Detailed information for compound 48308

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 579.576 | Formula: C18H37N5O14S--
  • H donors: 11 H acceptors: 10 LogP: -8.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 3
  • SMILES: [O-]S(=O)(=O)[O-].OCC1OC(OC2C(N)CC(C(C2O)OC2OC(CN)C(C(C2N)O)O)N)C(C(C1O)N)O
  • InChi: 1S/C18H37N5O10.H2O4S/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18;1-5(2,3)4/h4-18,24-29H,1-3,19-23H2;(H2,1,2,3,4)/p-2
  • InChiKey: YGTPKDKJVZOVCO-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii LsmAD domain-containing protein 0.0345 0.0758 0.261
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0403 0.0806
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0243 0.0515 0.1773
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0052 0.0104
Echinococcus multilocularis tar DNA binding protein 0.0902 0.2096 0.2096
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0243 0.0515 0.1724
Onchocerca volvulus 0.0139 0.0265 0.1127
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0052 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Brugia malayi proteasome subunit alpha type 2 0.0243 0.0515 0.0624
Loa Loa (eye worm) hypothetical protein 0.0103 0.0177 0.0215
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0243 0.0515 0.0916
Brugia malayi 20S proteasome alpha5 subunit 0.0243 0.0515 0.0624
Echinococcus multilocularis Niemann Pick C1 protein 0.0196 0.04 0.04
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0243 0.0515 0.0515
Echinococcus multilocularis proteasome subunit alpha type 6 0.0243 0.0515 0.0515
Onchocerca volvulus 0.0077 0.0115 0.0476
Schistosoma mansoni lamin 0.0033 0.0009 0.0015
Brugia malayi MH1 domain containing protein 0.013 0.0242 0.0293
Brugia malayi protein ZK524.3 0.0086 0.0137 0.0166
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0573 0.1306 0.4497
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0052 0.0063
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0243 0.0515 0.1773
Schistosoma mansoni topbp1 0.008 0.0123 0.0218
Leishmania major proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.008 0.0123 0.0422
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0243 0.0515 0.1724
Loa Loa (eye worm) isocitrate dehydrogenase 0.0371 0.0821 0.0994
Loa Loa (eye worm) proteasome subunit beta type 2 0.0596 0.1362 0.165
Echinococcus multilocularis geminin 0.0725 0.1672 0.1672
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0052 0.0063
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0637 0.146 0.5025
Schistosoma mansoni survival motor neuron protein 0.0048 0.0045 0.0079
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0052 0.0052
Loa Loa (eye worm) TAR-binding protein 0.0902 0.2096 0.2539
Loa Loa (eye worm) MH1 domain-containing protein 0.0234 0.0493 0.0598
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0243 0.0515 0.0916
Leishmania major proteasome beta 2 subunit, putative 0.0243 0.0515 0.1773
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0243 0.0515 0.1773
Treponema pallidum methionyl-tRNA synthetase 0.0086 0.0137 0.0355
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0053 0.0182
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0243 0.0515 0.1773
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0196 0.04 0.1327
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0087 0.0139 0.0248
Echinococcus multilocularis segment polarity protein dishevelled 0.0039 0.0024 0.0024
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0115 0.0396
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0183 0.0369 0.6681
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0243 0.0515 0.1724
Echinococcus granulosus lamin dm0 0.0033 0.0009 0.0017
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0963 0.2241 0.7712
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.1097 0.2565 0.2565
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0035 0.0071
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0005 0.0019
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0006 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0052 0.0063
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0251 0.0533 0.1837
Mycobacterium ulcerans proteasome PrcB 0.1239 0.2904 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0096 0.0329
Echinococcus granulosus regulator of G protein signaling 7 0.0058 0.0069 0.0138
Toxoplasma gondii proteasome subunit 0.0243 0.0515 0.1773
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0243 0.0515 0.1757
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0052 0.0063
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0052 0.0063
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0052 0.0093
Onchocerca volvulus 0.0049 0.0048 0.0183
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0132 0.0264
Schistosoma mansoni kinase 0.0142 0.0272 0.0483
Plasmodium falciparum glutathione reductase 0.0087 0.0139 0.0462
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0005 0.0005
Echinococcus granulosus peregrin 0.0031 0.0005 0.0011
Brugia malayi Pre-SET motif family protein 0.0127 0.0234 0.0284
Schistosoma mansoni smad 0.0105 0.0182 0.0324
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0243 0.0515 0.1773
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0087 0.0139 0.0279
Giardia lamblia 20S proteasome alpha subunit 1 0.0243 0.0515 0.1757
Brugia malayi Probable isocitrate dehydrogenase 0.0045 0.0039 0.0047
Plasmodium vivax thioredoxin reductase, putative 0.0251 0.0533 0.1822
Loa Loa (eye worm) MH2 domain-containing protein 0.3442 0.8191 0.9922
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0069 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0096 0.0329
Trypanosoma cruzi GMP reductase 0.0183 0.0369 0.1271
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0005 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0378 0.0837 0.1013
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0039 0.0024 0.0028
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0052 0.0104
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0087 0.0139 0.0139
Echinococcus granulosus proteasome subunit alpha type 2 0.0243 0.0515 0.103
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1239 0.2904 1
Brugia malayi mbt repeat family protein 0.0051 0.0052 0.0063
Echinococcus granulosus subfamily T1A non peptidase ue 0.0243 0.0515 0.103
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0243 0.0515 0.1757
Schistosoma mansoni hypothetical protein 0.0048 0.0045 0.0079
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0035 0.0121
Mycobacterium ulcerans proteasome PrcA 0.0243 0.0515 0.1773
Entamoeba histolytica acyl-CoA synthetase, putative 0.0094 0.0155 0.0479
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0551 0.1797
Trypanosoma cruzi PAB1-binding protein , putative 0.0345 0.0758 0.261
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0155 0.0535
Schistosoma mansoni hypothetical protein 0.1097 0.2565 0.4562
Loa Loa (eye worm) thioredoxin reductase 0.0251 0.0533 0.0646
Trypanosoma brucei cytochrome P450, putative 0.0047 0.0043 0.0148
Schistosoma mansoni dishevelled 0.0039 0.0024 0.0042
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0251 0.0533 0.0533
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0132 0.0132
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0053 0.0061
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0596 0.1362 0.469
Loa Loa (eye worm) PAS-3 protein 0.0243 0.0515 0.0624
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0596 0.1362 0.4625
Brugia malayi proteasome subunit beta type 3 0.0243 0.0515 0.0624
Mycobacterium leprae Probable lipase LipE 0.0077 0.0115 0.0396
Schistosoma mansoni methionine-tRNA synthetase 0.0086 0.0137 0.0244
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0028
Schistosoma mansoni Smad4 0.0234 0.0493 0.0877
Echinococcus multilocularis Endoplasmic reticulum oxidoreductin 1 0.0056 0.0066 0.0066
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0165 0.0326 0.1121
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0371 0.0821 0.2812
Brugia malayi Cytochrome P450 family protein 0.0107 0.0187 0.0227
Toxoplasma gondii peptidase, T1 family protein 0.0243 0.0515 0.1773
Schistosoma mansoni hypothetical protein 0.0081 0.0125 0.0222
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0115 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0052 0.0063
Brugia malayi Probable ClpP-like protease 0.0251 0.0533 0.0646
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0052 0.0063
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0243 0.0515 0.1773
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0089 0.0307
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0049 0.0047 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0123 0.0304
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 1
Brugia malayi Probable isocitrate dehydrogenase 0.0045 0.0039 0.0047
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0371 0.0821 0.2812
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0243 0.0515 0.0624
Loa Loa (eye worm) hypothetical protein 0.0077 0.0115 0.0139
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0573 0.1306 0.4497
