)19(15)23/h6-7,12-14,16,18,22,25H,3-5,8-11H2,1-2H3/t12-,13-,16?,18?,22?,23?/m0/s1
  • InChiKey: HWXCULOUOMXWMG-AMNKYZLYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0095 0.033 0.033
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0069 0.0361
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0445 0.1903 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0285 0.3845
Toxoplasma gondii exonuclease III APE 0.0038 0.0075 0.1005
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0196 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0179 0.0399
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0237 0.0583
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Schistosoma mansoni ap endonuclease 0.0038 0.0075 0.0075
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0295 0.1229 1
Mycobacterium ulcerans phosphoglycerate kinase 0.0177 0.0697 0.1719
Brugia malayi TAR-binding protein 0.0273 0.1128 0.1127
Echinococcus granulosus histone lysine methyltransferase setb 0.013 0.0485 0.0484
Echinococcus granulosus Smad4 0.0026 0.0019 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0075 0.0607
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0095 0.033 0.033
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0065 0.0196 0.0195
Echinococcus multilocularis tar DNA binding protein 0.0273 0.1128 0.1127
Schistosoma mansoni hypothetical protein 0.0053 0.0141 0.0141
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0114 0.0416 0.1433
Brugia malayi G protein-coupled receptor F59B2.13 0.0065 0.0196 0.0195
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0065 0.0196 0.0195
Brugia malayi Dopamine receptor protein 2 0.0065 0.0196 0.0195
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0065 0.0196 0.0195
Echinococcus granulosus fibroblast growth factor receptor 4 0.0118 0.0431 0.0431
Brugia malayi hypothetical protein 0.005 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0273 0.1128 0.1127
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0095 0.033 0.033
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0374 0.0833
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0065 0.0196 0.0195
Brugia malayi RNA recognition motif domain containing protein 0.0273 0.1128 0.1127
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0141 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0069 0.0069
Trypanosoma cruzi trans-sialidase, putative 0.0059 0.0166 0.0572
Schistosoma mansoni nuclear hormone receptor 0.0095 0.033 0.033
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0076 0.0168
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.0969 0.5092
Schistosoma mansoni hypothetical protein 0.0423 0.1804 0.1804
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0108 0.0261
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0618 0.2681 0.9243
Loa Loa (eye worm) mucolipin 1 0.0074 0.0233 0.0233
Echinococcus granulosus neuropeptide receptor 0.0065 0.0196 0.0195
Brugia malayi Nuclear hormone receptor-like 1 0.0095 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Schistosoma mansoni neuropeptide F-like receptor 0.0065 0.0196 0.0195
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0104 0.0104
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0237 0.0236
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0285 0.0285
Echinococcus granulosus L aminoadipate semialdehyde 0.0182 0.0719 0.0719
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Echinococcus multilocularis G protein coupled receptor 139 0.0065 0.0196 0.0195
Brugia malayi hypothetical protein 0.0065 0.0196 0.0195
Brugia malayi Probable ClpP-like protease 0.0085 0.0285 0.0285
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0069
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0118 0.0431 0.0431
Schistosoma mansoni smad1 5 8 and 0.0026 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0187 0.0742 0.1653
Echinococcus granulosus mitogen activated protein kinase 14 0.0618 0.2681 0.268
Loa Loa (eye worm) hypothetical protein 0.005 0.0128 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0095 0.033 0.033
Mycobacterium tuberculosis Conserved protein 0.0037 0.0069 0.0361
Schistosoma mansoni neuropeptide receptor 0.0065 0.0196 0.0195
Loa Loa (eye worm) TK protein kinase 0.0124 0.0459 0.0459
Entamoeba histolytica hypothetical protein 0.0079 0.0257 0.0643
Trypanosoma cruzi trans-sialidase, putative 0.0059 0.0166 0.0572
Brugia malayi MH1 domain containing protein 0.0026 0.0019 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 0.3998 0.8913
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0179 0.2411
Trypanosoma cruzi trans-sialidase, putative 0.0059 0.0166 0.0572
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0069 0.0361
Brugia malayi nuclear receptor RXR 0.0045 0.0104 0.0104
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0065 0.0196 0.0195
Trypanosoma brucei phosphoglycerate kinase, putative 0.0065 0.0194 0.0667
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0104 0.0104
Onchocerca volvulus Huntingtin homolog 0.0124 0.046 0.1024
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0139 0.0526 0.1814
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0316 0.1321 0.4554
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Brugia malayi RNA binding protein 0.0273 0.1128 0.1127
Echinococcus multilocularis neuropeptide receptor 0.0065 0.0196 0.0195
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0104 0.0104
Echinococcus multilocularis transcription factor Dp 1 0.008 0.0263 0.0263
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0019 0.0019
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.0685 0.0685
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Onchocerca volvulus 0.0065 0.0196 0.0435
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0124 0.0458 0.0457
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0177 0.0697 0.1553
Echinococcus multilocularis mitogen activated protein kinase 14 0.0618 0.2681 0.268
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0095 0.033 0.033
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.017 0.0667 0.0667
Schistosoma mansoni thyroid hormone receptor 0.0095 0.033 0.033
Echinococcus multilocularis neuropeptide Y receptor 0.0065 0.0196 0.0195
Echinococcus multilocularis dna polymerase eta 0.0023 0.0004 0.0004
Echinococcus multilocularis orexin receptor type 2 0.0065 0.0196 0.0195
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0127 0.0282
Echinococcus granulosus geminin 0.1473 0.6525 0.6525
Brugia malayi Serotonin receptor 0.0065 0.0196 0.0195
Echinococcus granulosus dna polymerase eta 0.0023 0.0004 0.0004
Schistosoma mansoni smad1 5 8 and 0.0026 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0124 0.046 0.046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0195
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0095 0.033 0.033
Brugia malayi hypothetical protein 0.0065 0.0196 0.0195
Echinococcus granulosus tar DNA binding protein 0.0273 0.1128 0.1127
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0069 0.0153
Loa Loa (eye worm) Smad1 0.0026 0.0019 0.0019
Schistosoma mansoni histamine h1 receptor 0.0065 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.0074 0.0237 0.0237
Loa Loa (eye worm) glutaminase 0.0923 0.4054 0.4054
Loa Loa (eye worm) hypothetical protein 0.0209 0.0842 0.0842
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0065 0.0196 0.0195
Brugia malayi Phosphoglycerate kinase 0.0177 0.0697 0.0697
Onchocerca volvulus 0.0065 0.0196 0.0435
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Onchocerca volvulus 0.0065 0.0196 0.0435
Brugia malayi nuclear hormone receptor family member nhr-6 0.0045 0.0104 0.0104
