Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0462 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0462 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0462 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0462 | 0.5 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0462 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0462 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0462 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0462 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0462 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0462 | 0.5 | 0.5 | |
Echinococcus multilocularis | peroxidasin | 0.0462 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0462 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = -6.34 | PEC50 for functional potassium channel opening activity in isolated bladder strips | ChEMBL. | 12031324 |
EC50 (functional) | = 155 nM | Potassium channel opening activity determined in cultured guinea pig urinary bladder cells | ChEMBL. | 12031324 |
EC50 (functional) | = 155 nM | Potassium channel opening activity determined in cultured guinea pig urinary bladder cells | ChEMBL. | 12031324 |
Efficacy (functional) | = 95 % | Potassium channel opening activity compared to P1075 in isolated Landrace pig bladder strips | ChEMBL. | 12031324 |
Efficacy (functional) | = 95 % | Potassium channel opening activity compared to P1075 in isolated Landrace pig bladder strips | ChEMBL. | 12031324 |
Log EC50 (functional) | = 6.34 | PEC50 for functional potassium channel opening activity in isolated bladder strips | ChEMBL. | 12031324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.