Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 9 | Tested in delayed hypersensitivity skin reaction (DHSR) after subcutaneous administration, activity reported as percent inhibition of erythema/induration of lesion; 9/24 | ChEMBL. | 6218302 |
Inhibition (functional) | < 20 % | The compound was evaluated for the mouse active Arthus (MAA) reaction activity for an ip dose of 150 mg/kg in mouse | ChEMBL. | 6218302 |
Inhibition (functional) | < 20 % | The compound was evaluated for the mouse active Arthus (MAA) reaction activity for an ip dose of 150 mg/kg in mouse | ChEMBL. | 6218302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.