Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0294 | 0.5477 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0308 | 0.9588 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0274 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0308 | 0.9588 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0308 | 0.9588 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC100 (functional) | = 33.3 uM | In vitro Cytotoxic concentration in mock-infected A3.01 cells - 100% toxicity. | ChEMBL. | 1573638 |
CC100 (functional) | = 200 uM | In vitro Cytotoxic concentration in mock-infected A3.01 cells - 100% toxicity. | ChEMBL. | 1573638 |
CC25 (functional) | = 11.1 uM | In vitro Cytotoxic concentration in mock-infected A3.01 cells. | ChEMBL. | 1573638 |
CC25 (functional) | = 22 uM | In vitro Cytotoxic concentration in mock-infected A3.01 cells. | ChEMBL. | 1573638 |
IC50 (functional) | 0 uM | Compound was tested in vitro for inhibition of cytopathogenicity of LAV(IIIB) in CD4+ T-cells (A3.01); Not active | ChEMBL. | 1573638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.