Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0034 | 0.0644 | 0.0644 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.414 | 0.414 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0034 | 0.0644 | 0.0644 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.414 | 0.414 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.032 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0034 | 0.0644 | 0.0644 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.027 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0668 | 0.0668 |
Echinococcus multilocularis | musashi | 0.0026 | 0.032 | 0.032 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0103 | 0.3351 | 0.3351 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0034 | 0.0644 | 0.0644 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0034 | 0.0644 | 0.0644 |
Schistosoma mansoni | coup transcription factor | 0.0034 | 0.0644 | 0.0644 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0034 | 0.0644 | 0.0644 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | nuclear hormone receptor | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | amidase | 0.0103 | 0.3351 | 0.3351 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0034 | 0.0644 | 0.0644 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.027 | 1 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.032 | 0.032 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0034 | 0.0644 | 0.0644 |
Echinococcus granulosus | FTZ F1 alpha | 0.0034 | 0.0644 | 0.0644 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0034 | 0.0644 | 0.0644 |
Schistosoma mansoni | amidase | 0.0103 | 0.3351 | 0.3351 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0668 | 0.0668 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0034 | 0.0644 | 0.0644 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0034 | 0.0644 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0034 | 0.0644 | 0.0644 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0103 | 0.3351 | 0.3351 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0111 | 0.3692 | 0.3692 |
Brugia malayi | nuclear receptor NHR-88 | 0.0034 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.032 | 0.032 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0127 | 0.4308 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0034 | 0.0644 | 0.0644 |
Echinococcus multilocularis | lamin | 0.0026 | 0.032 | 0.032 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.032 | 0.032 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0034 | 0.0644 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0034 | 0.0644 | 0.0644 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0111 | 0.3692 | 0.3692 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.3351 | 0.3351 |
Schistosoma mansoni | lamin | 0.0026 | 0.032 | 0.032 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0111 | 0.3692 | 0.3692 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0034 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0644 | 0.0644 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0034 | 0.0644 | 0.0644 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.027 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.032 | 0.032 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0034 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0034 | 0.0644 | 0.0644 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0668 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.0151 | 0.0151 |
Echinococcus multilocularis | protein patched | 0.0111 | 0.3692 | 0.3692 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0034 | 0.0644 | 0.0644 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0668 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0668 | 0.0668 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0034 | 0.0644 | 0.0644 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0111 | 0.3692 | 0.3692 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0034 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0034 | 0.0644 | 0.0644 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0103 | 0.3351 | 0.3351 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.032 | 0.032 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0111 | 0.3692 | 0.3692 |
Echinococcus granulosus | lamin | 0.0026 | 0.032 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | CHE-14 protein | 0.0111 | 0.3692 | 0.3692 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0111 | 0.3692 | 0.3692 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0034 | 0.0644 | 0.0644 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0034 | 0.0644 | 0.0644 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0034 | 0.0644 | 0.0644 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0034 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.3692 | 0.3692 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.0151 | 0.0151 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.032 | 0.032 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.027 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.027 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.027 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.027 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0034 | 0.0644 | 0.0644 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0034 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | ecdysteroid receptor | 0.0034 | 0.0644 | 0.0644 |
Schistosoma mansoni | thyroid hormone receptor | 0.0157 | 0.5506 | 0.5506 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0644 | 0.0644 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0111 | 0.3692 | 0.3692 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.414 | 0.414 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | steroid hormone receptor | 0.0034 | 0.0644 | 0.0644 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0034 | 0.0644 | 0.0644 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0668 | 0.0668 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0644 | 0.0644 |
