TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 440.66 | Formula: C23H36O4S2
H donors: 2 H acceptors: 4 LogP: 8.55 Rotable bonds: 18
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCCCCCc1ccccc1C(SCC(=O)O)SCC(=O)O
InChi: 1S/C23H36O4S2/c1-2-3-4-5-6-7-8-9-10-11-14-19-15-12-13-16-20(19)23(28-17-21(24)25)29-18-22(26)27/h12-13,15-16,23H,2-11,14,17-18H2,1H3,(H,24,25)(H,26,27)
InChiKey: WWQFMCKPIBAFRI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cysteinyl leukotriene receptor 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0053	0.0585	0.0585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.1252	0.017
Brugia malayi	calpain family protein 1	0.0053	0.0585	0.109
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0128	0.4054	0.7561
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0087	0.2144	0.3998
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0068	0.1252	0.1252
Echinococcus multilocularis	caspase 3	0.0142	0.4741	0.4346
Echinococcus granulosus	cathepsin b	0.0155	0.5362	0.5014
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0112	0.3349	0.7526
Trypanosoma cruzi	cysteine peptidase, putative	0.0232	0.8946	1
Schistosoma mansoni	caspase-7 (C14 family)	0.0153	0.5233	0.5233
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0232	0.8946	1
Echinococcus granulosus	caspase	0.0255	1	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0112	0.3349	0.7526
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.3349	0.7526
Plasmodium vivax	metacaspase 1, putative	0.0112	0.3349	0.8261
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0112	0.3349	0.7526
Echinococcus multilocularis	cathepsin b	0.0155	0.5362	0.5014
Leishmania major	cathepsin L-like protease	0.0128	0.4054	0.3681
Leishmania major	cysteine peptidase A (CPA)	0.0128	0.4054	0.3681
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3349	0.6246
Entamoeba histolytica	cysteine proteinase, putative	0.0128	0.4054	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.2144	0.3298
Toxoplasma gondii	proteasome subunit beta type, putative	0.0069	0.1336	0.0463
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0232	0.8946	1
Echinococcus granulosus	cathepsin l1	0.0087	0.2144	0.1555
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0069	0.1336	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5233	0.9759
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0069	0.1336	0.3295
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0112	0.3349	0.7526
Plasmodium falciparum	proteasome subunit beta type-5	0.0069	0.1336	0.0298
Schistosoma mansoni	caspase-3 (C14 family)	0.0255	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0128	0.4054	1
Brugia malayi	Cathepsin L-like precursor	0.0087	0.2144	0.3998
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0069	0.1336	0.1493
Entamoeba histolytica	cysteine protease, putative	0.0128	0.4054	1
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0112	0.3349	0.7526
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0128	0.4054	0.7561
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0128	0.4054	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0232	0.8946	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0155	0.5362	0.5362
Plasmodium vivax	vivapain-1	0.0068	0.1252	0.3089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.2144	0.3998
Brugia malayi	Papain family cysteine protease containing protein	0.0128	0.4054	0.7561
Plasmodium vivax	vivapain-3	0.0068	0.1252	0.3089
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0155	0.5362	0.5362
Trypanosoma brucei	metacaspase 5, putative	0.0112	0.3349	0.2771
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0232	0.8946	1
Plasmodium vivax	unspecified product	0.0068	0.1252	0.3089
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0128	0.4054	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Brugia malayi	calpain family protein 1	0.0053	0.0585	0.109
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0068	0.1252	0.14
Leishmania major	metacaspase, putative	0.0112	0.3349	0.2771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0128	0.4054	0.3608
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0232	0.8946	1
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0069	0.1336	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0112	0.3349	0.7526
Trypanosoma cruzi	cysteine peptidase, putative	0.0232	0.8946	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0087	0.2144	0.2144
Leishmania major	cathepsin L-like protease	0.0128	0.4054	0.3681
Loa Loa (eye worm)	fibroinase	0.0128	0.4054	0.7561
Onchocerca volvulus	Cathepsin F homolog	0.0128	0.4054	0.6184
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0155	0.5362	0.5362
Echinococcus multilocularis	cathepsin L	0.0068	0.1252	0.0596
Trypanosoma cruzi	cysteine protease, putative	0.0068	0.1252	0.14
Echinococcus granulosus	caspase 8	0.0112	0.3349	0.285
Brugia malayi	Cathepsin L-like precursor	0.0087	0.2144	0.3998
