Detailed information for compound 47852

Basic information

Technical information
  • TDR Targets ID: 47852
  • Name: 2-bromo-N-[3,4,5-trihydroxy-6-(hydroxymethyl) oxan-2-yl]acetamide
  • MW: 300.104 | Formula: C8H14BrNO6
  • H donors: 5 H acceptors: 5 LogP: -1.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(NC(=O)CBr)C(C(C1O)O)O
  • InChi: 1S/C8H14BrNO6/c9-1-4(12)10-8-7(15)6(14)5(13)3(2-11)16-8/h3,5-8,11,13-15H,1-2H2,(H,10,12)
  • InChiKey: FBDRYZFAXBPZEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-bromo-N-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]acetamide
  • 2-bromo-N-[3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]acetamide
  • 2-bromo-N-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethanamide
  • 2-bromo-N-(3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl)acetamide
  • 33758-19-9
  • NSC302383

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nephrin 0.0012 0.0146 0.0146
Brugia malayi neuropeptide F receptor 0.0032 0.1415 0.1415
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Schistosoma mansoni hypothetical protein 0.0032 0.1415 0.1415
Leishmania major adenine aminohydrolase 0.017 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.1415 0.1415
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.1415 0.1415
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.1415 0.1415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.1415 0.1415
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.1415 0.1415
Trypanosoma cruzi AMP deaminase 2, putative 0.0055 0.2871 0.5
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0055 0.2871 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.1415 0.1415
Echinococcus granulosus allatostatin A receptor 0.0032 0.1415 0.1415
Echinococcus granulosus g protein coupled receptor 0.0032 0.1415 0.1415
Echinococcus granulosus neuropeptide s receptor 0.0032 0.1415 0.1415
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.1415 0.1415
Echinococcus multilocularis sex peptide receptor 0.0032 0.1415 0.1415
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.1415 0.1415
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.1415 0.1415
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.017 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0012 0.0187 0.0187
Trypanosoma cruzi AMP deaminase, putative 0.0055 0.2871 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.1415 0.1415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.1415 0.1415
Echinococcus granulosus fmrfamide receptor 0.0032 0.1415 0.1415
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.1415 0.1415
Echinococcus multilocularis neuroglian 0.0012 0.0146 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.1415 0.1415
Plasmodium falciparum adenosine deaminase 0.017 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.1415 0.1415
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Echinococcus granulosus g protein coupled receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.1415 0.1415
Brugia malayi hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0015 0.0333 0.0333
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.1415 0.1415
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0055 0.2871 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0149 0.8734 0.8734
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0187 0.0187
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.1415 0.1415
Echinococcus multilocularis neuropeptide receptor 0.0032 0.1415 0.1415
Brugia malayi hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.1415 0.1415
Brugia malayi G-protein coupled receptor 0.0032 0.1415 0.1415
Brugia malayi Serotonin receptor 0.0032 0.1415 0.1415
Brugia malayi Dopamine receptor protein 2 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus granulosus serotonin receptor 0.0032 0.1415 0.1415
Echinococcus granulosus neuroglian 0.0012 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0055 0.2871 0.2871
Brugia malayi ORL1-like opioid receptor 0.0032 0.1415 0.1415
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.1415 0.1415
Trypanosoma cruzi AMP deaminase, putative 0.0055 0.2871 0.5
Echinococcus multilocularis fmrfamide receptor 0.0032 0.1415 0.1415
Schistosoma mansoni myosin xvIII 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.1415 0.1415
Schistosoma mansoni hypothetical protein 0.0032 0.1415 0.1415
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Brugia malayi putative neuropeptide receptor 0.0032 0.1415 0.1415
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.1415 0.1415
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.1415 0.1415
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.1415 0.1415
Brugia malayi Immunoglobulin I-set domain containing protein 0.0149 0.8734 0.8734
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.1415 0.1415
Trichomonas vaginalis adenosine deaminase, putative 0.017 1 0.5
Echinococcus multilocularis serotonin receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Trypanosoma cruzi AMP deaminase, putative 0.0055 0.2871 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.1415 0.1415
Onchocerca volvulus 0.0136 0.7923 0.7581
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.1415 0.1415