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0075 0.0257
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0036 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0374 0.0833
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0257 0.0257
Onchocerca volvulus 0.0065 0.0196 0.0435
Brugia malayi beta-NAC-like protein 0.0187 0.0742 0.0741
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0051 0.0132 0.0324
Echinococcus multilocularis transcription factor btf3 0.0187 0.0742 0.0741
Brugia malayi conserved hypotetical protein 0.0045 0.0104 0.0104
Schistosoma mansoni neuropeptide receptor 0.0065 0.0196 0.0195
Schistosoma mansoni amine GPCR 0.0065 0.0196 0.0195
Brugia malayi photoreceptor-specific nuclear receptor 0.086 0.3768 0.3768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0095 0.033 0.033
Onchocerca volvulus 0.0065 0.0196 0.0435
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.013 0.0485 0.0484
Schistosoma mansoni serine/threonine protein kinase 0.2246 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0187 0.0742 0.1653
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0285 0.0634
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.0374 0.0373
Brugia malayi hypothetical protein 0.0065 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0139 0.0726
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0285 0.3384
Brugia malayi ecdysteroid receptor 0.0095 0.033 0.033
Schistosoma mansoni DNA polymerase eta 0.0023 0.0004 0.0004
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0034 0.0178
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0139 0.0526 0.0526
Schistosoma mansoni hypothetical protein 0.0053 0.0141 0.0141
Onchocerca volvulus Protein ultraspiracle homolog 0.0095 0.033 0.0736
Loa Loa (eye worm) hypothetical protein 0.0095 0.033 0.033
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0153 0.0153
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0177 0.0697 0.9397
Schistosoma mansoni lamin 0.0056 0.0153 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.033 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0095 0.033 0.033
Entamoeba histolytica hypothetical protein 0.0187 0.0742 0.1855
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Brugia malayi MAP kinase sur-1 0.0062 0.0179 0.0179
Schistosoma mansoni hypothetical protein 0.0053 0.0141 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0582 0.0582
Schistosoma mansoni amine GPCR 0.0065 0.0196 0.0195
Schistosoma mansoni microtubule-associated protein tau 0.0739 0.3225 0.3225
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0095 0.033 0.033
Toxoplasma gondii hypothetical protein 0.0108 0.0386 0.5196
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0069 0.0361
Schistosoma mansoni alpha-glucosidase 0.015 0.0576 0.0576
Brugia malayi steroid hormone receptor 0.0095 0.033 0.033
Schistosoma mansoni mucolipin 0.0068 0.0206 0.0205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 0.3998 0.8913
Schistosoma mansoni biogenic amine (5HT) receptor 0.0065 0.0196 0.0195
Schistosoma mansoni amine GPCR 0.0065 0.0196 0.0195
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0179 0.0617
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0177 0.0697 0.2403
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0237 0.0592
Mycobacterium ulcerans hypothetical protein 0.0351 0.1481 0.3653
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0194 0.0667
Plasmodium vivax basic transcription factor 3b, putative 0.0187 0.0742 0.6035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0196 0.0195
Schistosoma mansoni neuropeptide receptor 0.0065 0.0196 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Onchocerca volvulus 0.0026 0.0018 0.004
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0059 0.0166 0.0572
Onchocerca volvulus 0.0182 0.0719 0.1603
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0069 0.017
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0104 0.0231
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0069
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0295 0.1229 0.3031
Treponema pallidum hypothetical protein 0.0295 0.1229 0.3014
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0445 0.1903 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0095 0.033 0.033
Echinococcus granulosus nuclear receptor nhr 48 0.0045 0.0104 0.0104
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0045 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Brugia malayi hypothetical protein 0.0065 0.0196 0.0195
Schistosoma mansoni hypothetical protein 0.0115 0.0419 0.0419
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0076 0.0168
Echinococcus multilocularis dro:myosuppressin receptor 0.0065 0.0196 0.0195
Brugia malayi ORL1-like opioid receptor 0.0065 0.0196 0.0195
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0065 0.0196 0.0195
Loa Loa (eye worm) RNA binding protein 0.0273 0.1128 0.1128
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0065 0.0196 0.0195
Onchocerca volvulus 0.0162 0.0628 0.14
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0023 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0065 0.0196 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0582 0.0582
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.2246 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0285 0.2717
Echinococcus granulosus 7tm_1 domain containing protein 0.0065 0.0196 0.0195
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0004 0.0009
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.006 0.0059
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0065 0.0196 0.0196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0095 0.033 0.033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0582 0.0582
Brugia malayi hypothetical protein 0.0065 0.0196 0.0195
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0019 0.0019
Loa Loa (eye worm) glutaminase 2 0.0923 0.4054 0.4054
Loa Loa (eye worm) hypothetical protein 0.0056 0.0152 0.0152
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0139 0.0526 0.1316
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0127 0.1708
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0051 0.0132 0.0916
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.013 0.0485 0.6533
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0108 0.0878
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0316 0.1321 0.4554
Schistosoma mansoni hypothetical protein 0.1473 0.6525 0.6525
Echinococcus multilocularis mitogen activated protein kinase 11 0.0618 0.2681 0.268
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.0685 0.0685
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 0.3998 0.8913
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0195
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0316 0.1321 0.4554
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.017 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0056 0.0152 0.0152
Trichomonas vaginalis esterase, putative 0.0037 0.0069 0.0153
Schistosoma mansoni hypothetical protein 0.0065 0.0196 0.0195
Brugia malayi glutaminase DH11.1 0.0923 0.4054 0.4054
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0059 0.0166 0.0572
Brugia malayi nuclear receptor NHR-88 0.0045 0.0104 0.0104
Schistosoma mansoni zinc finger protein 0.0045 0.0104 0.0104
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0065 0.0196 0.0195
Loa Loa (eye worm) acetyltransferase 0.017 0.0667 0.0667
Onchocerca volvulus 0.0065 0.0196 0.0435
Echinococcus multilocularis musashi 0.0056 0.0153 0.0152
Mycobacterium leprae conserved hypothetical protein 0.0051 0.0132 0.0691
