Detailed information for compound 46774

Basic information

Technical information
  • TDR Targets ID: 46774
  • Name: 6'-fluorospiro[1,3-oxazolidine-5,4'-2,3-dihyd rochromene]-2,4-dione
  • MW: 237.184 | Formula: C11H8FNO4
  • H donors: 1 H acceptors: 2 LogP: 1.25 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cc2C3(CCOc2cc1)OC(=O)NC3=O
  • InChi: 1S/C11H8FNO4/c12-6-1-2-8-7(5-6)11(3-4-16-8)9(14)13-10(15)17-11/h1-2,5H,3-4H2,(H,13,14,15)
  • InChiKey: WLKYVYDQZGUGDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-fluorospiro[chromane-4,5'-oxazolidine]-2',4'-dione
  • 6-fluorospiro[3,4-dihydro-2H-1-benzopyran-4,5'-oxazolidine]-2',4'-dione
  • 6-fluorospiro[chroman-4,5'-oxazolidine]-2',4'-quinone
  • 6'-fluorospiro[1,3-oxazolidine-5,4'-chroman]-2,4-dione
  • 6-fluorospiro[chroman-4,5'-oxazolidine]-2',4'-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Aldose reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Aldose reductase   315 aa 324 aa 39.8 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 19.7 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   315 aa 294 aa 35.4 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   315 aa 279 aa 29.7 %
Leishmania mexicana aldo/keto reductase, putative,aldo/keto reductase family-like protein Aldose reductase   315 aa 349 aa 25.2 %
Mycobacterium tuberculosis Conserved protein Aldose reductase   315 aa 323 aa 25.4 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   315 aa 294 aa 35.4 %
Candida albicans similar to putative aryl alcohol dehydrogenase family Aldose reductase   315 aa 314 aa 18.2 %
Neospora caninum aldo/keto reductase family oxidoreductase, putative Aldose reductase   315 aa 291 aa 21.3 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 18.2 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   315 aa 279 aa 29.7 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   315 aa 310 aa 20.0 %
Onchocerca volvulus Multiple coagulation factor deficiency protein 2 homolog Aldose reductase   315 aa 323 aa 40.2 %
Toxoplasma gondii aldo/keto reductase family oxidoreductase Aldose reductase   315 aa 294 aa 24.8 %
Onchocerca volvulus Aldose reductase   315 aa 316 aa 36.7 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 18.2 %
Trypanosoma cruzi aldo/keto reductase, putative Aldose reductase   315 aa 304 aa 29.3 %
Mycobacterium ulcerans hypothetical protein Aldose reductase   315 aa 322 aa 24.8 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 19.7 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   315 aa 326 aa 20.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii isocitrate dehydrogenase 0.0054 0.04 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0917 0.9933 1
Trypanosoma cruzi aldo-keto reductase 0.0038 0.0231 0.4072
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0231 0.0375
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.0231 0.4072
Schistosoma mansoni hypothetical protein 0.0056 0.0428 0.0695
Echinococcus granulosus hypothetical protein 0.0038 0.0231 0.0375
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0181 0.0295
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0231 0.0375
Loa Loa (eye worm) hypothetical protein 0.0037 0.0222 0.0519
Echinococcus multilocularis aldo keto reductase 0.0038 0.0231 0.0232
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0065 0.0105
Toxoplasma gondii isocitrate dehydrogenase 0.0054 0.04 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0065 0.0151
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0054 0.04 0.065
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0622 0.0626
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0151
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.0231 0.4072
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0231 0.0375
Loa Loa (eye worm) hypothetical protein 0.0038 0.0231 0.0539
Echinococcus multilocularis shaker cognate 0.0021 0.0043 0.0043
Brugia malayi Pre-SET motif family protein 0.0235 0.2407 0.5624
Brugia malayi steroid hormone receptor 0.0023 0.0065 0.0151
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0336 0.0546
Echinococcus multilocularis aldehyde reductase 0.0027 0.0109 0.0109
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0231 0.0539
Onchocerca volvulus Huntingtin homolog 0.0139 0.1338 0.4715
Onchocerca volvulus Huntingtin homolog 0.0139 0.1338 0.4715
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0065 0.0151
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0054 0.04 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0065 0.0151
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0231 0.0375
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0231 0.0232
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0054 0.04 0.0403
Brugia malayi CHE-14 protein 0.0048 0.0336 0.0785
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0396 0.0925
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0151
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0043 0.007
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0181 0.0295
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.01
Loa Loa (eye worm) hypothetical protein 0.0275 0.2844 0.6644
Schistosoma mansoni smad1 5 8 and 0.0028 0.0113 0.0184
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.1038 0.8722
Plasmodium vivax SET domain protein, putative 0.0034 0.0181 0.2339
Echinococcus multilocularis aldo keto reductase 0.0038 0.0231 0.0232
Schistosoma mansoni hypothetical protein 0.0575 0.6155 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0065 0.0151
Echinococcus multilocularis protein dispatched 1 0.0055 0.0411 0.0413
Brugia malayi ecdysteroid receptor 0.0023 0.0065 0.0151
