Detailed information for compound 47587

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 293.36 | Formula: C19H19NO2
  • H donors: 1 H acceptors: 2 LogP: 1.01 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1ccccc1[C@@H]1CN2CCC[C@H]2c2c1cccc2
  • InChi: 1S/C19H19NO2/c21-19(22)16-9-4-2-7-14(16)17-12-20-11-5-10-18(20)15-8-3-1-6-13(15)17/h1-4,6-9,17-18H,5,10-12H2,(H,21,22)/t17-,18+/m1/s1
  • InChiKey: WLJIFNUTWQRJCE-MSOLQXFVSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.0624 0.0732
Giardia lamblia DINP protein human, muc B family 0.0025 0.0333 0.0625
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.0624 0.2046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0949 0.0949
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0055 0.0949 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.1058 0.2003
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0245 0.0245
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0907 0.1717
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0217 0.2258
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0266 0.5283 0.5283
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0002 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0002 0.0003
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0055 0.0949 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.006 0.105 0.3453
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Echinococcus granulosus single minded 2 0.0037 0.0583 0.0684
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0079 0.1447 0.274
Loa Loa (eye worm) glutathione reductase 0.0099 0.1846 0.1929
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0217 0.041
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.0624 0.0732
Treponema pallidum oxidoreductase 0.0009 0.0003 0.0021
Brugia malayi Uncoordinated protein 44 0.0015 0.0122 0.0128
Chlamydia trachomatis dihydrofolate reductase 0.0045 0.0749 0.5047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.1111 0.1304
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.116 0.1361
Mycobacterium ulcerans ferredoxin reductase 0.0009 0.0003 0.0006
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0009 0.0003 0.0021
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.052 0.1704
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0624 0.0652
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0266 0.5283 1
Brugia malayi Probable ClpP-like protease 0.0081 0.1481 0.1547
Schistosoma mansoni hypothetical protein 0.005 0.0843 0.0989
Mycobacterium tuberculosis Probable oxidoreductase 0.025 0.4963 0.9394
Trichomonas vaginalis DNA helicase recq, putative 0.0065 0.1161 0.1162
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.025 0.4963 0.9394
Schistosoma mansoni dihydrofolate reductase 0.0045 0.0749 0.0879
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.052 0.1704
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.052 0.1704
Plasmodium falciparum glutathione reductase 0.0099 0.1846 0.6078
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0172 0.0179
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0122 0.0128
Plasmodium vivax SET domain protein, putative 0.0063 0.1111 0.3654
Brugia malayi MH2 domain containing protein 0.0126 0.2401 0.2508
Toxoplasma gondii phosphorylase family protein 0.0055 0.0949 0.3118
Schistosoma mansoni cpg binding protein 0.0031 0.0462 0.0543
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0055 0.0949 0.0949
Schistosoma mansoni uridine phosphorylase 0.0055 0.0949 0.1113
Onchocerca volvulus 0.0056 0.0974 0.0974
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0086 0.0086
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0617 0.0645
Leishmania major nucleoside phosphorylase-like protein 0.0055 0.0949 0.3125
Echinococcus granulosus Ankyrin 0.0015 0.0125 0.0147
Trypanosoma brucei unspecified product 0.0012 0.0061 0.0192
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0624 0.0652
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.302 0.3155
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0172 0.0179
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0009 0.0003 0.0006
Schistosoma mansoni methylthioadenosine phosphorylase 0.0055 0.0949 0.1113
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0617 0.2033
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0172 0.0201
Plasmodium falciparum purine nucleoside phosphorylase 0.0055 0.0949 0.3118
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0041 0.0655 0.2148
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0009 0.0003 0.0011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.1111 0.1304
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0002 0.0003
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0086 0.0086
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0002 0.0003
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.0003 0.0003
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0055 0.0949 0.0949
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0266 0.5283 0.552
Entamoeba histolytica recQ family DNA helicase 0.002 0.0228 0.2377
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0122 0.0144
Echinococcus granulosus dna polymerase eta 0.0017 0.0172 0.0201
Leishmania major DNA polymerase kappa, putative 0.0025 0.0333 0.1098
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0002 0.0003
Echinococcus multilocularis cpg binding protein 0.0031 0.0462 0.0543
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Leishmania major hypothetical protein, conserved 0.0009 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Echinococcus granulosus purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Brugia malayi Pre-SET motif family protein 0.0063 0.1111 0.1161
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0122 0.0144
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.1481 0.1738
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0172 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0086 0.0086
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.052 0.0543