Schistosoma mansoni biogenic amine (5HT) receptor 0.0209 0.0842 0.0841
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0069 0.0069
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0004 0.0004
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0051 0.0132 0.0324
Onchocerca volvulus 0.0065 0.0196 0.0435
Brugia malayi hypothetical protein 0.0065 0.0196 0.0195
Brugia malayi intermediate filament protein 0.0056 0.0153 0.0152
Entamoeba histolytica transcription factor BTF3, putative 0.0187 0.0742 0.1855
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0075 0.0075
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0059 0.0166 0.0572
Echinococcus multilocularis cpg binding protein 0.0062 0.0181 0.018
Brugia malayi hypothetical protein 0.0065 0.0196 0.0195
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.033 0.033
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0153 0.0804
Schistosoma mansoni tar DNA-binding protein 0.0273 0.1128 0.1127
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0065 0.0196 0.0195
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0182 0.0719 0.0719
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Plasmodium falciparum basic transcription factor 3b, putative 0.0187 0.0742 0.6035
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.0442 0.5952
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.0196 0.0196
Schistosoma mansoni ap endonuclease 0.0038 0.0075 0.0075
Brugia malayi latrophilin 2 splice variant baaae 0.0115 0.0419 0.0419
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0069 0.0069
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0004 0.0019
Echinococcus multilocularis smad 0.0026 0.0019 0.0019
Echinococcus granulosus neuropeptide s receptor 0.0557 0.2406 0.2406
Onchocerca volvulus Neuropeptide F receptor homolog 0.0065 0.0196 0.0435
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0582 0.0582
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0196 0.0195
Echinococcus multilocularis L aminoadipate semialdehyde 0.0182 0.0719 0.0719
Schistosoma mansoni growth hormone secretagogue receptor 0.0065 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.0095 0.033 0.033
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0295 0.1229 0.6458
Echinococcus granulosus neuropeptide Y receptor 0.0065 0.0196 0.0195
Brugia malayi MH2 domain containing protein 0.0026 0.0019 0.0019
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.005 0.0128 0.0128
Brugia malayi RE15519p 0.0065 0.0196 0.0195
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0051 0.0132 0.0247
Onchocerca volvulus 0.1019 0.4486 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0104 0.0104
Brugia malayi MH1 domain containing protein 0.0026 0.0019 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0237 0.0236
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.1804 0.1804
Loa Loa (eye worm) hypothetical protein 0.005 0.0128 0.0128
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0237 0.0583
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.0132 0.0454
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0069 0.0361
Schistosoma mansoni opsin-like receptor 0.0065 0.0196 0.0195
Echinococcus granulosus lamin 0.0056 0.0153 0.0152
Echinococcus granulosus cpg binding protein 0.0062 0.0181 0.018
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0069 0.0237
Loa Loa (eye worm) hypothetical protein 0.0095 0.033 0.033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0104 0.0104
Echinococcus granulosus ecdysone induced protein 78C 0.0095 0.033 0.033
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0139 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.0056 0.0152 0.0152
Onchocerca volvulus 0.0065 0.0196 0.0435
Onchocerca volvulus 0.013 0.0485 0.108
Schistosoma mansoni neuropeptide f receptor 76f 0.0065 0.0196 0.0195
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.0374 0.0373
Brugia malayi hypothetical protein 0.0045 0.0104 0.0104
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.005 0.0128 0.0128
Brugia malayi neuropeptide F receptor 0.0065 0.0196 0.0195
Brugia malayi hypothetical protein 0.0065 0.0196 0.0195
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0179 0.0179
Echinococcus granulosus G protein coupled receptor 139 0.0065 0.0196 0.0195
Schistosoma mansoni kinase 0.0057 0.0158 0.0157
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0065 0.0196 0.0195
Brugia malayi nuclear hormone receptor 0.0045 0.0104 0.0104
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0104 0.0104
Echinococcus multilocularis thyroid hormone receptor alpha 0.0095 0.033 0.033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0139 0.0726
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Brugia malayi hypothetical protein 0.0078 0.0254 0.0253
Loa Loa (eye worm) DR-78 0.0045 0.0104 0.0104
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0152 0.0359
Echinococcus granulosus g protein coupled receptor 0.0065 0.0196 0.0195
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0076 0.1018
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.0196 0.0196
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0194 0.0667
Loa Loa (eye worm) hypothetical protein 0.0055 0.0148 0.0148
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0004 0.0019
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0019 0.0019
Loa Loa (eye worm) transcription factor SMAD2 0.0382 0.1619 0.1619
Loa Loa (eye worm) hypothetical protein 0.0095 0.033 0.033
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0065 0.0196 0.0195
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.0723 0.0723
Trypanosoma cruzi trans-sialidase, putative 0.0059 0.0166 0.0571
Trypanosoma brucei trans-sialidase, putative 0.0059 0.0166 0.0572
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 0.3998 0.8913
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0019 0.0019
Echinococcus granulosus neuropeptide Y receptor 0.0065 0.0196 0.0195
Brugia malayi nuclear receptor NHR-67 0.0045 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.013 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.005 0.0128 0.0128
Echinococcus granulosus c-Jun N-terminal kinases 0.2246 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0065 0.0196 0.0195
Mycobacterium leprae Probable lipase LipE 0.0037 0.0069 0.0361
Brugia malayi hypothetical protein 0.0124 0.046 0.0459
Schistosoma mansoni tar DNA-binding protein 0.0273 0.1128 0.1127
Echinococcus granulosus alpha 1A adrenergic receptor 0.0065 0.0196 0.0195
Schistosoma mansoni hypothetical protein 0.0065 0.0196 0.0195
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0237 0.1243
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0065 0.0196 0.0195
Echinococcus multilocularis neuropeptide receptor 0.0065 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0152 0.0338
Brugia malayi AKH receptor 0.0065 0.0196 0.0195
Brugia malayi GnHR receptor homolog 0.0065 0.0196 0.0195
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0069 0.0361
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Treponema pallidum fructose-bisphosphate aldolase 0.0911 0.3998 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0237 0.1243
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0295 0.1229 0.6458
Trypanosoma brucei protein kinase, putative 0.0062 0.0179 0.0617
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0254 0.0873
Echinococcus granulosus dnaJ subfamily B 0.0423 0.1804 0.1804
Loa Loa (eye worm) hypothetical protein 0.0074 0.0237 0.0237
Echinococcus granulosus mitogen activated protein kinase 11 0.0618 0.2681 0.268
