Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.035 uM | Inhibition of Dihydrohydrofolate reductase(DHFR) of Mycobacterium avium | ChEMBL. | 12699390 |
IC50 (binding) | = 0.035 uM | Inhibition of Dihydrohydrofolate reductase(DHFR) of Mycobacterium avium | ChEMBL. | 12699390 |
IC50 (binding) | = 0.058 uM | Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondii | ChEMBL. | 12699390 |
IC50 (binding) | = 0.058 uM | Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondii | ChEMBL. | 12699390 |
IC50 (binding) | = 0.15 uM | Inhibition of Dihydrohydrofolate reductase(DHFR) of Pneumocystis carinii | ChEMBL. | 12699390 |
IC50 (binding) | = 0.15 uM | Inhibition of Dihydrohydrofolate reductase(DHFR) of Pneumocystis carinii | ChEMBL. | 12699390 |
IC50 (binding) | = 3.2 uM | Inhibition Dihydrohydrofolate reductase(DHFR) of rat liver | ChEMBL. | 12699390 |
IC50 (binding) | = 3.2 uM | Inhibition Dihydrohydrofolate reductase(DHFR) of rat liver | ChEMBL. | 12699390 |
MIC (functional) | > 32 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC100 | ChEMBL. | 14998335 |
MIC (functional) | > 32 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC101 | ChEMBL. | 14998335 |
MIC (functional) | > 32 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC108 | ChEMBL. | 14998335 |
MIC (functional) | > 32 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC109 | ChEMBL. | 14998335 |
MIC (functional) | > 32 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC116 | ChEMBL. | 14998335 |
Selectivity index (binding) | = 21 | Relative affinity for Dihydrofolate reductase from rat liver and P. carinii | ChEMBL. | 12699390 |
Selectivity index (binding) | = 54 | Selective index for Dihydrofolate reductase was determined by IC50(rat liver) / IC50(T. gondii) | ChEMBL. | 12699390 |
Selectivity index (binding) | = 91 | Relative affinity for Dihydrofolate reductase of rat liver and Mycobacterium avium | ChEMBL. | 12699390 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.