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0052 0.0104
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0087 0.0139 0.048
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0279 0.0601 0.0728
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0035 0.0064
Echinococcus multilocularis lamin dm0 0.0033 0.0009 0.0009
Echinococcus granulosus thioredoxin glutathione reductase 0.0253 0.0537 0.1075
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0053 0.0061
Loa Loa (eye worm) MH1 domain-containing protein 0.0105 0.0182 0.022
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0115 0.0378
Brugia malayi isocitrate dehydrogenase 0.0371 0.0821 0.0994
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0035 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0123 0.0304
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0243 0.0515 0.1773
Brugia malayi hypothetical protein 0.0223 0.0465 0.0563
Leishmania major proteasome beta 3 subunit, putative 0.0243 0.0515 0.1773
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0086 0.0137 0.0416
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0148
Loa Loa (eye worm) hypothetical protein 0.3469 0.8256 1
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0243 0.0515 0.1724
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0963 0.2241 0.7716
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 0.1836
Loa Loa (eye worm) pigment dispersing factor receptor c 0.3469 0.8256 1
Plasmodium vivax ataxin-2 like protein, putative 0.0345 0.0758 0.2596
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0371 0.0821 0.1642
Leishmania major methionyl-tRNA synthetase, putative 0.0226 0.0472 0.1625
Loa Loa (eye worm) hypothetical protein 0.0251 0.0533 0.0646
Schistosoma mansoni patched 1 0.0084 0.0132 0.0235
Brugia malayi MH2 domain containing protein 0.0105 0.0182 0.022
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0087 0.0139 0.048
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0138 0.0379
Toxoplasma gondii ABC1 family protein 0.0077 0.0115 0.0396
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0243 0.0515 0.1671
Loa Loa (eye worm) hypothetical protein 0.0105 0.0182 0.022
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0053 0.0061
Giardia lamblia 20S proteasome alpha subunit 7 0.0243 0.0515 0.1757
Loa Loa (eye worm) hypothetical protein 0.0086 0.0137 0.0166
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0089 0.0307
Echinococcus granulosus smad 0.0234 0.0493 0.0987
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0243 0.0515 0.1757
Brugia malayi proteasome subunit beta type 2 0.0596 0.1362 0.165
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0052 0.0063
Mycobacterium tuberculosis Conserved protein 0.0077 0.0115 0.0396
Toxoplasma gondii proteasome beta subunit 0.0243 0.0515 0.1773
Brugia malayi N-terminal motif family protein 0.0788 0.1821 0.2206
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0052 0.0052
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0243 0.0515 0.1773
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0243 0.0515 0.1757
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0243 0.0515 0.1773
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0045 0.0054
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0053 0.0106
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Brugia malayi hypothetical protein 0.0345 0.0758 0.0918
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.0119
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0006 0.0012
Brugia malayi Endoplasmic Reticulum Oxidoreductin 1 0.0056 0.0066 0.0079
Leishmania major hypothetical protein, conserved 0.0345 0.0758 0.261
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0052 0.0063
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0115 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.0422 0.0943 0.3246
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0371 0.0821 0.0821
Schistosoma mansoni alpha-glucosidase 0.0169 0.0337 0.0599
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.001
Brugia malayi intermediate filament protein 0.0033 0.0009 0.001
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0052 0.0092
Toxoplasma gondii tRNA ligases class I (M) protein 0.0086 0.0137 0.0472
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0115 0.0139
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0596 0.1362 0.2423
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0087 0.0139 0.0942
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0085 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.0263 0.0793
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.1097 0.2565 0.5132
Echinococcus multilocularis Smad4 0.0234 0.0493 0.0493
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0243 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.0187 0.0227
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0243 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.1097 0.2565 0.3106
Onchocerca volvulus 0.0114 0.0204 0.0859
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0378 0.0837 0.1013
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0009 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0052 0.0063
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Brugia malayi ecdysteroid receptor 0.0051 0.0052 0.0063
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0087 0.0139 0.048
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1239 0.2904 1
Loa Loa (eye worm) proteasome subunit beta type 1 0.0963 0.2241 0.2714
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0551 0.1797
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0243 0.0515 0.0515
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0183 0.0369 0.0369
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0243 0.0515 0.0624
Mycobacterium tuberculosis Probable oxidoreductase 0.0637 0.146 0.5025
Toxoplasma gondii endoplasmic reticulum oxidoreductin, putative 0.0056 0.0066 0.0226
Trypanosoma cruzi 20S proteasome subunit 0.0596 0.1362 0.469
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0052 0.0063
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0637 0.146 0.5025
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0033 0.004
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0035 0.0035
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0105 0.0182 0.0766
Echinococcus multilocularis thioredoxin glutathione reductase 0.0253 0.0537 0.0537
Schistosoma mansoni hypothetical protein 0.0081 0.0125 0.0222
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0243 0.0515 0.0515
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0132 0.016
Echinococcus multilocularis peptidase Clp (S14 family) 0.0165 0.0326 0.0326
Leishmania major proteasome beta 7 subunit, putative 0.0243 0.0515 0.1773
Toxoplasma gondii IMP dehydrogenas 0.0183 0.0369 0.1271
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0189 0.0383 0.0682
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.008 0.0123 0.0304
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0098 0.0339
Brugia malayi Proteasome subunit alpha type 7-1 0.0243 0.0515 0.0624
Leishmania major hypothetical protein, conserved 0.0422 0.0943 0.3246
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0243 0.0515 0.0515
Onchocerca volvulus 0.0033 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0049 0.0048 0.0058
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0148
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0243 0.0515 0.1773
Echinococcus granulosus cpg binding protein 0.0092 0.0151 0.0301
Leishmania major proteasome beta 2 subunit, putative 0.0596 0.1362 0.469
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0069 0.0122
Brugia malayi CXXC zinc finger family protein 0.0087 0.0139 0.0168
Trypanosoma brucei proteasome beta 7 subunit 0.0243 0.0515 0.1773
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0005 0.0019
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0226 0.0472 0.1522
Toxoplasma gondii isocitrate dehydrogenase 0.0371 0.0821 0.2825
Schistosoma mansoni smad1 5 8 and 0.0234 0.0493 0.0877
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0371 0.0821 0.2825
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0243 0.0515 0.1671
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0053 0.0064
Echinococcus multilocularis microtubule associated protein 2 0.2111 0.4998 0.4998
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1239 0.2904 0.5167
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0096 0.017
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0052 0.0104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0234 0.0417
Loa Loa (eye worm) hypothetical protein 0.0084 0.0132 0.016
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0087 0.0139 0.0462
Schistosoma mansoni hypothetical protein 0.1236 0.2898 0.5155
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0371 0.0821 0.0821
Echinococcus multilocularis musashi 0.0033 0.0009 0.0009
Echinococcus granulosus peptidase Clp S14 family 0.0165 0.0326 0.0652
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0052 0.0093