Schistosoma mansoni voltage-gated potassium channel 0.0261 0.2688 0.4367
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0231 0.0232
Echinococcus multilocularis X box binding protein 1 0.0326 0.3406 0.3429
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.2407 0.5624
Brugia malayi Smad1 0.0028 0.0113 0.0265
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0413 0.0966
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0231 0.0232
Schistosoma mansoni hypothetical protein 0.0046 0.0317 0.0515
Mycobacterium ulcerans proteasome PrcA 0.0923 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0065 0.0105
Schistosoma mansoni Smad4 0.0028 0.0113 0.0184
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0065 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0065 0.0105
Trichomonas vaginalis set domain proteins, putative 0.0268 0.2766 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0043 0.0043
Loa Loa (eye worm) oxidoreductase 0.0038 0.0231 0.0539
Brugia malayi Pre-SET motif family protein 0.0034 0.0181 0.0424
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0336 0.0338
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0021 0.0043 0.007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0065 0.0105
Schistosoma mansoni vesicular amine transporter 0.0021 0.0043 0.007
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0231 0.0539
Loa Loa (eye worm) MH1 domain-containing protein 0.0028 0.0113 0.0265
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0065 0.0105
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0065 0.0151
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0231 0.0375
Echinococcus multilocularis Niemann Pick C1 protein 0.0159 0.1565 0.1576
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0336 0.0546
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0231 0.0375
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0168 0.0272
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0261 0.2688 0.4367
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0043 0.007
Giardia lamblia Aldose reductase 0.0038 0.0231 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0413 0.0966
Loa Loa (eye worm) RNA binding protein 0.0074 0.0622 0.1453
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0043 0.007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0065 0.0151
Echinococcus multilocularis protein patched 0.0048 0.0336 0.0338
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0043 0.0043
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.0231 0.4072
Loa Loa (eye worm) hypothetical protein 0.0048 0.0336 0.0785
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0231 0.0232
Brugia malayi hypothetical protein 0.0139 0.1338 0.3127
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0065 0.0151
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0065 0.0065
Echinococcus granulosus shaker cognate 0.0021 0.0043 0.007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0065 0.0151
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0249 0.2562 0.258
Loa Loa (eye worm) hypothetical protein 0.0034 0.0181 0.0424
Schistosoma mansoni hypothetical protein 0.0037 0.0222 0.0361
Brugia malayi MH2 domain containing protein 0.0028 0.0113 0.0265
Echinococcus granulosus tar DNA binding protein 0.0074 0.0622 0.101
Loa Loa (eye worm) transcription factor SMAD2 0.0405 0.428 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0413 0.0966
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0181 0.0183
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0065 0.0105
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0054 0.04 0.0403
Onchocerca volvulus 0.0038 0.0231 0.0616
Echinococcus multilocularis expressed conserved protein 0.0105 0.0963 0.097
Echinococcus multilocularis Smad4 0.0028 0.0113 0.0114
Brugia malayi MH1 domain containing protein 0.0028 0.0113 0.0265
Schistosoma mansoni hypothetical protein 0.0046 0.0317 0.0515
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.1057 0.1717
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0065 0.0105
Schistosoma mansoni aldo-keto reductase 0.0038 0.0231 0.0375
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0151
Echinococcus multilocularis potassium voltage gated channel protein 0.0261 0.2688 0.2706
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0231 0.0375
Brugia malayi MH1 domain containing protein 0.0028 0.0113 0.0265
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0065 0.0105
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0054 0.04 0.0173
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0065 0.0105
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0231 0.0539
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0231 0.0232
Echinococcus granulosus survival motor neuron protein 1 0.0275 0.2844 0.462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0396 0.0643
Onchocerca volvulus 0.0034 0.0181 0.0432
Brugia malayi hypothetical protein 0.0028 0.0114 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0151
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0231 0.0232
Loa Loa (eye worm) oxidoreductase 0.0038 0.0231 0.0539
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.1038 0.1686
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0622 0.1453
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0065 0.0151
Schistosoma mansoni hypothetical protein 0.0575 0.6155 1
Loa Loa (eye worm) hypothetical protein 0.0261 0.2688 0.6281
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0054 0.04 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0396 0.0925
Trypanosoma brucei prostaglandin f synthase 0.0038 0.0231 0.4072
