Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 202 aa | 29.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | 0.1754 | 0.442 | 0.4445 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3687 | 0.978 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3687 | 0.978 | 1 |
Brugia malayi | thymidylate synthase | 0.3687 | 0.978 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.3687 | 0.978 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3766 | 1 | 1 |
Onchocerca volvulus | 0.3687 | 0.978 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3766 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 0.0132 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 0.0132 | 0.0135 |
Brugia malayi | hypothetical protein | 0.1754 | 0.442 | 0.4445 |
Mycobacterium ulcerans | thymidylate synthase | 0.3687 | 0.978 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.3687 | 0.978 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1754 | 0.442 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.3687 | 0.978 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3766 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3766 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3687 | 0.978 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3766 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 61 uM | In vitro activity against the amastigote stage of the parasite cultured in mouse fibroblasts (L-6 cells) | ChEMBL. | 10360757 |
Ki (binding) | = 14.1 nM | Inhibitory activity against Trypanosoma cruzi dihydrofolate reductase | ChEMBL. | 10360757 |
Ki (binding) | = 14.1 nM | Inhibitory activity against Trypanosoma cruzi dihydrofolate reductase | ChEMBL. | 10360757 |
Ki (binding) | = 133 nM | Inhibitory activity against dihydrofolate reductase in humans | ChEMBL. | 10360757 |
Ki (binding) | = 133 nM | Inhibitory activity against dihydrofolate reductase in humans | ChEMBL. | 10360757 |
Selectivity (binding) | = 9.43 | Selectivity for Trypanosoma cruzi dihydrofolate reductase compared to methotrexate | ChEMBL. | 10360757 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.