Detailed information for compound 48322

Basic information

Technical information
  • TDR Targets ID: 48322
  • Name: (8Z)-4-methyl-8-[1-(4-methylphenyl)ethylidene ]-6,7-dihydro-5H-quinoline
  • MW: 263.377 | Formula: C19H21N
  • H donors: 0 H acceptors: 1 LogP: 4.97 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)/C(=C\1/CCCc2c1nccc2C)/C
  • InChi: 1S/C19H21N/c1-13-7-9-16(10-8-13)15(3)18-6-4-5-17-14(2)11-12-20-19(17)18/h7-12H,4-6H2,1-3H3/b18-15-
  • InChiKey: REEZUWPQDXCHBP-SDXDJHTJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (8Z)-4-methyl-8-[1-(p-tolyl)ethylidene]-6,7-dihydro-5H-quinoline

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.003 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0049 0.0101
Brugia malayi protein kinase C II. 0.0037 0.0194 0.0194
Onchocerca volvulus 0.0651 0.5512 0.5507
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.001 0.0021
Mycobacterium tuberculosis Probable oxidoreductase 0.0556 0.4693 1
Loa Loa (eye worm) oxidoreductase 0.0016 0.001 0.0007
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0042 0.0232 0.0421
Entamoeba histolytica protein kinase, putative 0.0021 0.0049 0.008
Loa Loa (eye worm) dehydrogenase 0.0016 0.001 0.0007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0174 0.0684
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.018 0.0371
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0054 0.034 0.134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0254 0.1002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0021 0.0085
Loa Loa (eye worm) hypothetical protein 0.0054 0.034 0.0337
Echinococcus multilocularis RNA directed DNA polymerase 0.009 0.0653 0.096
Schistosoma mansoni hypothetical protein 0.0075 0.0522 0.206
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.001 0.0018
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Brugia malayi nuclear hormone receptor family member odr-7 0.0048 0.029 0.029
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.004 0.0221 0.0436
Loa Loa (eye worm) nuclear hormone receptor 0.0048 0.029 0.0286
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0385 0.08
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0007
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0018 0.0027 0.0036
Schistosoma mansoni gliotactin 0.0035 0.0174 0.0684
Loa Loa (eye worm) AGC/PKN protein kinase 0.0021 0.0049 0.0046
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.004 0.0221 0.0872
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0048 0.029 0.0424
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.003 0.004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0713 0.0713
Plasmodium falciparum plasmepsin II 0.0073 0.0508 0.1971
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0016 0.001 0.0011
Echinococcus multilocularis synaptic glycoprotein sc2 0.0307 0.2535 0.3742
Loa Loa (eye worm) hypothetical protein 0.0102 0.0758 0.0756
Echinococcus granulosus steroid dehydrogenase 0.0016 0.001 0.004
Loa Loa (eye worm) hypothetical protein 0.0069 0.047 0.0467
Brugia malayi Bromodomain containing protein 0.0073 0.0506 0.0506
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0097 0.0342
Onchocerca volvulus Phospholipase A2 homolog 0.036 0.2988 0.2981
Loa Loa (eye worm) hypothetical protein 0.0054 0.034 0.0337
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.004 0.0221 0.0436
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0021 0.0049 0.0046
Onchocerca volvulus 0.0018 0.003 0.002
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.004 0.0221 0.0872
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0016 0.001 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0102 0.0758 0.1117
Echinococcus granulosus GPCR family 2 0.0031 0.0137 0.0541
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0137 0.0134
Schistosoma mansoni hypothetical protein 0.0075 0.0522 0.206
Echinococcus multilocularis ephrin type A receptor 4 A 0.0129 0.0986 0.1452
Mycobacterium ulcerans carboxylesterase, LipT 0.0035 0.0174 0.0338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0102 0.0758 0.2991
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0102 0.0758 0.0756
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0016 0.001 0.0018
Mycobacterium tuberculosis Conserved protein 0.0036 0.018 0.0363
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0137 0.0541
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0015 0.006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0102 0.0758 0.0758
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0016 0.001 0.0018
Leishmania major hypothetical protein, conserved 0.0016 0.001 0.0018
Onchocerca volvulus 0.0036 0.018 0.017
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.004 0.0221 0.0322
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Brugia malayi aspartic protease BmAsp-1, identical 0.0017 0.0021 0.0021
Loa Loa (eye worm) oxidoreductase 0.0016 0.001 0.0007
Plasmodium vivax plasmepsin IV, putative 0.0073 0.0508 0.1971
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.03 0.0439
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0102 0.0758 0.0756
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0102 0.0758 0.0758
Schistosoma mansoni thyroid hormone receptor 0.0102 0.0758 0.2991
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0307 0.2535 0.5228
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.001 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.003 0.003
Brugia malayi nuclear hormone receptor family member nhr-6 0.0048 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0307 0.2535 0.2533
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0102 0.0758 0.1117
Loa Loa (eye worm) dehydrogenase 0.0016 0.001 0.0007
Leishmania major short chain dehydrogenase/reductase, putative 0.0016 0.001 0.0018
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0102 0.0758 0.2991
Entamoeba histolytica methionine aminopeptidase, putative 0.0044 0.0255 0.0507
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0021 0.0085
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0574 0.485 0.8798
Trichomonas vaginalis spcc417.12 protein, putative 0.0035 0.0174 0.0358
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0307 0.2535 0.46
Loa Loa (eye worm) hypothetical protein 0.0037 0.0196 0.0193
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0108 0.0809 0.1468
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0174 0.0349
Plasmodium falciparum plasmepsin X 0.0017 0.0021 0.0045
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0054 0.034 0.0337
Loa Loa (eye worm) aspartyl protease 6 0.0017 0.0021 0.0018
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.001 0.0021
Loa Loa (eye worm) steroid hormone receptor 0.0102 0.0758 0.0756
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0017 0.0021 0.0023
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0042 0.0232 0.0421
Onchocerca volvulus 0.0651 0.5512 0.5507
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0021 0.0049 0.0194
Echinococcus multilocularis ecdysone induced protein 78C 0.0102 0.0758 0.1117
Brugia malayi p70 ribosomal S6 kinase beta 0.0021 0.0049 0.0049
Echinococcus multilocularis neuroligin 0.0035 0.0174 0.0252
Brugia malayi beta-lactamase family protein 0.0036 0.018 0.018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0254 0.0251
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.0021 0.0045
Leishmania major pteridine reductase 1 0.0016 0.001 0.0018
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.003 0.004
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0016 0.001 0.0043
Echinococcus granulosus ephrin type A receptor 4 A 0.0129 0.0986 0.3887
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Echinococcus multilocularis methionyl aminopeptidase 2 0.0044 0.0255 0.0373
Onchocerca volvulus 0.0036 0.018 0.017
Schistosoma mansoni nAChR subunit 0.0018 0.003 0.0118
Echinococcus granulosus neuroligin 0.0035 0.0174 0.0684
Schistosoma mansoni pyruvate dehydrogenase 0.0113 0.0847 0.3342