Schistosoma mansoni coup transcription factor 0.0023 0.0065 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.0028 0.0113 0.0265
Echinococcus granulosus aldo keto reductase 0.0038 0.0231 0.0375
Entamoeba histolytica hypothetical protein 0.0122 0.1156 1
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0065 0.0105
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0139 0.1338 0.3127
Echinococcus multilocularis isocitrate dehydrogenase 0.0054 0.04 0.0403
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0065 0.0151
Schistosoma mansoni pol-related 0.0038 0.0231 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0065 0.0151
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.0231 0.0124
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0622 0.1453
Toxoplasma gondii aldose reductase, putative 0.0038 0.0231 0.4072
Brugia malayi Isocitrate dehydrogenase 0.0054 0.04 0.0935
Echinococcus granulosus aldo keto reductase 0.0038 0.0231 0.0375
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0065 0.0105
Echinococcus granulosus Niemann Pick C1 protein 0.0159 0.1565 0.2543
Echinococcus multilocularis aldo keto reductase 0.0038 0.0231 0.0232
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.1038 0.1045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0065 0.0151
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0021 0.0043 0.0043
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0054 0.04 1
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0065 0.0105
Echinococcus granulosus geminin 0.0575 0.6155 1
Schistosoma mansoni smad1 5 8 and 0.0028 0.0113 0.0184
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0054 0.04 0.0403
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0065 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0622 0.101
Schistosoma mansoni hypothetical protein 0.0122 0.1156 0.1878
Brugia malayi nuclear hormone receptor 0.0023 0.0065 0.0151
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0054 0.04 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0622 0.101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0396 0.0643
Onchocerca volvulus 0.0056 0.0428 0.1344
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0065 0.0151
Echinococcus multilocularis transfer RNA-Gly 0.0021 0.0043 0.0043
Onchocerca volvulus 0.0038 0.0231 0.0616
Entamoeba histolytica hypothetical protein 0.0122 0.1156 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0231 0.0539
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0151
Brugia malayi hypothetical protein 0.0275 0.2844 0.6644
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0065 0.0151
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0622 0.101
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0231 0.0375
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.0231 0.4072
Echinococcus granulosus Smad4 0.0028 0.0113 0.0184
Echinococcus granulosus X box binding protein 1 0.0326 0.3406 0.5533
Brugia malayi hypothetical protein 0.0122 0.1156 0.2701
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0231 0.0232
Loa Loa (eye worm) Smad1 0.0028 0.0113 0.0265
Onchocerca volvulus 0.0268 0.2766 1
Echinococcus multilocularis geminin 0.0575 0.6155 0.6197
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0028 0.0113 0.0184
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0043 0.0043
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0181 0.2339
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0181 0.0183
Loa Loa (eye worm) hypothetical protein 0.0139 0.1338 0.3127
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0065 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0065 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0065 0.0151
Onchocerca volvulus 0.0038 0.0231 0.0616
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0043 0.007
Leishmania major aldo-keto reductase-like protein 0.0038 0.0231 0.4072
Brugia malayi RNA binding protein 0.0074 0.0622 0.1453
Schistosoma mansoni smad 0.0028 0.0113 0.0184
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0065 0.0151
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0054 0.04 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0028 0.0113 0.0114
Schistosoma mansoni voltage-gated potassium channel 0.0261 0.2688 0.4367
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0065 0.0105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0396 0.0643
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0043 0.007
Loa Loa (eye worm) oxidoreductase 0.0038 0.0231 0.0539
Entamoeba histolytica hypothetical protein 0.0122 0.1156 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0046 0.0317 0.0515
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0065 0.0065
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.1038 0.2425
Schistosoma mansoni patched 1 0.0048 0.0336 0.0546
Brugia malayi hypothetical protein 0.0018 0.0006 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0065 0.0151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0122 0.1156 0.1164
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0222 0.0519
Onchocerca volvulus 0.0038 0.0231 0.0616
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0065 0.0065
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0231 0.0232
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0065 0.0105
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0231 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0622 0.101
Echinococcus granulosus smad 0.0028 0.0113 0.0184
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0065 0.0065
Loa Loa (eye worm) oxidoreductase 0.0038 0.0231 0.0539
Schistosoma mansoni hypothetical protein 0.0046 0.0317 0.0515
Brugia malayi MH2 domain containing protein 0.0028 0.0113 0.0265