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.1415 0.1415
Schistosoma mansoni opsin-like receptor 0.0032 0.1415 0.1415
Echinococcus granulosus sex peptide receptor 0.0032 0.1415 0.1415
Echinococcus granulosus AMP deaminase 2 0.0055 0.2871 0.2871
Echinococcus granulosus g-protein coupled receptor 0.0032 0.1415 0.1415
Echinococcus granulosus g protein coupled receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0015 0.0333 0.0333
Loa Loa (eye worm) AMP deaminase 0.0055 0.2871 0.2871
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.1415 0.1415
Brugia malayi hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Schistosoma mansoni neuropeptide receptor 0.0032 0.1415 0.1415
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.1415 0.1415
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.1415 0.1415
Schistosoma mansoni biogenic amine receptor 0.0032 0.1415 0.1415
Schistosoma mansoni amine GPCR 0.0032 0.1415 0.1415
Schistosoma mansoni hypothetical protein 0.0032 0.1415 0.1415
Brugia malayi larval opioid receptor 0.0032 0.1415 0.1415
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.1415 0.1415
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.1415 0.1415
Echinococcus multilocularis somatostatin receptor 0.0032 0.1415 0.1415
Plasmodium vivax adenosine deaminase, putative 0.017 1 1
Brugia malayi G protein-coupled receptor 0.0032 0.1415 0.1415
Echinococcus multilocularis fmrfamide receptor 0.0032 0.1415 0.1415
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.1415 0.1415
Schistosoma mansoni adenoreceptor 0.0032 0.1415 0.1415
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.017 1 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.1415 0.1415
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.1415 0.1415
Schistosoma mansoni neuropeptide receptor 0.0032 0.1415 0.1415
Echinococcus multilocularis roundabout 2 0.0015 0.0333 0.0333
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Trypanosoma brucei AMP deaminase, putative 0.0055 0.2871 0.5
Schistosoma mansoni cell adhesion molecule 0.0012 0.0187 0.0187
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.1415 0.1415
Brugia malayi adenosine monophosphate deaminase 0.0055 0.2871 0.2871
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Schistosoma mansoni opsin-like receptor 0.0032 0.1415 0.1415
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Schistosoma mansoni histamine h1 receptor 0.0032 0.1415 0.1415
Schistosoma mansoni neuropeptide receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.1415 0.1415
Echinococcus granulosus somatostatin receptor 0.0032 0.1415 0.1415
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.1415 0.1415
Schistosoma mansoni adenosine deaminase 0.017 1 1
Trypanosoma cruzi AMP deaminase, putative 0.0055 0.2871 0.5
Echinococcus multilocularis adenosine deaminase 0.017 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.1415 0.1415
Schistosoma mansoni AMP deaminase 0.0055 0.2871 0.2871
Brugia malayi GnHR receptor homolog 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus multilocularis g protein coupled receptor 0.0032 0.1415 0.1415
Echinococcus granulosus neuropeptide receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Schistosoma mansoni neuropeptide receptor 0.0032 0.1415 0.1415
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.1415 0.1415
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.1415 0.1415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Echinococcus multilocularis serotonin receptor 0.0032 0.1415 0.1415
Brugia malayi hypothetical protein 0.0032 0.1415 0.1415
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.1415 0.1415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.1415 0.1415
Echinococcus multilocularis neuropeptide receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.1415 0.1415
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.1415 0.1415
Brugia malayi AKH receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.017 1 1
Echinococcus granulosus adenosine deaminase 0.017 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.1415 0.1415
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.1415 0.1415
Brugia malayi hypothetical protein 0.0032 0.1415 0.1415
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.1415 0.1415
Brugia malayi Serotonin receptor 0.0032 0.1415 0.1415
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.1415 0.1415
Onchocerca volvulus Adenosine deaminase homolog 0.017 1 1
Schistosoma mansoni biogenic amine receptor 0.0032 0.1415 0.1415
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0055 0.2871 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.1415 0.1415
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.1415 0.1415
Echinococcus granulosus orexin receptor type 2 0.0032 0.1415 0.1415
Echinococcus multilocularis allatostatin A receptor 0.0032 0.1415 0.1415
Schistosoma mansoni opsin-like receptor 0.0032 0.1415 0.1415
Schistosoma mansoni biogenic amine receptor 0.0032 0.1415 0.1415
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.1415 0.1415
Echinococcus granulosus roundabout 2 0.0015 0.0333 0.0333
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.1415 0.1415