Loa Loa (eye worm) hypothetical protein 0.0218 0.1759 0.1756
Loa Loa (eye worm) AGC/NDR protein kinase 0.0021 0.0049 0.0046
Echinococcus multilocularis GPCR, family 2 0.0031 0.0137 0.0198
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.017
Schistosoma mansoni hypothetical protein 0.002 0.0046 0.018
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0044 0.0255 0.0507
Plasmodium vivax aspartyl protease, putative 0.0017 0.0021 0.0045
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0021 0.0049 0.0194
Schistosoma mansoni cathepsin D (A01 family) 0.0073 0.0508 0.2003
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0307 0.2535 1
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0017 0.0016 0.0019
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0102 0.0758 0.2991
Schistosoma mansoni hypothetical protein 0.0169 0.1337 0.5272
Echinococcus multilocularis acetylcholinesterase 0.0207 0.1662 0.2452
Brugia malayi hypothetical protein 0.0017 0.0021 0.0021
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0016 0.001 0.0018
Toxoplasma gondii aspartyl protease ASP3 0.0017 0.0021 0.0023
Leishmania major geranylgeranyltransferase, putative 0.004 0.0221 0.04
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.029 0.0424
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.003 0.0027
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.003 0.0118
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0307 0.2535 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0054 0.034 0.134
Mycobacterium ulcerans hypothetical protein 0.0574 0.485 1
Echinococcus multilocularis conserved hypothetical protein 0.0016 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Plasmodium falciparum plasmepsin III 0.0017 0.0021 0.0045
Echinococcus granulosus serine:threonine protein kinase N2 0.0021 0.0049 0.0194
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0021 0.0085
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0137 0.0198
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0048 0.029 0.029
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.003 0.003
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0887 0.0884
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0175 0.0254
Echinococcus granulosus nuclear receptor nhr 48 0.0048 0.029 0.1142
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.0976 0.3849
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.018 0.0326
Giardia lamblia Methionine aminopeptidase 0.0044 0.0255 0.0971
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0042 0.0232 0.0459
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.003 0.0118
Brugia malayi beta-lactamase 0.0036 0.018 0.018
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0574 0.485 0.8798
Schistosoma mansoni nuclear hormone receptor 0.0048 0.029 0.1142
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0062 0.0087
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0526 0.5
Brugia malayi nuclear receptor NHR-67 0.0048 0.029 0.029
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0049 0.0194
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.029 0.1142
Echinococcus multilocularis voltage gated potassium channel 0.0018 0.0027 0.0036
Schistosoma mansoni protein kinase C 0.0017 0.0016 0.0061
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.018 0.0363
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0021 0.0049 0.0068
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.029 0.028
Schistosoma mansoni neuroligin 3 (S09 family) 0.0035 0.0174 0.0684
Trypanosoma cruzi short chain dehydrogenase, putative 0.0016 0.001 0.0018
Mycobacterium leprae Probable oxidoreductase 0.0016 0.001 0.0043
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0137 0.0198
Brugia malayi orphan nuclear receptor NR2E1 0.0048 0.029 0.029
Mycobacterium tuberculosis Carboxylesterase LipT 0.0035 0.0174 0.0349
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.018 0.0363
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0119 0.0905 0.1333
Loa Loa (eye worm) hypothetical protein 0.0213 0.1715 0.1713
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.009 0.0653 0.096
Brugia malayi PHD-finger family protein 0.0024 0.0082 0.0082
Entamoeba histolytica protein kinase, putative 0.0021 0.0049 0.008
Schistosoma mansoni carbonyl reductase 0.0016 0.001 0.004
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.004 0.0221 0.0221
Echinococcus granulosus voltage gated potassium channel 0.0018 0.0027 0.0107
Trypanosoma brucei lanosterol synthase 0.0295 0.2429 0.4407
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0102 0.0758 0.1117
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0102 0.0758 0.2991
Mycobacterium tuberculosis Conserved protein 0.0036 0.018 0.0363
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0307 0.2535 0.46
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0574 0.485 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0021 0.0085
Echinococcus granulosus carbonyl reductase 1 0.0016 0.001 0.004
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.003 0.004
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0016 0.001 0.0018
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0102 0.0758 0.2991
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0048 0.029 0.1142
Mycobacterium ulcerans hypothetical protein 0.0036 0.018 0.0351
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0048 0.029 0.1142
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.003 0.003
Echinococcus multilocularis endothelin converting enzyme 1 0.0288 0.2367 0.3493
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0574 0.485 0.8798
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0177
Schistosoma mansoni hypothetical protein 0.0066 0.0446 0.176
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0526 0.1066
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0307 0.2535 0.5228
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0075 0.0522 0.206
Schistosoma mansoni steroid hormone receptor ad4bp 0.0102 0.0758 0.2991
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0102 0.0758 0.2991
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Echinococcus granulosus carbonyl reductase 1 0.0016 0.001 0.004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0102 0.0758 0.2991
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0016 0.001 0.0018
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.004 0.0221 0.0436
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.003 0.004
Schistosoma mansoni steroid dehydrogenase 0.0016 0.001 0.004
Onchocerca volvulus 0.0017 0.0021 0.0011
Schistosoma mansoni zinc finger protein 0.0019 0.0037 0.0144
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0713 0.0713
Mycobacterium leprae conserved hypothetical protein 0.0036 0.018 0.0761
Loa Loa (eye worm) hypothetical protein 0.0102 0.0758 0.0756
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0073 0.0508 0.0505
Trypanosoma cruzi protein farnesyltransferase, putative 0.004 0.0221 0.04
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0049 0.0101
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.001 0.0018
Leishmania major developmentally regulated phosphoprotein-like protein 0.0119 0.0905 0.1641
Echinococcus granulosus synaptic glycoprotein sc2 0.0307 0.2535 1
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0027 0.0107
Loa Loa (eye worm) hypothetical protein 0.0218 0.1759 0.1756
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0526 0.2074
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0145 0.113 0.4457
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0137 0.0137
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0213 0.1715 0.1713
Leishmania major short chain dehydrogenase, putative 0.0016 0.001 0.0018
Schistosoma mansoni hypothetical protein 0.0169 0.1337 0.5272
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0307 0.2535 0.5218
Onchocerca volvulus Phospholipase A2 homolog 0.1168 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0102 0.0758 0.1117
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.003 0.0118