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0086 0.0086
Leishmania major hypothetical protein, conserved 0.0009 0.0003 0.0011
Schistosoma mansoni hypothetical protein 0.0175 0.3422 0.4017
Brugia malayi Death domain containing protein 0.0015 0.0122 0.0128
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0053 0.0055
Loa Loa (eye worm) hypothetical protein 0.0026 0.0354 0.037
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0002 0.0003
Echinococcus granulosus purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0086 0.0086
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0333 0.1098
Echinococcus multilocularis musashi 0.0056 0.0974 0.1143
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0002 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0002 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0016 0.0018
Brugia malayi PAS domain containing protein 0.005 0.0852 0.089
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0437 0.0456
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.1058 0.1106
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0003 0.0004
Mycobacterium ulcerans dehydrogenase 0.0009 0.0003 0.0006
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0009 0.0003 0.0006
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0003 0.0003
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0055 0.0949 0.3118
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.052 0.1713
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0002 0.0003
Echinococcus granulosus geminin 0.0175 0.3422 0.4017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0002 0.0003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.052 0.3511
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0009 0.0003 0.0006
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0009 0.0003 0.0006
Echinococcus multilocularis lamin dm0 0.0056 0.0974 0.1143
Schistosoma mansoni apoferritin-2 0.0009 0.0000071875 0.0000084361
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0735 0.2413
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.052 0.1704
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0217 0.0254
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0156 0.3035 1
Loa Loa (eye worm) hypothetical protein 0.0328 0.6567 0.6861
Mycobacterium ulcerans DNA polymerase IV 0.0049 0.0824 0.1559
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0086 0.0557
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0245 0.0465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0002 0.0003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0002 0.0003
Schistosoma mansoni cpg binding protein 0.003 0.0428 0.0502
Brugia malayi Pre-SET motif family protein 0.0435 0.8763 0.9155
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0009 0.0003 0.0006
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0002 0.0003
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0333 0.0348
Echinococcus multilocularis purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Echinococcus multilocularis Ankyrin 0.0015 0.0125 0.0147
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0211 0.4151 0.4872
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0639 0.2096
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.039 0.1275
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0002 0.0003
Mycobacterium ulcerans hypothetical protein 0.0009 0.0003 0.0006
Schistosoma mansoni intermediate filament proteins 0.0056 0.0974 0.1143
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0086 0.0086
Echinococcus granulosus death domain containing protein 0.0015 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0172 0.0179
Toxoplasma gondii phosphorylase family protein 0.0055 0.0949 0.3118
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0055 0.0949 0.1795
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0002 0.0003
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0086 0.01
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.1058 0.1242
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.052 0.0984
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0086 0.0282
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0003 0.0004
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.1481 0.2802
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0217 0.0217
Onchocerca volvulus 0.0013 0.0086 0.0086
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0217 0.0226
Echinococcus multilocularis dna polymerase kappa 0.0049 0.0824 0.0967
Echinococcus granulosus cpg binding protein 0.0031 0.0462 0.0543
Trypanosoma brucei DNA polymerase IV, putative 0.0049 0.0824 0.2706
Loa Loa (eye worm) hypothetical protein 0.0244 0.4848 0.5065
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.1058 0.1242
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.025 0.4963 0.9394
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0002 0.0003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1021 0.3358
Schistosoma mansoni glutamate synthase 0.0009 0.0003 0.0004
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0055 0.0949 0.6407
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0009 0.0003 0.0011
Echinococcus multilocularis geminin 0.0175 0.3422 0.4017
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.052 0.1713
Echinococcus multilocularis purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0055 0.0949 0.3118
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0217 0.041
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.052 0.1704
Schistosoma mansoni glutamate synthase 0.0009 0.0003 0.0004
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.1481 1
Brugia malayi uridine phosphorylase family protein 0.0055 0.0949 0.0991
Loa Loa (eye worm) uridine phosphorylase 0.0055 0.0949 0.0991
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Echinococcus granulosus purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0003 0.0003
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.052 0.061
Brugia malayi Dihydrofolate reductase 0.0045 0.0749 0.0782
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0974 0.1018
