Detailed information for compound 47538

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 187.281 | Formula: C13H17N
  • H donors: 0 H acceptors: 0 LogP: 2.5 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@]12CCCN1CCc1c2cccc1
  • InChi: 1S/C13H17N/c1-13-8-4-9-14(13)10-7-11-5-2-3-6-12(11)13/h2-3,5-6H,4,7-10H2,1H3/t13-/m0/s1
  • InChiKey: HQBLGRLDXFYZAW-ZDUSSCGKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0144 0.0231
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0078 0.0533 0.0505
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Schistosoma mansoni coup transcription factor 0.004 0.0144 0.0106
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0078 0.0533 0.6974
Loa Loa (eye worm) hypothetical protein 0.0049 0.0232 0.0423
Echinococcus multilocularis expressed conserved protein 0.0093 0.0684 0.0649
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0125 0.1227
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0144 0.0231
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0078 0.0533 0.0466
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0066 0.0304
Toxoplasma gondii LsmAD domain-containing protein 0.0099 0.0749 0.4984
Onchocerca volvulus 0.0048 0.0222 0.0401
Toxoplasma gondii Hsp90 domain-containing protein 0.0169 0.1464 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.0191 0.2154
Brugia malayi TAR-binding protein 0.0188 0.1655 0.353
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0144 0.0106
Loa Loa (eye worm) hypothetical protein 0.004 0.0144 0.0231
Onchocerca volvulus Huntingtin homolog 0.0123 0.0993 0.2084
Schistosoma mansoni tar DNA-binding protein 0.0188 0.1655 0.1624
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0144 0.0231
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0078 0.0533 0.0498
Trypanosoma cruzi PAB1-binding protein , putative 0.0099 0.0749 1
Brugia malayi Pax transcription factor protein 2 0.0478 0.462 1
Schistosoma mansoni tar DNA-binding protein 0.0188 0.1655 0.1624
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0144 0.0114
Loa Loa (eye worm) hypothetical protein 0.004 0.0144 0.0231
Schistosoma mansoni hypothetical protein 0.0041 0.0153 0.0116
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0191 0.2154
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0191 0.2154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0655 0.0627
Onchocerca volvulus 0.0478 0.462 1
Echinococcus granulosus heat shock protein 0.0045 0.0191 0.0161
Loa Loa (eye worm) hypothetical protein 0.0033 0.0074 0.008
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0169 0.0285
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0041 0.0003
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0044 0.019 0.0152
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.025 0.229 0.2261
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0144 0.0106
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0144 0.0106
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0191 1
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0144 0.0231
Brugia malayi ecdysteroid receptor 0.004 0.0144 0.0231
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0144 0.0231
Brugia malayi MH2 domain containing protein 0.0354 0.3355 0.724
Echinococcus granulosus endoplasmin 0.0042 0.0163 0.0133
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Toxoplasma gondii isocitrate dehydrogenase 0.0078 0.0533 0.3476
Echinococcus granulosus potassium voltage gated channel protein 0.0261 0.2407 0.2384
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0232 0.0423
Onchocerca volvulus 0.003 0.0041 0.0008
Plasmodium vivax SET domain protein, putative 0.003 0.0041 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0041 0.0003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0761 0.0726
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0213 0.1914 0.189
Schistosoma mansoni hypothetical protein 0.0041 0.0153 0.0116
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0655 0.062
Schistosoma mansoni hypothetical protein 0.1004 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.118 0.1153
Loa Loa (eye worm) hypothetical protein 0.004 0.0144 0.0231
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0163 0.0752
Schistosoma mansoni hypothetical protein 0.0041 0.0153 0.0116
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0191 0.0881
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0188 0.1655 0.353
Loa Loa (eye worm) hypothetical protein 0.0123 0.0993 0.2084
Brugia malayi hypothetical protein 0.0099 0.0749 0.1551
Loa Loa (eye worm) hypothetical protein 0.0261 0.2407 0.5169
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0144 0.0106
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0191 0.1074
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0213 0.1914 0.1884
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0144 0.0106
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0144 0.0231
Brugia malayi isocitrate dehydrogenase 0.0078 0.0533 0.1082
Loa Loa (eye worm) hypothetical protein 0.0052 0.0266 0.0498