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0045 0.0104 0.0104
Echinococcus granulosus thyroid hormone receptor alpha 0.0045 0.0104 0.0104
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0179 0.0617
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0128 0.0128
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0094 0.0324 0.1115
Brugia malayi hypothetical protein 0.005 0.0128 0.0128
Echinococcus multilocularis G-protein coupled receptor, putative 0.0065 0.0196 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Schistosoma mansoni amine GPCR 0.0065 0.0196 0.0195
Echinococcus multilocularis fmrfamide receptor 0.0065 0.0196 0.0195
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0075 0.0103
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0374 0.1288
Schistosoma mansoni alpha-glucosidase 0.015 0.0576 0.0576
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0667 0.29 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0075 0.0257
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0095 0.033 0.033
Leishmania major hypothetical protein, conserved 0.0078 0.0254 0.0873
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0237 0.0236
Echinococcus granulosus g protein coupled receptor 0.0065 0.0196 0.0195
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0667 0.29 1
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0152 0.1236
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0065 0.0196 0.0196
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0076 0.0168
Loa Loa (eye worm) ICD-1 protein 0.0187 0.0742 0.0742
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0285 0.0703
Brugia malayi MH2 domain containing protein 0.0026 0.0019 0.0019
Echinococcus multilocularis mucolipin 3 0.0074 0.0233 0.0233
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0051 0.0132 0.1774
Echinococcus granulosus twitchin 0.0025 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0095 0.033 0.033
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0065 0.0196 0.0195
Trypanosoma cruzi trans-sialidase, putative 0.0059 0.0166 0.0571
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0254 0.2061
Mycobacterium ulcerans hypothetical protein 0.0037 0.0069 0.017
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0004 0.0004
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0257 0.0257
Schistosoma mansoni tar DNA-binding protein 0.0273 0.1128 0.1127
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0065 0.0196 0.0195
Mycobacterium tuberculosis Conserved hypothetical protein 0.0351 0.1481 0.7784
Echinococcus granulosus biogenic amine 5HT receptor 0.0065 0.0196 0.0195
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0237 0.0583
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.0374 0.0833
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0065 0.0196 0.0195
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0051 0.0132 0.107
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Mycobacterium tuberculosis Conserved protein 0.0037 0.0069 0.0361
Loa Loa (eye worm) hypothetical protein 0.0124 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Onchocerca volvulus 0.0037 0.0069 0.0153
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Onchocerca volvulus 0.0494 0.2123 0.4732
Echinococcus granulosus neuropeptide FF receptor 2 0.0065 0.0196 0.0195
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.013 0.0485 0.0484
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0141 0.0141
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0177 0.0697 0.1553
Trichomonas vaginalis conserved hypothetical protein 0.0187 0.0742 0.1653
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0069
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0065 0.0196 0.0195
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0019 0.0019
Entamoeba histolytica phosphoglycerate kinase, putative 0.0177 0.0697 0.1743
Onchocerca volvulus 0.0065 0.0196 0.0435
Schistosoma mansoni glutaminase 0.0923 0.4054 0.4054
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0911 0.3998 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0124 0.0459 0.0459
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0254 0.0873
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0076 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0195
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0179 0.0179
Schistosoma mansoni nuclear receptor 0.0045 0.0104 0.0104
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Echinococcus multilocularis neuropeptides capa receptor 0.0065 0.0196 0.0195
Brugia malayi hypothetical protein 0.0065 0.0196 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Trypanosoma brucei transcription factor BTF3, putative 0.0187 0.0742 0.2557
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0075 0.0166
Onchocerca volvulus 0.0101 0.0355 0.079
Brugia malayi beta-lactamase family protein 0.0037 0.0069 0.0069
Echinococcus multilocularis neuropeptides capa receptor 0.0065 0.0196 0.0195
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0069 0.0153
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.0685 0.0685
Loa Loa (eye worm) MH2 domain-containing protein 0.0382 0.1619 0.1619
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0065 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Leishmania major hypothetical protein, conserved 0.0037 0.0069 0.0237
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0618 0.2681 0.9243
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0069 0.0069
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0065 0.0196 0.0435
Loa Loa (eye worm) hypothetical protein 0.0056 0.0152 0.0152
Echinococcus granulosus histone acetyltransferase KAT2B 0.0165 0.0645 0.0645
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Mycobacterium ulcerans glutaminase 0.0923 0.4054 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0153 0.0804
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0254 0.0873
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0004 0.0009
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0059 0.0166 0.0572
Onchocerca volvulus 0.0056 0.0153 0.034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Onchocerca volvulus 0.0065 0.0196 0.0435
Brugia malayi nuclear hormone receptor 0.0095 0.033 0.033
Schistosoma mansoni tar DNA-binding protein 0.0273 0.1128 0.1127
Onchocerca volvulus 0.0065 0.0196 0.0435
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0065 0.0196 0.0195
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0076 0.026
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0285 0.0285
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0374 0.0833
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0179 0.0179
Brugia malayi hypothetical protein 0.0045 0.0104 0.0104
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0237 0.1243
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0095 0.033 0.033
Trypanosoma cruzi trans-sialidase, putative 0.0059 0.0166 0.0571
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Brugia malayi Steroid receptor seven-up type 2 0.0095 0.033 0.033
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0069 0.056
Onchocerca volvulus Tyrosine kinase homolog 0.017 0.0666 0.1485
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0179 0.0399
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0065 0.0196 0.0195
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0179 0.0179
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0237 0.0583
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0104 0.0104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.033 0.033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0582 0.0582
