Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Brugia malayi | nuclear hormone receptor | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | squalene synthase, putative | 0.1596 | 1 | 1 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0497 | 0.2955 | 0.5 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.0497 | 0.2955 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0787 | 0.481 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0806 | 0.4934 | 1 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0497 | 0.2955 | 0.5989 |
Trypanosoma cruzi | squalene synthase, putative | 0.1596 | 1 | 1 |
Trypanosoma brucei | squalene synthase, putative | 0.1596 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.2955 | 0.6144 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.2955 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.4699 | 0.977 |
Brugia malayi | nuclear hormone receptor | 0.0787 | 0.481 | 1 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0497 | 0.2955 | 1 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0497 | 0.2955 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | nM | Transcriptional activation in CV-1 cells expressing RAR-alpha receptor;not active | ChEMBL. | 9733501 |
EC50 (binding) | 0 nM | Transcriptional activation in CV-1 cells expressing RAR-alpha receptor;not active | ChEMBL. | 9733501 |
EC50 (binding) | = 140 nM | Transcriptional activation in CV-1 cells expressing RAR-beta receptor | ChEMBL. | 9733501 |
EC50 (binding) | = 140 nM | Transcriptional activation in CV-1 cells expressing RAR-beta receptor | ChEMBL. | 9733501 |
EC50 (binding) | = 330 nM | Transcriptional activation in CV-1 cells expressing RAR-gamma receptor | ChEMBL. | 9733501 |
EC50 (binding) | = 330 nM | Transcriptional activation in CV-1 cells expressing RAR-gamma receptor | ChEMBL. | 9733501 |
EC50 (binding) | = 1100 nM | Transcriptional activation in CV-1 cells expressing RAR-alpha receptor | ChEMBL. | 9733501 |
EC50 (binding) | = 1100 nM | Transcriptional activation in CV-1 cells expressing RAR-alpha receptor | ChEMBL. | 9733501 |
Inhibition (functional) | = 43 % | Inhibition of TPA induced ODC(Ornithine decarboxylase) activity in mice epidermis at 34 nmol in the presence of TPA compared to control value | ChEMBL. | 3612691 |
Inhibition (functional) | = 43 % | Inhibition of TPA induced ODC(Ornithine decarboxylase) activity in mice epidermis at 34 nmol in the presence of TPA compared to control value | ChEMBL. | 3612691 |
Inhibition (functional) | = 92 % | Inhibition of TPA induced ODC(Ornithine decarboxylase) activity in mice epidermis at 17 nmol in the presence of 13-cis-retinoic acid + TPA compared to control value | ChEMBL. | 3612691 |
Inhibition (functional) | = 92 % | Inhibition of TPA induced ODC(Ornithine decarboxylase) activity in mice epidermis at 17 nmol in the presence of 13-cis-retinoic acid + TPA compared to control value | ChEMBL. | 3612691 |
ODC activity (functional) | = 0.14 (nM of CO2) hr-1 (mg of protein)-1 | Inhibition of TPA induced ODC(Ornithine decarboxylase) activity in mice epidermis at 17 nmol in the presence of 13-cis-retinoic acid + TPA | ChEMBL. | 3612691 |
ODC activity (functional) | = 0.14 (nM of CO2) hr-1 (mg of protein)-1 | Inhibition of TPA induced ODC(Ornithine decarboxylase) activity in mice epidermis at 17 nmol in the presence of 13-cis-retinoic acid + TPA | ChEMBL. | 3612691 |
ODC activity (functional) | = 0.95 (nM of CO2) hr-1 (mg of protein)-1 | Inhibition of TPA induced ODC(Ornithine decarboxylase) activity in mice epidermis at 34 nmol in the presence of TPA | ChEMBL. | 3612691 |
ODC activity (functional) | = 0.95 (nM of CO2) hr-1 (mg of protein)-1 | Inhibition of TPA induced ODC(Ornithine decarboxylase) activity in mice epidermis at 34 nmol in the presence of TPA | ChEMBL. | 3612691 |
ODC activity (functional) | = 1.67 (nM of CO2) hr-1 (mg of protein)-1 | Inhibition of TPA induced ODC(Ornithine decarboxylase) activity in mice epidermis at 0 nmol in the presence of acetone+ TPA | ChEMBL. | 3612691 |
ODC activity (functional) | = 1.67 (nM of CO2) hr-1 (mg of protein)-1 | Inhibition of TPA induced ODC(Ornithine decarboxylase) activity in mice epidermis at 0 nmol in the presence of acetone+ TPA | ChEMBL. | 3612691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.