Schistosoma mansoni methionine-tRNA synthetase 0.0226 0.0472 0.0839
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0226 0.0472 0.8759
Toxoplasma gondii methionyl-tRNA synthetase 0.0226 0.0472 0.1625
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0183 0.0369 0.1271
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0243 0.0515 0.103
Treponema pallidum leucyl-tRNA synthetase 0.0086 0.0137 0.0355
Echinococcus granulosus Smad4 0.0234 0.0493 0.0987
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Brugia malayi Isocitrate dehydrogenase 0.0371 0.0821 0.0994
Brugia malayi MH1 domain containing protein 0.0234 0.0493 0.0598
Loa Loa (eye worm) hypothetical protein 0.0131 0.0246 0.0297
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0243 0.0515 0.1724
Schistosoma mansoni unc-13 (munc13) 0.0045 0.0039 0.0069
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.0551 0.0667
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0199 0.0407 0.0725
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0033 0.0059
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0049 0.0047 0.0162
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0596 0.1362 0.4659
Plasmodium falciparum ataxin-2 like protein, putative 0.0345 0.0758 0.2596
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.036 0.113
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0243 0.0515 0.1773
Loa Loa (eye worm) nuclear factor I 0.013 0.0242 0.0293
Schistosoma mansoni cpg binding protein 0.0092 0.0151 0.0268
Schistosoma mansoni hypothetical protein 0.0307 0.0668 0.1189
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.01 0.0169 0.0583
Loa Loa (eye worm) hypothetical protein 0.0033 0.0009 0.001
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0243 0.0515 0.1671
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0243 0.0515 0.0916
Giardia lamblia Leucyl-tRNA synthetase 0.0086 0.0137 0.0454
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0087 0.0139 0.2039
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.008 0.0123 0.0422
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0115 0.0278
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1239 0.2904 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0094 0.0155 0.0535
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0243 0.0515 0.1773
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0243 0.0515 0.1757
Giardia lamblia 20S proteasome alpha subunit 5 0.0243 0.0515 0.1757
Leishmania major cytochrome p450-like protein 0.0047 0.0043 0.0148
Loa Loa (eye worm) transcription factor SMAD2 0.3442 0.8191 0.9922
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0087 0.0139 0.2039
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0123 0.0304
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0155 0.0535
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.0119
Brugia malayi MH1 domain containing protein 0.013 0.0242 0.0293
Mycobacterium tuberculosis Probable dehydrogenase 0.0573 0.1306 0.4497
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.008 0.0123 0.0304
Plasmodium falciparum ataxin-2 like protein, putative 0.0345 0.0758 0.2596
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0052 0.0063
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0052 0.0093
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0086 0.0137 0.0274
Loa Loa (eye worm) hypothetical protein 0.0077 0.0115 0.0139
Trypanosoma brucei polo-like protein kinase 0.0279 0.0601 0.2069
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0047 0.0162
Echinococcus multilocularis lamin 0.0033 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0123 0.0304
Mycobacterium tuberculosis Conserved protein 0.0077 0.0115 0.0396
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0148
Trypanosoma brucei PAB1-binding protein , putative 0.0345 0.0758 0.261
Echinococcus multilocularis expressed conserved protein 0.0184 0.0372 0.0372
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0243 0.0515 0.0916
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0052 0.0104
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0052 0.0063
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0243 0.0515 0.1724
Loa Loa (eye worm) hypothetical protein 0.0086 0.0137 0.0166
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0045 0.0039 0.0039
Mycobacterium ulcerans lipase LipD 0.0077 0.0115 0.0396
Trypanosoma brucei glucosidase, putative 0.0044 0.0035 0.0121
Entamoeba histolytica acyl-CoA synthetase, putative 0.0094 0.0155 0.0479
Chlamydia trachomatis DNA ligase 0.008 0.0123 0.0555
Echinococcus granulosus tm gpcr rhodopsin 0.0566 0.1289 0.2579
Brugia malayi Bromodomain containing protein 0.0031 0.0005 0.0007
Brugia malayi jmjC domain containing protein 0.0102 0.0176 0.0213
Echinococcus granulosus mothers against decapentaplegic 2 0.0105 0.0182 0.0364
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0115 0.0396
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0243 0.0515 0.1773
Plasmodium vivax proteasome subunit beta type-5, putative 0.1239 0.2904 1
Toxoplasma gondii NADPH-glutathione reductase 0.0087 0.0139 0.048
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0279 0.0601 0.1202
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0053 0.0182
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0052 0.0052
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0243 0.0515 0.1773
Plasmodium falciparum methionine--tRNA ligase, putative 0.0086 0.0137 0.0454
Schistosoma mansoni topbp1 0.008 0.0123 0.0218
Loa Loa (eye worm) hypothetical protein 0.0788 0.1821 0.2206
Loa Loa (eye worm) glutathione reductase 0.0251 0.0533 0.0646
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0058 0.0069 0.0083
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0139 0.0168
Brugia malayi beta-lactamase family protein 0.0077 0.0115 0.0139
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0183 0.0369 0.1271
Entamoeba histolytica serine/threonine protein kinase, putative 0.0279 0.0601 0.2022
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0243 0.0515 0.0916
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0245 0.0518 0.1736
Leishmania major inosine-5-monophosphate dehydrogenase 0.0183 0.0369 0.1271
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0052 0.0093
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0096 0.0191
Leishmania major proteasome alpha 3 subunit, putative 0.0243 0.0515 0.1773
Plasmodium vivax proteasome subunit beta type-7, putative 0.0243 0.0515 0.1757
Leishmania major hypothetical protein, conserved 0.0077 0.0115 0.0396
Schistosoma mansoni tar DNA-binding protein 0.0902 0.2096 0.3729
Echinococcus granulosus proteasome prosome macropain 0.1239 0.2904 0.5812
Leishmania major guanosine monophosphate reductase 0.0183 0.0369 0.1271
Loa Loa (eye worm) hypothetical protein 0.0058 0.0069 0.0083
Schistosoma mansoni alpha glucosidase 0.0044 0.0035 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0035 0.0121
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0138 0.0458
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0243 0.0515 0.1757
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0371 0.0821 0.2825
Onchocerca volvulus 0.0033 0.0009 0.0014
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0243 0.0515 0.1757
Leishmania major endoplasmic reticulum oxidoreductin, putative 0.0056 0.0066 0.0226
Loa Loa (eye worm) hypothetical protein 0.0086 0.0137 0.0166
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0115 0.0139
Trypanosoma cruzi GMP reductase 0.0183 0.0369 0.1271
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0596 0.1362 0.468
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0139 0.0265 0.0321
Echinococcus granulosus nibrin 0.008 0.0123 0.0245
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0226 0.0472 0.1625
Entamoeba histolytica acyl-coA synthetase, putative 0.0094 0.0155 0.0479
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0637 0.146 0.5025
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 0.1821
Onchocerca volvulus Huntingtin homolog 0.0131 0.0246 0.1041
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0087 0.0139 0.048
Schistosoma mansoni z-protein (S1r protein) 0.0058 0.0069 0.0123
Giardia lamblia 20S proteasome alpha subunit 4 0.0243 0.0515 0.1757
Trypanosoma cruzi polo-like protein kinase, putative 0.0279 0.0601 0.2069
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.0409 0.0409
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0251 0.0533 0.1836
Echinococcus multilocularis smad 0.0234 0.0493 0.0493
Echinococcus granulosus Pleckstrin G protein interacting region 0.0039 0.0024 0.0047
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0096 0.0329
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0045 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0115 0.0396
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0069 0.0137
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0052 0.0093
Mycobacterium ulcerans hypothetical protein 0.0049 0.0047 0.0162
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0115 0.0396
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0052 0.0093