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0195
Echinococcus granulosus intermediate filament protein 0.0056 0.0153 0.0152
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0582 0.0582
Treponema pallidum phosphoglycerate kinase 0.0177 0.0697 0.1673
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0153 0.0153
Onchocerca volvulus 0.0065 0.0196 0.0435
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0065 0.0196 0.0195
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0075 0.0166
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0069 0.0069
Brugia malayi hypothetical protein 0.0065 0.0196 0.0195
Echinococcus multilocularis serotonin receptor 0.0209 0.0842 0.0841
Echinococcus granulosus tachykinin peptides receptor 99D 0.0065 0.0196 0.0195
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0179 0.0439
Loa Loa (eye worm) hypothetical protein 0.0085 0.0285 0.0285
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0139 0.0726
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Brugia malayi Melatonin receptor type 1A 0.0065 0.0196 0.0195
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0196 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0095 0.033 0.033
Schistosoma mansoni phosphoglycerate kinase 0.0177 0.0697 0.0697
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0667 0.29 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0237 0.0592
Echinococcus granulosus microtubule associated protein 2 0.0739 0.3225 0.3225
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0152 0.0798
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Echinococcus multilocularis c Jun NH2 terminal kinase 0.2246 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0237 0.0583
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0005 0.0005
Echinococcus granulosus dro:myosuppressin receptor 0.0065 0.0196 0.0195
Echinococcus multilocularis somatostatin receptor 0.0065 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0179 0.0399
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0019 0.0019
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0004 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0004 0.0012
Echinococcus multilocularis neuropeptide FF receptor 2 0.0065 0.0196 0.0195
Echinococcus granulosus hypothetical protein 0.0065 0.0196 0.0195
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0075 0.0607
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0896 0.393 0.393
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0194 0.0667
Onchocerca volvulus 0.0056 0.0153 0.034
Schistosoma mansoni lamin 0.0056 0.0153 0.0152
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0095 0.033 0.033
Echinococcus multilocularis mitogen activated protein kinase 14 0.0618 0.2681 0.268
Mycobacterium ulcerans beta-lactamase 0.0037 0.0069 0.017
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0059 0.0166 0.0572
Schistosoma mansoni neuropeptide receptor 0.0065 0.0196 0.0195
Echinococcus multilocularis mitogen activated protein kinase 11 0.0618 0.2681 0.268
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0004 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0237 0.0815
Echinococcus multilocularis fmrfamide receptor 0.0065 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.0056 0.0153 0.0153
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0075 0.0257
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0076 0.0189
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Entamoeba histolytica hypothetical protein 0.0079 0.0257 0.0643
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0166 0.0166
Brugia malayi Calcitonin receptor-like protein seb-1 0.0168 0.0658 0.0658
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0065 0.0196 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0254 0.3415
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0095 0.033 0.033
Trypanosoma brucei trans-sialidase, putative 0.0059 0.0166 0.0572
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0494 0.2123 0.2123
Brugia malayi larval opioid receptor 0.0065 0.0196 0.0195
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0075 0.0075
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0059 0.0166 0.0572
Trichomonas vaginalis set domain proteins, putative 0.1019 0.4486 1
Brugia malayi CXXC zinc finger family protein 0.0059 0.0166 0.0165
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.033 0.033
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0153 0.0804
Brugia malayi G-protein coupled receptor 0.0065 0.0196 0.0195
Echinococcus granulosus 7TM GPCR rhodopsin 0.0065 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0069
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0285 0.0285
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0004 0.0012
Schistosoma mansoni opsin-like receptor 0.0065 0.0196 0.0195
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0196 0.0195
Echinococcus granulosus neuropeptides capa receptor 0.0065 0.0196 0.0195
Echinococcus multilocularis neuropeptide s receptor 0.0557 0.2406 0.2406
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Schistosoma mansoni opsin-like receptor 0.0065 0.0196 0.0195
Schistosoma mansoni alpha glucosidase 0.0039 0.0076 0.0075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 0.3998 0.8913
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0065 0.0196 0.0196
Trypanosoma brucei phosphoglycerate kinase 0.0065 0.0194 0.0667
Toxoplasma gondii hypothetical protein 0.0029 0.0034 0.0456
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0069 0.017
Loa Loa (eye worm) TYRA-2 protein 0.0065 0.0196 0.0196
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0168 0.0658 0.0658
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0065 0.0194 0.0667
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0069 0.0237
Echinococcus granulosus somatostatin receptor 0.0065 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Giardia lamblia Phosphoglycerate kinase 0.0177 0.0697 0.1736
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0075 0.0186
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0076 0.0168
Schistosoma mansoni nuclear receptor 0.0045 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0074 0.0237 0.0237
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.0374 0.0374
Echinococcus granulosus GPCR family 2 0.0053 0.0141 0.0141
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0139 0.0526 0.1814
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0196 0.0195
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0005 0.0005
Trypanosoma brucei trans-sialidase 0.0059 0.0166 0.0572
Brugia malayi nuclear hormone receptor family member odr-7 0.0045 0.0104 0.0104
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0179 0.0617
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0075 0.0392
Schistosoma mansoni tyrosine kinase 0.0118 0.0431 0.0431
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0152 0.0375
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0127 0.0282
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0095 0.033 0.033
Echinococcus granulosus dna polymerase kappa 0.0023 0.0004 0.0004
Echinococcus granulosus neuropeptide receptor 0.0065 0.0196 0.0195
Onchocerca volvulus 0.0059 0.0166 0.0369
Echinococcus multilocularis lamin dm0 0.0056 0.0153 0.0152
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Trypanosoma brucei phosphoglycerate kinase 0.0177 0.0697 0.2403
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.0194 0.0667
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0196 0.0195
Brugia malayi follicle stimulating hormone receptor 0.0065 0.0196 0.0195
