Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0993 | 0.1654 | 0.1654 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0352 | 0.0558 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0993 | 0.1654 | 0.1654 |
Echinococcus multilocularis | carboxylesterase 5A | 0.5879 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0993 | 0.1654 | 0.1654 |
Echinococcus granulosus | acetylcholinesterase | 0.5879 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0091 | 0.0111 | 0.0111 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0038 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0993 | 0.1654 | 0.1654 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0214 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.5879 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0993 | 0.1654 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 0.0558 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0993 | 0.1654 | 0.1654 |
Schistosoma mansoni | lipoxygenase | 0.0065 | 0.0067 | 0.0067 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0065 | 0.0068 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0993 | 0.1654 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0165 | 0.0239 | 0.0239 |
Loa Loa (eye worm) | hypothetical protein | 0.5879 | 1 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.017 | 0.0247 | 0.0247 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0065 | 0.0067 | 0.0067 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0038 | 0.0022 | 0.0022 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.005 | 0.0042 | 0.0042 |
Brugia malayi | hypothetical protein | 0.0993 | 0.1654 | 0.1654 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0993 | 0.1654 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0046 | 0.0035 | 0.5 |
Onchocerca volvulus | 0.0993 | 0.1654 | 1 | |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0071 | 0.0078 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0993 | 0.1654 | 0.1654 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0065 | 0.0067 | 0.0067 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0038 | 0.0022 | 0.0022 |
Schistosoma mansoni | gliotactin | 0.0993 | 0.1654 | 0.1654 |
Loa Loa (eye worm) | hypothetical protein | 0.0993 | 0.1654 | 0.1654 |
Echinococcus multilocularis | acetylcholinesterase | 0.5879 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.0011 | 0.0011 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0993 | 0.1654 | 0.1654 |
Loa Loa (eye worm) | carboxylesterase | 0.5879 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0993 | 0.1654 | 0.1654 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0993 | 0.1654 | 0.1654 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0993 | 0.1654 | 0.1654 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0078 | 0.0078 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0078 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.0294 | 0.0294 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0993 | 0.1654 | 0.1654 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0214 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.001 | 0.001 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0011 | 0.0011 |
Echinococcus multilocularis | musashi | 0.0032 | 0.0011 | 0.0011 |
Brugia malayi | Carboxylesterase family protein | 0.0993 | 0.1654 | 0.1654 |
Onchocerca volvulus | 0.0993 | 0.1654 | 1 | |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0038 | 0.0022 | 0.0022 |
Schistosoma mansoni | acetylcholinesterase | 0.0993 | 0.1654 | 0.1654 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0078 | 0.0064 |
Onchocerca volvulus | 0.0993 | 0.1654 | 1 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0993 | 0.1654 | 0.1654 |
Loa Loa (eye worm) | carboxylesterase | 0.0993 | 0.1654 | 0.1654 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0352 | 0.0558 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0038 | 0.0022 | 0.0022 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0167 | 0.0241 | 0.3871 |
Brugia malayi | Cytochrome P450 family protein | 0.0057 | 0.0054 | 0.0054 |
Echinococcus granulosus | geminin | 0.0197 | 0.0294 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0993 | 0.1654 | 0.1654 |
Echinococcus granulosus | acetylcholinesterase | 0.5879 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.5879 | 1 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.017 | 0.0247 | 0.0247 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0091 | 0.0111 | 0.0111 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.017 | 0.0247 | 0.0247 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0065 | 0.0068 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0993 | 0.1654 | 0.1654 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.0241 | 0.3871 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.017 | 0.0247 | 0.0247 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.0078 | 0.0078 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0091 | 0.0111 | 0.0111 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.005 | 0.0042 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0185 | 0.0273 | 0.1294 |
Onchocerca volvulus | 0.0993 | 0.1654 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0993 | 0.1654 | 0.1654 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.0053 | 0.3206 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0046 | 0.0035 | 0.5 |
Schistosoma mansoni | lamin | 0.0032 | 0.0011 | 0.0011 |
Chlamydia trachomatis | glutamine binding protein | 0.0065 | 0.0068 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0993 | 0.1654 | 0.1654 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0993 | 0.1654 | 0.1654 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.5879 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5879 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0993 | 0.1654 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.0011 | 0.0011 |
Echinococcus granulosus | glutamate receptor 2 | 0.0038 | 0.0022 | 0.0022 |
Echinococcus granulosus | carboxylesterase 5A | 0.5879 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.006 | 0.006 | 0.0358 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0993 | 0.1654 | 1 |
Echinococcus granulosus | lamin | 0.0032 | 0.0011 | 0.0011 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.0241 | 0.3397 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.0294 | 0.0294 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0185 | 0.0273 | 0.1294 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0038 | 0.0022 | 0.0022 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0993 | 0.1654 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0993 | 0.1654 | 0.1654 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0038 | 0.0022 | 0.0022 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.0011 | 0.0011 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.0011 | 0.0011 |
Echinococcus granulosus | neuroligin | 0.0993 | 0.1654 | 0.1654 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0046 | 0.0035 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.0078 | 1 |
Schistosoma mansoni | lamin | 0.0032 | 0.0011 | 0.0011 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0065 | 0.0068 | 0.5 |
Echinococcus multilocularis | geminin | 0.0197 | 0.0294 | 0.0294 |
Echinococcus multilocularis | lamin | 0.0032 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0078 | 0.0064 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0993 | 0.1654 | 0.1654 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0038 | 0.0022 | 0.0022 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.0011 | 0.0011 |
Brugia malayi | Carboxylesterase family protein | 0.0993 | 0.1654 | 0.1654 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0038 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | carboxylesterase | 0.0993 | 0.1654 | 0.1654 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0057 | 0.0054 | 0.0054 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.0078 | 0.0078 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0038 | 0.0022 | 0.0022 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.0011 | 0.0011 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.5879 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0011 | 0.0011 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0214 | 0.0323 | 0.0323 |
Echinococcus multilocularis | neuroligin | 0.0993 | 0.1654 | 0.1654 |
Onchocerca volvulus | 0.0993 | 0.1654 | 1 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 0.0558 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 1 % | Inhibition of chick optic lobe choline acetyltransferase (ChAT) at 10e-4 M | ChEMBL. | No reference |
Inhibition (binding) | < 1 % | Inhibition of chick optic lobe choline acetyltransferase (ChAT) at 10e-4 M | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.