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0232	0.8946	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.1252	0.14
Echinococcus granulosus	caspase 2	0.0153	0.5233	0.4876
Echinococcus granulosus	proteasome prosome macropain	0.0069	0.1336	0.0686
Plasmodium falciparum	metacaspase 1	0.0112	0.3349	0.7484
Echinococcus multilocularis	caspase 8	0.0112	0.3349	0.285
Echinococcus multilocularis	cathepsin b	0.0155	0.5362	0.5014
Loa Loa (eye worm)	cysteine protease	0.0128	0.4054	0.7561
Brugia malayi	Cathepsin L-like precursor	0.0128	0.4054	0.7561
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0056	0.0698	0.0698
Brugia malayi	Cathepsin L-like precursor	0.0128	0.4054	0.7561
Trypanosoma brucei	metacaspase MCA3	0.0112	0.3349	0.2771
Trypanosoma cruzi	metacaspase 5, putative	0.0112	0.3349	0.3744
Brugia malayi	Cathepsin L-like precursor	0.0128	0.4054	0.7561
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0069	0.1336	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0128	0.4054	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0128	0.4054	0.4532
Brugia malayi	Cell death protein 3 precursor	0.0153	0.5233	0.9759
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0232	0.8946	1
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0255	1	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0112	0.3349	0.7526
Loa Loa (eye worm)	ctsf protein	0.0128	0.4054	0.7561
Echinococcus granulosus	cysteine protease	0.0068	0.1252	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0155	0.5362	1
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0069	0.1336	0.5
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0069	0.1336	0.0463
Onchocerca volvulus		0.0128	0.4054	0.6184
Echinococcus multilocularis	cysteine protease	0.0128	0.4054	0.3608
Schistosoma mansoni	cathepsin F (C01 family)	0.0128	0.4054	0.4054
Brugia malayi	Proteasome A-type and B-type family protein	0.0069	0.1336	0.2491
Brugia malayi	cathepsin B-like cysteine proteinase	0.0155	0.5362	1
Brugia malayi	Cathepsin L-like precursor	0.0128	0.4054	0.7561
Trypanosoma brucei	Metacaspase-4	0.0112	0.3349	0.2771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.2144	0.3298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.1252	0.017
Loa Loa (eye worm)	hypothetical protein	0.0128	0.4054	0.7561
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0128	0.4054	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0128	0.4054	0.3608
Brugia malayi	Papain family cysteine protease containing protein	0.0068	0.1252	0.2336
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0112	0.3349	0.7526
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.3349	0.7526
Trypanosoma brucei	metacaspase	0.0112	0.3349	0.2771
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0191	0.7036	0.7865
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0155	0.5362	0.5994
Loa Loa (eye worm)	hypothetical protein	0.0087	0.2144	0.3998
Brugia malayi	Papain family cysteine protease containing protein	0.0068	0.1252	0.2336
Toxoplasma gondii	cathepsin CPL	0.0128	0.4054	1
Brugia malayi	Cathepsin L-like precursor	0.0128	0.4054	0.7561
Loa Loa (eye worm)	cathepsin B	0.0067	0.1204	0.2246
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0585	0.109
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0128	0.4054	1
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0112	0.3349	0.3349
Plasmodium falciparum	metacaspase-like protein	0.0112	0.3349	0.7484
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.3349	0.7526
Trypanosoma cruzi	cruzipain precursor, putative	0.0232	0.8946	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0068	0.1252	0.1252
Brugia malayi	Cathepsin L-like precursor	0.0128	0.4054	0.7561
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.3349	0.7526
Leishmania major	cathepsin L-like protease	0.0128	0.4054	0.3681
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0232	0.8946	1
Leishmania major	cathepsin L-like protease	0.0232	0.8946	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0128	0.4054	1
Leishmania major	proteasome beta 5 subunit, putative	0.0069	0.1336	0.017
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0067	0.1204	0.1346
Schistosoma mansoni	cathepsin F (C01 family)	0.0128	0.4054	0.4054
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0128	0.4054	0.3608
Onchocerca volvulus	Cell death protein 3 homolog	0.0153	0.5233	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0232	0.8946	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0232	0.8946	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0128	0.4054	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.2144	0.3998
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.3349	0.7526
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1252	0.0063
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Onchocerca volvulus		0.0128	0.4054	0.6184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1252	0.0063