Onchocerca volvulus 0.0036 0.018 0.017
Brugia malayi hypothetical protein 0.0054 0.034 0.034
Plasmodium falciparum polyprenol reductase, putative 0.0307 0.2535 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0102 0.0758 0.0756
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0044 0.0255 0.0527
Schistosoma mansoni steroid dehydrogenase 0.0016 0.001 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.018 0.0326
Trypanosoma cruzi phospholipase A1, putative 0.0651 0.5512 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0174 0.0684
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0651 0.5512 0.5512
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.004 0.0221 0.0221
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.001 0.0018
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0102 0.0758 0.2991
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.001 0.0021
Leishmania major sterol 24-c-methyltransferase, putative 0.0208 0.167 0.303
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0012
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.004 0.0221 0.0218
Echinococcus granulosus thyroid hormone receptor alpha 0.0048 0.029 0.1142
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0446 0.0446
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.003 0.003
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0376 0.0552
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.001 0.0021
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.007 0.0479 0.1888
Loa Loa (eye worm) oxidoreductase 0.0016 0.001 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0003 0.0012
Plasmodium falciparum plasmepsin V 0.0017 0.0021 0.0045
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0094 0.069 0.0687
Leishmania major hypothetical protein, conserved 0.0016 0.001 0.0018
Brugia malayi Carboxylesterase family protein 0.0035 0.0174 0.0174
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0018 0.0027 0.0027
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0016 0.001 0.0011
Trypanosoma brucei oxidoreductase-like protein 0.0016 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Trypanosoma brucei rac serine-threonine kinase, putative 0.0021 0.0049 0.0089
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0574 0.485 0.485
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.001 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0254 0.1002
Brugia malayi nuclear receptor RXR 0.0054 0.034 0.034
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0044 0.0255 0.0527
Schistosoma mansoni protein farnesyltransferase subunit beta 0.004 0.0221 0.0872
Brugia malayi kinase, mitochondrial precursor 0.0119 0.0905 0.0905
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0102 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.017
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0208 0.167 0.303
Echinococcus granulosus protein kinase c iota type 0.0034 0.0169 0.0667
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0102 0.0758 0.0756
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0307 0.2535 0.5218
Trypanosoma brucei Sterol methyltransferase, putative 0.0208 0.167 0.303
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0049 0.0101
Mycobacterium leprae probable zinc metalloprotease 0.0288 0.2367 1
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.003 0.0118
Loa Loa (eye worm) hypothetical protein 0.0073 0.0508 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0102 0.0758 0.0758
Plasmodium falciparum plasmepsin IV 0.0073 0.0508 0.1971
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0017 0.0016 0.0061
Loa Loa (eye worm) hypothetical protein 0.0574 0.485 0.4848
Schistosoma mansoni serine/threonine kinase 0.0021 0.0049 0.0194
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0102 0.0758 0.0749
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.018 0.0177
Brugia malayi oxidoreductase 0.0016 0.001 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0102 0.0758 0.2991
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0713 0.071
Echinococcus granulosus Protein kinase C brain isozyme 0.0127 0.0976 0.3849
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0048 0.029 0.1142
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0015 0.006
Toxoplasma gondii aspartyl protease 0.0017 0.0021 0.0023
Echinococcus multilocularis steroid dehydrogenase 0.0016 0.001 0.0011
Echinococcus granulosus protein kinase c epsilon type 0.0037 0.0194 0.0765
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0385 0.0774
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0049 0.0101
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0021 0.0085
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0044 0.0255 0.0463
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0177
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0307 0.2535 1
Brugia malayi ecdysone receptor 0.0048 0.029 0.029
Leishmania major hypothetical protein, conserved 0.0036 0.018 0.0326
Echinococcus granulosus acetylcholinesterase 0.0207 0.1662 0.6556
Loa Loa (eye worm) hypothetical protein 0.0076 0.0526 0.0523
Onchocerca volvulus 0.0651 0.5512 0.5507
Loa Loa (eye worm) hypothetical protein 0.0054 0.034 0.0337
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.004 0.0221 0.0436
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0016 0.0012 0.0022
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0016 0.001 0.0043
Brugia malayi nuclear receptor NHR-88 0.0102 0.0758 0.0758
Echinococcus granulosus acetylcholinesterase 0.0207 0.1662 0.6556
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.003 0.003
Onchocerca volvulus 0.0035 0.0174 0.0164
Onchocerca volvulus Bile acid receptor homolog 0.0102 0.0758 0.0749
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.003 0.004
Mycobacterium ulcerans beta-lactamase 0.0036 0.018 0.0351
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0021 0.0085
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.004 0.0221 0.04
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0102 0.0758 0.2991
Brugia malayi aspartic protease BmAsp-2, identical 0.0017 0.0021 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0254 0.1002
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.007 0.0479 0.1888
Schistosoma mansoni retinoic acid receptor RXR 0.0102 0.0758 0.2991
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0003 0.0011
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0048 0.029 0.0424
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0526 0.1066
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0015 0.006
Echinococcus multilocularis serine:threonine protein kinase 38 0.0021 0.0049 0.0068
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0037 0.0194 0.0191
Schistosoma mansoni coup transcription factor 0.0102 0.0758 0.2991
Schistosoma mansoni steroid dehydrogenase 0.0016 0.001 0.004
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0035 0.0174 0.0252
Brugia malayi hypothetical protein 0.0016 0.0007 0.0007
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.004 0.0221 0.0436
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0035 0.0174 0.0684
Brugia malayi hypothetical protein 0.0054 0.034 0.034
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0046 0.0042
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.003 0.004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0526 0.2042
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.004 0.0221 0.0221
Brugia malayi Carboxylesterase family protein 0.0035 0.0174 0.0174
Onchocerca volvulus 0.0018 0.003 0.002
Schistosoma mansoni neprilysin-2 (M13 family) 0.0145 0.113 0.4457
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0044 0.0255 0.0463
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0016 0.001 0.0011
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0016 0.001 0.004
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.034 0.034
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0049 0.0101
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0082 0.0148
