Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Duration (functional) | = 0 min | Amount of time during which increase in administered orally in conscious dogs at 1 mg/kg | ChEMBL. | 2544724 |
ED1.5 (functional) | NT 0 mg kg-1 | Effective dose required to produce an increase in dP/dt5 by 1500 mmHg/s in dogs;NT means not tested. | ChEMBL. | 2544724 |
ED1.5 (functional) | = 0.15 mg kg-1 | Effective dose required to produce an increase in dP/dt5 by 1500 mmHg/s in cats | ChEMBL. | 2544724 |
ED1.5 (functional) | = 0.37 mg kg-1 | Effective dose required to produce an increase in dP/dt5 by 1500 mmHg/s in rats | ChEMBL. | 2544724 |
Max (functional) | ND 0 mmHg s-1 | Maximum increase in dP/dt when administered intravenously in dogs; ND means no data. | ChEMBL. | 2544724 |
Max (functional) | = 0 mmHg s-1 | Maximum increase in dP/dt60 when administered orally in dogs at dose 1 mg/kg. | ChEMBL. | 2544724 |
Max (functional) | = 3 mmHg s-1 | Maximum increase in dP/dt when administered intravenously in cats at 3 mg/kg dose. | ChEMBL. | 2544724 |
Max (functional) | = 4.2 mmHg s-1 | Maximum increase in dP/dt when administered intravenously in rats at 10 mg/kg dose. | ChEMBL. | 2544724 |
Time (functional) | ND 0 min | Time after which maximum increase in contractility was observed when administered orally in conscious dogs at 1 mg/kg; ND means no data. | ChEMBL. | 2544724 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.