Schistosoma mansoni | nuclear hormone receptor | 0.0034 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0034 | 0.0644 | 0.0644 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0668 | 0.0668 |
Schistosoma mansoni | patched 1 | 0.0111 | 0.3692 | 0.3692 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.032 | 0.032 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0034 | 0.0644 | 0.0644 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0034 | 0.0644 | 0.0644 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0668 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0127 | 0.4308 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0034 | 0.0644 | 0.0644 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.027 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0034 | 0.0644 | 0.0644 |
Schistosoma mansoni | lamin | 0.0026 | 0.032 | 0.032 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0668 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0103 | 0.3351 | 0.3351 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0034 | 0.0644 | 0.0644 |
Onchocerca volvulus | 0.0034 | 0.0644 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0034 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0301 | 0.0301 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0127 | 0.4308 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0157 | 0.5506 | 0.5506 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.032 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.035 | 0.035 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0127 | 0.4308 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0157 | 0.5506 | 0.5506 |
Echinococcus multilocularis | protein dispatched 1 | 0.0111 | 0.3692 | 0.3692 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0034 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0034 | 0.0644 | 0.0644 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0034 | 0.0644 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0103 | 0.3351 | 0.3351 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Immobility (functional) | = 13 % | Evaluated for catalepsy activity in mice and percentage immobility was determined at a concentration of 0 mg/Kg. | ChEMBL. | 2158563 |
Immobility (functional) | = 13 % | Evaluated for catalepsy activity in mice and percentage immobility was determined at a concentration of 0 mg/Kg. | ChEMBL. | 2158563 |
Immobility (functional) | = 16 % | Evaluated for catalepsy activity in mice and percentage immobility was determined at a concentration of 5 mg/Kg. | ChEMBL. | 2158563 |
Immobility (functional) | = 16 % | Evaluated for catalepsy activity in mice and percentage immobility was determined at a concentration of 5 mg/Kg. | ChEMBL. | 2158563 |
Immobility (functional) | = 20 % | Evaluated for catalepsy activity in mice and percentage immobility was determined at a concentration of 3 mg/kg. | ChEMBL. | 2158563 |
Immobility (functional) | = 20 % | Evaluated for catalepsy activity in mice and percentage immobility was determined at a concentration of 3 mg/kg. | ChEMBL. | 2158563 |
Spont activity (functional) | = 35 Counts 10min-1 | Evaluated for reduction in spontaneous locomotor activity in mice at a dose of 3 mg/Kg | ChEMBL. | 2158563 |
Spont activity (functional) | = 35 Counts 10min-1 | Evaluated for reduction in spontaneous locomotor activity in mice at a dose of 5 mg/Kg | ChEMBL. | 2158563 |
Spont activity (functional) | = 35 Counts 10min-1 | Evaluated for reduction in spontaneous locomotor activity in mice at a dose of 3 mg/Kg | ChEMBL. | 2158563 |
Spont activity (functional) | = 35 Counts 10min-1 | Evaluated for reduction in spontaneous locomotor activity in mice at a dose of 5 mg/Kg | ChEMBL. | 2158563 |
Spont activity (functional) | = 52 Counts 10min-1 | Evaluated for reduction in spontaneous locomotor activity in mice, at a dose of 0 mg/Kg | ChEMBL. | 2158563 |
Spont activity (functional) | = 52 Counts 10min-1 | Evaluated for reduction in spontaneous locomotor activity in mice, at a dose of 0 mg/Kg | ChEMBL. | 2158563 |
Tail flick latency (functional) | = 1 s | Tail-flick latency was determined at a concentration of 0 mg/Kg. | ChEMBL. | 2158563 |
Tail flick latency (functional) | = 1 s | Tail-flick latency was determined at a concentration of 0 mg/Kg. | ChEMBL. | 2158563 |
Tail flick latency (functional) | = 2.2 s | Tail-flick latency was determined at a concentration of 5 mg/Kg. | ChEMBL. | 2158563 |
Tail flick latency (functional) | = 2.2 s | Tail-flick latency was determined at a concentration of 5 mg/Kg. | ChEMBL. | 2158563 |
Tail flick latency (functional) | < 2.8 s | Tail-flick latency was determined at a concentration of 3 mg/Kg. | ChEMBL. | 2158563 |
Tail flick latency (functional) | < 2.8 s | Tail-flick latency was determined at a concentration of 3 mg/Kg. | ChEMBL. | 2158563 |
Temperature (functional) | = -1.5 degrees C | Evaluated for hypothermic activity in mice at a dose of 3 mg/Kg. | ChEMBL. | 2158563 |
Temperature (functional) | = -1.5 degrees C | Evaluated for hypothermic activity in mice at a dose of 3 mg/Kg. | ChEMBL. | 2158563 |
Temperature (functional) | = -0.9 degrees C | Evaluated for hypothermic activity in mice at a dose of 0 mg/Kg. | ChEMBL. | 2158563 |
Temperature (functional) | = -0.9 degrees C | Evaluated for hypothermic activity in mice at a dose of 0 mg/Kg. | ChEMBL. | 2158563 |
Temperature (functional) | = -0.7 degrees C | Evaluated for hypothermic activity in mice at a dose of 5 mg/Kg. | ChEMBL. | 2158563 |
Temperature (functional) | = -0.7 degrees C | Evaluated for hypothermic activity in mice at a dose of 5 mg/Kg. | ChEMBL. | 2158563 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.