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0122 0.0144
Entamoeba histolytica recQ family helicase, putative 0.0045 0.0735 0.7739
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0156 0.3035 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.1111 0.1161
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0002 0.0003
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0086 0.0272
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.005 0.0053
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0435 0.8763 0.9155
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0002 0.0003
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0055 0.0949 0.3118
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0225 0.4446 0.8416
Brugia malayi intermediate filament protein 0.0056 0.0974 0.1018
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0375 0.044
Treponema pallidum uridine phosphorylase (udp) 0.0055 0.0949 0.6407
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0617 0.0724
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0003 0.0003
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.052 0.1704
Brugia malayi hypothetical protein 0.0169 0.3289 0.3437
Schistosoma mansoni coup transcription factor 0.0009 0.0002 0.0003
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.0624 0.0732
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0009 0.0003 0.0006
Brugia malayi steroid hormone receptor 0.0009 0.0002 0.0003
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0003 0.0003
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0735 0.0735
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0002 0.0003
Schistosoma mansoni ferritin 0.0009 0.0000071875 0.0000084361
Brugia malayi dihydrofolate reductase family protein 0.0045 0.0749 0.0782
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.052 0.1704
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.0624 0.0732
Loa Loa (eye worm) hypothetical protein 0.0039 0.0617 0.0645
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0002 0.0003
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.1481 0.4872
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0904 0.0904
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0003 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.1111 0.3654
Schistosoma mansoni ap endonuclease 0.0019 0.0217 0.0254
Onchocerca volvulus 0.0063 0.1111 0.1111
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.052 0.061
Brugia malayi hypothetical protein 0.0053 0.0904 0.0945
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.039 0.0738
Schistosoma mansoni DNA helicase recq1 0.0039 0.0624 0.0732
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0002 0.0003
Schistosoma mansoni glutamate synthase 0.0009 0.0003 0.0004
Schistosoma mansoni ferritin light chain 0.0009 0.0000071875 0.0000084361
Echinococcus granulosus dihydrofolate reductase 0.0045 0.0749 0.0879
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0003 0.0003
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0974 0.1018
Brugia malayi polk-prov protein 0.0037 0.0579 0.0605
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0003 0.0003
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0003 0.0004
Echinococcus multilocularis bloom syndrome protein 0.0065 0.1161 0.1363
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0907 0.1065
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0003 0.0003
Echinococcus multilocularis purine nucleoside phosphorylase 0.0211 0.4151 0.4872
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0907 0.1717
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0079 0.1447 0.1512
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0228 0.0741
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0156 0.3035 1
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0055 0.0949 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0002 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.052 0.1704
Loa Loa (eye worm) hypothetical protein 0.0015 0.0125 0.0131
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0843 0.0881
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0617 0.0724
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0002 0.0003
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0055 0.0949 0.3118
Mycobacterium leprae Possible regulatory protein 0.0013 0.0086 0.0162
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0055 0.0949 0.0949
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.1051 0.1233
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0228 0.0741
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0045 0.0749 0.1417
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0975 0.1018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.052 0.1704
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0055 0.0949 0.1795
Treponema pallidum NADH oxidase 0.0034 0.052 0.3511
Toxoplasma gondii hypothetical protein 0.0028 0.039 0.1275
Echinococcus granulosus purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0089 0.0281
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0907 0.1065
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0003 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0579 0.1898
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0122 0.0144
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.4848 0.569
Brugia malayi glutamate synthase 0.0009 0.0003 0.0003
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.0624 0.0652
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.1481 0.1738
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0086 0.0272
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0172 0.0555
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0009 0.0003 0.0006
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0617 0.0724
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0009 0.0003 0.0006
Schistosoma mansoni purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.1111 0.1304
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0019 0.0212 0.0689
