Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0655 | 0.0627 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.004 | 0.0144 | 0.0231 |
Schistosoma mansoni | thyroid hormone receptor | 0.004 | 0.0144 | 0.0106 |
Plasmodium vivax | endoplasmin, putative | 0.0045 | 0.0191 | 0.1074 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0191 | 0.2154 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0078 | 0.0533 | 0.0498 |
Schistosoma mansoni | hypothetical protein | 0.0289 | 0.2693 | 0.2665 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0191 | 0.2154 |
Schistosoma mansoni | thyroid hormone receptor | 0.004 | 0.0144 | 0.0106 |
Brugia malayi | heat shock protein 90 | 0.0045 | 0.0191 | 0.0334 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Plasmodium falciparum | endoplasmin, putative | 0.0032 | 0.0066 | 0.045 |
Echinococcus granulosus | tar DNA binding protein | 0.0188 | 0.1655 | 0.163 |
Brugia malayi | Endoplasmin precursor | 0.0045 | 0.0191 | 0.0334 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.004 | 0.0144 | 0.0231 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0261 | 0.2407 | 0.2378 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0814 | 0.8062 | 0.8054 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0169 | 0.1464 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.004 | 0.0144 | 0.0114 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.0746 | 0.0711 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0478 | 0.462 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.019 | 0.0152 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.004 | 0.0144 | 0.0231 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0128 | 0.1045 | 0.2198 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.004 | 0.0144 | 0.0231 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0099 | 0.0749 | 0.5114 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.004 | 0.0144 | 0.0231 |
Brugia malayi | nuclear receptor NHR-88 | 0.004 | 0.0144 | 0.0231 |
Brugia malayi | hypothetical protein | 0.0064 | 0.0389 | 0.0767 |
Loa Loa (eye worm) | TAR-binding protein | 0.0188 | 0.1655 | 0.353 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0144 | 0.0231 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.1655 | 0.1624 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.004 | 0.0144 | 0.0231 |
Onchocerca volvulus | 0.0238 | 0.2167 | 0.4647 | |
Schistosoma mansoni | heat shock protein | 0.0045 | 0.0191 | 0.0154 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.004 | 0.0144 | 0.0231 |
Echinococcus multilocularis | tar DNA binding protein | 0.0188 | 0.1655 | 0.1624 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0074 | 0.0037 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0222 | 0.0401 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.2121 | 0.2091 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.004 | 0.0144 | 0.0106 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0655 | 0.062 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.004 | 0.0144 | 0.0114 |
Mycobacterium ulcerans | proteasome PrcA | 0.082 | 0.8117 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.1655 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0993 | 0.2084 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0655 | 0.062 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.004 | 0.0144 | 0.0231 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.004 | 0.0144 | 0.0114 |
Leishmania major | hypothetical protein, conserved | 0.0099 | 0.0749 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0169 | 0.0139 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.004 | 0.0144 | 0.0231 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0078 | 0.0533 | 0.0498 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0749 | 0.1551 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0045 | 0.0191 | 0.0334 |
Entamoeba histolytica | hypothetical protein | 0.0213 | 0.1914 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.004 | 0.0144 | 0.0106 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0655 | 0.062 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0041 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0144 | 0.0231 |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.1872 | 0.4003 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0045 | 0.0191 | 0.0816 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.0993 | 0.2084 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.004 | 0.0144 | 0.0231 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Echinococcus granulosus | heat shock protein 90 | 0.0038 | 0.0125 | 0.0095 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.0746 | 0.0718 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0045 | 0.0191 | 0.2154 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Echinococcus granulosus | heat shock protein 90 | 0.0045 | 0.0191 | 0.0161 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.004 | 0.0144 | 0.0231 |
Trichomonas vaginalis | endoplasmin, putative | 0.0032 | 0.0066 | 0.0304 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0078 | 0.0533 | 0.1082 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.0655 | 0.1347 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0078 | 0.0533 | 0.3476 |
Loa Loa (eye worm) | RNA binding protein | 0.0188 | 0.1655 | 0.353 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0169 | 0.0285 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.004 | 0.0144 | 0.0106 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0099 | 0.0749 | 0.4984 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.082 | 0.8117 | 1 |
