Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0105 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0105 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0105 | 0.5 | 0.5 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0105 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0105 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0105 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0105 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0105 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0105 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0105 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0105 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0105 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0105 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0105 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0105 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0105 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0105 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0105 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0105 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0105 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0105 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0105 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0105 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0105 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0105 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 1.3 nM | Effective concentration for half-maximal activation of human progesterone receptor expressed in CV-1 cells | ChEMBL. | 9667968 |
EC50 (binding) | = 1.3 nM | Effective concentration for half-maximal activation of human progesterone receptor expressed in CV-1 cells | ChEMBL. | 9667968 |
EC50 (functional) | = 2.8 nM | Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cells | ChEMBL. | 10212133 |
EC50 (functional) | = 2.8 nM | Agonistic activity was measured for modulation of hPR-B (human progesterone receptor) in cotransfected CV-1 cells. | ChEMBL. | 9464361 |
EC50 (binding) | = 2.8 nM | Effective concentration for half-maximal activation of human progesterone receptor expressed in CV-1 cells | ChEMBL. | 9667968 |
EC50 (functional) | = 2.8 nM | Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cells | ChEMBL. | 10212133 |
EC50 (functional) | = 2.8 nM | Agonistic activity was measured for modulation of hPR-B (human progesterone receptor) in cotransfected CV-1 cells. | ChEMBL. | 9464361 |
EC50 (binding) | = 2.8 nM | Effective concentration for half-maximal activation of human progesterone receptor expressed in CV-1 cells | ChEMBL. | 9667968 |
EC50 (binding) | = 3.6 nM | Effective concentration for half-maximal activation of human progesterone receptor expressed in CV-1 cells | ChEMBL. | 9667968 |
EC50 (functional) | = 27 nM | Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cells | ChEMBL. | 10212133 |
EC50 (functional) | = 27 nM | Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cells | ChEMBL. | 10212133 |
EC50 (binding) | = 135 nM | Effective concentration for half-maximal activation of human progesterone receptor expressed in CV-1 cells | ChEMBL. | 9667968 |
EC50 (binding) | = 135 nM | Effective concentration for half-maximal activation of human progesterone receptor expressed in CV-1 cells | ChEMBL. | 9667968 |
Efficacy (binding) | = 83 | Efficacy for progesterone receptor relative to progesterone | ChEMBL. | 9667968 |
Efficacy (binding) | = 95 | Efficacy for progesterone receptor relative to progesterone | ChEMBL. | 9667968 |
Efficacy (binding) | = 117 | Efficacy for progesterone receptor relative to progesterone | ChEMBL. | 9667968 |
Efficacy (binding) | = 125 | Efficacy for progesterone receptor relative to progesterone | ChEMBL. | 9667968 |
Efficacy (functional) | = 47 % | Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cells | ChEMBL. | 10212133 |
Efficacy (functional) | = 47 % | Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cells | ChEMBL. | 10212133 |
Efficacy (functional) | = 117 % | Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cells | ChEMBL. | 10212133 |
Efficacy (functional) | = 117 % | Agonistic activity of the compound towards hPR-B (human progesterone receptor) in terms of efficacy expressed as percent relative to progesterone 100%. | ChEMBL. | 9464361 |
Efficacy (functional) | = 117 % | Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cells | ChEMBL. | 10212133 |
Efficacy (functional) | = 117 % | Agonistic activity of the compound towards hPR-B (human progesterone receptor) in terms of efficacy expressed as percent relative to progesterone 100%. | ChEMBL. | 9464361 |
Fold induction (functional) | = 3.6 | Fold induction as increase in BrdU labeling index over estrone treatment alone in lobular-aveolar rat mammary buds by progestin treatment at 3 mg/kg | ChEMBL. | 9667968 |
Fold induction (functional) | = 3.6 | Fold induction as increase in BrdU labeling index over estrone treatment alone in lobular-aveolar rat mammary buds by progestin treatment at 3 mg/kg | ChEMBL. | 9667968 |
Ki (binding) | = 0.1 nM | Binding affinity for human progesterone receptor isoform A expressed in CV-1 cells | ChEMBL. | 9667968 |
Ki (binding) | = 0.1 nM | Binding affinity for human progesterone receptor isoform A expressed in CV-1 cells | ChEMBL. | 9667968 |
Ki (binding) | = 0.32 nM | Compound was evaluated for its binding affinity against baculovirus expressed Progesterone receptor | ChEMBL. | 10212133 |
Ki (binding) | = 0.32 nM | The binding affinity measured using baculovirus-expressed hPR-A in sf21 cells. | ChEMBL. | 9464361 |
Ki (binding) | = 0.32 nM | Binding affinity for human progesterone receptor isoform A expressed in CV-1 cells | ChEMBL. | 9667968 |
Ki (binding) | = 0.32 nM | Compound was evaluated for its binding affinity against baculovirus expressed Progesterone receptor | ChEMBL. | 10212133 |
Ki (binding) | = 0.32 nM | The binding affinity measured using baculovirus-expressed hPR-A in sf21 cells. | ChEMBL. | 9464361 |
Ki (binding) | = 0.32 nM | Binding affinity for human progesterone receptor isoform A expressed in CV-1 cells | ChEMBL. | 9667968 |
Ki (binding) | = 0.48 nM | Binding affinity for human progesterone receptor isoform A expressed in CV-1 cells | ChEMBL. | 9667968 |
Ki (binding) | = 6.3 nM | Binding affinity for human glucocorticoid receptor expressed in CV-1 cells | ChEMBL. | 9667968 |
Ki (binding) | = 30 nM | Binding affinity for human progesterone receptor isoform A expressed in CV-1 cells | ChEMBL. | 9667968 |
Ki (binding) | = 30 nM | Binding affinity for human progesterone receptor isoform A expressed in CV-1 cells | ChEMBL. | 9667968 |
Ki (binding) | = 133 nM | Binding affinity for human glucocorticoid receptor expressed in CV-1 cells | ChEMBL. | 9667968 |
Ki (binding) | = 133 nM | Binding affinity for human glucocorticoid receptor expressed in CV-1 cells | ChEMBL. | 9667968 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.