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0735 0.2421
Schistosoma mansoni blooms syndrome DNA helicase 0.0045 0.075 0.088
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0002 0.0003
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0225 0.4446 0.8416
Mycobacterium tuberculosis Probable reductase 0.0225 0.4446 0.8416
Echinococcus multilocularis uridine phosphorylase 1 0.0055 0.0949 0.1113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.052 0.1704
Loa Loa (eye worm) hypothetical protein 0.0081 0.1481 0.1547
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0111 0.2103 0.398
Mycobacterium tuberculosis Hypothetical protein 0.0053 0.0904 0.1712
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0617 0.2024
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0055 0.0949 0.3118
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0217 0.0704
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.1058 0.2003
Echinococcus granulosus lamin dm0 0.0056 0.0974 0.1143
Echinococcus granulosus intermediate filament protein 0.0056 0.0974 0.1143
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.052 0.1704
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0003 0.0004
Leishmania major trypanothione reductase 0.0099 0.1846 0.6083
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0002 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.852 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.052 0.3511
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0617 0.0724
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0122 0.0144
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0016 0.0018
Trypanosoma brucei DNA polymerase IV, putative 0.0049 0.0824 0.2706
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0217 0.0217
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0003 0.0003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.052 0.1713
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0009 0.0003 0.0006
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.039 0.2633
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0583 0.1103
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.1481 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.1111 0.1304
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0086 0.0272
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0016 0.0018
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0169 0.3289 0.3437
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0217 0.1463
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0217 0.0704
Giardia lamblia UPL-1 0.0055 0.0949 0.179
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0266 0.5283 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0211 0.4151 0.4872
Loa Loa (eye worm) thymidylate synthase 0.0111 0.2103 0.2197
Echinococcus granulosus dnaJ subfamily B 0.0423 0.852 1
Trypanosoma brucei uridine phosphorylase 0.0055 0.0949 0.3118
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0086 0.0086
Echinococcus granulosus lamin 0.0056 0.0974 0.1143
Echinococcus granulosus purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0086 0.01
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0172 0.0201
Echinococcus multilocularis purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Echinococcus multilocularis lamin 0.0056 0.0974 0.1143
Echinococcus multilocularis thymidylate synthase 0.0111 0.2103 0.2468
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0003 0.0004
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0974 0.1018
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0172 0.0555
Echinococcus granulosus glutamate synthase 0.0009 0.0003 0.0004
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.1481 0.2802
Toxoplasma gondii exonuclease III APE 0.0019 0.0217 0.0704
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.1846 0.3494
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0156 0.3035 1
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0045 0.0749 0.1417
Trypanosoma brucei trypanothione reductase 0.0099 0.1846 0.6078
Echinococcus granulosus bloom syndrome protein 0.0065 0.1161 0.1363
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0055 0.0949 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0217 0.1463
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0003 0.0004
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0003 0.0003
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.1481 0.4872
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0009 0.0003 0.0006
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0245 0.0256
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.052 0.1704
Loa Loa (eye worm) hypothetical protein 0.0013 0.0086 0.0089
Schistosoma mansoni uridine phosphorylase 0.0055 0.0949 0.1113
Brugia malayi follicle stimulating hormone receptor 0.0474 0.9572 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0086 0.01
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0086 0.0086
Mycobacterium tuberculosis Hypothetical protein 0.0055 0.0949 0.1795
Mycobacterium ulcerans hypothetical protein 0.0021 0.0245 0.0465
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0617 0.6493
Mycobacterium leprae probable uridine phosphorylase 0.0055 0.0949 0.1795
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0002 0.0003
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0079 0.1447 0.274
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0003 0.0004
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0003 0.0004
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.025 0.4963 0.9394
Brugia malayi Protein kinase domain containing protein 0.0015 0.0122 0.0128
Toxoplasma gondii Purine nucleoside phosphorylase 0.0055 0.0949 0.3118
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0055 0.0949 0.179
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0045 0.0749 0.1417
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0086 0.0086
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0086 0.0272