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Loa Loa (eye worm) hypothetical protein 0.0143 0.1107 0.1105
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0015 0.0018
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.007 0.0479 0.1888
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0082 0.0148
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0016 0.001 0.0018
Brugia malayi Peptidase family M13 containing protein 0.0288 0.2367 0.2367
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0073 0.0508 0.2003
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0298 0.2458 0.4458
Schistosoma mansoni unc-13 (munc13) 0.0017 0.0016 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0015 0.006
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.029 0.1142
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.003 0.0118
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0016 0.001 0.0007
Plasmodium vivax farnesyltransferase beta subunit, putative 0.004 0.0221 0.0835
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0049 0.0194
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0102 0.0758 0.1117
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0016 0.001 0.0043
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.004 0.0221 0.0456
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.003 0.0118
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.001 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.0102 0.0758 0.0758
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0049 0.0101
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.004 0.0221 0.0456
Schistosoma mansoni memapsin-2 (A01 family) 0.0017 0.0021 0.0085
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0298 0.2458 0.4458
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.003 0.003
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0049 0.0101
Mycobacterium ulcerans zinc metalloprotease 0.0288 0.2367 0.4869
Plasmodium vivax methionine aminopeptidase 2, putative 0.0044 0.0255 0.0971
Leishmania major dehydrogenase-like protein 0.0016 0.001 0.0018
Brugia malayi Dehydrogenases, short chain protein 30 0.0016 0.001 0.001
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.03 0.0619
Schistosoma mansoni nAChR subunit 0.0018 0.003 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0221 0.04
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0016 0.001 0.0021
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0288 0.2367 0.5032
Schistosoma mansoni steroid dehydrogenase 0.0016 0.001 0.004
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0082 0.0284
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.003 0.004
Plasmodium falciparum plasmepsin VI 0.0073 0.0508 0.1971
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0376 0.1484
Echinococcus granulosus NDR protein kinase 0.0021 0.0049 0.0194
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0073 0.0508 0.2003
Echinococcus multilocularis protein kinase c epsilon type 0.0037 0.0194 0.0282
Schistosoma mansoni pyruvate dehydrogenase 0.0119 0.0905 0.3569
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0016 0.001 0.0011
Echinococcus granulosus oxidoreductase 0.0016 0.001 0.004
Loa Loa (eye worm) hypothetical protein 0.0307 0.2535 0.2533
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0049 0.0101
Leishmania major sterol 24-c-methyltransferase, putative 0.0208 0.167 0.303
Brugia malayi Cation transporter family protein 0.0018 0.003 0.003
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.003 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0221 0.04
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0307 0.2535 0.5218
Loa Loa (eye worm) hypothetical protein 0.0218 0.1759 0.1756
Entamoeba histolytica protein kinase, putative 0.0021 0.0049 0.008
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.018 0.0371
Brugia malayi Protein kinase c protein 2 0.0108 0.081 0.081
Schistosoma mansoni acetylcholinesterase 0.0035 0.0174 0.0684
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0019 0.0037 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0254 0.1002
Loa Loa (eye worm) TK/EPH protein kinase 0.0163 0.1288 0.1285
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.004 0.0221 0.04
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0177
Mycobacterium leprae Probable lipase LipE 0.0036 0.018 0.0761
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.017
Loa Loa (eye worm) oxidoreductase 0.0016 0.001 0.0007
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0385 0.0565
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Schistosoma mansoni neprilysin 0.0075 0.0522 0.206
Schistosoma mansoni atypical protein kinase C 0.0034 0.0169 0.0667
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0015 0.0018
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0102 0.0758 0.2991
Echinococcus multilocularis serine:threonine protein kinase N2 0.0021 0.0049 0.0068
Loa Loa (eye worm) hypothetical protein 0.0102 0.0758 0.0756
Loa Loa (eye worm) ACC-1 protein 0.0018 0.003 0.0027
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0101 0.0748 0.0748
Leishmania major hypothetical protein, conserved 0.0016 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.004 0.0221 0.0218
Onchocerca volvulus 0.0018 0.003 0.002
Brugia malayi ecdysteroid receptor 0.0102 0.0758 0.0758
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.004 0.0221 0.0835
Schistosoma mansoni steroid dehydrogenase 0.0016 0.001 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0049 0.0194
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.004 0.0221 0.0322
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0079
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1846 0.392
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.018 0.0363
Schistosoma mansoni nAChR subunit 0.0018 0.003 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0102 0.0758 0.0758
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0027 0.0107
Echinococcus multilocularis acetylcholinesterase 0.0207 0.1662 0.2452
Echinococcus multilocularis steroid dehydrogenase 0.0016 0.001 0.0011
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0887 0.0884
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0082 0.0148
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.034 0.034
Onchocerca volvulus 0.0035 0.0174 0.0164
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0101 0.0748 0.0745
Loa Loa (eye worm) hypothetical protein 0.0104 0.0773 0.077
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0307 0.2535 0.5228
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0016 0.001 0.004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0054 0.034 0.0498
Entamoeba histolytica protein kinase, putative 0.0021 0.0049 0.008
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Onchocerca volvulus 0.0018 0.003 0.002
Loa Loa (eye worm) oxidoreductase 0.0016 0.001 0.0007
Brugia malayi Carboxylesterase family protein 0.0207 0.1662 0.1662
Schistosoma mansoni nAChR subunit 0.0018 0.003 0.0118
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0007
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0574 0.485 1
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0307 0.2535 1
Echinococcus granulosus zinc finger protein 0.0019 0.0037 0.0144
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.003 0.0118
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0027 0.0107
Echinococcus granulosus raf serine:threonine protein kinase 0.0015 0.0003 0.0011
Loa Loa (eye worm) peptidase family M13 containing protein 0.0213 0.1715 0.1713
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.003 0.0118
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0208 0.167 0.303
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.001 0.0011
Trypanosoma brucei phospholipase A1, putative 0.0651 0.5512 1
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.001 0.0018
Leishmania major phospholipase A1, putative 0.0651 0.5512 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0015 0.006