Brugia malayi RNA recognition motif domain containing protein 0.0188 0.1655 0.353
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0144 0.0231
Entamoeba histolytica hypothetical protein 0.0213 0.1914 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0144 0.0106
Schistosoma mansoni hypothetical protein 0.0048 0.0222 0.0184
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0041 0.0003
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0078 0.0533 0.0498
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0144 0.0106
Plasmodium falciparum ataxin-2 like protein, putative 0.0099 0.0749 0.5114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0655 0.062
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0041 0.0024
Brugia malayi Isocitrate dehydrogenase 0.0078 0.0533 0.1082
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0191 0.0816
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0169 0.0131
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0144 0.0106
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0128 0.1045 0.1011
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0144 0.0106
Trypanosoma brucei heat shock protein, putative 0.0045 0.0191 0.2154
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0144 0.0231
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0191 0.1074
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0144 0.0106
Schistosoma mansoni hypothetical protein 0.0041 0.0153 0.0116
Schistosoma mansoni voltage-gated potassium channel 0.0261 0.2407 0.2378
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.082 0.8117 1
Treponema pallidum heat shock protein 90 0.0042 0.0163 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0354 0.3355 0.724
Schistosoma mansoni endoplasmin 0.0045 0.0191 0.0154
Brugia malayi RNA binding protein 0.0188 0.1655 0.353
Loa Loa (eye worm) endoplasmin 0.0045 0.0191 0.0334
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0191 0.2154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0144 0.0231
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.118 0.1146
Echinococcus multilocularis X box binding protein 1 0.0289 0.2693 0.2665
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0125 0.0577
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0191 0.1074
Echinococcus multilocularis heat shock protein 90 0.0038 0.0125 0.0088
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1872 0.4003
Loa Loa (eye worm) nuclear hormone receptor 0.0107 0.0829 0.1726
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0038 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0144 0.0231
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0078 0.0533 0.0498
Plasmodium vivax heat shock protein, putative 0.0169 0.1464 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0144 0.0106
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0078 0.0533 0.0498
Trichomonas vaginalis set domain proteins, putative 0.0238 0.2167 1
Schistosoma mansoni patched 1 0.0042 0.0169 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0144 0.0231
Schistosoma mansoni tar DNA-binding protein 0.0188 0.1655 0.1624
Echinococcus granulosus expressed conserved protein 0.0093 0.0684 0.0656
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0144 0.0231
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0191 0.2154
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0144 0.0114
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0144 0.0231
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0191 0.2154
Loa Loa (eye worm) hypothetical protein 0.004 0.0144 0.0231
Entamoeba histolytica hypothetical protein 0.0213 0.1914 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0163 0.176
Loa Loa (eye worm) hypothetical protein 0.0042 0.0169 0.0285
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0746 0.0718
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0191 0.2154
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Onchocerca volvulus Huntingtin homolog 0.0123 0.0993 0.2084
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0144 0.0231
Echinococcus granulosus heat shock protein 90 0.0038 0.0125 0.0095
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Entamoeba histolytica hypothetical protein 0.0213 0.1914 1
Schistosoma mansoni nuclear hormone receptor 0.004 0.0144 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0655 0.062
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0041 0.0003
Brugia malayi Pre-SET motif family protein 0.0209 0.1872 0.4003
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0191 0.0816
Loa Loa (eye worm) hypothetical protein 0.004 0.0144 0.0231
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0169 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0144 0.0231
Loa Loa (eye worm) hypothetical protein 0.0099 0.0749 0.1551
Echinococcus multilocularis isocitrate dehydrogenase 0.0078 0.0533 0.0498
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0191 0.0334
Schistosoma mansoni tar DNA-binding protein 0.0188 0.1655 0.1624