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0115 0.0396
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0115 0.0205
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0086 0.0137 0.1993
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0045 0.0039 0.0077
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0052 0.0093
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0243 0.0515 0.0916
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0243 0.0515 0.1773
Brugia malayi methionyl-tRNA synthetase 0.0226 0.0472 0.0572
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0165 0.0326 0.1121
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0243 0.0515 0.1724
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0087 0.0139 0.048
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0226 0.0472 0.1625
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0035 0.0043
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0176 0.0352
Brugia malayi Cytochrome P450 family protein 0.0047 0.0043 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0551 0.1797
Brugia malayi Proteasome A-type and B-type family protein 0.0243 0.0515 0.0624
Echinococcus multilocularis tumor protein p63 0.0334 0.0732 0.0732
Brugia malayi hypothetical protein 0.0036 0.0017 0.002
Mycobacterium ulcerans hypothetical protein 0.0077 0.0115 0.0396
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0183 0.0369 0.1271
Giardia lamblia Kinase, PLK 0.0279 0.0601 0.2054
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 1
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Brugia malayi MH2 domain containing protein 0.0234 0.0493 0.0598
Schistosoma mansoni hypothetical protein 0.1097 0.2565 0.4562
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0115 0.0396
Brugia malayi nuclear receptor NHR-88 0.0051 0.0052 0.0063
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.003 0.0036
Onchocerca volvulus 0.0051 0.0052 0.0203
Plasmodium vivax acyl-CoA synthetase, putative 0.007 0.0098 0.0321
Plasmodium falciparum methionine--tRNA ligase 0.0226 0.0472 0.1609
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0243 0.0515 0.0624
Echinococcus multilocularis GPCR, family 2 0.1097 0.2565 0.2565
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0251 0.0533 0.1836
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0243 0.0515 0.0624
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0053 0.0182
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0155 0.0535
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0243 0.0515 0.1773
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.3469 0.8256 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.01 0.0169 0.0583
Plasmodium vivax methionine--tRNA ligase, putative 0.0226 0.0472 0.1609
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0053 0.0163
Leishmania major isocitrate dehydrogenase, putative 0.0045 0.0039 0.0133
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0251 0.0533 0.1067
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0183 0.0369 0.1271
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0243 0.0515 0.9626
Echinococcus granulosus proteasome subunit alpha type 6 0.0243 0.0515 0.103
Echinococcus multilocularis citrate lyase subunit beta protein 0.0049 0.0047 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0378 0.0837 0.0837
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0053 0.0182
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0043 0.0148
Trichomonas vaginalis glutathione reductase, putative 0.0087 0.0139 0.0363
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0127 0.0234 0.0807
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0052 0.0063
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0243 0.0515 0.1773
Brugia malayi nuclear hormone receptor 0.0051 0.0052 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Loa Loa (eye worm) CYP4Cod1 0.0047 0.0043 0.0052
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0052 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0243 0.0515 0.1757
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0243 0.0515 0.1757
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.0119
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0017 0.003
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0243 0.0515 0.0624
Plasmodium vivax replication factor C subunit 1, putative 0.008 0.0123 0.0404
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0052 0.0063
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0049 0.0047 0.0162
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0902 0.2096 0.2539
Echinococcus multilocularis regulator of G protein signaling 7 0.0058 0.0069 0.0069
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0035 0.007
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0243 0.0515 0.1724
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.0234 0.0234
Plasmodium vivax methionine--tRNA ligase, putative 0.0086 0.0137 0.0454
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0083 0.013 0.0449
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0052 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0378 0.0837 0.1488
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0045 0.0039 0.0012
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0094 0.0155 0.0535
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Loa Loa (eye worm) IMP dehydrogenase 1 0.0183 0.0369 0.0447
Onchocerca volvulus 0.0077 0.0115 0.0476
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0033 0.0066
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1239 0.2904 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0176 0.0176
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0243 0.0515 0.1724
Trypanosoma brucei hypothetical protein, conserved 0.0422 0.0943 0.3246
Echinococcus granulosus Proteasome subunit alpha type 7 0.0243 0.0515 0.103
Mycobacterium tuberculosis Probable reductase 0.0573 0.1306 0.4497
Giardia lamblia Proteasome subunit beta type 3 0.0243 0.0515 0.1757
Echinococcus multilocularis isocitrate dehydrogenase 0.0371 0.0821 0.0821
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0243 0.0515 0.1773
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0243 0.0515 0.0624
Loa Loa (eye worm) hypothetical protein 0.0077 0.0115 0.0139
Toxoplasma gondii isocitrate dehydrogenase 0.0371 0.0821 0.2825
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.008 0.0123 0.0422
Brugia malayi MH2 domain containing protein 0.0234 0.0493 0.0598
Plasmodium vivax proteasome subunit beta type-6, putative 0.0243 0.0515 0.1757
Brugia malayi Proteasome A-type and B-type family protein 0.0243 0.0515 0.0624
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0087 0.0139 0.048
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.0139 0.048
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0243 0.0515 0.1757
Plasmodium vivax proteasome subunit beta type-3, putative 0.0243 0.0515 0.1757
Leishmania major proteasome beta 5 subunit, putative 0.1239 0.2904 1
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0045 0.0039 0.0077
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0115 0.0278
Echinococcus multilocularis dnaJ subfamily B 0.1236 0.2898 0.2898
Leishmania major proteasome alpha 1 subunit, putative 0.0243 0.0515 0.1773
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0052 0.0063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0378 0.0837 0.1674
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0123 0.0304
Brugia malayi proteasome subunit alpha type 3 0.0243 0.0515 0.0624
Trichomonas vaginalis set domain proteins, putative 0.0992 0.2311 0.7932
Brugia malayi jmjC domain containing protein 0.0043 0.0033 0.004
Echinococcus granulosus proteasome subunit beta type 7 0.0243 0.0515 0.103
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0178 0.0358 0.1217
Echinococcus granulosus dnaJ subfamily B 0.1236 0.2898 0.5798
Plasmodium vivax proteasome subunit beta type-1, putative 0.0963 0.2241 0.7712
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.008 0.0123 0.0366
Loa Loa (eye worm) hypothetical protein 0.013 0.0242 0.0293
Trichomonas vaginalis replication factor C large subunit, putative 0.008 0.0123 0.0304
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0596 0.1362 0.469
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0053 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0127 0.0234 0.0417
Echinococcus multilocularis proteasome subunit alpha type 2 0.0243 0.0515 0.0515
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0243 0.0515 0.1773
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0043 0.0148
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0052 0.0104
Schistosoma mansoni smad1 5 8 and 0.0234 0.0493 0.0877
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0048 0.0085
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1239 0.2904 1
Brugia malayi proteasome subunit beta type 1 0.0963 0.2241 0.2714
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0049 0.0047 0.0041
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0243 0.0515 0.1757
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0243 0.0515 0.1773
Plasmodium vivax glutathione reductase, putative 0.0251 0.0533 0.1822