Echinococcus multilocularis zinc finger protein 0.0019 0.0037 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0027 0.0107
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0288 0.2367 0.2367
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0526 0.1066
Onchocerca volvulus 0.0035 0.0174 0.0164
Brugia malayi steroid hormone receptor 0.0102 0.0758 0.0758
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0119 0.0905 0.1333
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0385 0.0774
Echinococcus multilocularis serine threonine protein kinase 0.0114 0.0856 0.1261
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.029 0.1142
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0574 0.485 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0758 0.0756
Echinococcus multilocularis nuclear receptor nhr 48 0.0048 0.029 0.0424
Echinococcus granulosus geminin 0.0169 0.1337 0.5272
Brugia malayi Carboxylesterase family protein 0.0035 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0288 0.2367 0.2364
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Onchocerca volvulus Protein ultraspiracle homolog 0.0102 0.0758 0.0749
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0016 0.001 0.0011
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Schistosoma mansoni steroid dehydrogenase 0.0016 0.001 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0044 0.0255 0.0245
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0097 0.0408
Echinococcus granulosus nAChR subunit 0.0018 0.003 0.0118
Loa Loa (eye worm) oxidoreductase 0.0016 0.001 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.001 0.0018
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0027 0.0107
Brugia malayi Protein kinase domain containing protein 0.0021 0.0049 0.0049
Brugia malayi Cation transporter family protein 0.0018 0.003 0.003
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0163 0.1287 0.2727
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0208 0.167 0.303
Schistosoma mansoni nuclear receptor 0.0048 0.029 0.1142
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Brugia malayi nuclear receptor RXR 0.0048 0.029 0.029
Plasmodium vivax plasmepsin V, putative 0.0017 0.0021 0.0045
Giardia lamblia Prenyltransferase 0.004 0.0221 0.0835
Echinococcus multilocularis carboxylesterase 5A 0.0207 0.1662 0.2452
Brugia malayi beta-lactamase family protein 0.0036 0.018 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0102 0.0758 0.0756
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.003 0.003
Toxoplasma gondii hypothetical protein 0.0026 0.0097 0.0178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.017
Trichomonas vaginalis steroid dehydrogenase, putative 0.0016 0.001 0.0021
Loa Loa (eye worm) oxidoreductase 0.0016 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0097 0.0713 0.071
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0049 0.0194
Loa Loa (eye worm) hypothetical protein 0.0054 0.034 0.0337
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0385 0.0774
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0574 0.485 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0446 0.0443
Brugia malayi initiation factor 2-associated protein. 0.0044 0.0255 0.0255
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.003 0.003
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.004 0.0221 0.0322
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.001 0.0021
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0127 0.0976 0.1438
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0254 0.0371
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.001 0.0018
Schistosoma mansoni hypothetical protein 0.0031 0.0137 0.0541
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0044 0.0255 0.0463
Onchocerca volvulus 0.0035 0.0174 0.0164
Brugia malayi Bromodomain containing protein 0.0037 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0102 0.0758 0.0756
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0042 0.0232 0.0421
Entamoeba histolytica hypothetical protein 0.0307 0.2535 0.5218
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.004 0.0221 0.0835
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.003 0.004
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0044 0.0255 0.0527
Leishmania major hypothetical protein, conserved 0.0016 0.001 0.0018
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0016 0.001 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.001 0.0018
Trypanosoma cruzi phospholipase A1, putative 0.0651 0.5512 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.029 0.028
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.018 0.018
Schistosoma mansoni steroid dehydrogenase 0.0016 0.001 0.004
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0016 0.001 0.004
Loa Loa (eye worm) beta-lactamase 0.0036 0.018 0.0177
Loa Loa (eye worm) hypothetical protein 0.0065 0.0432 0.0429
Echinococcus granulosus para nitrobenzyl esterase 0.0035 0.0174 0.0684
Schistosoma mansoni nuclear receptor nhr-48 0.0048 0.029 0.1142
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0007
Schistosoma mansoni hypothetical protein 0.0031 0.0137 0.0541
Trypanosoma cruzi protein farnesyltransferase, putative 0.004 0.0221 0.04
Plasmodium vivax aspartyl protease, putative 0.0017 0.0021 0.0045
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.004 0.0221 0.0872
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0016 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.036 0.2988 0.2986
Echinococcus multilocularis geminin 0.0169 0.1337 0.1971
Schistosoma mansoni pyruvate dehydrogenase 0.0113 0.0847 0.3342
Brugia malayi nuclear hormone receptor 0.0048 0.029 0.029
Echinococcus granulosus protein kinase C gamma type 0.0114 0.0856 0.3376
Plasmodium vivax aspartyl proteinase, putative 0.0073 0.0508 0.1971
Schistosoma mansoni nuclear receptor 0.0048 0.029 0.1142
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0015 0.006
Schistosoma mansoni unc-13 (munc13) 0.0017 0.0016 0.0061
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0075 0.0522 0.206
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0016 0.001 0.0018
Onchocerca volvulus 0.0307 0.2535 0.2528
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Brugia malayi Pepsin A precursor 0.0017 0.0021 0.0021
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0102 0.0758 0.0756
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.017
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.0976 0.3849
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0054 0.034 0.0337
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0021 0.0049 0.0068
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0016 0.001 0.001
Onchocerca volvulus 0.0018 0.003 0.002
Echinococcus multilocularis retinol dehydrogenase 11 0.0016 0.001 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.003 0.003
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0021 0.0049 0.0068
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0021 0.0049 0.0046
Schistosoma mansoni retinal dehydrogenase 0.0016 0.001 0.004
Trypanosoma brucei protein farnesyltransferase beta subunit 0.004 0.0221 0.04
Plasmodium falciparum plasmepsin VIII, putative 0.0017 0.0021 0.0045
Brugia malayi tailless protein 0.0048 0.029 0.029
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.003 0.003
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.003 0.004
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0.0021 0.0018
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0102 0.0758 0.0758
Plasmodium vivax hypothetical protein, conserved 0.0036 0.018 0.0672
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.003 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.018 0.0326
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0021 0.0049 0.0046
Leishmania major short chain dehydrogenase/reductase, putative 0.0016 0.001 0.0018
Echinococcus granulosus peptidase Clp S14 family 0.005 0.03 0.1184
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.004 0.0221 0.0436