Echinococcus multilocularis AMP deaminase 2 0.0055 0.2871 0.2871
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Schistosoma mansoni amine GPCR 0.0032 0.1415 0.1415
Echinococcus multilocularis g protein coupled receptor 0.0032 0.1415 0.1415
Brugia malayi hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.017 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Trichomonas vaginalis adenosine deaminase, putative 0.017 1 0.5
Schistosoma mansoni adenosine deaminase-related 0.017 1 1
Schistosoma mansoni amine GPCR 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Brugia malayi sulfakinin receptor protein 0.0032 0.1415 0.1415
Brugia malayi Dopamine receptor 0.0032 0.1415 0.1415
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.1415 0.1415
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0114 0.6556 0.6556
Entamoeba histolytica adenosine deaminase, putative 0.017 1 1
Brugia malayi G-protein coupled receptor 0.0032 0.1415 0.1415
Schistosoma mansoni amine GPCR 0.0032 0.1415 0.1415
Onchocerca volvulus Tyrosine kinase homolog 0.014 0.8121 0.7812
Schistosoma mansoni hypothetical protein 0.0032 0.1415 0.1415
Treponema pallidum adenosine deaminase 0.017 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.1415 0.1415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Brugia malayi Dopamine receptor protein 1 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Brugia malayi hypothetical protein 0.0032 0.1415 0.1415
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.1415 0.1415
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.1415 0.1415
Brugia malayi Melatonin receptor type 1A 0.0032 0.1415 0.1415
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.1415 0.1415
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.017 1 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.1415 0.1415
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.1415 0.1415
Echinococcus multilocularis g protein coupled receptor 0.0032 0.1415 0.1415
Onchocerca volvulus 0.0055 0.2871 0.1697
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Trypanosoma brucei AMP deaminase, putative 0.0055 0.2871 0.5
Brugia malayi RE15519p 0.0032 0.1415 0.1415
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.1415 0.1415
Entamoeba histolytica adenosine deaminase, putative 0.017 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.1415 0.1415
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.1415 0.1415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Trypanosoma cruzi AMP deaminase, putative 0.0055 0.2871 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0114 0.6556 0.6556
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.1415 0.1415
Brugia malayi hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.1415 0.1415
Echinococcus granulosus twitchin 0.0012 0.0146 0.0146
Echinococcus granulosus neuropeptide receptor 0.0032 0.1415 0.1415
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.1415 0.1415
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.1415 0.1415
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.1415 0.1415
Brugia malayi hypothetical protein 0.0032 0.1415 0.1415
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0032 0.1415 0.1415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.1415 0.1415
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Brugia malayi neuropeptide F receptor 0.0032 0.1415 0.1415
Brugia malayi hypothetical protein 0.0032 0.1415 0.1415
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.1415 0.1415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.1415 0.1415
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.1415 0.1415
Trypanosoma brucei AMP deaminase, putative 0.0055 0.2871 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Mycobacterium ulcerans adenosine deaminase 0.017 1 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Echinococcus multilocularis orexin receptor type 2 0.0032 0.1415 0.1415
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.1415 0.1415
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.1415 0.1415
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.1415 0.1415
Brugia malayi follicle stimulating hormone receptor 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Onchocerca volvulus AMP deaminase 2 homolog 0.0055 0.2871 0.1697
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.1415 0.1415
Schistosoma mansoni amine GPCR 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0114 0.6556 0.6556
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.1415 0.1415
Echinococcus granulosus hypothetical protein 0.0032 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0114 0.6556 0.6556

Activities

Activity type Activity value Assay description Source Reference
-Log Ki (binding) = 4.357 Inhibitory activity against glycogen phosphorylase, activity expressed as -logKi ChEMBL. 12502357
Ki (binding) = 0.044 mM Inhibition of rabbit glycogen phosphorylase B enzyme ChEMBL. 9154968
Ki (binding) = 0.044 mM The compound was evaluated for the inhibition of glycogen phosphorylase ChEMBL. 10377222
Log Ki (binding) = 4.36 mM Inhibitory activity against rabbit muscle glycogen phosphorylase ChEMBL. 9406599

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.