Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity index (functional) | = 3.2 | Activity index by dog hypotension screen assay at 10 ug/Kg per min for 15 min. | ChEMBL. | 2999403 |
ID50 (functional) | = 0.3 mg kg-1 | Inhibitory dose by PCA test in rat peritoneal mast cells. | ChEMBL. | 2999403 |
Inhibition (functional) | = 32 % | Percent inhibition by dog hypotension screen assay at 10 ug/Kg per min for 15 min. | ChEMBL. | 2999403 |
Log PR (ADMET) | = -0.4 | log PR value | ChEMBL. | 2455052 |
Potency ratio (functional) | = 0.4 | In vitro inhibition of anti-IgE induced histamine release from bronchoalveolar mast cells of monkey infected with Ascaris suum | ChEMBL. | 2455052 |
Potency ratio (functional) | = 8.47 | Potency ratio of the compound to that of sodium cromoglycate (1.0) using PCA test. | ChEMBL. | 2999403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.