Echinococcus multilocularis | endoplasmin | 0.0042 | 0.0163 | 0.0126 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0045 | 0.0191 | 0.2154 |
Trichomonas vaginalis | heat shock protein, putative | 0.0042 | 0.0163 | 0.0752 |
Echinococcus granulosus | X box binding protein 1 | 0.0289 | 0.2693 | 0.2671 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.2121 | 0.4547 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0354 | 0.3355 | 0.724 |
Schistosoma mansoni | heat shock protein | 0.0045 | 0.0191 | 0.0154 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0042 | 0.0163 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0099 | 0.0749 | 1 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0261 | 0.2407 | 0.2378 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0191 | 0.2154 |
Onchocerca volvulus | 0.004 | 0.0144 | 0.0231 | |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0045 | 0.0191 | 0.2154 |
Schistosoma mansoni | hypothetical protein | 0.1004 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0191 | 0.2154 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0852 | 0.1777 |
Schistosoma mansoni | endoplasmin | 0.0045 | 0.0191 | 0.0154 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.0655 | 0.1347 |
Echinococcus multilocularis | heat shock protein | 0.0045 | 0.0191 | 0.0154 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0191 | 0.2154 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0041 | 0.0008 |
Giardia lamblia | Grp94/Hsp90 | 0.0042 | 0.0163 | 0.5748 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0232 | 0.0423 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.2121 | 0.2098 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0128 | 0.1045 | 0.1018 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0099 | 0.0749 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0144 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0746 | 0.1545 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0038 | 0.0125 | 0.1227 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.023 | 0.0193 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0038 | 0.0125 | 0.0095 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.0746 | 0.3773 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0078 | 0.0533 | 0.6974 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.004 | 0.0144 | 0.0114 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.004 | 0.0144 | 0.0106 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0213 | 0.1914 | 0.1884 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0222 | 0.0184 |
Entamoeba histolytica | hypothetical protein | 0.0213 | 0.1914 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.0746 | 0.1545 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0041 | 0.0003 |
Brugia malayi | hypothetical protein | 0.0123 | 0.0993 | 0.2084 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0191 | 0.2154 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.004 | 0.0144 | 0.0231 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0078 | 0.0533 | 0.6974 |
Schistosoma mansoni | hypothetical protein | 0.0213 | 0.1914 | 0.1884 |
Echinococcus multilocularis | heat shock protein 90 | 0.0045 | 0.0191 | 0.0154 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0078 | 0.0533 | 0.3645 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0044 | 0.019 | 0.016 |
Brugia malayi | hypothetical protein | 0.0233 | 0.2121 | 0.4547 |
Brugia malayi | nuclear hormone receptor | 0.004 | 0.0144 | 0.0231 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.004 | 0.0144 | 0.0106 |
Brugia malayi | steroid hormone receptor | 0.004 | 0.0144 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0144 | 0.0231 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0261 | 0.2407 | 0.2384 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.004 | 0.0144 | 0.0106 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0078 | 0.0533 | 0.3476 |
Echinococcus multilocularis | geminin | 0.1004 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.004 | 0.0144 | 0.0231 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0169 | 0.0139 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0041 | 0.0003 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.004 | 0.0144 | 0.0114 |
Plasmodium falciparum | heat shock protein 90 | 0.0045 | 0.0191 | 0.1305 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0041 | 0.0011 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0078 | 0.0533 | 0.6974 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0169 | 0.0778 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0074 | 0.008 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.004 | 0.0144 | 0.0106 |
Echinococcus granulosus | FTZ F1 alpha | 0.004 | 0.0144 | 0.0114 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0261 | 0.2407 | 0.5169 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0169 | 0.0131 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0041 | 0.0008 |
Brugia malayi | hypothetical protein | 0.0213 | 0.1914 | 0.4095 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0232 | 0.0423 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0078 | 0.0533 | 0.6974 |
Brugia malayi | hypothetical protein | 0.0099 | 0.0749 | 0.1551 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.2407 | 0.5169 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.004 | 0.0144 | 0.0106 |
Trichomonas vaginalis | heat shock protein, putative | 0.0042 | 0.0163 | 0.0752 |
