Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cysteinyl leukotriene receptor 2 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log KB (functional) | = 6.2 | In vitro ability to antagonize a leukotriene D4 induced contraction of guinea pig trachea. | ChEMBL. | 3016267 |
Ki (binding) | = 147 nM | Compound is evaluated for its ability to inhibit [3H]-LTD4 binding to Cysteinyl leukotriene D4 receptor in guinea pig lung membranes | ChEMBL. | 3016267 |
Ki (binding) | = 147 nM | Compound is evaluated for its ability to inhibit [3H]-LTD4 binding to Cysteinyl leukotriene D4 receptor in guinea pig lung membranes | ChEMBL. | 3016267 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.