Trypanosoma cruzi trypanothione reductase, putative 0.0251 0.0533 0.1837
Echinococcus granulosus TGF beta signal transducer SmadC 0.0234 0.0493 0.0987
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0052 0.0052
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0243 0.0515 0.1773
Schistosoma mansoni hypothetical protein 0.0155 0.0302 0.0537
Echinococcus granulosus proteasome subunit beta t family 0.0243 0.0515 0.103
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0963 0.2241 0.2241
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0243 0.0515 0.1757
Loa Loa (eye worm) hypothetical protein 0.0698 0.1605 0.1944
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0127 0.0234 0.0234
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0043 0.0052
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.0155 0.0535
Loa Loa (eye worm) hypothetical protein 0.0077 0.0115 0.0139
Brugia malayi Calcitonin receptor-like protein seb-1 0.3469 0.8256 1
Brugia malayi MH1 domain containing protein 0.0234 0.0493 0.0598
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1239 0.2904 0.3518
Chlamydia trachomatis methionine--tRNA ligase 0.0086 0.0137 0.089
Trichomonas vaginalis esterase, putative 0.0077 0.0115 0.0278
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0573 0.1306 0.4497
Onchocerca volvulus Notchless protein homolog 0.0243 0.0515 0.2209
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0226 0.0472 0.0572
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0551 0.1797
Schistosoma mansoni alpha-glucosidase 0.0169 0.0337 0.0599
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0017 0.0034
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0049 0.0047 0.0162
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0371 0.0821 0.2825
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0243 0.0515 0.1757
Schistosoma mansoni tar DNA-binding protein 0.0902 0.2096 0.3729
Giardia lamblia Proteasome subunit beta type 1 0.0963 0.2241 0.7712
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0243 0.0515 0.0916
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.0119
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0045 0.0039 0.0047
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0028
Onchocerca volvulus Putative GMP reductase 0.0079 0.0119 0.0495
Trypanosoma cruzi FHA domain containing protein, putative 0.008 0.0123 0.0422
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.0493 0.0598
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.049 0.049
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0052 0.0052
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0035 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0115 0.0278
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0086 0.0137 0.0137
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 0.1836
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0596 0.1362 0.469
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0243 0.0515 0.1671
Onchocerca volvulus 0.0051 0.0052 0.0201
Mycobacterium ulcerans hypothetical protein 0.0049 0.0047 0.0162
Brugia malayi small heat shock protein 0.0698 0.1605 0.1944
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0371 0.0821 0.2825
Onchocerca volvulus Huntingtin homolog 0.0131 0.0246 0.1041
Schistosoma mansoni Smad4 0.0105 0.0182 0.0324
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0243 0.0515 0.1757
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0052 0.0093
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1239 0.2904 1
Echinococcus granulosus expressed conserved protein 0.0184 0.0372 0.0744
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0079 0.0119 0.0145
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0052 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0422 0.0943 0.3246
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0243 0.0515 0.0916
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.007 0.0098 0.0339
Loa Loa (eye worm) hypothetical protein 0.0131 0.0246 0.0297
Entamoeba histolytica hypothetical protein 0.008 0.0123 0.0366
Brugia malayi DKFZp564C0469 protein 0.008 0.0123 0.0148
Echinococcus granulosus Endoplasmic reticulum oxidoreductin 1 0.0056 0.0066 0.0131
Brugia malayi Cytochrome P450 family protein 0.0047 0.0043 0.0052
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0243 0.0515 0.103
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.0601 0.1069
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0243 0.0515 0.103
Brugia malayi RNA recognition motif domain containing protein 0.0902 0.2096 0.2539
Echinococcus granulosus tumor protein p63 0.0334 0.0732 0.1464
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0039 0.0024 0.0078
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0115 0.0115
Brugia malayi proteasome subunit alpha type 1 0.0243 0.0515 0.0624
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0053 0.0106
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0243 0.0515 0.0624
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0052 0.0203
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0243 0.0515 0.0916
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0115 0.0278
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.0018 0.0032
Schistosoma mansoni smad1 5 8 and 0.0234 0.0493 0.0877
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0052 0.0063
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0243 0.0515 0.1724
Echinococcus multilocularis peregrin 0.0031 0.0005 0.0005
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0087 0.0139 0.048
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0251 0.0533 0.1836
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0052 0.0063
Brugia malayi PHD-finger family protein 0.0031 0.0005 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0053 0.0094
Brugia malayi Proteasome A-type and B-type family protein 0.1239 0.2904 0.3518
Schistosoma mansoni ero1-related 0.0056 0.0066 0.0117
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Brugia malayi DIX domain containing protein 0.0039 0.0024 0.0028
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0087 0.0139 0.048
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0069 0.0069
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0155 0.0188
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0596 0.1362 0.4625
Brugia malayi hypothetical protein 0.0233 0.049 0.0594
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0596 0.1362 0.1362
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0566 0.1289 0.1289
Echinococcus multilocularis cpg binding protein 0.0092 0.0151 0.0151
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.0515 0.1671
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.036 0.113
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0069 0.0083
Echinococcus multilocularis Niemann Pick C1 protein 0.028 0.0602 0.0602
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0052 0.0104
Echinococcus multilocularis nibrin 0.008 0.0123 0.0123
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0115 0.0396
Echinococcus multilocularis replication factor c subunit 1 0.008 0.0123 0.0123
Brugia malayi proteasome subunit alpha type 4 0.0243 0.0515 0.0624
Onchocerca volvulus 0.0032 0.0006 0.0004
Echinococcus granulosus Niemann Pick C1 protein 0.028 0.0602 0.1204
Plasmodium vivax proteasome subunit beta type-2, putative 0.0596 0.1362 0.468
Loa Loa (eye worm) latrophilin receptor protein 2 0.1097 0.2565 0.3106
Brugia malayi MAP kinase sur-1 0.0051 0.0053 0.0064
Schistosoma mansoni intermediate filament proteins 0.0033 0.0009 0.0015
Leishmania major proteasome alpha 1 subunit, putative 0.0243 0.0515 0.1773
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0045 0.0039 0.0047
Loa Loa (eye worm) hypothetical protein 0.0345 0.0758 0.0918
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0045 0.0039 0.0133
Trypanosoma brucei GMP reductase 0.0183 0.0369 0.1271
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0096 0.017
Onchocerca volvulus 0.0127 0.0234 0.0993
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0052 0.0063
Echinococcus granulosus mothers against decapentaplegic 5 0.0234 0.0493 0.0987
Brugia malayi regulator of G-protein signaling egl-10 0.0058 0.0069 0.0083
Chlamydia trachomatis leucine--tRNA ligase 0.0086 0.0137 0.089
Brugia malayi hypothetical protein 0.008 0.0123 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0052 0.0063
Giardia lamblia Proteasome subunit beta type 2 0.0596 0.1362 0.468
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0096 0.0329
Schistosoma mansoni isocitrate dehydrogenase 0.0045 0.0039 0.0069
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0089 0.0307
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0009
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0243 0.0515 0.0624
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0371 0.0821 0.0821
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0052 0.0052
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0052 0.0203
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0243 0.0515 0.1724
Giardia lamblia 20S proteasome alpha subunit 6 0.0243 0.0515 0.1757