Loa Loa (eye worm) hypothetical protein 0.0123 0.0993 0.2084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0655 0.062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0144 0.0231
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0144 0.0114
Leishmania major hypothetical protein, conserved 0.0099 0.0749 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0144 0.0106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0655 0.062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0144 0.0114
Mycobacterium ulcerans proteasome PrcA 0.082 0.8117 1
Echinococcus multilocularis tar DNA binding protein 0.0188 0.1655 0.1624
Schistosoma mansoni hypothetical protein 0.0033 0.0074 0.0037
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0222 0.0401
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.2121 0.2091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0144 0.0231
Onchocerca volvulus 0.0238 0.2167 0.4647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0144 0.0231
Schistosoma mansoni heat shock protein 0.0045 0.0191 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0144 0.0231
Brugia malayi nuclear receptor NHR-88 0.004 0.0144 0.0231
Brugia malayi hypothetical protein 0.0064 0.0389 0.0767
Loa Loa (eye worm) TAR-binding protein 0.0188 0.1655 0.353
Schistosoma mansoni tar DNA-binding protein 0.0188 0.1655 0.1624
Loa Loa (eye worm) hypothetical protein 0.004 0.0144 0.0231
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0144 0.0231
Plasmodium falciparum ataxin-2 like protein, putative 0.0099 0.0749 0.5114
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0746 0.0711
Loa Loa (eye worm) pax transcription factor protein 2 0.0478 0.462 1
Schistosoma mansoni hypothetical protein 0.0044 0.019 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0144 0.0231
Brugia malayi Steroid receptor seven-up type 2 0.0128 0.1045 0.2198
Schistosoma mansoni voltage-gated potassium channel 0.0261 0.2407 0.2378
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0814 0.8062 0.8054
Plasmodium falciparum heat shock protein 90, putative 0.0169 0.1464 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0144 0.0114
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Plasmodium falciparum endoplasmin, putative 0.0032 0.0066 0.045
Echinococcus granulosus tar DNA binding protein 0.0188 0.1655 0.163
Brugia malayi Endoplasmin precursor 0.0045 0.0191 0.0334
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0144 0.0231
Trypanosoma brucei heat shock protein, putative 0.0045 0.0191 0.2154
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0078 0.0533 0.0498
Trypanosoma brucei heat shock protein, putative 0.0045 0.0191 0.2154
Schistosoma mansoni hypothetical protein 0.0289 0.2693 0.2665
Schistosoma mansoni thyroid hormone receptor 0.004 0.0144 0.0106
Brugia malayi heat shock protein 90 0.0045 0.0191 0.0334
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0655 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0144 0.0231
Plasmodium vivax endoplasmin, putative 0.0045 0.0191 0.1074
Schistosoma mansoni thyroid hormone receptor 0.004 0.0144 0.0106
Echinococcus multilocularis protein patched 0.0042 0.0169 0.0131
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0261 0.2407 0.5169
Brugia malayi Pre-SET motif family protein 0.003 0.0041 0.0008
Brugia malayi hypothetical protein 0.0213 0.1914 0.4095
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0232 0.0423
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0078 0.0533 0.6974
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0074 0.008
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0144 0.0106
Echinococcus granulosus FTZ F1 alpha 0.004 0.0144 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0041 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0144 0.0114
Plasmodium falciparum heat shock protein 90 0.0045 0.0191 0.1305
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0041 0.0011
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0078 0.0533 0.6974
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0169 0.0778
Loa Loa (eye worm) hypothetical protein 0.004 0.0144 0.0231
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0261 0.2407 0.2384
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0144 0.0106
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0078 0.0533 0.3476
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0144 0.0231
Echinococcus multilocularis geminin 0.1004 1 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0169 0.0139
Brugia malayi nuclear hormone receptor 0.004 0.0144 0.0231
Brugia malayi hypothetical protein 0.0233 0.2121 0.4547
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0044 0.019 0.016
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0144 0.0106
Brugia malayi steroid hormone receptor 0.004 0.0144 0.0231
Schistosoma mansoni hypothetical protein 0.0213 0.1914 0.1884
Echinococcus multilocularis heat shock protein 90 0.0045 0.0191 0.0154
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0078 0.0533 0.3645
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0144 0.0231
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0078 0.0533 0.6974