Echinococcus granulosus purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Loa Loa (eye worm) hypothetical protein 0.0026 0.0354 0.037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0055 0.0949 0.1795
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0002 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.1111 0.1304
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0333 0.0631
Onchocerca volvulus 0.0111 0.2103 0.2103
Schistosoma mansoni cpg binding protein 0.0031 0.0462 0.0543
Brugia malayi ecdysteroid receptor 0.0009 0.0002 0.0003
Toxoplasma gondii endonuclease IV APN 0.0079 0.1447 0.4763
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0172 0.0201
Schistosoma mansoni survival motor neuron protein 0.005 0.0843 0.0989
Loa Loa (eye worm) programmed cell death 8 0.0009 0.0003 0.0003
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.052 0.061
Echinococcus granulosus purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Schistosoma mansoni netrin receptor unc5 0.0015 0.0122 0.0144
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0212 0.2211
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.1384 0.1624
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0009 0.0003 0.0003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.1481 0.2802
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0009 0.0003 0.0006
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0617 0.0724
Treponema pallidum ATP-dependent DNA helicase 0.002 0.0228 0.1539
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.052 0.1704
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0002 0.0003
Schistosoma mansoni single-minded 0.005 0.0852 0.1
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0079 0.1447 0.4763
Trichomonas vaginalis set domain proteins, putative 0.0495 0.9997 1
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0055 0.0949 0.3118
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0579 0.1898
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0002 0.0003
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0617 0.0724
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0624 0.0652
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0055 0.0949 0.0949
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0617 0.0617
Echinococcus granulosus dna polymerase kappa 0.0049 0.0824 0.0967
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.1111 0.1304
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0055 0.0949 0.0949
Schistosoma mansoni ferritin light chain 0.0009 0.0000071875 0.0000084361
Schistosoma mansoni lamin 0.0056 0.0974 0.1143
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0617 0.0724
Loa Loa (eye worm) hypothetical protein 0.0211 0.4151 0.4337
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.1058 0.1242
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0735 0.2413
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0217 0.0704
Schistosoma mansoni hypothetical protein 0.0423 0.852 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0953 0.0996
Echinococcus granulosus thioredoxin glutathione reductase 0.0099 0.1846 0.2167
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0223 0.0725
Schistosoma mansoni DNA polymerase eta 0.0017 0.0172 0.0201
Echinococcus multilocularis dihydrofolate reductase 0.0045 0.0749 0.0879
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0086 0.0086
Onchocerca volvulus 0.003 0.0428 0.0428
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0002 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.1111 0.1304
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.1481 0.1738
Echinococcus multilocularis purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Schistosoma mansoni hypothetical protein 0.0015 0.0122 0.0144
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0009 0.0003 0.0021
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0055 0.0949 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0055 0.0949 0.0949
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0122 0.0122
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Mycobacterium tuberculosis Probable dehydrogenase 0.0225 0.4446 0.8416
Chlamydia trachomatis endonuclease IV 0.0079 0.1447 0.9776
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.052 0.0978
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0003 0.0004
Echinococcus multilocularis purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Entamoeba histolytica hypothetical protein 0.0055 0.0949 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0002 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0333 0.1089
Brugia malayi thymidylate synthase 0.0111 0.2103 0.2197
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0002 0.0003
Echinococcus multilocularis glutamate synthase 0.0009 0.0003 0.0004
Echinococcus granulosus uridine phosphorylase 1 0.0055 0.0949 0.1113
Plasmodium falciparum thioredoxin reductase 0.0034 0.052 0.1704
Plasmodium vivax glutathione reductase, putative 0.0099 0.1846 0.6078
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0002 0.0003
Leishmania major hypothetical protein, conserved 0.0009 0.0003 0.0011
Onchocerca volvulus 0.0056 0.0974 0.0974
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0217 0.0714
Schistosoma mansoni ap endonuclease 0.0019 0.0217 0.0254
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0852 0.1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0624 0.2046
Toxoplasma gondii thioredoxin reductase 0.0099 0.1846 0.6078
Echinococcus granulosus methylthioadenosine phosphorylase 0.0055 0.0949 0.1113
Trypanosoma cruzi DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.1846 0.6078
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0428 0.0447
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0225 0.4446 0.8416
Brugia malayi hypoxia-induced factor 1 0.0156 0.302 0.3155
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.1481 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0766 0.08
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0172 0.0325
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0049 0.0824 0.0824