Echinococcus granulosus methionyl aminopeptidase 2 0.0044 0.0255 0.1007
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0016 0.001 0.001
Brugia malayi Nuclear hormone receptor E75 0.0048 0.029 0.029
Brugia malayi protein kinase C3,putative 0.0015 0.0003 0.0003
Brugia malayi Hr1 repeat family protein 0.0021 0.0049 0.0049
Onchocerca volvulus 0.0048 0.029 0.028
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.018 0.0363
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Trypanosoma cruzi short chain dehydrogenase, putative 0.0016 0.001 0.0018
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0016 0.001 0.004
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.004 0.0221 0.0872
Schistosoma mansoni hypothetical protein 0.0031 0.0137 0.0541
Schistosoma mansoni ephrin receptor 0.0129 0.0986 0.3887
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.003 0.0027
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.018 0.0262
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0208 0.167 0.303
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Echinococcus multilocularis nAChR subunit 0.0018 0.003 0.004
Schistosoma mansoni BC026374 protein (S09 family) 0.0035 0.0174 0.0684
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0073 0.0508 0.1047
Plasmodium falciparum protein farnesyltransferase subunit beta 0.004 0.0221 0.0835
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0102 0.0758 0.1117
Echinococcus granulosus FTZ F1 alpha 0.0102 0.0758 0.2991
Brugia malayi Protein kinase domain containing protein 0.0021 0.0049 0.0049
Schistosoma mansoni protein kinase C mu 0.0015 0.0003 0.0012
Echinococcus granulosus BC026374 protein S09 family 0.0035 0.0174 0.0684
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0307 0.2535 0.3742
Mycobacterium ulcerans lipase LipD 0.0036 0.018 0.0351
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.001 0.0018
Brugia malayi hypothetical protein 0.0016 0.001 0.001
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0082 0.0148
Loa Loa (eye worm) ACC-1 protein 0.0018 0.003 0.0027
Leishmania major oxidoreductase-like protein 0.0016 0.001 0.0018
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.003 0.0027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0137 0.0541
Loa Loa (eye worm) hypothetical protein 0.0127 0.0973 0.0971
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0213 0.1715 0.1713
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0119 0.0905 0.3569
Echinococcus multilocularis protein kinase c iota type 0.0034 0.0169 0.0245
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0016 0.001 0.0018
Brugia malayi Steroid receptor seven-up type 2 0.0102 0.0758 0.0758
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0015 0.0003 0.0003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.003 0.003
Loa Loa (eye worm) carboxylesterase 0.0035 0.0174 0.017
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Plasmodium falciparum plasmepsin I 0.0073 0.0508 0.1971
Echinococcus granulosus hypothetical protein 0.0016 0.001 0.004
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.03 0.1269
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0137 0.0137
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0049 0.0101
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.017
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0016 0.001 0.004
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0288 0.2367 0.9334
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.003 0.004
Schistosoma mansoni steroid dehydrogenase 0.0016 0.001 0.004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.017
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0097 0.0342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0102 0.0758 0.0756
Toxoplasma gondii peptidase family M13 protein 0.0288 0.2367 0.4869
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.003 0.0118
Plasmodium vivax polyprenol reductase, putative 0.0307 0.2535 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0035 0.0174 0.0252
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0018
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0016 0.001 0.004
Brugia malayi peptidase family M13 containing protein 0.007 0.0479 0.0479
Brugia malayi nuclear receptor NHR-88 0.0048 0.029 0.029
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0016 0.001 0.004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0134
Leishmania major methionine aminopeptidase 2, putative 0.0044 0.0255 0.0463
Onchocerca volvulus Putative nachr subunit 0.0018 0.003 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.018 0.0371
Plasmodium falciparum plasmepsin IX 0.0017 0.0021 0.0045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.029 0.0424
Loa Loa (eye worm) zinc metallopeptidase 4 0.007 0.0479 0.0476
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0102 0.0758 0.2991
Brugia malayi Carboxylesterase family protein 0.0035 0.0174 0.0174
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0526 1
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0574 0.485 0.8798
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0102 0.0758 0.0758
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0016 0.001 0.0018
Brugia malayi C1-like domain containing protein 0.0015 0.0003 0.0003
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0016 0.001 0.0018
Schistosoma mansoni zinc finger protein 0.0048 0.029 0.1142
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0049 0.0101
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0003 0.0012
Schistosoma mansoni hypothetical protein 0.0031 0.0137 0.0541
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.018 0.071
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0016 0.001 0.0021
Echinococcus multilocularis serine:threonine protein kinase N2 0.0021 0.0049 0.0068
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0016 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0207 0.1662 0.166
Brugia malayi hypothetical protein 0.0048 0.029 0.029
Onchocerca volvulus 0.0127 0.0973 0.0964
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0016 0.001 0.0018
Trichomonas vaginalis esterase, putative 0.0036 0.018 0.0371
Loa Loa (eye worm) acetylcholinesterase 1 0.0207 0.1662 0.166
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.003 0.0118
Schistosoma mansoni steroid dehydrogenase 0.0016 0.001 0.004
Schistosoma mansoni nAChR subunit 0.0018 0.003 0.0118
Brugia malayi photoreceptor-specific nuclear receptor 0.0102 0.0758 0.0758
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0102 0.0758 0.0758
Brugia malayi hypothetical protein 0.0035 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0651 0.5512 0.551
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0177
Echinococcus granulosus endothelin converting enzyme 1 0.0288 0.2367 0.9334
Brugia malayi Eukaryotic aspartyl protease family protein 0.0017 0.0021 0.0021
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0016 0.001 0.0018
Leishmania major farnesyltransferase beta subunit 0.004 0.0221 0.04
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0177
Trypanosoma cruzi lanosterol synthase, putative 0.0295 0.2429 0.4407
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Brugia malayi hypothetical protein 0.0017 0.0021 0.0021
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0213 0.1715 0.1713
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0062 0.0243
Echinococcus granulosus RNA directed DNA polymerase 0.009 0.0653 0.2574
Echinococcus granulosus unc 13 munc13 0.0017 0.0016 0.0061
Echinococcus multilocularis FTZ F1 alpha 0.0102 0.0758 0.1117
Loa Loa (eye worm) oxidoreductase 0.0016 0.001 0.0007
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0174 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.2535 0.5228
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Brugia malayi nuclear hormone receptor 0.0102 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0177
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0048 0.029 0.0578