Trichomonas vaginalis | heat shock protein, putative | 0.0045 | 0.0191 | 0.0881 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0153 | 0.0116 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0188 | 0.1655 | 0.353 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0993 | 0.2084 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0153 | 0.0116 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0655 | 0.062 |
Schistosoma mansoni | hypothetical protein | 0.1004 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0144 | 0.0231 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0141 | 0.118 | 0.1153 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0041 | 0.0024 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0041 | 0.0003 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.01 | 0.0761 | 0.0726 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0213 | 0.1914 | 0.189 |
Echinococcus granulosus | endoplasmin | 0.0042 | 0.0163 | 0.0133 |
Brugia malayi | MH2 domain containing protein | 0.0354 | 0.3355 | 0.724 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0078 | 0.0533 | 0.3476 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0261 | 0.2407 | 0.2384 |
Onchocerca volvulus | 0.003 | 0.0041 | 0.0008 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0232 | 0.0423 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.004 | 0.0144 | 0.0106 |
Brugia malayi | ecdysteroid receptor | 0.004 | 0.0144 | 0.0231 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.004 | 0.0144 | 0.0231 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0045 | 0.0191 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.004 | 0.0144 | 0.0231 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.025 | 0.229 | 0.2261 |
Echinococcus multilocularis | FTZ F1 alpha | 0.004 | 0.0144 | 0.0106 |
Echinococcus granulosus | heat shock protein | 0.0045 | 0.0191 | 0.0161 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0169 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0074 | 0.008 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0041 | 0.0003 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0044 | 0.019 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0153 | 0.0116 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0045 | 0.0191 | 0.2154 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0045 | 0.0191 | 0.2154 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0655 | 0.0627 |
Onchocerca volvulus | 0.0478 | 0.462 | 1 | |
Brugia malayi | Pax transcription factor protein 2 | 0.0478 | 0.462 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.1655 | 0.1624 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.004 | 0.0144 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0144 | 0.0231 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.004 | 0.0144 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0144 | 0.0231 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.004 | 0.0144 | 0.0231 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.0993 | 0.2084 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.1655 | 0.1624 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0078 | 0.0533 | 0.0498 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0099 | 0.0749 | 1 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0169 | 0.1464 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0191 | 0.2154 |
Brugia malayi | TAR-binding protein | 0.0188 | 0.1655 | 0.353 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0099 | 0.0749 | 0.4984 |
Trichomonas vaginalis | heat shock protein, putative | 0.0032 | 0.0066 | 0.0304 |
Onchocerca volvulus | 0.0048 | 0.0222 | 0.0401 | |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.0684 | 0.0649 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0038 | 0.0125 | 0.1227 |
Loa Loa (eye worm) | steroid hormone receptor | 0.004 | 0.0144 | 0.0231 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0078 | 0.0533 | 0.0466 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0078 | 0.0533 | 0.0505 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.004 | 0.0144 | 0.0231 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Schistosoma mansoni | coup transcription factor | 0.004 | 0.0144 | 0.0106 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0078 | 0.0533 | 0.6974 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0232 | 0.0423 |
Entamoeba histolytica | hypothetical protein | 0.0213 | 0.1914 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0042 | 0.0163 | 0.176 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0169 | 0.0285 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.004 | 0.0144 | 0.0114 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.004 | 0.0144 | 0.0231 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0045 | 0.0191 | 0.2154 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0144 | 0.0231 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.004 | 0.0144 | 0.0231 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.1655 | 0.1624 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.004 | 0.0144 | 0.0231 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.0684 | 0.0656 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0045 | 0.0191 | 0.2154 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0078 | 0.0533 | 0.0498 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.004 | 0.0144 | 0.0106 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0169 | 0.0131 |