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0002 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0002 0.0003
Treponema pallidum thioredoxin reductase (trxB) 0.0009 0.0003 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0002 0.0003
Brugia malayi Bloom's syndrome protein homolog 0.0065 0.1161 0.1213
Onchocerca volvulus 0.0037 0.0583 0.0583
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.052 0.0984
Loa Loa (eye worm) hypothetical protein 0.0037 0.0579 0.0605
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0223 0.0725
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0662 0.2172
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0086 0.0272
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0583 0.0684
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0156 0.3035 1
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0111 0.2103 0.398
Schistosoma mansoni ferritin 0.0009 0.0000071875 0.0000084361
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.039 0.1275
Mycobacterium ulcerans monoxygenase 0.0009 0.0003 0.0006
Plasmodium falciparum thioredoxin reductase 0.0099 0.1846 0.6078
Loa Loa (eye worm) hypothetical protein 0.0056 0.0974 0.1018
Chlamydia trachomatis AMP nucleosidase 0.0055 0.0949 0.6399
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0002 0.0003
Trypanosoma brucei unspecified product 0.0012 0.0061 0.0192
Brugia malayi MTAP 0.0055 0.0949 0.0991
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0223 0.0725
Leishmania major protein kinase, putative 0.0013 0.0086 0.0282
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.1481 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0617 0.0617
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0617 0.0724
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.052 0.1704
Mycobacterium ulcerans DNA polymerase IV 0.0049 0.0824 0.1559
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.1846 0.6078
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0245 0.0256
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0003 0.0003
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0002 0.0003
Onchocerca volvulus 0.005 0.0843 0.0843
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0583 0.0609
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0002 0.0003
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0009 0.0003 0.0006
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.052 0.3497
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Trichomonas vaginalis DNA polymerase eta, putative 0.0049 0.0824 0.0824
Leishmania major NADH dehydrogenase, putative 0.0009 0.0003 0.0011
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0003 0.0004
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.1058 0.3487
Leishmania major DNA polymerase eta, putative 0.0017 0.0172 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0949 0.0949
Schistosoma mansoni ferritin 0.0009 0.0000071875 0.0000084361
Schistosoma mansoni purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0266 0.5283 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0217 0.0704
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.052 0.052
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.1481 0.4872
Trichomonas vaginalis apoptosis inducing factor, putative 0.0009 0.0003 0.0003
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0217 0.0704
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0086 0.0089
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0009 0.0003 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.2401 0.2508
Schistosoma mansoni lamin 0.0056 0.0974 0.1143
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0009 0.0003 0.0003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0225 0.4446 0.8416
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0245 0.0464
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0002 0.0002
Echinococcus granulosus purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Schistosoma mansoni methylthioadenosine phosphorylase 0.0055 0.0949 0.1113
Mycobacterium ulcerans NADH dehydrogenase 0.0009 0.0003 0.0006
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.052 0.0984
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0122 0.0128
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0617 0.1162
Schistosoma mansoni ferritin 0.0009 0.0000071875 0.0000084361
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0111 0.2103 0.2468
Brugia malayi glutathione reductase 0.0099 0.1846 0.1929
Plasmodium falciparum glutathione reductase 0.0034 0.052 0.1704
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0053 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0122 0.0128
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0437 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0824 0.2706
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0002 0.0003
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0156 0.3035 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0949 0.1795
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0009 0.0003 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0002 0.0003
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0016 0.0018
Mycobacterium ulcerans endonuclease IV 0.0079 0.1447 0.274
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.1058 0.2003
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0055 0.0949 0.0949
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0617 0.2024
Mycobacterium ulcerans glutamate synthase subunit beta 0.0009 0.0003 0.0006
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0086 0.0272
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0086 0.0086
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0055 0.0949 0.1113
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.4848 0.569
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0053 0.0904 0.2972
Brugia malayi nuclear hormone receptor 0.0009 0.0002 0.0003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0624 0.2046
Brugia malayi hypothetical protein 0.0244 0.4848 0.5065
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0086 0.01