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0174 0.0684
Loa Loa (eye worm) hypothetical protein 0.0119 0.0905 0.0902
Brugia malayi hypothetical protein 0.0024 0.0082 0.0082
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0526 0.5
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0021 0.0085
Leishmania major hypothetical protein, conserved 0.0024 0.0082 0.0148
Toxoplasma gondii aspartyl protease ASP1 0.0073 0.0508 0.1028
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0007
Brugia malayi MH2 domain containing protein 0.0117 0.0887 0.0887
Plasmodium falciparum plasmepsin VII 0.0017 0.0021 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0194 0.0765
Echinococcus multilocularis unc 13 (munc13) 0.0017 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0102 0.0758 0.0758
Echinococcus multilocularis retinol dehydrogenase 11 0.0016 0.001 0.0011
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0016 0.001 0.0043
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0044 0.0255 0.0463
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.001 0.0021
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.018 0.0351
Loa Loa (eye worm) hypothetical protein 0.0288 0.2367 0.2364
Loa Loa (eye worm) hypothetical protein 0.009 0.0653 0.065
Brugia malayi Protein kinase domain containing protein 0.0015 0.0003 0.0003
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0288 0.2367 0.2364
Leishmania major 3-keto-dihydrosphingosine reductase 0.0016 0.001 0.0018
Trypanosoma brucei developmentally regulated phosphoprotein 0.0119 0.0905 0.1641
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0062 0.0243
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0307 0.2535 0.5228
Loa Loa (eye worm) oxidoreductase 0.0016 0.001 0.0007
Mycobacterium ulcerans short chain dehydrogenase 0.0556 0.4693 0.9676
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.018 0.0371
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.007 0.0479 0.1888
Schistosoma mansoni hypothetical protein 0.0075 0.0522 0.206
Schistosoma mansoni steroid dehydrogenase 0.0016 0.001 0.004
Schistosoma mansoni nuclear hormone receptor 0.0048 0.029 0.1142
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0082 0.0284
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0145 0.113 0.4457
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0307 0.2535 0.5218
Loa Loa (eye worm) hypothetical protein 0.0218 0.1759 0.1756
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0048 0.029 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0102 0.0758 0.0758
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.004 0.0221 0.0456
Loa Loa (eye worm) hypothetical protein 0.0102 0.0758 0.0756
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.018 0.0371
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.003 0.0118
Leishmania major short chain dehydrogenase-like protein 0.0016 0.001 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0102 0.0758 0.0756
Loa Loa (eye worm) hypothetical protein 0.0042 0.0232 0.0229
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.1892 0.1889
Schistosoma mansoni bromodomain containing protein 0.0062 0.0407 0.1604
Giardia lamblia Rab geranylgeranyltransferase 0.004 0.0221 0.0835
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0073 0.0508 0.0746
Brugia malayi Cation transporter family protein 0.0018 0.003 0.003
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0145 0.113 0.4457
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.001 0.0018
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.004 0.0221 0.0456
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0102 0.0758 0.1117
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0307 0.2535 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0286
Brugia malayi Carboxylesterase family protein 0.0207 0.1662 0.1662
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.004 0.0221 0.0456
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.003 0.0118
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.003 0.004
Toxoplasma gondii AGC kinase 0.0021 0.0049 0.008
Loa Loa (eye worm) DR-78 0.0048 0.029 0.0286
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0385 0.1518
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0145 0.113 0.4457
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Echinococcus granulosus protein farnesyltransferase subunit beta 0.004 0.0221 0.0872
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.004 0.0221 0.0456
Brugia malayi Probable ClpP-like protease 0.0076 0.0526 0.0526
Schistosoma mansoni zinc finger protein 0.0015 0 0.0001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0526 0.2222
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0035 0.0174 0.0358
Leishmania major short chain dehydrogenase, putative 0.0016 0.001 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0254 0.0371
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.004 0.0221 0.0456
Loa Loa (eye worm) hypothetical protein 0.0207 0.1662 0.166
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0007
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.003 0.003
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0574 0.485 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.003 0.0118
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.677 1
Leishmania major hypothetical protein, conserved 0.0016 0.001 0.0018
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0016 0.001 0.0018
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0073 0.0508 0.1028
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0207 0.1662 0.6556
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Brugia malayi follicle stimulating hormone receptor 0.0233 0.1892 0.1892
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0385 0.1518
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.003 0.0118
Loa Loa (eye worm) hypothetical protein 0.0218 0.1759 0.1756
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0016 0.001 0.0018
Echinococcus granulosus carbonyl reductase 1 0.0016 0.001 0.004
Mycobacterium tuberculosis Conserved protein 0.0036 0.018 0.0363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0102 0.0758 0.2991
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0082 0.0284
Schistosoma mansoni endothelin-converting enzyme-related 0.007 0.0479 0.1888
Brugia malayi Nuclear hormone receptor E75 0.0048 0.029 0.029
Echinococcus granulosus retinol dehydrogenase 11 0.0016 0.001 0.004
Onchocerca volvulus 0.0143 0.1107 0.1098
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0049 0.0101
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0526 0.2042
Brugia malayi dehydrogenases, short chain protein 2 0.0016 0.001 0.001
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0208 0.167 0.303
Schistosoma mansoni hypothetical protein 0.0075 0.0522 0.206
Echinococcus granulosus retinol dehydrogenase 11 0.0016 0.001 0.004
Toxoplasma gondii ABC1 family protein 0.0036 0.018 0.0351
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0016 0.001 0.0018
Onchocerca volvulus 0.0017 0.0021 0.0011
Schistosoma mansoni nAChR subunit 0.0018 0.003 0.0118
Brugia malayi hypothetical protein 0.0048 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0007
Plasmodium vivax geranylgeranyltransferase, putative 0.004 0.0221 0.0835
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0015 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0102 0.0758 0.0756
Echinococcus granulosus carboxylesterase 5A 0.0207 0.1662 0.6556
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.004 0.0221 0.0456
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.018 0.071
Brugia malayi Dehydrogenases, short chain protein 2 0.0016 0.001 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0385 0.1518
Loa Loa (eye worm) hypothetical protein 0.004 0.0221 0.0218
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.001 0.0018
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0016 0.001 0.0043
Loa Loa (eye worm) carboxylesterase 0.0035 0.0174 0.017
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.003 0.0118