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Schistosoma mansoni	caspase-7 (C14 family)	0.0255	1	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0563
Trypanosoma brucei	metacaspase MCA2	0.0112	0.3349	0.2771
Onchocerca volvulus	Cathepsin L homolog	0.0128	0.4054	0.6184
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0069	0.1336	0.017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0232	0.8946	1
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0112	0.3349	0.7526
Echinococcus granulosus	cathepsin L cysteine protease	0.0068	0.1252	0.0596
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0069	0.1336	0.0686
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0112	0.3349	0.6246
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0128	0.4054	1
Plasmodium vivax	vivapain-2	0.0128	0.4054	1
Leishmania major	cathepsin L-like protease	0.0128	0.4054	0.3681
Onchocerca volvulus		0.0128	0.4054	0.6184
Entamoeba histolytica	cysteine proteinase, putative	0.0087	0.2144	0.3182
Trypanosoma cruzi	cysteine proteinase, putative	0.0068	0.1252	0.14
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0232	0.8946	1
Onchocerca volvulus	Cathepsin L homolog	0.0128	0.4054	0.6184
Loa Loa (eye worm)	calpain family protein 1	0.0053	0.0585	0.109
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Trypanosoma cruzi	metacaspase, putative	0.0112	0.3349	0.3744
Trypanosoma cruzi	metacaspase, putative	0.0112	0.3349	0.3744
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0128	0.4054	0.3608
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0067	0.1204	0.1204
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.3349	0.7526
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0069	0.1336	0.2491
Mycobacterium ulcerans	proteasome PrcB	0.0069	0.1336	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0128	0.4054	0.3608
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0128	0.4054	1
Brugia malayi	cathepsin L-like precursor	0.0087	0.2144	0.3998
Echinococcus multilocularis	cathepsin L cysteine protease	0.0128	0.4054	0.3608
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0155	0.5362	0.5362
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0128	0.4054	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Trypanosoma cruzi	metacaspase 5, putative	0.0112	0.3349	0.3744
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0112	0.3349	0.7526
Echinococcus multilocularis	caspase 2	0.0153	0.5233	0.4876
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0069	0.1336	0.1493
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0128	0.4054	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0128	0.4054	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0068	0.1252	0.1252
Onchocerca volvulus		0.0128	0.4054	0.6184
Onchocerca volvulus		0.0128	0.4054	0.6184
Trypanosoma cruzi	metacaspase, putative	0.0112	0.3349	0.3744
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0128	0.4054	1
Echinococcus granulosus	caspase 3	0.0142	0.4741	0.4346
Onchocerca volvulus		0.0128	0.4054	0.6184
Echinococcus granulosus	cathepsin l1	0.0128	0.4054	0.3608
Trypanosoma cruzi	major cysteine proteinase, putative	0.0131	0.4234	0.4733
Leishmania major	cathepsin L-like protease	0.0128	0.4054	0.3681
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Onchocerca volvulus		0.0128	0.4054	0.6184
Echinococcus multilocularis	cysteine protease	0.0128	0.4054	0.3608
Echinococcus multilocularis	caspase	0.0255	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.4054	1
Leishmania major	cathepsin L-like protease	0.0232	0.8946	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0056	0.0698	0.0698
Plasmodium vivax	vivapain-2	0.0128	0.4054	1
Echinococcus granulosus	cathepsin L	0.0068	0.1252	0.0596
Echinococcus granulosus	cathepsin b	0.0155	0.5362	0.5014
Trypanosoma cruzi	metacaspase, putative	0.0112	0.3349	0.3744
Plasmodium vivax	hypothetical protein, conserved	0.0112	0.3349	0.8261
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0112	0.3349	0.7526
Leishmania major	cathepsin L-like protease	0.0232	0.8946	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0128	0.4054	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0068	0.1252	0.14
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0112	0.3349	0.7526
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0069	0.1336	0.1336

Activities

Activity type	Activity value	Assay description	Source	Reference
-Log KB (functional)	= 5.9	In vitro ability to antagonize a leukotriene D4 induced contraction of guinea pig trachea.	ChEMBL.	3016267
Ki (binding)	= 846 nM	Compound is evaluated for its ability to inhibit [3H]-LTD4 binding to Cysteinyl leukotriene D4 receptor in guinea pig lung membranes	ChEMBL.	3016267
Ki (binding)	= 846 nM	Compound is evaluated for its ability to inhibit [3H]-LTD4 binding to Cysteinyl leukotriene D4 receptor in guinea pig lung membranes	ChEMBL.	3016267

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 46866