Schistosoma mansoni hypothetical protein 0.0065 0.0196 0.0195
Schistosoma mansoni amine GPCR 0.0065 0.0196 0.0195
Giardia lamblia Fructose-bisphosphate aldolase 0.0911 0.3998 1
Plasmodium vivax SET domain protein, putative 0.013 0.0485 0.3943
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0179 0.0399
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0065 0.0196 0.0195
Echinococcus granulosus smad 0.0026 0.0019 0.0019
Leishmania major phosphopantetheinyl transferase-like protein 0.0051 0.0132 0.0454
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0127 0.1031
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0095 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0237 0.0592
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0911 0.3998 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0015
Trypanosoma cruzi trans-sialidase, putative 0.0059 0.0166 0.0571
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0065 0.0196 0.0195
Trypanosoma cruzi transcription factor btf3, putative 0.0187 0.0742 0.2557
Leishmania major phosphoglycerate kinase C, glycosomal 0.0177 0.0697 0.2403
Schistosoma mansoni biogenic amine receptor 0.0065 0.0196 0.0195
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0045 0.0104 0.0104
Echinococcus granulosus g-protein coupled receptor 0.0065 0.0196 0.0195
Loa Loa (eye worm) nuclear hormone receptor 0.0045 0.0104 0.0104
Schistosoma mansoni myosin xvIII 0.0065 0.0196 0.0195
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0051 0.0132 0.0691
Onchocerca volvulus 0.0037 0.0069 0.0153
Echinococcus granulosus serotonin receptor 0.0065 0.0196 0.0195
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Onchocerca volvulus 0.0095 0.033 0.0736
Schistosoma mansoni biogenic amine receptor 0.0065 0.0196 0.0195
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0139 0.0526 0.1814
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0059 0.0166 0.0572
Echinococcus granulosus peptide allatostatin:somatostatin 0.0065 0.0196 0.0195
Onchocerca volvulus 0.0045 0.0104 0.0231
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0445 0.1903 0.4693
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0095 0.033 0.033
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0179 0.0179
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0141 0.0141
Echinococcus multilocularis roundabout 2 0.0025 0.0015 0.0015
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0153 0.0153
Schistosoma mansoni smad 0.0026 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0195
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0045 0.0104 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.033 0.033
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.005 0.0128 0.0128
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0065 0.0196 0.0195
Echinococcus multilocularis ecdysone induced protein 78C 0.0095 0.033 0.033
Echinococcus granulosus neuropeptides capa receptor 0.0065 0.0196 0.0195
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0151 0.0582 0.0582
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0095 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0053 0.0141 0.0141
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0069 0.0153
Brugia malayi Pre-SET motif family protein 0.0896 0.393 0.393
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0095 0.033 0.033
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0004 0.0012
Entamoeba histolytica hypothetical protein 0.0079 0.0257 0.0643
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0179 0.0617
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.0723 0.0723
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0177 0.0697 0.3662
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0842 0.369 0.369
Loa Loa (eye worm) hypothetical protein 0.0182 0.0719 0.0719
Echinococcus multilocularis microtubule associated protein 2 0.0739 0.3225 0.3225
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0374 0.0833
Toxoplasma gondii NAC domain-containing protein 0.0187 0.0742 1
Echinococcus granulosus transcription factor Dp 1 0.008 0.0263 0.0263
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0295 0.1229 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0254 0.2061
Schistosoma mansoni coup transcription factor 0.0095 0.033 0.033
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0023 0.0023
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0059 0.0166 0.0572
Schistosoma mansoni neuropeptide F-like receptor 0.0065 0.0196 0.0195
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0069 0.0069
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0196 0.0195
Echinococcus granulosus mucolipin 3 0.0074 0.0233 0.0233
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0152 0.0338
Brugia malayi MH2 domain containing protein 0.0382 0.1619 0.1619
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0151 0.0582 0.0582
Trypanosoma brucei phosphoglycerate kinase 0.0177 0.0697 0.2403
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0139 0.0526 0.0526
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0069 0.0361
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0168 0.0658 0.0658
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0582 0.0582
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0094 0.0324 0.1115
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0065 0.0196 0.0195
Onchocerca volvulus Bile acid receptor homolog 0.0095 0.033 0.0736
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.0194 0.0667
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0076 0.0168
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0004 0.0004
Plasmodium vivax phosphoglycerate kinase, putative 0.0177 0.0697 0.5671
Trypanosoma brucei polo-like protein kinase 0.0105 0.0374 0.1288
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0045 0.0104 0.0104
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.013 0.0485 0.0484
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0027 0.0023 0.0023
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0051 0.0132 0.1774
Brugia malayi Tachykinin-like peptides receptor 99D 0.0065 0.0196 0.0195
Toxoplasma gondii ABC1 family protein 0.0037 0.0069 0.0927
Brugia malayi beta-lactamase family protein 0.0037 0.0069 0.0069
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0374 0.1288
Loa Loa (eye worm) hypothetical protein 0.0056 0.0152 0.0152
Brugia malayi G-protein coupled receptor 0.0065 0.0196 0.0195
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.013 0.0485 0.0484
Echinococcus multilocularis g-protein coupled receptor 0.0065 0.0196 0.0195
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0065 0.0196 0.0195
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 0.3998 0.8913
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0095 0.033 0.033
Chlamydia trachomatis phosphoglycerate kinase 0.0177 0.0697 1
Loa Loa (eye worm) histone methyltransferase 0.0023 0.0005 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0141 0.0141
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.005 0.0128 0.0128
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0075 0.0184
Mycobacterium tuberculosis Conserved protein 0.0037 0.0069 0.0361
Schistosoma mansoni transcription factor btf3 0.0187 0.0742 0.0741
Loa Loa (eye worm) TAR-binding protein 0.0273 0.1128 0.1128
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0285 0.1498
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0051 0.0132 0.107
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0065 0.0196 0.0195
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.033 0.033
Brugia malayi Serotonin receptor 0.0065 0.0196 0.0195