Loa Loa (eye worm) hypothetical protein 0.0094 0.0155 0.0188
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.012 0.0219 0.0438
Schistosoma mansoni tar DNA-binding protein 0.0902 0.2096 0.3729
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0371 0.0821 0.2825
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0183 0.0369 0.0447
Echinococcus granulosus GPCR family 2 0.1097 0.2565 0.5132
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0052 0.0104
Brugia malayi Proteasome subunit alpha type 1 0.0243 0.0515 0.0624
Brugia malayi hypothetical protein 0.0131 0.0246 0.0297
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0234 0.0493 0.0493
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0053 0.0182
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0053 0.0182
Brugia malayi hypothetical protein 0.0039 0.0024 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0033 0.0059
Brugia malayi Pre-SET motif family protein 0.0872 0.2023 0.245
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0053 0.0182
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.0263 0.0793
Schistosoma mansoni hypothetical protein 0.0081 0.0125 0.0222
Schistosoma mansoni lamin 0.0033 0.0009 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0902 0.2096 0.3729
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0243 0.0515 0.1773
Loa Loa (eye worm) hypothetical protein 0.0233 0.049 0.0594
Brugia malayi methionyl-tRNA synthetase 0.0086 0.0137 0.0166
Brugia malayi Latrophilin receptor protein 2 0.1097 0.2565 0.3106
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0087 0.0139 0.0169
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0243 0.0515 0.0515
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0039 0.0024 0.0024
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0492 0.111 0.3823
Schistosoma mansoni dishevelled 0.0039 0.0024 0.0042
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0052 0.0201
Echinococcus multilocularis segment polarity protein dishevelled 0.0039 0.0024 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Loa Loa (eye worm) GMP reductase 0.0079 0.0119 0.0145
Schistosoma mansoni microtubule-associated protein tau 0.2111 0.4998 0.889
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0243 0.0515 0.1773
Brugia malayi beta-lactamase 0.0077 0.0115 0.0139
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0096 0.0329
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.049 0.0981
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Leishmania major leucyl-tRNA synthetase, putative 0.0086 0.0137 0.0472
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0052 0.0104
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0087 0.0139 0.048
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0378 0.0837 0.0837
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0243 0.0515 0.1773
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0243 0.0515 0.1773
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0115 0.0396
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0371 0.0821 0.0821
Echinococcus granulosus Niemann Pick C1 protein 0.0196 0.04 0.0801
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0243 0.0515 0.1773
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0035 0.0064
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0243 0.0515 0.1773
Loa Loa (eye worm) hypothetical protein 0.0058 0.0069 0.0083
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0052 0.0093
Echinococcus granulosus regulator of G protein signaling 7 0.0058 0.0069 0.0138
Echinococcus granulosus intermediate filament protein 0.0033 0.0009 0.0017
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0243 0.0515 0.1724
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0155 0.0302 0.0604
Schistosoma mansoni Smad4 0.0105 0.0182 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0052 0.0063
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.008 0.0123 0.0304
Toxoplasma gondii hypothetical protein 0.0039 0.0024 0.0081
Brugia malayi Pax transcription activation domain interacting protein 0.008 0.0123 0.0148
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0045 0.0039 0.0039
Toxoplasma gondii hypothetical protein 0.0087 0.0138 0.0476
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0963 0.2241 0.7702
Schistosoma mansoni peptidase Clp (S14 family) 0.0251 0.0533 0.0949
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0243 0.0515 0.0515
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0378 0.0837 0.1488
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.008 0.0123 0.0422
Loa Loa (eye worm) hypothetical protein 0.0054 0.0059 0.0071
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0788 0.1821 0.7875
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0279 0.0601 0.2069
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0052 0.0063
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0243 0.0515 0.1773
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0155 0.0535
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0243 0.0515 0.1757
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0243 0.0515 0.1757
Mycobacterium ulcerans hypothetical protein 0.0094 0.0155 0.0535
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0083 0.013 0.0449
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0371 0.0821 0.2825
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0047 0.0043 0.0148
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Trichomonas vaginalis mercuric reductase, putative 0.0087 0.0139 0.0363
Brugia malayi GMP reductase 0.0079 0.0119 0.0145
Brugia malayi Proteasome A-type and B-type family protein 0.0243 0.0515 0.0624
Loa Loa (eye worm) MBCTL1 0.0058 0.0069 0.0083
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0243 0.0515 0.1773
Brugia malayi proteasome subunit alpha type 6 0.0243 0.0515 0.0624
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0115 0.0396
Schistosoma mansoni hypothetical protein 0.0725 0.1672 0.2974
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.0119
Brugia malayi mothers against decapentaplegic homolog 3 0.0105 0.0182 0.022
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0243 0.0515 0.1773
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0243 0.0515 0.0916
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0052 0.0093
Giardia lamblia Methionyl-tRNA synthetase 0.0226 0.0472 0.1609
Brugia malayi MH2 domain containing protein 0.3442 0.8191 0.9922
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0243 0.0515 0.0916
Plasmodium falciparum replication factor C subunit 1, putative 0.008 0.0123 0.0404
Brugia malayi steroid hormone receptor 0.0051 0.0052 0.0063
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0178 0.0358 0.1217
Schistosoma mansoni hypothetical protein 0.1097 0.2565 0.4562
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0079 0.0119 0.0145
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0243 0.0515 0.1757
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0052 0.0093
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0132 0.0264
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0052 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0089 0.0307
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0243 0.0515 0.1773
Brugia malayi latrophilin 2 splice variant baaae 0.2371 0.5621 0.6809
Echinococcus multilocularis methionine tRNA synthetase 0.0226 0.0472 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0052 0.0063
Trypanosoma cruzi endoplasmic reticulum oxidoreductin, putative 0.0056 0.0066 0.0226
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0243 0.0515 0.1773
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0165 0.0326 0.1121
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.008 0.0123 0.0148
Onchocerca volvulus 0.008 0.0123 0.0508
Loa Loa (eye worm) proteasome subunit beta type 3 0.0243 0.0515 0.0624
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0378 0.0837 0.1488
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0155 0.0188
Plasmodium falciparum proteasome subunit beta type-5 0.1239 0.2904 1
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0243 0.0515 0.1773
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0086 0.0137 0.0472
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0007
Echinococcus granulosus proteasome subunit beta type 6 0.0243 0.0515 0.103
Echinococcus granulosus mothers against decapentaplegic 6 0.0105 0.0182 0.0364
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0338 0.1054
Echinococcus multilocularis protein dispatched 1 0.0096 0.0161 0.0161
Schistosoma mansoni tar DNA-binding protein 0.0902 0.2096 0.3729
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.0409 0.0818
Brugia malayi hypothetical protein 0.008 0.0123 0.0148
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0243 0.0515 0.0916
Plasmodium falciparum endoplasmic reticulum oxidoreductin, putative 0.0056 0.0066 0.0208
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1097 0.2565 0.2565
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0183 0.0369 0.1271
Echinococcus granulosus geminin 0.0725 0.1672 0.3345