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0746 0.1545
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0041 0.0003
Brugia malayi hypothetical protein 0.0123 0.0993 0.2084
Trypanosoma brucei heat shock protein, putative 0.0045 0.0191 0.2154
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0125 0.0095
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0746 0.3773
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0144 0.0114
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0078 0.0533 0.6974
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0144 0.0106
Schistosoma mansoni transcription factor LCR-F1 0.0213 0.1914 0.1884
Entamoeba histolytica hypothetical protein 0.0213 0.1914 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0222 0.0184
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0232 0.0423
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.2121 0.2098
Loa Loa (eye worm) hypothetical protein 0.004 0.0144 0.0231
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0128 0.1045 0.1018
Trypanosoma cruzi PAB1-binding protein , putative 0.0099 0.0749 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0746 0.1545
Echinococcus multilocularis protein dispatched 1 0.0048 0.023 0.0193
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0125 0.1227
Echinococcus multilocularis heat shock protein 0.0045 0.0191 0.0154
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Trypanosoma brucei heat shock protein, putative 0.0045 0.0191 0.2154
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0008
Giardia lamblia Grp94/Hsp90 0.0042 0.0163 0.5748
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Schistosoma mansoni hypothetical protein 0.1004 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0191 0.2154
Trypanosoma brucei heat shock protein, putative 0.0045 0.0191 0.2154
Loa Loa (eye worm) hypothetical protein 0.0109 0.0852 0.1777
Schistosoma mansoni endoplasmin 0.0045 0.0191 0.0154
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0655 0.1347
Loa Loa (eye worm) hypothetical protein 0.0233 0.2121 0.4547
Loa Loa (eye worm) transcription factor SMAD2 0.0354 0.3355 0.724
Schistosoma mansoni heat shock protein 0.0045 0.0191 0.0154
Trypanosoma brucei PAB1-binding protein , putative 0.0099 0.0749 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0163 0.5
Trypanosoma brucei heat shock protein, putative 0.0045 0.0191 0.2154
Echinococcus multilocularis potassium voltage gated channel protein 0.0261 0.2407 0.2378
Onchocerca volvulus 0.004 0.0144 0.0231
Loa Loa (eye worm) RNA binding protein 0.0188 0.1655 0.353
Brugia malayi CHE-14 protein 0.0042 0.0169 0.0285
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0144 0.0106
Plasmodium vivax ataxin-2 like protein, putative 0.0099 0.0749 0.4984
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.082 0.8117 1
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0191 0.2154
Echinococcus multilocularis endoplasmin 0.0042 0.0163 0.0126
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0163 0.0752
Echinococcus granulosus X box binding protein 1 0.0289 0.2693 0.2671
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0066 0.0304
Loa Loa (eye worm) isocitrate dehydrogenase 0.0078 0.0533 0.1082
Toxoplasma gondii isocitrate dehydrogenase 0.0078 0.0533 0.3476
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0655 0.1347
Leishmania major heat shock protein 83-1 0.0045 0.0191 0.2154
Echinococcus granulosus heat shock protein 90 0.0045 0.0191 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0144 0.0231

Activities

Activity type Activity value Assay description Source Reference
behavior (functional) Gross behavioral effects ascertained in mice; W indicates weak stimulant or depressant activity of little significance. ChEMBL. 3039136
behavior (functional) W 0 Gross behavioral effects ascertained in mice; W indicates weak stimulant or depressant activity of little significance. ChEMBL. 3039136
ED50 (functional) mg kg-1 Ability to antagonise intraperitoneal dose; inactive (<10% antagonism) at 30 mgjkg is represented as I-30. ChEMBL. 3039136
ED50 (functional) I-30 0 mg kg-1 Ability to antagonise intraperitoneal dose; inactive (<10% antagonism) at 30 mgjkg is represented as I-30. ChEMBL. 3039136
Inhibition (functional) = 2 % Ability to inhibit the uptake of [3H]- serotonin(5-HT) 0.1 microM concentration at rat brain synaptosomes ChEMBL. 3039136
Inhibition (functional) = 2 % Ability to inhibit the uptake of [3H]- serotonin(5-HT) 0.1 microM concentration at rat brain synaptosomes ChEMBL. 3039136
Inhibition (functional) = 6 % Ability to inhibit the uptake of [3H]-norepinephrine (NE) 0.1 microM concentration at rat brain synaptosomes ChEMBL. 3039136
Inhibition (functional) = 6 % Ability to inhibit the uptake of [3H]-norepinephrine (NE) 0.1 microM concentration at rat brain synaptosomes ChEMBL. 3039136
Inhibition (functional) = 15 % Ability to inhibit the uptake of tritiated dopamine (DA) 1 uM concentration ChEMBL. 3039136

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.