Trichomonas vaginalis | set domain proteins, putative | 0.0238 | 0.2167 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0107 | 0.0829 | 0.1726 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.004 | 0.0144 | 0.0231 |
Echinococcus granulosus | heat shock protein 75 kDa mitochondrial | 0.003 | 0.0038 | 0.0008 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0078 | 0.0533 | 0.0498 |
Plasmodium vivax | heat shock protein, putative | 0.0169 | 0.1464 | 1 |
Echinococcus multilocularis | X box binding protein 1 | 0.0289 | 0.2693 | 0.2665 |
Plasmodium vivax | heat shock protein 86, putative | 0.0045 | 0.0191 | 0.1074 |
Trichomonas vaginalis | heat shock protein, putative | 0.0038 | 0.0125 | 0.0577 |
Echinococcus multilocularis | heat shock protein 90 | 0.0038 | 0.0125 | 0.0088 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0209 | 0.1872 | 0.4003 |
Loa Loa (eye worm) | endoplasmin | 0.0045 | 0.0191 | 0.0334 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0045 | 0.0191 | 0.2154 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0141 | 0.118 | 0.1146 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.004 | 0.0144 | 0.0231 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.004 | 0.0144 | 0.0106 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0153 | 0.0116 |
Mycobacterium leprae | probable proteasome (alpha subunit) PrcA | 0.082 | 0.8117 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0261 | 0.2407 | 0.2378 |
Schistosoma mansoni | endoplasmin | 0.0045 | 0.0191 | 0.0154 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0354 | 0.3355 | 0.724 |
Treponema pallidum | heat shock protein 90 | 0.0042 | 0.0163 | 0.5 |
Brugia malayi | RNA binding protein | 0.0188 | 0.1655 | 0.353 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0128 | 0.1045 | 0.1011 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.004 | 0.0144 | 0.0106 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0191 | 0.2154 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.004 | 0.0144 | 0.0231 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0045 | 0.0191 | 0.1074 |
Brugia malayi | Isocitrate dehydrogenase | 0.0078 | 0.0533 | 0.1082 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0045 | 0.0191 | 0.0816 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0169 | 0.0131 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.004 | 0.0144 | 0.0106 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0041 | 0.0024 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0041 | 0.0003 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0078 | 0.0533 | 0.0498 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.004 | 0.0144 | 0.0106 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0099 | 0.0749 | 0.5114 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0655 | 0.062 |
Entamoeba histolytica | hypothetical protein | 0.0213 | 0.1914 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.004 | 0.0144 | 0.0106 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0222 | 0.0184 |
Brugia malayi | isocitrate dehydrogenase | 0.0078 | 0.0533 | 0.1082 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0266 | 0.0498 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0188 | 0.1655 | 0.353 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.004 | 0.0144 | 0.0231 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.004 | 0.0144 | 0.0231 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0045 | 0.0191 | 0.1074 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0213 | 0.1914 | 0.1884 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0191 | 0.2154 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.004 | 0.0144 | 0.0106 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
behavior (functional) | Gross behavioral effects ascertained in mice; W/C indicates weak stimulant or depressant activity of little significance/ overt convulsant | ChEMBL. | 3039136 | |
behavior (functional) | W/C 0 | Gross behavioral effects ascertained in mice; W/C indicates weak stimulant or depressant activity of little significance/ overt convulsant | ChEMBL. | 3039136 |
ED50 (functional) | mg kg-1 | Ability to antagonise intraperitoneal dose; inactive (<10% antagonism) at 30 mgjkg is represented as I-30. | ChEMBL. | 3039136 |
ED50 (functional) | mg kg-1 | Ability to antagonise intraperitoneal dose; inactive (<10% antagonism) at 30 mg/kg is represented as I-30. | ChEMBL. | 3039136 |
ED50 (functional) | I-30 0 mg kg-1 | Ability to antagonise intraperitoneal dose; inactive (<10% antagonism) at 30 mg/kg is represented as I-30. | ChEMBL. | 3039136 |
ED50 (functional) | I-30 0 mg kg-1 | Ability to antagonise intraperitoneal dose; inactive (<10% antagonism) at 30 mgjkg is represented as I-30. | ChEMBL. | 3039136 |
Inhibition (functional) | = -10 % | Ability to inhibit the uptake of [3H]- serotonin(5-HT) 0.1 microM concentration at rat brain synaptosomes | ChEMBL. | 3039136 |
Inhibition (functional) | = -10 % | Ability to inhibit the uptake of [3H]- serotonin(5-HT) 0.1 microM concentration at rat brain synaptosomes | ChEMBL. | 3039136 |
Inhibition (functional) | = 1 % | Ability to inhibit the uptake of [3H]-norepinephrine (NE) 0.1 microM concentration at rat brain synaptosomes | ChEMBL. | 3039136 |
Inhibition (functional) | = 1 % | Ability to inhibit the uptake of [3H]-norepinephrine (NE) 0.1 microM concentration at rat brain synaptosomes | ChEMBL. | 3039136 |
Inhibition (functional) | = 18 % | Ability to inhibit the uptake of tritiated dopamine (DA) 1 uM concentration | ChEMBL. | 3039136 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.