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0094 0.0155 0.0535
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0234 0.0493 0.0877
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0551 0.1797
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0052 0.0052
Leishmania major proteasome alpha 2 subunit, putative 0.0243 0.0515 0.1773
Plasmodium falciparum glutathione reductase 0.0251 0.0533 0.1822
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0052 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0551 0.1797
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0052 0.0093
Trypanosoma brucei trypanothione reductase 0.0251 0.0533 0.1837
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0035 0.0121
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0155 0.0535
Toxoplasma gondii proteasome subunit beta type, putative 0.1239 0.2904 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.0155 0.0535
Brugia malayi CHE-14 protein 0.0084 0.0132 0.016
Brugia malayi Niemann-Pick C1 protein precursor 0.0196 0.04 0.0485
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0596 0.1362 0.2725
Schistosoma mansoni hypothetical protein 0.2371 0.5621 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0052 0.0063
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0403 0.0403
Toxoplasma gondii histone lysine methyltransferase SET1 0.0169 0.0336 0.1157
Onchocerca volvulus 0.0077 0.0115 0.0476
Echinococcus multilocularis mothers against decapentaplegic 2 0.0105 0.0182 0.0182
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0872 0.2023 0.245
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0183 0.0369 0.1271
Toxoplasma gondii ATPase, AAA family protein 0.008 0.0123 0.0422
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0243 0.0515 0.1773
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0126 0.0223
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1239 0.2904 1
Trypanosoma brucei proteasome beta 6 subunit 0.0963 0.2241 0.7716
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0963 0.2241 0.4484
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0087 0.0139 0.048
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0115 0.023
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0243 0.0515 0.0916
Schistosoma mansoni leucyl-tRNA synthetase 0.0086 0.0137 0.0244
Echinococcus granulosus tar DNA binding protein 0.0902 0.2096 0.4194
Loa Loa (eye worm) hypothetical protein 0.2371 0.5621 0.6809
Echinococcus multilocularis leucyl tRNA synthetase 0.0086 0.0137 0.0137
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0963 0.2241 0.7716
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0123 0.0422
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0047 0.0162
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0039 0.0024 0.0042
Loa Loa (eye worm) hypothetical protein 0.0127 0.0234 0.0284
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0087 0.0139 0.048
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0087 0.0139 0.048
Loa Loa (eye worm) hypothetical protein 0.0094 0.0155 0.0188
Brugia malayi RNA binding protein 0.0902 0.2096 0.2539
Schistosoma mansoni hypothetical protein 0.1097 0.2565 0.4562
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0403 0.0403
Plasmodium falciparum thioredoxin reductase 0.0251 0.0533 0.1822
Onchocerca volvulus 0.0048 0.0045 0.017
Loa Loa (eye worm) hypothetical protein 0.0051 0.0052 0.0063
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0087 0.0138 0.0476
Giardia lamblia 20S proteasome alpha subunit 3 0.0243 0.0515 0.1757
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0243 0.0515 0.1757
Plasmodium vivax proteasome subunit beta type-4, putative 0.0243 0.0515 0.1757
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0963 0.2241 0.3986
Echinococcus granulosus methionine tRNA synthetase 0.0226 0.0472 0.0944
Echinococcus granulosus citrate lyase subunit beta protein 0.0049 0.0047 0.0094
Toxoplasma gondii proteasome subunit alpha type, putative 0.0243 0.0515 0.1773
Schistosoma mansoni cpg binding protein 0.0092 0.0151 0.0268
Echinococcus multilocularis proteasome (prosome, macropain) 0.1239 0.2904 0.2904
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0087 0.0139 0.048
Echinococcus granulosus replication factor c subunit 1 0.008 0.0123 0.0245
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0226 0.0472 0.1625
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0403 0.0488
Schistosoma mansoni DNA ligase IV 0.008 0.0123 0.0218
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0251 0.0533 1
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0137 0.0454
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1239 0.2904 1
Plasmodium falciparum acyl-CoA synthetase 0.007 0.0098 0.0321
Echinococcus multilocularis proteasome subunit beta type 7 0.0243 0.0515 0.0515
Leishmania major trypanothione reductase 0.0251 0.0533 0.1837
Trypanosoma brucei pol-associated gene 1 0.0056 0.0066 0.0226
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0403 0.0488
Brugia malayi Thioredoxin reductase 0.0251 0.0533 0.0646
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0963 0.2241 0.7688
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0052 0.0203
Treponema pallidum NADH oxidase 0.0087 0.0139 0.041
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0243 0.0515 0.1757
Brugia malayi beta-lactamase family protein 0.0077 0.0115 0.0139
Leishmania major proteasome beta-1 subunit, putative 0.0243 0.0515 0.1773
Schistosoma mansoni dep domain containing protein 0.0039 0.0024 0.0042
Loa Loa (eye worm) hypothetical protein 0.0094 0.0155 0.0188
Echinococcus granulosus Proteasome subunit alpha beta 0.0243 0.0515 0.103
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0243 0.0515 0.1773
Loa Loa (eye worm) MH2 domain-containing protein 0.0105 0.0182 0.022
Toxoplasma gondii proteasome subunit alpha1, putative 0.0243 0.0515 0.1773
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0043 0.0052
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0573 0.1306 0.4497
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0045 0.0039 0.0133
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0226 0.0472 0.1625
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0009 0.001
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0243 0.0515 0.1773
Mycobacterium tuberculosis Conserved protein 0.0049 0.0047 0.0162
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0005 0.0011
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.008 0.0123 0.0304
Echinococcus granulosus microtubule associated protein 2 0.2111 0.4998 1
Schistosoma mansoni coup transcription factor 0.0051 0.0052 0.0093
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0243 0.0515 0.1724
Toxoplasma gondii thioredoxin reductase 0.0251 0.0533 0.1837
Loa Loa (eye worm) beta-lactamase 0.0077 0.0115 0.0139
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0045 0.0039 0.0133
Onchocerca volvulus 0.0087 0.0139 0.0578
Giardia lamblia Replication factor C, subunit 1 0.008 0.0123 0.0404
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0243 0.0515 0.1724
Loa Loa (eye worm) hypothetical protein 0.0056 0.0066 0.0079
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0226 0.0472 0.1625
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0243 0.0515 0.1773
Plasmodium vivax endoplasmic reticulum oxidoreductin, putative 0.0056 0.0066 0.0208
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0035 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0234 0.0417
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0052 0.0104
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.008 0.0123 0.0422
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0183 0.0369 0.1271
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.1097 0.2565 0.3106
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0148
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0183 0.0369 0.0657
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0115 0.0396
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0243 0.0515 0.0916
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0243 0.0515 0.1724
Brugia malayi TAR-binding protein 0.0902 0.2096 0.2539
Echinococcus multilocularis proteasome subunit beta type 6 0.0243 0.0515 0.0515
Plasmodium vivax SET domain protein, putative 0.0127 0.0234 0.079
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0087 0.0139 0.0462
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0596 0.1362 0.2423
Echinococcus multilocularis regulator of G protein signaling 7 0.0058 0.0069 0.0069
Giardia lamblia NADH oxidase lateral transfer candidate 0.0087 0.0139 0.0462
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0087 0.0139 0.0462
Loa Loa (eye worm) hypothetical protein 0.0077 0.0115 0.0139
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0148
Brugia malayi hypothetical protein 0.0039 0.0024 0.0028
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0096 0.0329
Onchocerca volvulus 0.0039 0.0024 0.0078
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0243 0.0515 0.1773
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0234 0.0417