Loa Loa (eye worm) CAMK/CAMKL/PASK protein kinase 0.0149 0.1166 0.1163
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0018 0.0027 0.0107
Echinococcus granulosus ecdysone induced protein 78C 0.0102 0.0758 0.2991
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.004 0.0221 0.0218
Brugia malayi conserved hypotetical protein 0.0048 0.029 0.029
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0526 0.1066
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.03 0.0619
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0027 0.0107
Onchocerca volvulus 0.0035 0.0174 0.0164
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0044 0.0255 0.1007
Echinococcus multilocularis oxidoreductase 0.0016 0.001 0.0011
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.001 0.0018
Schistosoma mansoni nuclear hormone receptor 0.0102 0.0758 0.2991
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0021 0.0085
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0021 0.0049 0.0046
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0016 0.001 0.0018
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.001 0.0011
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0016 0.001 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0102 0.0758 0.0758
Schistosoma mansoni hypothetical protein 0.0075 0.0522 0.206
Giardia lamblia Synaptic glycoprotein SC2 0.0307 0.2535 1
Loa Loa (eye worm) hypothetical protein 0.1168 1 1
Brugia malayi Synaptic glycoprotein SC2 0.0307 0.2535 0.2535
Schistosoma mansoni cathepsin D (A01 family) 0.0073 0.0508 0.2003
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0007
Echinococcus multilocularis para nitrobenzyl esterase 0.0035 0.0174 0.0252
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0119 0.0905 0.1641
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0102 0.0758 0.0758
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.003 0.003
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0526 0.0773
Echinococcus multilocularis transient receptor potential cation channel 0.0016 0.001 0.0011
Loa Loa (eye worm) LGC-31 protein 0.0018 0.003 0.0027
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0526 0.2074
Schistosoma mansoni carbonyl reductase 0.0016 0.001 0.004
Schistosoma mansoni thyroid hormone receptor 0.0102 0.0758 0.2991
Brugia malayi Retinol dehydrogenase 12 0.0016 0.001 0.001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Onchocerca volvulus 0.0048 0.029 0.028
Onchocerca volvulus 0.0017 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Onchocerca volvulus 0.0102 0.0758 0.0749
Plasmodium vivax aspartyl protease, putative 0.0017 0.0021 0.0045
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.001 0.0011
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0385 0.0698
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.029 0.0424
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.018 0.0363
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.034 0.134
Loa Loa (eye worm) carboxylesterase 0.0207 0.1662 0.166
Schistosoma mansoni hypothetical protein 0.0015 0 0.0001
Brugia malayi Protein kinase domain containing protein 0.0021 0.0049 0.0049
Brugia malayi dehydrogenases, short chain protein 9 0.0016 0.001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0254 0.1002
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0007
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0044 0.0255 0.0527
Brugia malayi ephrin receptor 1 precursor 0.0061 0.0403 0.0403
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0175 0.069
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0016 0.001 0.0018
Loa Loa (eye worm) initiation factor 2-associated protein 0.0044 0.0255 0.0252
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0021 0.0049 0.0194
Loa Loa (eye worm) peptidase family M13 containing protein 0.0213 0.1715 0.1713
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0016 0.001 0.001
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0526 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.003 0.003
Echinococcus multilocularis retinol dehydrogenase 13 0.0016 0.001 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0385 0.0774
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.001 0.001
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.003 0.004
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0016 0.001 0.0018
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.004 0.0221 0.0456
Echinococcus granulosus hypothetical protein 0.0016 0.001 0.004
Schistosoma mansoni RAR-like nuclear receptor 0.0102 0.0758 0.2991
Plasmodium falciparum methionine aminopeptidase 2 0.0044 0.0255 0.0971
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.018 0.0351
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.018 0.071
Echinococcus granulosus WW domain containing oxidoreductase 0.0016 0.001 0.004
Loa Loa (eye worm) AGC/AKT protein kinase 0.0021 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0216 0.0213
Onchocerca volvulus 0.0149 0.1166 0.1157
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.001 0.0011
Echinococcus granulosus carbonyl reductase 1 0.0016 0.001 0.004
Schistosoma mansoni carbonyl reductase 0.0016 0.001 0.004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.018 0.0363
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.018 0.0363
Plasmodium falciparum geranylgeranyltransferase, putative 0.004 0.0221 0.0835
Onchocerca volvulus 0.0018 0.003 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0102 0.0758 0.0758
Leishmania major lanosterol synthase, putative 0.0255 0.2079 0.3771
Loa Loa (eye worm) nuclear receptor NHR-67 0.0048 0.029 0.0286
Trypanosoma cruzi lanosterol synthase, putative 0.0295 0.2429 0.4407
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0027
Schistosoma mansoni nAChR subunit 0.0018 0.003 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.2535 0.5228
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.003 0.0118
Brugia malayi hypothetical protein 0.0016 0.001 0.001
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.007 0.0479 0.1888
Loa Loa (eye worm) hypothetical protein 0.0218 0.1759 0.1756
Schistosoma mansoni short chain dehydrogenase 0.0016 0.001 0.004
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.003 0.0118

Activities

Activity type Activity value Assay description Source Reference
Change (binding) = -22 % Inhibition of 5-lipoxygenase pathway in rat polymorphonuclear assay, by ability to inhibit formation of LTB4 AT 10 microM. ChEMBL. 7739006
Change (binding) = -22 % Inhibition of prostaglandin G/H synthase pathway in rat polymorphonuclear assay by ability to inhibit formation of TXB2 at 10 uM. ChEMBL. 7739006
Change (binding) = -22 % Inhibition of 5-lipoxygenase pathway in rat polymorphonuclear assay, by ability to inhibit formation of LTB4 AT 10 microM. ChEMBL. 7739006
Change (binding) = -22 % Inhibition of prostaglandin G/H synthase pathway in rat polymorphonuclear assay by ability to inhibit formation of TXB2 at 10 uM. ChEMBL. 7739006
Change (functional) = -15 % Antiinflammatory activity by rat Carrageenan edema assay at 50 mg/kg peroral administration (3h edema). ChEMBL. 7739006
Change (functional) = -14 % Antiinflammatory activity by rat adjuvant arthritis assay at 30 mg/kg peroral administration (3h edema). ChEMBL. 7739006
Change (binding) = 7 % 5-lipoxygenase Inhibitory activity against rat polymorphonuclear leucocytes using 5-HETE ChEMBL. 7739006
Change (binding) = 7 % Inhibition of Prostaglandin G/H synthase pathway in rat polymorphonuclear assay by ability to inhibit formation of PGE-2 at 10 microM. ChEMBL. 7739006
Change (binding) = 7 % 5-lipoxygenase Inhibitory activity against rat polymorphonuclear leucocytes using 5-HETE ChEMBL. 7739006
Change (binding) = 7 % Inhibition of Prostaglandin G/H synthase pathway in rat polymorphonuclear assay by ability to inhibit formation of PGE-2 at 10 microM. ChEMBL. 7739006

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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