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.052 0.1704
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.052 0.1704
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0079 0.1447 0.4763
Onchocerca volvulus 0.0009 0.0002 0.0002
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0375 0.044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.052 0.1704
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0474 0.9572 1
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0055 0.0949 0.0991
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.1846 0.1929
Leishmania major protein kinase, putative 0.0013 0.0086 0.0282
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0245 0.0465
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.052 0.1704
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0125 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0002 0.0003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0217 0.0226
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0217 0.0254
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.052 0.1704
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0266 0.5283 0.5285
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.052 0.0984
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0003 0.0004
Brugia malayi Thioredoxin reductase 0.0099 0.1846 0.1929
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0225 0.4446 0.8416
Brugia malayi CXXC zinc finger family protein 0.003 0.0428 0.0447
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.2401 0.2508
Onchocerca volvulus 0.0009 0.0003 0.0003
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0002 0.0003
Mycobacterium ulcerans epimerase 0.0021 0.0245 0.0465
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0228 0.0238
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0907 0.1717
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0617 0.2024
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.0003 0.0003
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0003 0.0004
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0009 0.0003 0.0021
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0333 0.0348
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0002 0.0003
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.052 0.1713
Mycobacterium ulcerans thymidylate synthase 0.0111 0.2103 0.398
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.0624 0.1175
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0228 0.0741
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0002 0.0003
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0266 0.5283 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.1384 0.1624
Leishmania major methylthioadenosine phosphorylase, putative 0.0055 0.0949 0.3125
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0228 0.0268
Echinococcus multilocularis purine nucleoside phosphorylase 0.0266 0.5283 0.6201
Schistosoma mansoni apoferritin-2 0.0009 0.0000071875 0.0000084361
Brugia malayi hypothetical protein 0.0126 0.2407 0.2514
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.052 0.052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0375 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0617 0.0617
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0003 0.0004
Echinococcus multilocularis dna polymerase eta 0.0017 0.0172 0.0201
Trypanosoma brucei unspecified product 0.0041 0.0662 0.2172
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0055 0.0949 0.179
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0002 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0172 0.0179
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0055 0.0949 0.3118
Loa Loa (eye worm) hypothetical protein 0.0079 0.1447 0.1512
Echinococcus multilocularis thioredoxin glutathione reductase 0.0099 0.1846 0.2167
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0217 0.0404
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0009 0.0003 0.0006
Loa Loa (eye worm) dihydrofolate reductase 0.0045 0.0749 0.0782
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0055 0.0949 1
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0009 0.0003 0.0006
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.1481 0.4872
Loa Loa (eye worm) RecQ helicase 0.0065 0.1161 0.1213
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0002 0.0003
Treponema pallidum pfs protein (pfs) 0.0055 0.0949 0.6407
Brugia malayi nuclear receptor NHR-88 0.0009 0.0002 0.0003
Schistosoma mansoni methylthioadenosine phosphorylase 0.0055 0.0949 0.1113
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0175 0.3422 0.4017
Echinococcus granulosus thymidylate synthase 0.0111 0.2103 0.2468
Schistosoma mansoni DNA helicase recq5 0.0039 0.0624 0.0732
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0016 0.0018
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0172 0.178
Trichomonas vaginalis DNA helicase recq1, putative 0.0065 0.1161 0.1162
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0009 0.0003 0.0006

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 1 % Ability to inhibit the uptake of [3H]-norepinephrine (NE) 0.1 microM concentration at rat brain synaptosomes ChEMBL. 3039136
Inhibition (functional) = 1 % Ability to inhibit the uptake of [3H]- serotonin(5-HT) 0.1 microM concentration at rat brain synaptosomes ChEMBL. 3039136
Inhibition (functional) = 1 % Ability to inhibit the uptake of [3H]-norepinephrine (NE) 0.1 microM concentration at rat brain synaptosomes ChEMBL. 3039136
Inhibition (functional) = 1 % Ability to inhibit the uptake of [3H]- serotonin(5-HT) 0.1 microM concentration at rat brain synaptosomes ChEMBL. 3039136
Inhibition (functional) = 5 % Ability to inhibit the uptake of [3H]-dopamine (DA) 0.1 uM concentration at rat brain synaptosomes ChEMBL. 3039136
Inhibition (functional) = 5 % Ability to inhibit the uptake of [3H]-dopamine (DA) 0.1 uM concentration at rat brain synaptosomes ChEMBL. 3039136

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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