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0034 0.0275
Brugia malayi G protein-coupled receptor 0.0065 0.0196 0.0195
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Brugia malayi nuclear receptor NHR-88 0.0095 0.033 0.033
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0076 0.0168
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0076 0.0076
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0004 0.0004
Echinococcus multilocularis neuropeptide Y receptor 0.0065 0.0196 0.0195
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0237 0.0815
Mycobacterium ulcerans lipase LipD 0.0037 0.0069 0.017
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0237 0.0583
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Brugia malayi ecdysone receptor 0.0045 0.0104 0.0104
Onchocerca volvulus 0.0065 0.0196 0.0435
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0177 0.0697 0.9397
Echinococcus multilocularis serotonin receptor 0.0209 0.0842 0.0841
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0285 0.3845
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Trypanosoma brucei unspecified product 0.0023 0.0004 0.0012
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0196 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Brugia malayi orphan nuclear receptor NR2E1 0.0045 0.0104 0.0104
Schistosoma mansoni Smad4 0.0026 0.0019 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0069 0.0153
Brugia malayi Dopamine receptor protein 1 0.0065 0.0196 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0505 0.2172 0.4842
Brugia malayi Smad1 0.0026 0.0019 0.0019
Brugia malayi Dopamine receptor 0.0065 0.0196 0.0195
Leishmania major DNA polymerase eta, putative 0.0023 0.0004 0.0012
Brugia malayi beta-lactamase 0.0037 0.0069 0.0069
Trypanosoma brucei trans-sialidase, putative 0.0059 0.0166 0.0572
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0076 0.0168
Schistosoma mansoni RAR-like nuclear receptor 0.0095 0.033 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0104 0.0104
Schistosoma mansoni thyroid hormone receptor 0.0095 0.033 0.033
Brugia malayi P38 map kinase family protein 2 0.0618 0.2681 0.268
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0179 0.0617
Onchocerca volvulus 0.0037 0.0069 0.0153
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0004 0.0012
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0004 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0314 0.1314 0.2928
Echinococcus granulosus biogenic amine 5HT receptor 0.0209 0.0842 0.0841
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Brugia malayi Coelomocyte uptake defective protein 5 0.0074 0.0233 0.0233
Schistosoma mansoni nuclear receptor nhr-48 0.0045 0.0104 0.0104
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.0374 0.1288
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0618 0.2681 0.9243
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0095 0.033 0.033
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0075 0.0075
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0076 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0374 0.0373
Brugia malayi neuropeptide F receptor 0.0065 0.0196 0.0195
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0139 0.0526 0.1814
Echinococcus multilocularis FTZ F1 alpha 0.0095 0.033 0.033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0139 0.0726
Loa Loa (eye worm) hypothetical protein 0.005 0.0128 0.0128
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0034 0.0275
Echinococcus granulosus phosphoglycerate kinase 1 0.0177 0.0697 0.0697
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0257 0.0257
Echinococcus multilocularis geminin 0.1473 0.6525 0.6525
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0273 0.1128 0.1128
Onchocerca volvulus 0.0065 0.0196 0.0435
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0285 0.2717
Echinococcus multilocularis phosphoglycerate kinase 1 0.0177 0.0697 0.0697
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.0685 0.0685
Echinococcus granulosus allatostatin A receptor 0.0065 0.0196 0.0195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0195
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0094 0.0324 0.1115
Brugia malayi nuclear receptor RXR 0.005 0.0128 0.0128
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0285 0.0703
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0177 0.0697 0.3662
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0095 0.033 0.033
Schistosoma mansoni retinoic acid receptor RXR 0.0095 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.005 0.0128 0.0128
Onchocerca volvulus Huntingtin homolog 0.0124 0.046 0.1024
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0045 0.0104 0.0104
Mycobacterium ulcerans hypothetical protein 0.0074 0.0237 0.0583
Schistosoma mansoni hypothetical protein 0.0079 0.0257 0.0257
Giardia lamblia Kinase, PLK 0.0105 0.0374 0.0926
Echinococcus granulosus fmrfamide receptor 0.0065 0.0196 0.0195
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 0.3998 0.8913
Leishmania major mitochondrial DNA polymerase beta 0.0667 0.29 1
Trypanosoma brucei trans-sialidase, putative 0.0059 0.0166 0.0572
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0065 0.0196 0.0195
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.0285 0.232
Schistosoma mansoni cpg binding protein 0.0062 0.0181 0.018
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0095 0.033 0.033
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0141 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Loa Loa (eye worm) steroid hormone receptor 0.0095 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0196 0.0195
Schistosoma mansoni adenoreceptor 0.0065 0.0196 0.0195
Schistosoma mansoni alpha-1 adrenergic receptor 0.0065 0.0196 0.0195
Trypanosoma cruzi transcription factor btf3, putative 0.0187 0.0742 0.2557
Brugia malayi Phosphoglycerate kinase 0.0065 0.0194 0.0194
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0177 0.0697 0.2403
Leishmania major DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Trichomonas vaginalis glutaminase, putative 0.0923 0.4054 0.9038
Schistosoma mansoni cpg binding protein 0.0062 0.0181 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0115 0.0419 0.0419
Trichomonas vaginalis Sialidase-1 precursor, putative 0.0505 0.2172 0.4842
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0075 0.0178
Brugia malayi tailless protein 0.0045 0.0104 0.0104
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.0196 0.0196
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0195
Schistosoma mansoni mucolipin 0.0074 0.0233 0.0233
Schistosoma mansoni hypothetical protein 0.0035 0.006 0.0059
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0374 0.0833
Echinococcus multilocularis GPCR, family 2 0.0053 0.0141 0.0141
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0141 0.0141
Onchocerca volvulus 0.0045 0.0104 0.0231
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0004 0.0008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0095 0.033 0.033
Brugia malayi putative neuropeptide receptor 0.0065 0.0196 0.0195
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0069 0.0361
Echinococcus granulosus sex peptide receptor 0.0065 0.0196 0.0195
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0483 0.0482
Schistosoma mansoni phosphoglycerate kinase 0.0177 0.0697 0.0697
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0059 0.0166 0.0572
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0139 0.0526 0.0526
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.006 0.0059
