Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | In vivo inhibitory activity against LTB4-induced bronchoconstriction of guinea pig at dose of 5 mg/kg after 2 min of iv administration; Active | ChEMBL. | No reference |
Activity (functional) | 0 | In vivo inhibitory activity against LTB4-induced bronchoconstriction of guinea pig at dose of 5 mg/kg after 10 min of iv administration; Active | ChEMBL. | No reference |
Activity (functional) | 0 | In vivo inhibitory activity against LTB4-induced bronchoconstriction of guinea pig at dose of 5 mg/kg after 30 min of iv administration; Active | ChEMBL. | No reference |
Activity (functional) | 0 | In vivo inhibitory activity against LTB4-induced bronchoconstriction of guinea pig at dose of 40 mg/kg after 60 min of po administration; relatively active | ChEMBL. | No reference |
IC50 (functional) | = 0.3 uM | Concentration required for inhibitory activity against human PMNLs chemotaxis | ChEMBL. | No reference |
IC50 (functional) | = 0.3 uM | Concentration required for inhibitory activity against human PMNLs chemotaxis | ChEMBL. | No reference |
logD | = -0.3 | Partition coefficient of the compound was determined in n-octanol/phosphate buffer, at pH 7.4 | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.