Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1709 | 0.1709 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.6129 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.6129 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.2225 | 0.2225 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.2225 | 0.2225 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.1646 | 0.1646 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1709 | 0.1709 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1709 | 0.1709 |
Echinococcus granulosus | protein prune | 0.0126 | 0.1646 | 0.1646 |
Giardia lamblia | Manganese-dependent inorganic pyrophosphatase, putative | 0.0043 | 0.0386 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 0.2225 | 0.2225 |
Entamoeba histolytica | cyclin, putative | 0.0017 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0676 | 0.0676 |
Brugia malayi | Dihydrofolate reductase | 0.0676 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.6129 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0421 | 0.6129 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.1646 | 0.1646 |
Onchocerca volvulus | 0.013 | 0.1709 | 1 | |
Leishmania major | acidocalcisomal exopolyphosphatase, putative | 0.0126 | 0.1646 | 0.2685 |
Trypanosoma brucei | exopolyphosphatase | 0.0126 | 0.1646 | 0.2685 |
Giardia lamblia | Manganese-dependent inorganic pyrophosphatase, putative | 0.0043 | 0.0386 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.1709 | 0.1108 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0043 | 0.0386 | 0.0629 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.2225 | 0.2225 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0676 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0676 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0676 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0676 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0676 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0676 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0676 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0062 | 0.0676 | 0.1103 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0676 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.6129 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.1709 | 0.1709 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0667 | 0.9864 | 0.9864 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.6129 | 1 |
Trypanosoma cruzi | acidocalcisomal exopolyphosphatase, putative | 0.0126 | 0.1646 | 0.2685 |
Entamoeba histolytica | cyclin family protein | 0.0017 | 0 | 0.5 |
Trypanosoma cruzi | exopolyphosphatase | 0.0126 | 0.1646 | 0.2685 |
Entamoeba histolytica | cyclin family protein | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0667 | 0.9864 | 0.9864 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1709 | 0.1709 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0676 | 1 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0667 | 0.9864 | 0.9864 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25 nM | Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium | ChEMBL. | 14998335 |
IC50 (binding) | = 25 nM | Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium | ChEMBL. | 14998335 |
IC50 (binding) | = 210 nM | Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondii | ChEMBL. | 14998335 |
IC50 (binding) | = 210 nM | Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondii | ChEMBL. | 14998335 |
IC50 (binding) | = 1100 nM | Inhibitory concentration against dihdrofolate reductace enzyme of Pneumocystis carinii | ChEMBL. | 14998335 |
IC50 (binding) | = 1100 nM | Inhibitory concentration against dihdrofolate reductace enzyme of Pneumocystis carinii | ChEMBL. | 14998335 |
IC50 (binding) | = 4000 nM | Inhibitory concentration against dihydrofolate reductase of rat liver | ChEMBL. | 14998335 |
IC50 (binding) | = 4000 nM | Inhibitory concentration against dihydrofolate reductase of rat liver | ChEMBL. | 14998335 |
SI (binding) | = 3.6 | Ratio of DHFR inhibition of rat liver to that of Pneumocystis carinii | ChEMBL. | 14998335 |
SI (binding) | = 19 | Ratio of DHFR inhibition of rat liver to that of Toxoplasma gondii | ChEMBL. | 14998335 |
SI (binding) | = 160 | Ratio of DHFR inhibition of rat liver to that of Mycobacterium avium | ChEMBL. | 14998335 |
SI (binding) | = 3.6 | Ratio of DHFR inhibition of rat liver to that of Pneumocystis carinii | ChEMBL. | 14998335 |
SI (binding) | = 19 | Ratio of DHFR inhibition of rat liver to that of Toxoplasma gondii | ChEMBL. | 14998335 |
SI (binding) | = 160 | Ratio of DHFR inhibition of rat liver to that of Mycobacterium avium | ChEMBL. | 14998335 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.