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0021 0.0043 0.01
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0054 0.04 0.065
Schistosoma mansoni survival motor neuron protein 0.0056 0.0428 0.0695
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0043 0.0043
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0043 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0396 0.0643
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0428 0.0999
Entamoeba histolytica hypothetical protein 0.0122 0.1156 1
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0043 0.007
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0021 0.0043 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0336 0.0415
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0043 0.007
Loa Loa (eye worm) oxidoreductase 0.0038 0.0231 0.0539
Echinococcus granulosus potassium voltage gated channel protein 0.0261 0.2688 0.4367
Giardia lamblia Aldose reductase 0.0038 0.0231 0.5
Echinococcus granulosus mothers against decapentaplegic 5 0.0028 0.0113 0.0184
Schistosoma mansoni hypothetical protein 0.0326 0.3406 0.5533
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0065 0.0065
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0065 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0065 0.0151
Schistosoma mansoni aldo-keto reductase 0.0038 0.0231 0.0375
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0043 0.007
Echinococcus multilocularis smad 0.0028 0.0113 0.0114
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0261 0.2688 0.6281
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0151
Echinococcus multilocularis survival motor neuron protein 1 0.0275 0.2844 0.2863
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0065 0.0105
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0054 0.04 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0021 0.0043 0.01
Echinococcus granulosus aldo keto reductase 0.0038 0.0231 0.0375
Loa Loa (eye worm) hypothetical protein 0.0028 0.0114 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0181 0.0295
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0622 0.101
Loa Loa (eye worm) hypothetical protein 0.0111 0.1038 0.2425
Brugia malayi TAR-binding protein 0.0074 0.0622 0.1453
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0065 0.0065
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0923 1 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0028 0.0113 0.0184
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0054 0.04 1
Onchocerca volvulus 0.0038 0.0231 0.0616
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0622 0.1453
Echinococcus granulosus expressed conserved protein 0.0105 0.0963 0.1565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0065 0.0151
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0054 0.04 0.0403
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0231 0.0375
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0065 0.0105
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0336 0.0785
Brugia malayi isocitrate dehydrogenase 0.0054 0.04 0.0935
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0065 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0396 0.0643
Echinococcus multilocularis mothers against decapentaplegic 5 0.0028 0.0113 0.0114
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0231 0.0232
Echinococcus granulosus aldehyde reductase 0.0027 0.0109 0.0176
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0396 0.0398
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0231 0.0232
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0043 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0181 0.0295
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0043 0.007
Brugia malayi nuclear receptor NHR-88 0.0023 0.0065 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0181 0.0295
Echinococcus multilocularis aldo keto reductase 0.0038 0.0231 0.0232
Onchocerca volvulus 0.0038 0.0231 0.0616
Leishmania major prostaglandin f synthase, putative 0.0038 0.0231 0.4072
Loa Loa (eye worm) MH2 domain-containing protein 0.0405 0.428 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0054 0.04 0.0935
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0021 0.0043 0.01
Schistosoma mansoni smad1 5 8 and 0.0028 0.0113 0.0184
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0065 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0065 0.0151
Schistosoma mansoni transcription factor LCR-F1 0.0122 0.1156 0.1878
Brugia malayi MH2 domain containing protein 0.0405 0.428 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0455 0.1063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0065 0.0065
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0122 0.1156 0.1878
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0413 0.0966
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0396 0.0398
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0065 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0065 0.0105

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 1.5 mg kg-1 Dose required for reduction of sorbitol accumulation in the sciatic nerve in streptozotocin-diabetic rats in vivo ChEMBL. 6818344
IC50 (binding) = 0.00001 M Inhibitory concentration was determined against partially purified calf lens aldose reductase using glyceraldehyde as a substrate; 10e-6/10e-7 ChEMBL. 6818344
IC50 (binding) = 0.00001 M Inhibitory concentration was determined against partially purified calf lens aldose reductase using glyceraldehyde as a substrate; 10e-6/10e-7 ChEMBL. 6818344

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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