Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glutathione reductase, putative | 0.0276 | 0.0112 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0276 | 0.0112 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0305 | 0.0157 | 0.0161 |
Toxoplasma gondii | thioredoxin reductase | 0.0796 | 0.0912 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0305 | 0.0157 | 0.056 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0305 | 0.0157 | 0.0161 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0305 | 0.0157 | 0.056 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0276 | 0.0112 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0796 | 0.0912 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0796 | 0.0912 | 1 |
Brugia malayi | glutathione reductase | 0.0796 | 0.0912 | 0.0935 |
Loa Loa (eye worm) | glutathione reductase | 0.0796 | 0.0912 | 0.0786 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0796 | 0.0912 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0305 | 0.0157 | 0.0161 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0276 | 0.0112 | 0.0115 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0305 | 0.0157 | 0.056 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0305 | 0.0157 | 0.056 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0276 | 0.0112 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0305 | 0.0157 | 0.0161 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0305 | 0.0157 | 0.056 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0305 | 0.0157 | 0.056 |
Treponema pallidum | NADH oxidase | 0.0276 | 0.0112 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.6554 | 0.9753 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0305 | 0.0157 | 0.056 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0305 | 0.0157 | 0.056 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0305 | 0.0157 | 0.0161 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0305 | 0.0157 | 0.056 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0305 | 0.0157 | 0.0161 |
Plasmodium falciparum | thioredoxin reductase | 0.0796 | 0.0912 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0305 | 0.0157 | 0.056 |
Brugia malayi | steroid hormone receptor | 0.0305 | 0.0157 | 0.0161 |
Schistosoma mansoni | nuclear hormone receptor | 0.0305 | 0.0157 | 0.056 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0796 | 0.0912 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0796 | 0.0912 | 0.0935 |
Loa Loa (eye worm) | hypothetical protein | 0.641 | 0.9532 | 0.977 |
Echinococcus granulosus | FTZ F1 alpha | 0.0305 | 0.0157 | 0.056 |
Schistosoma mansoni | thyroid hormone receptor | 0.0305 | 0.0157 | 0.056 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0305 | 0.0157 | 0.056 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0305 | 0.0157 | 0.0161 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0305 | 0.0157 | 0.056 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0276 | 0.0112 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0305 | 0.0157 | 0.0161 |
Leishmania major | trypanothione reductase | 0.0796 | 0.0912 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0796 | 0.0912 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0796 | 0.0912 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0305 | 0.0157 | 0.056 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0276 | 0.0112 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0305 | 0.0157 | 0.056 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0305 | 0.0157 | 0.0161 |
Brugia malayi | nuclear hormone receptor | 0.6554 | 0.9753 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0305 | 0.0157 | 0.056 |
Brugia malayi | ecdysteroid receptor | 0.0305 | 0.0157 | 0.0161 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0305 | 0.0157 | 0.0161 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0305 | 0.0157 | 0.0161 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0796 | 0.0912 | 0.0786 |
Brugia malayi | nuclear receptor NHR-88 | 0.0305 | 0.0157 | 0.0161 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0305 | 0.0157 | 0.056 |
Schistosoma mansoni | coup transcription factor | 0.0305 | 0.0157 | 0.056 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0305 | 0.0157 | 0.0161 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0276 | 0.0112 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0305 | 0.0157 | 0.056 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0305 | 0.0157 | 0.0161 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0305 | 0.0157 | 0.056 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0305 | 0.0157 | 0.056 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0796 | 0.0912 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0305 | 0.0157 | 0.0161 |
Trypanosoma brucei | trypanothione reductase | 0.0796 | 0.0912 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0305 | 0.0157 | 0.056 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0305 | 0.0157 | 0.056 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0305 | 0.0157 | 0.056 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0305 | 0.0157 | 0.056 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0305 | 0.0157 | 0.056 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0305 | 0.0157 | 0.056 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0305 | 0.0157 | 0.056 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0276 | 0.0112 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0305 | 0.0157 | 0.0161 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0305 | 0.0157 | 0.0161 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0276 | 0.0112 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0305 | 0.0157 | 0.0161 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0276 | 0.0112 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0305 | 0.0157 | 0.056 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
behavior (functional) | D 0 | Gross behavioral effects ascertained in mice; D indicates significant depressant properties. | ChEMBL. | 3039136 |
ED50 (functional) | I-30 0 mg kg-1 | Ability to antagonise intraperitoneal dose; inactive (<10% antagonism) at 30 mg/kg is represented as I-30. | ChEMBL. | 3039136 |
ED50 (functional) | I-30 0 mg kg-1 | Ability to antagonise intraperitoneal dose; inactive (<10% antagonism) at 30 mgjkg is represented as I-30. | ChEMBL. | 3039136 |
Inhibition (functional) | = -21 % | Ability to inhibit the uptake of tritiated serotonin(5-HT) 0.1 mg/kg concentration | ChEMBL. | 3039136 |
Inhibition (functional) | = 0 % | Ability to inhibit the uptake of tritiated dopamine (DA) 0.1 mg/kg concentration | ChEMBL. | 3039136 |
Inhibition (functional) | = 7 % | Ability to inhibit the uptake of tritiated norepinephrine(NE) 0.1 mg/kg concentration | ChEMBL. | 3039136 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.