Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0607 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0607 | 1 | 0.5 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0607 | 1 | 0.5 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0607 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0603 | 0.988 | 0.9728 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0603 | 0.988 | 0.9728 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0607 | 1 | 0.5 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0607 | 1 | 0.5 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0607 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0607 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0607 | 1 | 0.5 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0607 | 1 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0607 | 1 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0607 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0603 | 0.988 | 0.9728 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0607 | 1 | 0.5 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0607 | 1 | 0.5 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0607 | 1 | 0.5 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0607 | 1 | 0.5 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0607 | 1 | 0.5 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0607 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14.4 ug ml-1 | Concentration required for inhibition of beef liver dihydrofolate reductase | ChEMBL. | 2810330 |
IC50 (binding) | = 14.4 ug ml-1 | Concentration required for inhibition of beef liver dihydrofolate reductase | ChEMBL. | 2810330 |
ID50 (binding) | = 0.0021 uM | Compound was tested for inhibition of L. casei dihydrofolate reductase using spectrophotometric assay at 340 nm | ChEMBL. | 6796689 |
ID50 (binding) | = 0.0021 uM | Compound was tested for inhibition of L. casei dihydrofolate reductase using spectrophotometric assay at 340 nm | ChEMBL. | 6796689 |
ID50 (binding) | = 0.012 uM | Compound was tested for inhibition of L1210 dihydrofolate reductase by competitive [3H]-MTX binding assay in L1210 mouse leukemia cell lines | ChEMBL. | 6796689 |
ID50 (binding) | = 0.012 uM | Compound was tested for inhibition of L1210 dihydrofolate reductase by competitive [3H]-MTX binding assay in L1210 mouse leukemia cell lines | ChEMBL. | 6796689 |
ID50 (binding) | = 0.013 uM | Compound was tested for inhibition of L. casei dihydrofolate reductase using competitive [3H]-MTX binding assay | ChEMBL. | 6796689 |
ID50 (binding) | = 0.013 uM | Compound was tested for inhibition of L. casei dihydrofolate reductase using competitive [3H]-MTX binding assay | ChEMBL. | 6796689 |
ID50 (functional) | = 0.02 uM | Growth inhibitory activity of the compound against L1210 mouse leukemia cell line | ChEMBL. | 6796689 |
ID50 (functional) | = 0.02 uM | Growth inhibitory activity of the compound against L1210 mouse leukemia cell line | ChEMBL. | 6796689 |
Ratio (binding) | = 75 | Compound was evaluated for inhibition index as ratio of IC50 of MTX to IC50 of compound x 100 | ChEMBL. | 2810330 |
Ratio (binding) | = 0.34 | Ratio of compound ID50 relative to methotrexate, against L. casei dihydrofolate reductase using spectrophotometric assay at 340 nm | ChEMBL. | 6796689 |
Ratio (binding) | = 0.8 | Ratio of compound ID50 relative to methotrexate, against L. casei dihydrofolate reductase by competitive [3H]-MTX binding assay | ChEMBL. | 6796689 |
Ratio (binding) | = 3.5 | Ratio of compound ID50 relative to methotrexate against dihydrofolate reductase by competitive [3H]-MTX binding assay in mouse leukemia L1210 cell line | ChEMBL. | 6796689 |
Ratio (binding) | = 75 | Compound was evaluated for inhibition index as ratio of IC50 of MTX to IC50 of compound x 100 | ChEMBL. | 2810330 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.