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0015
Loa Loa (eye worm) melatonin receptor type 1A 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0095 0.033 0.033
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0285 0.232
Schistosoma mansoni cpg binding protein 0.0059 0.0166 0.0165
Schistosoma mansoni intermediate filament proteins 0.0056 0.0153 0.0152
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0065 0.0196 0.0195
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.0685 0.0685
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0065 0.0196 0.0196
Echinococcus multilocularis lamin 0.0056 0.0153 0.0152
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0182 0.0719 0.0719
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0045 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.0374 0.0934
Entamoeba histolytica hypothetical protein 0.0051 0.0132 0.0329
Brugia malayi hypothetical protein 0.005 0.0128 0.0128
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.0374 0.0373
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0618 0.2681 0.2681
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0196 0.0195
Brugia malayi sulfakinin receptor protein 0.0065 0.0196 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0069 0.0237
Echinococcus granulosus transcription factor btf3 0.0187 0.0742 0.0741
Brugia malayi hypothetical protein 0.0079 0.0257 0.0257
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0076 0.0189
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0104 0.0231
Echinococcus multilocularis Smad4 0.0026 0.0019 0.0019
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0095 0.033 0.0736
Trypanosoma brucei glucosidase, putative 0.0039 0.0076 0.026
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0374 0.0833
Loa Loa (eye worm) hypothetical protein 0.0209 0.0842 0.0842
Onchocerca volvulus 0.0065 0.0196 0.0435
Loa Loa (eye worm) hypothetical protein 0.0095 0.033 0.033
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0153 0.0152
Leishmania major phosphoglycerate kinase B, cytosolic 0.0177 0.0697 0.2403
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0196 0.0195
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0177 0.0697 1
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0196 0.0195
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0004 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0004 0.0004
Loa Loa (eye worm) beta-lactamase 0.0037 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0127 0.1708
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0094 0.0324 0.1115
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0104
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0237 0.0583
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0374 0.0833
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0237 0.1243
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0076 0.0168
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0179 0.0617
Echinococcus granulosus roundabout 2 0.0025 0.0015 0.0015
Brugia malayi hypothetical protein 0.0494 0.2123 0.2123
Schistosoma mansoni steroid hormone receptor ad4bp 0.0095 0.033 0.033
Schistosoma mansoni smad1 5 8 and 0.0026 0.0019 0.0019
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0152 0.1236
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0075 0.0257
Echinococcus multilocularis allatostatin A receptor 0.0065 0.0196 0.0195
Echinococcus granulosus g protein coupled receptor 0.0065 0.0196 0.0195
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0108 0.027
Plasmodium falciparum phosphoglycerate kinase 0.0177 0.0697 0.5671
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0075 0.0075
Brugia malayi acetyltransferase, GNAT family protein 0.017 0.0667 0.0667
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0618 0.2681 0.9243
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.013 0.0485 0.0484
Echinococcus multilocularis sex peptide receptor 0.0065 0.0196 0.0195
Schistosoma mansoni hypothetical protein 0.1473 0.6525 0.6525
Echinococcus granulosus orexin receptor type 2 0.0065 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.033 0.033
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0118 0.0431 0.0431
Onchocerca volvulus 0.0074 0.0237 0.0527
Echinococcus multilocularis nuclear receptor nhr 48 0.0045 0.0104 0.0104
Echinococcus granulosus lamin dm0 0.0056 0.0153 0.0152
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0059 0.0166 0.0572
Echinococcus multilocularis neuropeptide receptor A26 0.0557 0.2406 0.2406
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0237 0.0815
Loa Loa (eye worm) hypothetical protein 0.0095 0.033 0.033
Schistosoma mansoni hypothetical protein 0.0053 0.0141 0.0141
Onchocerca volvulus 0.0065 0.0196 0.0435
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0059 0.0166 0.0572
Echinococcus granulosus FTZ F1 alpha 0.0095 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0065 0.0196 0.0196
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0095 0.033 0.033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0196 0.0195
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0177 0.0697 0.0697
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0179 0.0617
Loa Loa (eye worm) hypothetical protein 0.0078 0.0254 0.0254
Trypanosoma brucei trans-sialidase, putative 0.0059 0.0166 0.0572
Echinococcus granulosus neuropeptide receptor A26 0.0557 0.2406 0.2406
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0118 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0069 0.0361
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.0196 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0004 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0076 0.026
Brugia malayi putative neuropeptide receptor NPR1 0.0065 0.0196 0.0195
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 0.3998 0.8913
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.013 0.0485 0.0484
Leishmania major basic transcription factor 3a, putative 0.0187 0.0742 0.2557
Loa Loa (eye worm) hypothetical protein 0.0065 0.0196 0.0196
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0254 0.2061
Brugia malayi Pre-SET motif family protein 0.013 0.0485 0.0484
Onchocerca volvulus 0.0065 0.0196 0.0435
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0139 0.0526 0.0526
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0069 0.0153
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0104 0.0104
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0127 0.0127
Loa Loa (eye worm) nuclear receptor NHR-67 0.0045 0.0104 0.0104
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0065 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.086 0.3768 0.3768
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0104 0.0104
Entamoeba histolytica hypothetical protein 0.0079 0.0257 0.0643
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0168 0.0658 0.0658
Schistosoma mansoni biogenic amine receptor 0.0065 0.0196 0.0195
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0095 0.033 0.033

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 6.5 uM kg-1 Narcotic antagaonist activity in heat stimulus rat tail flick assay after subcutaneous administration ChEMBL. 7310822
ED50 (functional) = 15 uM kg-1 Narcotic agonistic activity in acetic acid mouse writhing assay after subcutaneous administration of the drug ChEMBL. 7310822
ED50 (functional) = 15 uM kg-1 Narcotic agonistic activity in acetic acid mouse writhing assay after subcutaneous administration of the drug ChEMBL. 7310822

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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