Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.1 nM | Affinity at rat dopamine transporter using [125I]-RTI-55 displacement. | ChEMBL. | 12672246 |
Ki (binding) | = 2.1 nM | Displacement of [125I]RTI55 from DAT in rat brain synaptosomes | ChEMBL. | 17127069 |
Ki (binding) | = 2.1 nM | Affinity at rat dopamine transporter using [125I]-RTI-55 displacement. | ChEMBL. | 12672246 |
Ki (binding) | = 2.1 nM | Displacement of [125I]RTI55 from DAT in rat brain synaptosomes | ChEMBL. | 17127069 |
Ki (binding) | = 13.6 nM | Inhibition of [3H]-dopamine uptake via rat dopamine receptor. | ChEMBL. | 12672246 |
Ki (binding) | = 13.6 nM | Inhibition of [3H]-dopamine uptake via rat dopamine receptor. | ChEMBL. | 12672246 |
Ki (binding) | = 205 nM | Affinity at rat serotonin transporter using [125I]-RTI-55 displacement. | ChEMBL. | 12672246 |
Ki (binding) | = 205 nM | Displacement of [125I]RTI55 from SERT in rat brain synaptosomes | ChEMBL. | 17127069 |
Ki (binding) | = 205 nM | Affinity at rat serotonin transporter using [125I]-RTI-55 displacement. | ChEMBL. | 12672246 |
Ki (binding) | = 205 nM | Displacement of [125I]RTI55 from SERT in rat brain synaptosomes | ChEMBL. | 17127069 |
Ki (binding) | = 546 nM | Inhibition of [3H]-norepinephrine uptake at the rat norepinephrine transporter. | ChEMBL. | 12672246 |
Ki (binding) | = 546 nM | Inhibition of [3H]-norepinephrine uptake at the rat norepinephrine transporter. | ChEMBL. | 12672246 |
Ki (binding) | = 1020 nM | Inhibition of [3H]-5-HT uptake at the rat serotonin transporter. | ChEMBL. | 12672246 |
Ki (binding) | = 1020 nM | Inhibition of [3H]-5-HT uptake at the rat serotonin transporter. | ChEMBL. | 12672246 |
Ratio (binding) | = 40 | Ratio between the inhibition of norepinephrine and dopamine uptake. | ChEMBL. | 12672246 |
Ratio (binding) | = 75 | Ratio between the inhibition of serotonin and dopamine uptake. | ChEMBL. | 12672246 |
Ratio (binding) | = 98 | Ratio between affinities at the rat dopamine and serotonin transporters. | ChEMBL. | 12672246 |
Ratio pKi (binding) | = 1.99 | Selectivity for rat DAT over rat SERT | ChEMBL. | 17127069 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.