Schistosoma mansoni chromosome transmission fidelity factor 0.008 0.0123 0.0218
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0155 0.0302 0.0302
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0053 0.0061
Loa Loa (eye worm) DIX domain-containing protein 0.0039 0.0024 0.0028
Schistosoma mansoni hypothetical protein 0.0036 0.0017 0.003
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Echinococcus granulosus expressed protein 0.0368 0.0814 0.1629
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0009 0.001
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0243 0.0515 0.1757
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.0234 0.0469
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0115 0.0205
Leishmania major proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0243 0.0515 0.0515
Brugia malayi Smad1 0.0234 0.0493 0.0598
Echinococcus multilocularis mothers against decapentaplegic 5 0.0234 0.0493 0.0493
Schistosoma mansoni regulator of G protein signaling 0.0058 0.0069 0.0123
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0155 0.0535
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0094 0.0155 0.0535
Brugia malayi topoisomerase 0.008 0.0123 0.0148
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0052 0.0052
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0115 0.0396
Loa Loa (eye worm) hypothetical protein 0.0196 0.04 0.0485
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0045 0.0039 0.0047
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0096 0.0096
Trypanosoma brucei proteasome alpha 7 subunit 0.0243 0.0515 0.1773
Echinococcus granulosus segment polarity protein dishevelled 0.0039 0.0024 0.0047
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0243 0.0515 0.1773
Entamoeba histolytica tartrate dehydrogenase, putative 0.0045 0.0039 0.0075
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0178 0.0358 0.1234
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0139 0.048
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0123 0.0422
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0573 0.1306 0.4497
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0094 0.0155 0.0535
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0251 0.0533 0.1821
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0094 0.0155 0.0535
Trichomonas vaginalis CAMK family protein kinase 0.0279 0.0601 0.1971
Giardia lamblia 20S proteasome alpha subunit 2 0.0243 0.0515 0.1757
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0047 0.0162
Onchocerca volvulus 0.0094 0.0155 0.065
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0132 0.0337
Loa Loa (eye worm) hypothetical protein 0.0077 0.0115 0.0139
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0371 0.0821 0.146
Brugia malayi serine/threonine-protein kinase plk-2 0.0279 0.0601 0.0728
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0052 0.0104
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0243 0.0515 0.1757
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0279 0.0601 0.0601
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0064 0.0084 0.0102
Echinococcus multilocularis mothers against decapentaplegic 6 0.0105 0.0182 0.0182
Plasmodium falciparum thioredoxin reductase 0.0087 0.0139 0.0462
Brugia malayi glutathione reductase 0.0251 0.0533 0.0646
Mycobacterium ulcerans beta-lactamase 0.0077 0.0115 0.0396
Schistosoma mansoni hypothetical protein 0.0081 0.0125 0.0222
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0039 0.0024 0.0028
Trypanosoma cruzi polo-like protein kinase, putative 0.0279 0.0601 0.2069
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0243 0.0515 0.1773
Trypanosoma cruzi PAB1-binding protein , putative 0.0345 0.0758 0.261
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0243 0.0515 0.0916
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0115 0.0396
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0243 0.0515 0.1773
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0378 0.0837 0.1674
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0155 0.0188
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0069 0.0137
Echinococcus granulosus lamin 0.0033 0.0009 0.0017
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0963 0.2241 0.7716
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0243 0.0515 0.1757
Trypanosoma brucei protein kinase, putative 0.0051 0.0053 0.0182
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0087 0.0139 0.0462
Schistosoma mansoni cpg binding protein 0.0087 0.0139 0.0247
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0045 0.0039 0.0047
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0017 0.0017
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0005 0.0007
Loa Loa (eye worm) RNA binding protein 0.0902 0.2096 0.2539
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1097 0.2565 0.5132
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0064 0.0084 0.0102
Mycobacterium tuberculosis Conserved protein 0.0077 0.0115 0.0396
Echinococcus multilocularis protein patched 0.0084 0.0132 0.0132
Toxoplasma gondii heat shock protein hslv, putative 0.0243 0.0515 0.1773
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0243 0.0515 0.1773
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0338 0.1441
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0148
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0183 0.0369 0.0739
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0963 0.2241 0.7716
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0243 0.0515 0.0624
Echinococcus multilocularis expressed protein 0.0368 0.0814 0.0814
Schistosoma mansoni hypothetical protein 0.0725 0.1672 0.2974
Plasmodium falciparum proteasome subunit beta type-4 0.0243 0.0515 0.1757
Onchocerca volvulus 0.0992 0.2311 1
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.008 0.0123 0.1698
Loa Loa (eye worm) Smad1 0.0234 0.0493 0.0598
Brugia malayi mbt repeat family protein 0.0051 0.0052 0.0063
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.0551 0.0667
Onchocerca volvulus Serine\/threonine kinase homolog 0.0279 0.0601 0.2582
Echinococcus granulosus segment polarity protein dishevelled 0.0039 0.0024 0.0047
Schistosoma mansoni smad 0.0234 0.0493 0.0877
Loa Loa (eye worm) hypothetical protein 0.0045 0.0039 0.0047
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0138 0.0458

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) < 1 ug ml-1 Compound was tested in vitro for antibacterial activity against Klebsiella pneumoniae UC 58 ChEMBL. 7310825
MIC (functional) = 2 ug ml-1 Compound was tested in vitro for antibacterial activity against Salmonella schottmuelleri UC 126 ChEMBL. 7310825
MIC (functional) = 3.9 ug ml-1 Compound was tested in vitro for antibacterial activity against Escherichia coli UC 45 ChEMBL. 7310825
MIC (functional) = 7.8 ug ml-1 Compound was tested in vitro for antibacterial activity against Staphylococcus aureus UC76 ChEMBL. 7310825
MIC (functional) = 7.8 ug ml-1 Compound was tested in vitro for antibacterial activity against Serratia marcescens UC 131 ChEMBL. 7310825
MIC (functional) = 15.6 ug ml-1 Compound was tested in vitro for antibacterial activity against Streptococcus pyogenes UC 152 ChEMBL. 7310825
MIC (functional) = 15.6 ug ml-1 Compound was tested in vitro for antibacterial activity against Proteus vulgaris UC 93 ChEMBL. 7310825
MIC (functional) = 15.6 ug ml-1 Compound was tested in vitro for antibacterial activity against Salmonella flexneri UC 143 ChEMBL. 7310825
MIC (functional) = 15.6 ug ml-1 Compound was tested in vitro for antibacterial activity against Pseudomonas aeruginosa UC 3679 ChEMBL. 7310825
MIC (functional) = 15.6 ug ml-1 Compound was tested in vitro for antibacterial activity against Pseudomonas aeruginosa UC 3683 ChEMBL. 7310825
MIC (functional) = 15.6 ug ml-1 Compound was tested in vitro for antibacterial activity against Pseudomonas aeruginosa UC 3681 ChEMBL. 7310825
MIC (functional) = 31.2 ug ml-1 Compound was tested in vitro for antibacterial activity against Pseudomonas aeruginosa UC 3680 ChEMBL. 7310825
MIC (functional) = 31.2 ug ml-1 Compound was tested in vitro for antibacterial activity against Pseudomonas aeruginosa UC 95 ChEMBL. 7310825
MIC (functional) = 62.5 ug ml-1 Compound was tested in vitro for antibacterial activity against Pseudomonas aeruginosa UC 95 ChEMBL. 7310825
MIC (functional) = 62.5 ug ml-1 Compound was tested in vitro for antibacterial activity against Proteus mirabilis UC 6671 ChEMBL. 7310825
MIC (functional) = 62.5 ug ml-1 Compound was tested in vitro for antibacterial activity against Pseudomonas aeruginosa UC 3682 ChEMBL. 7310825
MIC (functional) = 125 ug ml-1 Compound was tested in vitro for antibacterial activity against Streptococcus pneumoniae UC 41 ChEMBL. 7310825
MIC (functional) > 125 ug ml-1 Compound was tested in vitro for antibacterial activity against Pseudomonas aeruginosa UC 6436 ChEMBL. 7310825
MIC (functional) = 250 ug ml-1 Compound was tested in vitro for antibacterial activity against Streptococcus faecalis UC 694 ChEMBL. 7310825

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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